The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Characterization of biometal profiles in neurological disorders
Abstract
Many neurodegenerative and neuropsychiatric disorders have been reported to coincide with the dysregulation of metal ions in the body and central nervous system. However, in most cases, it is not the imbalance of a single divalent metal ion but a plethora of metal ions reported to be altered. Given that different divalent metal ions are often able to bind to a protein in a competitive manner, although with different affinities, and that they might use similar transporters for uptake and regulation, it is likely that the imbalance of one metal ion will downstream affect the homeostasis of other metal ions. Thus, based on this assumption, we hypothesize that the dysregulation of a specific metal ion will lead to a characteristic biometal profile. Similar profiles might therefore be detected in various neurological disorders. Moreover, if such shared biometal profiles exist across different neurological disorders, it is possible that shared behavioural impairments in these disorders result from the imbalance in metal ion homeostasis. Thus, here, we evaluate the reported excess or deficiency of metal ions in various neurological disorders and aim to integrate reported alterations in metal ions to generate a characteristic biometal profile for the disorder. Based on this, we try to predict which alterations in biometals will be caused by the overload or deficiency of one particular metal ion. Moreover, investigating the behavioural phenotypes of rodent models suffering from alterations in biometals, we assess whether a shared behavioural phenotype exists for disorders with similar biometal profiles. Our results show that observed behavioural aspects of some neurological disorders are reflected in their specific biometal profile and mirrored by mouse models suffering from similar biometal deregulations.
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“Metal ion imbalance in the brain is among the primary triggers in the etiology of AD and hence it is appropriate to tackle this said illness with a chelation therapy technique employing metal ions (Pfaender et al., 2014).”
From An update on the novel and approved drugs for Alzheimer disease (2022) · cites this paper as Pfaender et al., 2014
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Cites
Copper, iron and zinc in Alzheimer's disease senile plaques
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120
The Role of Copper in Neurodegenerative Disease
Waggoner, D., Bartnikas, T. B., & Gitlin, J. D. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0250 · Cited by 864
Geddes, J. R., & Miklowitz, D. J. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60857-0 · Cited by 848
The Genetics of Alzheimer's Disease
Bertram, L., & Tanzi, R. E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00008-4 · Cited by 794
TOXIC AND ESSENTIAL METAL INTERACTIONS
Goyer, R. A. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.37 · Cited by 791
The genetics of Alzheimer disease
Tanzi, R. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006296 · Cited by 727
Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
Platt, F. M., Boland, B., & van der Spoel, A. C. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201208152 · Cited by 689
Colonic inflammation in Parkinson's disease
Devos, D., Lebouvier, T., Lardeux, B., Biraud, M., Rouaud, T., Pouclet, H., Coron, E., Bruley des Varannes, S., Naveilhan, P., Nguyen, J.-M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.09.007 · Cited by 627
Kuchibhotla, K. V., Goldman, S. T., Lattarulo, C. R., Wu, H.-Y., Hyman, B. T., & Bacskai, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.008 · Cited by 614
Miller, L. M., Wang, Q., Telivala, T. P., Smith, R., Lanzirotti, A., & Judith Miklossy, A. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.09.004 · Cited by 588
Flagged first, then by citations
Research works printed but not linked: 22
- Caserta, 2013, Eur. Rev. Med. Pharmacol. Sci., 17, 2198
- Rolston, 2009, Agro Food Ind. Hi-Tech, 19, 33
- Basun, 1991, J. Neural Transm.: Parkinson's Dis. Dementia Sect., 3, 231
- Basha, 2010, Indian J. Exp. Biol., 48, 636
- Schmidt, 2008, Neuropsychiatr., 22, 1
- Blaurock-Busch, 2012, Mædica, 7, 38
- Al-Ayadhi, 2005, Neurosciences, 10, 213
- Franke, 2012, Mol. Psychiatry, 17, 960, 10.1038/mp.2011 · DOI
