Combatting antibiotic-resistant bacteria using nanomaterials

The antibiotic resistance crisis: part 1: causes and threats.

Ventola, C. L. (2015) · PubMed · Cited by 4,516

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Wang, L., Hu, C., & Shao, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s121956 · Cited by 4,062

Antimicrobial resistance: a global multifaceted phenomenon

Prestinaci, F., Pezzotti, P., & Pantosti, A. (2015) · Pathogens and Global Health · doi:10.1179/2047773215y.0000000030 · Cited by 3,296

The crisis in antibiotic resistance

Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834

Antibacterial properties of nanoparticles

Hajipour, M. J., Fromm, K. M., Akbar Ashkarran, A., Jimenez de Aberasturi, D., Larramendi, I. R. D., Rojo, T., Serpooshan, V., Parak, W. J., & Mahmoudi, M. (2012) · Trends in Biotechnology · doi:10.1016/j.tibtech.2012.06.004 · Cited by 2,710

Integrated Nanoparticle–Biomolecule Hybrid Systems: Synthesis, Properties, and Applications

Katz, E., & Willner, I. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200400651 · Cited by 2,450

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,663

Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains

Goodman, C. M., McCusker, C. D., Yilmaz, T., & Rotello, V. M. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049951i · Cited by 1,601

Nanotechnology as a therapeutic tool to combat microbial resistance

Pelgrift, R. Y., & Friedman, A. J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.011 · Cited by 1,432

Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria

Fayaz, A. M., Balaji, K., Girilal, M., Yadav, R., Kalaichelvan, P. T., & Venketesan, R. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2009.04.006 · Cited by 1,417

The drug-resistant bacteria that pose the greatest health threats

Willyard, C. (2017) · Nature · doi:10.1038/nature.2017.21550 · Cited by 1,221

Toxicology of nanoparticles

Elsaesser, A., & Howard, C. V. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.09.001 · Cited by 895

Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria

Li, X., Robinson, S. M., Gupta, A., Saha, K., Jiang, Z., Moyano, D. F., Sahar, A., Riley, M. A., & Rotello, V. M. (2014) · ACS Nano · doi:10.1021/nn5042625 · Cited by 765

Silver bromide nanoparticle/polymer composites: dual action tunable antimicrobial materials

Sambhy, V., MacBride, M. M., Peterson, B. R., & Sen, A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061442z · Cited by 748

Presenting Vancomycin on Nanoparticles to Enhance Antimicrobial Activities

Gu, H., Ho, P. L., Tong, E., Wang, L., & Xu, B. (2003) · Nano Letters · doi:10.1021/nl034396z · Cited by 703

Biodegradable nanostructures with selective lysis of microbial membranes

Nederberg, F., Zhang, Y., Tan, J. P. K., Xu, K., Wang, H., Yang, C., Gao, S., Guo, X. D., Fukushima, K., Li, L., et al. (2011) · Nature Chemistry · doi:10.1038/nchem.1012 · Cited by 614

Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria

Zhao, Y., Tian, Y., Cui, Y., Liu, W., Ma, W., & Jiang, X. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1028843 · Cited by 592

Photothermal Nanotherapeutics and Nanodiagnostics for Selective Killing of Bacteria Targeted with Gold Nanoparticles

Zharov, V. P., Mercer, K. E., Galitovskaya, E. N., & Smeltzer, M. S. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.061895 · Cited by 567

Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics

Radovic-Moreno, A. F., Lu, T. K., Puscasu, V. A., Yoon, C. J., Langer, R., & Farokhzad, O. C. (2012) · ACS Nano · doi:10.1021/nn3008383 · Cited by 539

Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles—A brief study

Nirmala Grace, A., & Pandian, K. (2007) · Colloids and Surfaces A: Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2006.10.024 · Cited by 317

Bacterial Toxin-Triggered Drug Release from Gold Nanoparticle-Stabilized Liposomes for the Treatment of Bacterial Infection

Pornpattananangkul, D., Zhang, L., Olson, S., Aryal, S., Obonyo, M., Vecchio, K., Huang, C.-M., & Zhang, L. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111110e · Cited by 293

Core–Shell Supramolecular Gelatin Nanoparticles for Adaptive and “On-Demand” Antibiotic Delivery

Li, L.-L., Xu, J.-H., Qi, G.-B., Zhao, X., Yu, F., & Wang, H. (2014) · ACS Nano · doi:10.1021/nn501040h · Cited by 291

Inorganic nanoparticles engineered to attack bacteria

Miller, K. P., Wang, L., Benicewicz, B. C., & Decho, A. W. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00041f · Cited by 290

Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces

Hayden, S. C., Zhao, G., Saha, K., Phillips, R. L., Li, X., Miranda, O. R., Rotello, V. M., El-Sayed, M. A., Schmidt-Krey, I., & Bunz, U. H. F. (2012) · Journal of the American Chemical Society · doi:10.1021/ja301167y · Cited by 267

Recyclable Antibacterial Magnetic Nanoparticles Grafted with Quaternized Poly(2-(dimethylamino)ethyl methacrylate) Brushes

Dong, H., Huang, J., Koepsel, R. R., Ye, P., Russell, A. J., & Matyjaszewski, K. (2011) · Biomacromolecules · doi:10.1021/bm200031v · Cited by 208

Recent Developments in Antimicrobial-Peptide-Conjugated Gold Nanoparticles

Rajchakit, U., & Sarojini, V. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00368 · Cited by 204

