Cited by 118Trace Elements in HealthHeavy Metal Exposure and ToxicityNeurological diseases and metabolism

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Characterization of biometal profiles in neurological disorders

Pfaender, Stefanie, Grabrucker, Andreas M.·2014·Metallomics

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Abstract

Many neurodegenerative and neuropsychiatric disorders have been reported to coincide with the dysregulation of metal ions in the body and central nervous system. However, in most cases, it is not the imbalance of a single divalent metal ion but a plethora of metal ions reported to be altered. Given that different divalent metal ions are often able to bind to a protein in a competitive manner, although with different affinities, and that they might use similar transporters for uptake and regulation, it is likely that the imbalance of one metal ion will downstream affect the homeostasis of other metal ions. Thus, based on this assumption, we hypothesize that the dysregulation of a specific metal ion will lead to a characteristic biometal profile. Similar profiles might therefore be detected in various neurological disorders. Moreover, if such shared biometal profiles exist across different neurological disorders, it is possible that shared behavioural impairments in these disorders result from the imbalance in metal ion homeostasis. Thus, here, we evaluate the reported excess or deficiency of metal ions in various neurological disorders and aim to integrate reported alterations in metal ions to generate a characteristic biometal profile for the disorder. Based on this, we try to predict which alterations in biometals will be caused by the overload or deficiency of one particular metal ion. Moreover, investigating the behavioural phenotypes of rodent models suffering from alterations in biometals, we assess whether a shared behavioural phenotype exists for disorders with similar biometal profiles. Our results show that observed behavioural aspects of some neurological disorders are reflected in their specific biometal profile and mirrored by mouse models suffering from similar biometal deregulations.

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Background
Rice: a potential vehicle for micronutrient fortification
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The new role of dipyrromethene chemosensor for absorbance-ratiometic and fluorescence “turn-on” sensing Zn2+ ions in water-organic solutions and real water samples
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“com pathological changes in the neuronal balance of metal ions such as zinc, calcium, iron and copper [3–5] in these diseases.”
Background
N-cadherin-mediated cell adhesion is regulated by extracellular Zn2+
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“Low serum zinc levels were also observed in neuropsychiatric disorders (Pfaender & Grabrucker, 2014), including ASD (Grabrucker, 2014).”
Background
Elemental analysis of hair provides biomarkers of maternal hardship linked to adverse behavioural outcomes in 4-year-old children: The QF2011 Queensland Flood Study
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“Biometals such as zinc, iron, copper, vanadium, and calcium play key roles in diverse physiological processes for living organisms, including humans, but can be toxic in excess [3].”
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“Biometals are considered the trace metals that play a role in the normal body function [1].”
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Authors: Pfaender, S., & Grabrucker, A. M.
Affiliations: Universität Ulm (DE)
Corresponding author: Grabrucker, Andreas M.
ORCID: Pfaender, Stefanie
Grabrucker, Andreas M.
Venue: Metallomics
Publisher: Oxford University Press (OUP)
Published: 2014
Volume: 6
Issue: 5
Pages: 960-977
ISSN: 1756-5901 (ISSN-L)
1756-591X
DOI: 10.1039/c4mt00008k
OpenAlex: W2018891401
Cited by: 117
References: 169
Citations by year: 2026: 5 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 14 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 11 · 2015: 9 · 2014: 6
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Locations: Metallomics (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association (NIRG-12-235441, L.SBN.0083)
Royal Society
Royal Society of Chemistry
Universität Ulm (“Baustein 3.2”)
International Graduate School in Molecular Medicine Ulm
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: metal homeostasis, neurological disorders, neurodegenerative diseases, neuropsychiatric disorders, metal transporters, behavioral phenotypes, rodent models, metal deficiency
MeSH terms: Humans, Metals, Nervous System Diseases

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Characterization of biometal profiles in neurological disorders

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