- Wenk, 1982, Neurotoxicology, 3, 93
- Manser, 1989, J. Pak. Med. Assoc., 39, 269
- Nowak, 2002, Pol. J. Pharmacol., 54, 587
- Wójcik, 2006, Pharmacol. Rep., 58, 571
- Mclardy, 1973, IRCS Med. Sci., 2, 1010
- Rahman, 2009, Biol. Trace Elem. Res., 127, 102
- Younes-Mhenni, 2013, Tunis. Med., 91, 402
- Tolleson, 2013, Discov. Med., 15, 61
- Etebary, 2010, Iran. J. Psychiatry, 5, 40
- Cornett, 1998, Neurotoxicology, 19, 339
- Hill, 1970, Fed. Proc., 29, 1474
- Ranjbar, 2013, Iran. J. Psychiatry, 8, 73
- Grabrucker, 2011, Drug Delivery Lett., 1, 13
- Stedman, 1995, Nutrition, 11, 542
Cited by
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Items 101–118 of 118
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Rainey‐Smith, S. R., Creegan, R., Fuller, S. J., Callisaya, M. L., & Srikanth, V. K. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch5 · Cited by 1
Pakyürek, M., Azarang, A., Iosif, A., & NORDAHL, T. E. (2018) · Acta Psychopathologica · doi:10.4172/2469-6676.100149
Introduction to metallomics: the science of biometals
Grabrucker, A. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821132-8.00001-x
Animal models for trace metal abnormalities—links to autism
Grabrucker, A. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821132-8.00009-4
Medicinal Effect of Zinc for the cure of Autism Spectrum Disorder
Rizwan, B., Sani, A., Niazi, M. K., Azam, M. B., Fatima, T., Bano, S., Jaffar, H. M., & Masood, I. (2022) · Pakistan BioMedical Journal · doi:10.54393/pbmj.v5i1.196
Nutritional Deficiencies in Obsessive-Compulsive Disorder and Possible Treatment Interventions
Sethi, P., Kumar, S., Prajapati, A., Irfanullah, Z., Jatchavala, C., Vadivel, R., & Hayek, S. E. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-5021-6_9
Cezar, L. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2022.tde-20012023-112002
Neurological Health Hazards Associated with Biological Contaminants
Shweta, Yadav, H., Jaldhi, Thapliyal, A., Bakshi, A., Anamika, A., & Maurya, S. K. (2024) · Wiley eBooks · doi:10.1002/9781394178964.ch8
Neurodiversidad y comunidad LGBTQ+ en la FMUS: Prevalencia y percepción social
Ruiz-Padrón, J. I., Vásquez-Lozano, A. P., Salinas-Santander, M. A., & Suárez‐Valencia, V. D. J. (2025) · PSICUMEX · doi:10.36793/psicumex.v15i1.777
Development of chelating materials for localized metal extraction in neurodegenerative diseases
Ariza, J. F. S. (2024) · theses.fr (ABES) · doi:10.70675/f7b37b1dz1608z4009zae5cz453748e7aaaf
Kamareh, P., Hassanpour, S., & Hosseini, R. (2026) · Scientific Reports · doi:10.1038/s41598-026-44929-z
“Furthermore, zinc insufficiency is correlated with symptoms akin to depression, which are well-documented as facilitators of substance-seeking behavior 46 .”
Introduction to Brain Metallomics and Its Relevance to Neuroscience
Lowe, N. M., & Grabrucker, A. M. (2026) · Neuromethods · doi:10.1007/978-1-0716-5468-2_2
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Bederska‐Łojewska, D., Turek, J., & Szewczyk, B. (2026) · Neuromethods · doi:10.1007/978-1-0716-5468-2_10
Foundations of Brain Metallomics
Grabrucker, A. M. (2026) · Neuromethods · doi:10.1007/978-1-0716-5468-2_1
Practical application trends of chromo-fluorogenic sensors in recognition of metal ions
Bumagina, N. A., & Antina, E. V. (2026) · Dyes and Pigments · doi:10.1016/j.dyepig.2026.114178
Metadata
- Authors
- Pfaender, S., & Grabrucker, A. M.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Grabrucker, Andreas M.
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2014
- Volume
- 6
- Issue
- 5
- Pages
- 960-977
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- OpenAlex
- W2018891401
- Cited by
- 117
- References
- 169
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 14 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 11 · 2015: 9 · 2014: 6
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metallomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association (NIRG-12-235441, L.SBN.0083)
- Royal Society
- Royal Society of Chemistry
- Universität Ulm (“Baustein 3.2”)
- International Graduate School in Molecular Medicine Ulm
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- metal homeostasis, neurological disorders, neurodegenerative diseases, neuropsychiatric disorders, metal transporters, behavioral phenotypes, rodent models, metal deficiency
- MeSH terms
- Humans, Metals, Nervous System Diseases
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