The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
Selenium, selenoproteins and neurodegenerative diseases
Open accessAbstract
It is unsurprising that our understanding of the role of selenium in neurological function is somewhat immature, considering its relatively recent discovery as an essential element to human health. Selenocysteine, the 21st amino acid, is the defining feature of the 25 selenoprotein-encoding genes so far discovered within the human genome. The low abundance of these proteins in the brain belies the integral role they play in normal neurological function, from well-characterised antioxidant activity in the periphery to poorly understood mechanisms that modulate mitochondrial function and response to brain pathology. Selenium has been identified as playing a role in several neurodegenerative disorders, including Alzheimer's and Parkinson's disease, though its function as a ‘cause or effect’ of disease process remains unclear. This review discusses selenium metabolism in detail, specifically with regard to the role it plays within the central nervous system, and examines the most current literature investigating how selenium may be involved in chronic diseases of the central nervous system.
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Cites
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Self-citationSelenoproteins: Molecular Pathways and Physiological Roles
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Cited by
Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins
Zoidis, E., Seremelis, I., Kontopoulos, N., & Danezis, G. (2018) · Antioxidants · doi:10.3390/antiox7050066 · Cited by 473
Iron and dopamine: a toxic couple
Hare, D. J., & Double, K. L. (2016) · Brain · doi:10.1093/brain/aww022 · Cited by 283
Self-citationDíaz, M., Mesa-Herrera, F., & Marín, R. (2021) · Antioxidants · doi:10.3390/antiox10060907 · Cited by 84
Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review
Alehagen, U., Opstad, T. B., Alexander, J., Larsson, A., & Aaseth, J. (2021) · Biomolecules · doi:10.3390/biom11101478 · Cited by 69
Apolipoprotein E-mediated regulation of selenoprotein P transportation via exosomes
Jin, Y., Chung, Y. W., Jung, M. K., Lee, J. H., Ko, K. Y., Jang, J. K., Ham, M., Kang, H., Pack, C. G., Mihara, H., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03287-y · Cited by 39
Metadata
- Authors
- Cardoso, B. R., Roberts, B. R., Bush, A. I., & Hare, D. J.
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-05-13
- Volume
- 7
- Issue
- 8
- Pages
- 1213-1228
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- OpenAlex
- W2117089459
- Cited by
- 295
- References
- 184
- FWCI
- 20.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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