Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
Open accessAbstract
Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time. We found that Akkermansia muciniphila abundance was strongly and negatively affected by age and HFD feeding and to a lower extend Bilophila wadsworthia was the only taxa following an opposite trend. Different approaches, including multifactorial analysis, showed that these changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice. Thus, our data shows the existence of a link between gut Akkermansia muciniphila abundance and adipose tissue homeostasis on the onset of obesity, thus reinforcing the beneficial role of this bacterium on metabolism.
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Akkermansia muciniphila suggests great potential for the treatment of obesity.
“Akkermansia muciniphila undergoes changes according to the diet consumed, modulates the intestinal microbiota, changes inflammatory conditions in adipose tissue, and improves metabolic parameters, like body weight, adiposity, inflammation markers and biochemical parameters, which suggests a great potential for the treatment of obesity (74).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [74]
The Discussion (page unavailable) reports that A. muciniphila abundance changes with diet and is associated with adipose-tissue inflammation and metabolic measures in mice. It also cites studies in which administering the bacterium mitigated weight and fat-mass gain, supporting the suggestion of obesity-treatment potential. But this study primarily establishes correlations; it does not show that A. muciniphila itself modulates the wider gut microbiota or improves every listed parameter. (LLM, conf=0.84)
Experimental — accuracy not yet measuredAkkermansia muciniphila modulates intestinal microbiota, changes inflammatory conditions in adipose tissue, and improves metabolic parameters such as body weight, adiposity, inflammation markers, and biochemical parameters.
“Akkermansia muciniphila undergoes changes according to the diet consumed, modulates the intestinal microbiota, changes inflammatory conditions in adipose tissue, and improves metabolic parameters, like body weight, adiposity, inflammation markers and biochemical parameters, which suggests a great potential for the treatment of obesity (74).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [74]
The Results and Discussion (page not provided) link Akkermansia muciniphila abundance in high-fat-diet-fed mice to adipose-tissue inflammation and metabolic markers; the Discussion also reports prior studies in which its administration mitigated weight and fat-mass gain. But this paper's findings are correlations, not evidence that the bacterium itself modulates the intestinal microbiota or causes the listed improvements. The Discussion says a direct effect on adipose-tissue function warrants further investigation. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSchneeberger et al. found that the abundance of A. muciniphila progressively decreases with HFD feeding and is inversely correlated with WAT inflammation and serum concentrations of leptin and insulin.
“Schneeberger et al. found that the abundance of A. muciniphila progressively decrease with HFD feeding and is inversely correlated with WAT inflammation and serum concentrations of leptin and insulin (Schneeberger et al., 2015).”
From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Schneeberger et al., 2015
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A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice
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- Authors
- Schneeberger, M., Everard, A., Gómez-Valadés, A. G., Matamoros, S., Ramírez, S., Delzenne, N. M., Gomis, R., Claret, M., & Cani, P. D.
- Affiliations
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Corresponding author
- Claret, Marc
- Cani, Patrice D.
- ORCID
- Venue
- Scientific Reports
- Published
- 2015-11-13
- Volume
- 5
- Issue
- 1
- Pages
- 16643-16643
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4643218
- OpenAlex
- W2206854629
- Cited by
- 798
- References
- 10
- Citations by year
- 2026: 37 · 2025: 47 · 2024: 63 · 2023: 70 · 2022: 88 · 2021: 101 · 2020: 106 · 2019: 101 · 2018: 84 · 2017: 69 · 2016: 31
- FWCI
- 26.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion, other-oa)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by-nc-nd)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by-nc-nd)
- Funders
- European Commission (267248)
- Fonds De La Recherche Scientifique - FNRS (12/17-047, WELBIO-CR-2012S-02R, T.0138.14, 3.4579.11)
- Generalitat de Catalunya (2014 SGR 659)
- Fédération Wallonie-Bruxelles
- Ministerio de Ciencia e Innovación
- Walloon excellence in life sciences and biotechnology
- Instituto de Salud Carlos III (PI13/01500, PI13/01604)
- European Regional Development Fund
- FP7 Ideas: European Research Council (336452)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Akkermansia muciniphila, gut microbiota, diet-induced obesity, high-fat diet, adipose tissue inflammation, adipose tissue lipid metabolism, low-grade inflammation, Bilophila wadsworthia, metabolic disorders, insulin, leptin, triglycerides, age-related changes
- MeSH terms
- Gastrointestinal Microbiome, Adipose Tissue, Age Factors, Animals, Bacteria, Homeostasis, Inflammation, Male, Metabolic Diseases, Mice, Inbred C57BL, Obesity, RNA, Ribosomal, 16S, Species Specificity, Time Factors, Gene Expression, Reverse Transcriptase Polymerase Chain Reaction, Gastrointestinal Tract, Bilophila, Lipid Metabolism, Host-Pathogen Interactions, Bacterial Load, Diet, High-Fat, Verrucomicrobia
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