Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release

Kakde, Deepak; Taresco, Vincenzo; Bansal, Kuldeep K.; Magennis, E. Peter; Howdle, Steven M.; Mantovani, Giuseppe; Irvine, Derek J.; Alexander, Cameron

doi:10.1039/c6tb01839d

Cited by 39Nanoparticle-Based Drug Deliverybiodegradable polymer synthesis and propertiesAdvanced Drug Delivery Systems

Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release

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Kakde, Deepak, Taresco, Vincenzo, Bansal, Kuldeep K., Magennis, E. Peter, Howdle, Steven M., Mantovani, Giuseppe, Irvine, Derek J., Alexander, Cameron·2016·Journal of Materials Chemistry B

DOI 10.1039/c6tb01839d

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Abstract

Block co-polymers with a block derived from a sustainable monomer source are used to encapsulate and release the drug indomethacin.

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The erroneous prediction was attributed to decreased crystallinity of the poly(ε-decalactone) core compared to PCL, which classic Flory-Huggins does not account for.
“The erroneous prediction was attributed to the decreased crystallinity of the poly(ε-decalactone) core compared to PCL that was not accounted for in the classic Flory-Huggins approach.”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [200]
Kakde et al. found that χFH estimates predicted lower indomethacin solubility in poly(ε-decalactone) core than in PCL core, contradicting experimental data.
“The χFH values estimated in this work predicted that the drug solubility in poly(ε-decalactone) core was less than that in PCL core, which contradicted the experimental data.”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [200]

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Authors: Kakde, D., Taresco, V., Bansal, K. K., Magennis, E. P., Howdle, S. M., Mantovani, G., Irvine, D. J., & Alexander, C.
Affiliations: University of Nottingham (GB)
Corresponding author: Irvine, Derek J.
Alexander, Cameron
ORCID: Taresco, Vincenzo
Bansal, Kuldeep K.
Magennis, E. Peter
Howdle, Steven M.
Mantovani, Giuseppe
Irvine, Derek J.
Alexander, Cameron
Venue: Journal of Materials Chemistry B
Publisher: Royal Society of Chemistry (RSC)
Published: 2016
Volume: 4
Issue: 44
Pages: 7119-7129
ISSN: 2050-750X (ISSN-L)
2050-7518
DOI: 10.1039/c6tb01839d
OpenAlex: W2526175804
Cited by: 39
References: 58
Citations by year: 2026: 1 · 2023: 1 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 6
FWCI: 1.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Materials Chemistry B (publishedVersion)
PubMed (publishedVersion)
Repository@Nottingham (University of Nottingham) (acceptedVersion, other-oa)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Åbo Akademi University Research Portal (submittedVersion)
Funders: Engineering and Physical Sciences Research Council (EP/H005625/1, EP/J021180/1)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: amphiphilic block copolymers, polycaprolactone, micelles, drug encapsulation, drug release, Hansen solubility parameters, amorphous content, semicrystalline polymers, indomethacin

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Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release

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