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An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles
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The biomolecular corona promotes a switch of both the cell entry mechanism and the intracellular dynamics of liposomes.
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“Considering that apolipoproteins on nanoparticle play an important role in association with cellular uptake to target cells32–34, targeting capability of PCSN partly could be linked with some serum proteins recruited at the surface of PCSN.”
From Cloaking nanoparticles with protein corona shield for targeted drug delivery. (2018) · cites this paper as [34]
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Metadata
- Authors
- Digiacomo, L., Cardarelli, F., Pozzi, D., Palchetti, S., Digman, M. A., Gratton, E., Capriotti, A. L., Mahmoudi, M., & Caracciolo, G.
- Affiliations
- Università di Camerino (IT)
- Scuola Normale Superiore (IT)
- Sapienza University of Rome (IT)
- University of California, Irvine (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Mahmoudi, M.
- Caracciolo, G.
- ORCID
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 9
- Issue
- 44
- Pages
- 17254-17262
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- PMC
- PMC5700750
- OpenAlex
- W2766823924
- Cited by
- 109
- References
- 52
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 8 · 2020: 13 · 2019: 18 · 2018: 12
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Scuola Normale Superiore di Pisa (submittedVersion, other-oa)
- Funders
- National Institutes of Health (NIH P50, NIH‐P50 GM076516, GM-076516, NIH P41-GM103540, GM103540)
- National Institute of General Medical Sciences (P41GM103540, P50GM076516)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- biomolecular corona, apolipoproteins, lipid nanoparticles, cellular uptake, macropinocytosis, clathrin-mediated endocytosis, intracellular trafficking, LDL receptor, HeLa cells, plasma exposure, targeted delivery
- MeSH terms
- Protein Corona, Apolipoproteins, Endocytosis, HeLa Cells, Humans, Lipids, Pinocytosis, Tissue Distribution, Drug Delivery Systems, Nanoparticles
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