Cited by 118Trace Elements in HealthHeavy Metal Exposure and ToxicityNeurological diseases and metabolism

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Characterization of biometal profiles in neurological disorders

Pfaender, Stefanie, Grabrucker, Andreas M.·2014·Metallomics

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Abstract

Many neurodegenerative and neuropsychiatric disorders have been reported to coincide with the dysregulation of metal ions in the body and central nervous system. However, in most cases, it is not the imbalance of a single divalent metal ion but a plethora of metal ions reported to be altered. Given that different divalent metal ions are often able to bind to a protein in a competitive manner, although with different affinities, and that they might use similar transporters for uptake and regulation, it is likely that the imbalance of one metal ion will downstream affect the homeostasis of other metal ions. Thus, based on this assumption, we hypothesize that the dysregulation of a specific metal ion will lead to a characteristic biometal profile. Similar profiles might therefore be detected in various neurological disorders. Moreover, if such shared biometal profiles exist across different neurological disorders, it is possible that shared behavioural impairments in these disorders result from the imbalance in metal ion homeostasis. Thus, here, we evaluate the reported excess or deficiency of metal ions in various neurological disorders and aim to integrate reported alterations in metal ions to generate a characteristic biometal profile for the disorder. Based on this, we try to predict which alterations in biometals will be caused by the overload or deficiency of one particular metal ion. Moreover, investigating the behavioural phenotypes of rodent models suffering from alterations in biometals, we assess whether a shared behavioural phenotype exists for disorders with similar biometal profiles. Our results show that observed behavioural aspects of some neurological disorders are reflected in their specific biometal profile and mirrored by mouse models suffering from similar biometal deregulations.

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“Like NC, PrLD-containing proteins are intrinsic to SGs and can multimerize into Zn2+-dependent LLPS processes of aggregate-prone neurodegenerative disease markers TIA-1, TDP-43, FUS/TLS, Tau, amyloid-β, synucleins, and SOD1 (Caragounis et al., 2010; Garnier et al., 2017; Pfaender and Grabrucker, 2014; Rayman et al., 2…”
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Authors: Pfaender, S., & Grabrucker, A. M.
Affiliations: Universität Ulm (DE)
Corresponding author: Grabrucker, Andreas M.
ORCID: Pfaender, Stefanie
Grabrucker, Andreas M.
Venue: Metallomics
Publisher: Oxford University Press (OUP)
Published: 2014
Volume: 6
Issue: 5
Pages: 960-977
ISSN: 1756-5901 (ISSN-L)
1756-591X
DOI: 10.1039/c4mt00008k
OpenAlex: W2018891401
Cited by: 117
References: 169
Citations by year: 2026: 5 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 14 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 11 · 2015: 9 · 2014: 6
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Locations: Metallomics (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association (NIRG-12-235441, L.SBN.0083)
Royal Society
Royal Society of Chemistry
Universität Ulm (“Baustein 3.2”)
International Graduate School in Molecular Medicine Ulm
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: metal homeostasis, neurological disorders, neurodegenerative diseases, neuropsychiatric disorders, metal transporters, behavioral phenotypes, rodent models, metal deficiency
MeSH terms: Humans, Metals, Nervous System Diseases

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Characterization of biometal profiles in neurological disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

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