Nanoparticle-Based Antimicrobials: Surface Functionality is Critical

Gupta, A., Landis, R. F., & Rotello, V. M. (2016) · F1000Research · doi:10.12688/f1000research.7595.1 · Cited by 186

Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections

Wang, Y., Ding, X., Chen, Y., Guo, M., Zhang, Y., Guo, X., & Gu, H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.004 · Cited by 183

One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model

Rai, A., Pinto, S., Velho, T. R., Ferreira, A. F., Moita, C., Trivedi, U., Evangelista, M., Comune, M., Rumbaugh, K. P., Simões, P. N., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.051 · Cited by 177

Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices against Multidrug-Resistant Bacteria and Biofilms

Gupta, A., Landis, R. F., Li, C.-H., Schnurr, M., Das, R., Lee, Y.-W., Yazdani, M., Liu, Y., Kozlova, A., & Rotello, V. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b06961 · Cited by 173

Efficacy of tetracycline encapsulated O-carboxymethyl chitosan nanoparticles against intracellular infections of Staphylococcus aureus

Maya, S., Indulekha, S., Sukhithasri, V., Smitha, K. T., Nair, S. V., Jayakumar, R., & Biswas, R. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.06.009 · Cited by 172

Mechanism of Enhanced Activity of Liposome-Entrapped Aminoglycosides against Resistant Strains of Pseudomonas aeruginosa

Mugabe, C., Halwani, M., Azghani, A. O., Lafrenie, R. M., & Omri, A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01547-05 · Cited by 169

Polymer-Ag Nanocomposites with Enhanced Antimicrobial Activity against Bacterial Infection

Mei, L., Lu, Z., Zhang, X., Li, C., & Jia, Y. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am502886m · Cited by 152

Design of nanoparticles of less than 50 nm diameter: preparation, characterization and drug loading

Seijo, B., Fattal, E., Roblot-Treupel, L., & Couvreur, P. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90024-x · Cited by 151

Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure

Huo, S., Jiang, Y. Y., Gupta, A., Jiang, Z., Landis, R. F., Hou, S., Liang, X., & Rotello, V. M. (2016) · ACS Nano · doi:10.1021/acsnano.6b04207 · Cited by 148

Biodegradable Nanocomposite Antimicrobials for the Eradication of Multidrug-Resistant Bacterial Biofilms without Accumulated Resistance

Landis, R. F., Li, C., Gupta, A., Lee, Y.-W., Yazdani, M., Ngernyuang, N., Altinbasak, I., Mansoor, S., Khichi, M. A. S., Sanyal, A., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b03575 · Cited by 137

Designing carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide

Bi, L., Yang, L. J., Narsimhan, G., Bhunia, A. K., & Yao, Y. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.024 · Cited by 127

Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges

Pillai, P. P., Kowalczyk, B., Kandere‐Grzybowska, K., Borkowska, M. J., & Grzybowski, B. A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201602965 · Cited by 115

Synergistic antimicrobial therapy using nanoparticles and antibiotics for the treatment of multidrug-resistant bacterial infection

Gupta, A., Saleh, N. M., Das, R., Landis, R. F., Bigdeli, A., Motamedchaboki, K., Campos, A. R., Pomeroy, K., Mahmoudi, M., & Rotello, V. M. (2017) · Nano Futures · doi:10.1088/2399-1984/aa69fb · Cited by 113

Enhanced Antibacterial Activity of Silver/Polyrhodanine-Composite-Decorated Silica Nanoparticles

Song, J., Kim, H., Jang, Y., & Jang, J. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am402310u · Cited by 108

Cell surface-based sensing with metallic nanoparticles

Jiang, Z., Le, N. D. B., Gupta, A., & Rotello, V. M. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00387j · Cited by 91

Enhanced antibacterial performance of cationic polymer modified silica nanoparticles

Song, J., Kong, H., & Jang, J. (2009) · Chemical Communications · doi:10.1039/b908060k · Cited by 82

Killing Mechanism of Stable N-Halamine Cross-Linked Polymethacrylamide Nanoparticles That Selectively Target Bacteria

Natan, M., Gutman, O., Lavi, R., Margel, S., & Banin, E. (2015) · ACS Nano · doi:10.1021/nn507168x · Cited by 82

A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery

Chu, L., Gao, H., Cheng, T., et al. (2016) · Chemical Communications · doi:10.1039/c6cc01269h · Cited by 81

Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles

Jayawardana, K. W., Jayawardena, H. S. N., Wijesundera, S. A., Zoysa, T. D., Sundhoro, M., & Yan, M. (2015) · Chemical Communications · doi:10.1039/c5cc04251h · Cited by 44

Nanocatalytic Medicine

Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Shahbazi, M.-A., Faghfouri, L., Ferreira, M. P. A., Figueiredo, P., Maleki, H., Sefat, F., Hirvonen, J., & Santos, H. A. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00283a · Cited by 523

Inorganic nanomaterials with rapid clearance for biomedical applications

Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509

Synergistic antibacterial strategy based on photodynamic therapy: Progress and perspectives

Hu, X., Zhang, H., Wang, Y., Shiu, B.-C., Lin, J.-H., Zhang, S., Lou, C.-W., & Li, T.-T. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138129 · Cited by 365

Synthesis, bioactive properties, and biomedical applications of intrinsically therapeutic nanoparticles for disease treatment

Nguyen, D. D., & Lai, J.-Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.134970 · Cited by 178