Cited by 89Probiotics and Fermented FoodsGut microbiota and healthTryptophan and brain disorders

Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota

Sun, Ye, Geng, Weitao, Pan, Yajing, Wang, Jinju, Xiao, Ping, Wang, Yanping·2019·Food & Function

Abstract

ZW3 regulated the biomarkers and behaviors associated with tryptophan metabolism, the HPA axis, and the immune system in depressed mice by regulating the gut microbiota.

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Crossref · 10.1039/c8fo02096e

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59 of 59 references verified0 citation errors · 0 not checkable

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  • Consumption of kefir was able to alter the metabolic pathways that led to the development of depression.

    “All of these benefits indicate that the consumption of kefir was able to alter the metabolic pathways that led to the development of depression; however, further studies are needed to identify the optimal dosage to be consumed, so that the benefits of kefir are acquired by the host that consumes it (38).”
  • The ability to modulate the intestinal microbiota and, consequently, anxiety and depression suggests a positive role of kefir in these diseases.

    “The ability to modulate the intestinal microbiota and, consequently, anxiety and depression also suggests a positive role of kefir in these diseases (38, 42) (Table 1).”
  • In these mice, there was an improvement in tryptophan metabolism, an increase in anti-inflammatory cytokines, a reduction in pro-inflammatory cytokines, and changes in the composition of the intestinal microbiota, with an increase in Actinobacteria, Bacteroides, Lachnospiraceae, Coriobacteriaceae, Bifidobacteriaceae and Akkermansia, and a reduction in Proteobacteria.

    “In addition, there was an improvement in tryptophan metabolism, an increase in anti-inflammatory cytokines, a reduction in pro-inflammatory cytokines, and changes in the composition of the intestinal microbiota, with an increase in Actinobacteria, Bacteroides, Lachnospiraceae, Coriobacteriaceae, Bifidobacteriaceae and Akkermansia, and reduction in Proteobacteria (38).”

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Authors
Sun, Y., Geng, W., Pan, Y., Wang, J., Xiao, P., & Wang, Y.
Affiliations
  • Tianjin University of Science and Technology (CN)
  • Tianjin Agricultural University (CN)
Corresponding author
  • Xiao, Ping
  • Wang, Yanping
Venue
Food & Function
Published
2019
Volume
10
Issue
2
Pages
925-937
ISSN
  • 2042-6496 (ISSN-L)
  • 2042-650X
OpenAlex
W2910568824
Cited by
89
References
59
Citations by year
2026: 7 · 2025: 10 · 2024: 13 · 2023: 14 · 2022: 17 · 2021: 17 · 2020: 6 · 2019: 5
FWCI
8.69
Type
journal article
Language
en
Open access
closed
Locations
  • Food & Function (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31801514)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
Lactobacillus kefiranofaciens, probiotics, depression-like behavior, chronic unpredictable mild stress, gut microbiota, hypothalamic-pituitary-adrenal axis, tryptophan metabolism, immune system, constipation, fecal water content, stress resilience, kefir grains
MeSH terms
Gastrointestinal Microbiome, Kefir, Animals, Bacteria, Behavior, Animal, Depression, Feces, Lactobacillus, Male, Spleen, Stress, Physiological, Sucrose, Swimming, Tryptophan, Cytokines, Tibet, Probiotics, Mice

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