Natural rewards, neuroplasticity, and non-drug addictions

Olsen, Christopher M.

doi:10.1016/j.neuropharm.2011.03.010

Cited by 339Neurotransmitter Receptor Influence on BehaviorGambling Behavior and TreatmentsNeural and Behavioral Psychology Studies

Natural rewards, neuroplasticity, and non-drug addictions

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Olsen, Christopher M.·2011·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.03.010PMC PMC3139704

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Abstract

There is a high degree of overlap between brain regions involved in processing natural rewards and drugs of abuse. "Non-drug" or "behavioral" addictions have become increasingly documented in the clinic, and pathologies include compulsive activities such as shopping, eating, exercising, sexual behavior, and gambling. Like drug addiction, non-drug addictions manifest in symptoms including craving, impaired control over the behavior, tolerance, withdrawal, and high rates of relapse. These alterations in behavior suggest that plasticity may be occurring in brain regions associated with drug addiction. In this review, I summarize data demonstrating that exposure to non-drug rewards can alter neural plasticity in regions of the brain that are affected by drugs of abuse. Research suggests that there are several similarities between neuroplasticity induced by natural and drug rewards and that, depending on the reward, repeated exposure to natural rewards might induce neuroplasticity that either promotes or counteracts addictive behavior.

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So-called behavioral addictions are associated with supraphysiological stimulation and plasticity within regions of the brain that also show these effects in response to addictive drugs.
“However, so-called behavioral addictions are associated with supraphysiological stimulation and plasticity within regions of the brain that also show these effects in response to addictive drugs, (Olsen, 2011), (Section 3.4).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Olsen, 2011
The Introduction reports that non-drug rewards activate many of the same brain regions as drugs of abuse and can produce similar neural plasticity. It does not describe that activation as supraphysiological, and it frames comparable neuroadaptations in non-drug addictions as suggested by emerging evidence rather than established across behavioral addictions. (LLM, conf=0.87)
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The Principles of Psychology
James, W. (1891) · Henry Holt and Company eBooks · doi:10.1037/11059-000 · Cited by 25,799 · see citing works
Principles of neural science
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Internet Addiction: The Emergence of a New Clinical Disorder
YOUNG, K. S. (1998) · CyberPsychology & Behavior · doi:10.1089/cpb.1998.1.237 · Cited by 5,513 · see citing works
Neurocircuitry of Addiction
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication
Hudson, J. I., Hiripi, E., Pope, H. G., & Kessler, R. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.040 · Cited by 4,973 · see citing works
PRINCIPLES OF NEURAL SCIENCE
Henry, M. A. (1995) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1995.0108 · Cited by 3,454 · see citing works
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
Neurogenetic Adaptive Mechanisms in Alcoholism
Cloninger, C. R. (1987) · Science · doi:10.1126/science.2882604 · Cited by 2,203 · see citing works
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
Bechara, A. (2005) · Nature Neuroscience · doi:10.1038/nn1584 · Cited by 2,149 · cited 1× · see citing works
“In humans, some of these changes include impaired decision making, decreased pleasure from natural rewards (anhedonia), and craving (Majewska, 1996; Bechara, 2005; O'Brien, 2005).”
Background
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity
Kalivas, P. W., & Stewart, J. (1991) · Brain Research Reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,021 · see citing works
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771 · see citing works
Learning and Memory Functions of the Basal Ganglia
Packard, M. G., & Knowlton, B. J. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142937 · Cited by 1,717 · see citing works
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717 · see citing works
An opponent-process theory of motivation. I. Temporal dynamics of affect
Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704 · see citing works
Habits, Rituals, and the Evaluative Brain
Graybiel, A. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112851 · Cited by 1,697 · see citing works
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610 · see citing works
A role for brown adipose tissue in diet-induced thermogenesis
Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606 · see citing works
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541 · see citing works
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495 · see citing works
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works
Incentive-sensitization and addiction
Robinson, T. E., & Berridge, K. C. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.9611038.x · Cited by 1,435 · see citing works
Functional imaging of neural responses to expectancy and experience of monetary gains and losses
Breiter, H. C., Aharon, I., Kahneman, D., Dale, A., & Shizgal, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00303-8 · Cited by 1,404 · see citing works
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works
Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355 · see citing works
Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey
Anthony, J. C., Warner, L. A., & Kessler, R. C. (1994) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.2.3.244 · Cited by 1,341 · see citing works
REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works
Evidence for striatal dopamine release during a video game
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Bench, C. J., & Grasby, P. M. (1998) · Nature · doi:10.1038/30498 · Cited by 1,279 · see citing works
Introduction to Behavioral Addictions
Grant, J. E., Potenza, M. N., Weinstein, A., & Gorelick, D. A. (2010) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2010.491884 · Cited by 1,242 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
The opponent-process theory of acquired motivation: The costs of pleasure and the benefits of pain.
Solomon, R. L. (1980) · American Psychologist · doi:10.1037//0003-066x.35.8.691 · Cited by 1,196 · see citing works
The opponent-process theory of acquired motivation: the costs of pleasure and the benefits of pain
Solomon, R. L. (1980) · American Psychologist · doi:10.1037/0003-066x.35.8.691 · Cited by 1,194 · see citing works
Neural Predictors of Purchases
Knutson, B., Rick, S., Wimmer, G. E., Prelec, D., & Loewenstein, G. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.010 · Cited by 1,171 · see citing works
Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point
Ahmed, S. H., & Koob, G. F. (1998) · Science · doi:10.1126/science.282.5387.298 · Cited by 1,159 · see citing works
Animal behavior. An evolutionary approach
(1978) · Journal of Human Evolution · doi:10.1016/s0047-2484(78)80102-x · Cited by 1,150 · see citing works
Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons
Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works
Evidence for Addiction-like Behavior in the Rat
Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004) · Science · doi:10.1126/science.1099020 · Cited by 1,135 · see citing works
Structural plasticity associated with exposure to drugs of abuse
Robinson, T. E., & Kolb, B. E. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.025 · Cited by 1,104 · see citing works
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
How can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089 · see citing works
TASTE PREFERENCES AND FOOD INTAKE
Drewnowski, A. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.237 · Cited by 1,045 · see citing works
Modification in the Proposed Diagnostic Criteria for Internet Addiction
Beard, K. W., & Wolf, E. (2001) · CyberPsychology & Behavior · doi:10.1089/109493101300210286 · Cited by 1,018 · see citing works
Incubation of cocaine craving after withdrawal
Grimm, J. W., Hope, B. T., Wise, R. A., & Shaham, Y. (2001) · Nature · doi:10.1038/35084134 · Cited by 1,003 · see citing works
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0089 · Cited by 974 · see citing works
Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
Kelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942 · see citing works
Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli
Garavan, H., Pankiewicz, J., Bloom, A., Cho, J.-K., Sperry, L., Ross, T. J., Salmeron, B. J., Risinger, R., Kelley, D., & Stein, E. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1789 · Cited by 931 · see citing works
Decreased dopamine D<sub>2</sub> receptor availability is associated with reduced frontal metabolism in cocaine abusers
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works
Plasticity of Sensory and Motor Maps in Adult Mammals
Kaas, J. H. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.001033 · Cited by 913 · see citing works
Stress dysregulation of drug reward pathways, and the transition to drug dependence
Koob, & Kreek, M. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.05030503 · Cited by 868 · see citing works
The neuropsychological basis of addictive behaviour
Everitt, B. J., Dickinson, A., & Robbins, T. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00088-1 · Cited by 808 · see citing works
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine
Aghajanian, G. K. (1978) · Nature · doi:10.1038/276186a0 · Cited by 803 · see citing works
BRAIN PLASTICITY AND BEHAVIOR
Kolb, B. E., & Whishaw, I. Q. (1998) · Annual Review of Psychology · doi:10.1146/annurev.psych.49.1.43 · Cited by 781 · see citing works
'Behavioral' Addictions: Do They Exist?
Holden, C. (2001) · Science · doi:10.1126/science.294.5544.980 · Cited by 746 · see citing works
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
Rampon, C., Tang, Y.-P., Goodhouse, J., Shimizu, E., Kyin, M., & Tsien, J. Z. (2000) · Nature Neuroscience · doi:10.1038/72945 · Cited by 737 · cited 3× · see citing works
“More recent data from microarray studies have shown that EE housing induces expression of gene cascades involved with NMDAdependent plasticity and neuroprotection (Rampon et al, 2000).”
BackgroundResultInfluential
Drug Addiction as a Pathology of Staged Neuroplasticity
Kalivas, P. W., & O’Brien, C. P. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301564 · Cited by 735 · see citing works
Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00152.2002 · Cited by 724 · see citing works
Neurobiological mechanisms for opponent motivational processes in addiction
Koob, G. F., & Moal, M. L. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0094 · Cited by 702 · see citing works
Dramatic decreases in brain reward function during nicotine withdrawal
Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., & Markou, A. (1998) · Nature · doi:10.1038/30001 · Cited by 674 · see citing works
Should addictive disorders include non-substance-related conditions?
Potenza, M. N. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01591.x · Cited by 663 · see citing works
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.002 · Cited by 654 · see citing works
Neural plasticity to stress and antidepressant treatment
Duman, R. S., Malberg, J. E., & Thome, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00177-8 · Cited by 644 · see citing works
Animal Models of Alcoholism: Neurobiology of High Alcohol-Drinking Behavior in Rodents
McBride, W. J. H., & Li, T. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i4.40 · Cited by 618 · see citing works
Proposed diagnostic criteria for internet addiction
Tao, R., Huang, X., Wang, J., Zhang, H., Zhang, Y., & Li, M. (2010) · Addiction · doi:10.1111/j.1360-0443.2009.02828.x · Cited by 614 · see citing works
Decreases in dopamine receptors but not in dopamine transporters in alcoholics
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y., Pappas, N., Shea, C., & Piscani, K. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb05936.x · Cited by 612 · see citing works
Intense Sweetness Surpasses Cocaine Reward
Lenoir, M., Serre, F., Cantin, L., & Ahmed, S. H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000698 · Cited by 608 · see citing works
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
Segal, D. S., & Mandell, A. J. (1974) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(74)90060-4 · Cited by 604 · see citing works
Dopamine and reward: The anhedonia hypothesis 30 years on
Wise, R. A. (2008) · Neurotoxicity Research · doi:10.1007/bf03033808 · Cited by 580 · see citing works
Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice
Lin, S., Thomas, T. C., Storlien, L., & Huang, X. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801209 · Cited by 570 · see citing works
Molecular Mechanisms of Drug Reinforcement and Addiction
Self, D. W., & Nestler, E. J. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.002335 · Cited by 565 · see citing works
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways
Olson, A. K., Eadie, B. D., Ernst, C., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20157 · Cited by 565 · see citing works
Interchangeability of Stress and Amphetamine in Sensitization
Antelman, S. M., Eichler, A. J., Black, C. A., & Kocan, D. J. (1980) · Science · doi:10.1126/science.7188649 · Cited by 562 · see citing works
Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
Carlezon, W. A., & Thomas, M. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.075 · Cited by 561 · see citing works
Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes
Vucetic, Z., Kimmel, J. N., Totoki, K., Hollenbeck, E., & Reyes, T. M. (2010) · Endocrinology · doi:10.1210/en.2010-0505 · Cited by 556 · see citing works
Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence
Colantuoni, C., Rada, P. V., McCarthy, J., Patten, C. S., Avena, N. M., Chadeayne, A., & Hoebel, B. G. (2002) · Obesity Research · doi:10.1038/oby.2002.66 · Cited by 544 · see citing works
Areas of brain activation in males and females during viewing of erotic film excerpts
Karama, S., Lecours, A. R., Leroux, J., Bourgouin, P., Beaudoin, G., Joubert, S., & Beauregard, M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10014 · Cited by 522 · see citing works
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction
Thomas, M. J., Kalivas, P. W., & Shaham, Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.77 · Cited by 513 · see citing works
The neurobiology of pathological gambling and drug addiction: an overview and new findings
Potenza, M. N. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0100 · Cited by 508 · see citing works
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Markou, A., & Koob, G. F. (1991) · PubMed · Cited by 505 · see citing works
Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling
Kim, S. W., Grant, J. E., Adson, D. E., & Shin, Y. C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01079-4 · Cited by 503 · see citing works
Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging: A Concept Review
Wang, G.-J., Volkow, N. D., Thanos, P. K., & Fowler, J. S. (2004) · Journal of Addictive Diseases · doi:10.1300/j069v23n03_04 · Cited by 502 · see citing works
Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine
Lett, B. T. (1989) · Psychopharmacology · doi:10.1007/bf00451687 · Cited by 479 · see citing works
Compulsive overeating as an addiction disorder. A review of theory and evidence
Davis, C. A., & Carter, J. C. (2009) · Appetite · doi:10.1016/j.appet.2009.05.018 · Cited by 479 · see citing works
Role of Corticotropin-Releasing Factor in Drug Addiction
Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 476 · see citing works
Measuring problem video game playing in adolescents
Tejeiro, R. A., & Bersabé, R. M. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00218.x · Cited by 473 · see citing works
Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P. (2006) · Annals of Neurology · doi:10.1002/ana.20822 · Cited by 473 · see citing works
Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain
Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J.-L., Schwartz, G. J., Moran, T. H., & Hoebel, B. G. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00035 · Cited by 471 · see citing works
Alcohol and gambling pathology among U.S. adults: prevalence, demographic patterns and comorbidity.
Welte, J. W., Barnes, G. M., Wieczorek, W. F., Tidwell, M. O., & Parker, J. C. (2001) · Journal of Studies on Alcohol · doi:10.15288/jsa.2001.62.706 · Cited by 470 · see citing works
An Opponent-Process Theory of Motivation
Solomon, R. L., & Corbit, J. D. (2008) · Cited by 461 · see citing works
Self-starvation of rats living in activity wheels on a restricted feeding schedule.
Routtenberg, A., & Kuznesof, A. W. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025205 · Cited by 450 · see citing works
Incubation of cocaine craving after withdrawal: a review of preclinical data
Lü, L., Grimm, J. W., Hope, B. T., & Shaham, Y. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.027 · Cited by 446 · see citing works
Differential effects of acute and chronic exercise on plasticity‐related genes in the rat hippocampus revealed by microarray
Molteni, R., Ying, Z., & Gómez‐Pinilla, F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02158.x · Cited by 441 · see citing works
Addictive and non‐addictive drugs induce distinct and specific patterns of ERK activation in mouse brain
Valjent, E., Pagès, C., Hervé, D., Girault, J., & Caboche, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03278.x · Cited by 434 · see citing works
The effects of early experience on problem-solving at maturity
Hebb, D. O. (1947) · American Psychologist · Cited by 425 · see citing works
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.6.719 · Cited by 421 · see citing works
Behavioural (non‐chemical) addictions
Marks, I. M. (1990) · British Journal of Addiction · doi:10.1111/j.1360-0443.1990.tb01618.x · Cited by 421 · see citing works
Internet addiction: Does it really exist?
Griffiths, M. D. (1998) · Cited by 420 · see citing works
Anticraving Medications for Relapse Prevention: A Possible New Class of Psychoactive Medications
O’Brien, C. P. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1423 · Cited by 405 · see citing works
Exposure to appetitive food stimuli markedly activates the human brain
Wang, G.-J., Volkow, N. D., Telang, F., Jayne, M., Ma, J., Rao, M., Zhu, W., Wong, C. T., Pappas, N. R., Geliebter, A., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.026 · Cited by 402 · see citing works
Pain sensitivity, mood and plasma endocrine levels in man following long-distance running: Effects of naloxone
Janal, M. N., Colt, E. W. D., Clark, C. W., & Glusman, M. (1984) · Pain · doi:10.1016/0304-3959(84)90061-7 · Cited by 400 · see citing works
ΔFosB: a molecular switch for long-term adaptation in the brain
McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., & Nestler, E. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.014 · Cited by 398 · see citing works
The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
Wee, S., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1825-8 · Cited by 398 · see citing works
Prelude to Passion: Limbic Activation by “Unseen” Drug and Sexual Cues
Childress, A. R., Ehrman, R. N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. G., Jens, W., Suh, J. J., Listerud, J., Marquez, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001506 · Cited by 395 · see citing works
Glutamate transmission in addiction
Kalivas, P. W., LaLumiere, R. T., Knackstedt, L. A., & Shen, H. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.011 · Cited by 389 · see citing works
Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task
Zeeb, F. D., Robbins, T. W., & Winstanley, C. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.62 · Cited by 384 · see citing works
The Role of Corticotropin-Releasing Factor in Drug Addiction
Sarnyai, Z., Shaham, Y., & Heinrichs, S. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01492-3 · Cited by 381 · see citing works
The Neurobiology of Substance and Behavioral Addictions
Grant, J. E., Brewer, J. A., & Potenza, M. N. (2006) · CNS Spectrums · doi:10.1017/s109285290001511x · Cited by 372 · see citing works
Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition
Cao, L., Liu, X., Lin, E.-J. D., Wang, C., Choi, E., Riban, V., Lin, B., & During, M. J. (2010) · Cell · doi:10.1016/j.cell.2010.05.029 · Cited by 368 · see citing works
Philosophy of environmental enrichment: Past, present, and future
Mellen, J. D., & Sevenich, M. (2001) · Zoo Biology · doi:10.1002/zoo.1021 · Cited by 367 · see citing works
Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior
Steiner, H., & Gerfen, C. R. (1998) · Experimental Brain Research · doi:10.1007/s002210050545 · Cited by 365 · see citing works
Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity
Kasanetz, F., Deroche‐Gamonet, V., Berson, N., Balado, É., Lafourcade, M., Manzoni, O. J., & Piazza, P. V. (2010) · Science · doi:10.1126/science.1187801 · Cited by 364 · see citing works
Multicenter Investigation of the Opioid Antagonist Nalmefene in the Treatment of Pathological Gambling
Grant, J. E., Potenza, M. N., Hollander, E., Cunningham‐Williams, R. M., Nurminen, T., Smits, G. J., & Kallio, A. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.303 · Cited by 364 · see citing works
Refined food addiction: A classic substance use disorder
Ifland, J., Preuss, H. G., Marcus, M. T., Rourke, K. M., Taylor, W. C., Burau, K. D., Jacobs, W. S., Kadish, W., & Manso, G. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.11.035 · Cited by 364 · see citing works
Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.
Stewart, J. (2000) · PubMed Central · Cited by 361 · see citing works
Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA
Chen, B. T., Bowers, M. S., Martín, M., Hopf, F. W., Guillory, A. M., Carelli, R. M., Chou, J., & Bonci, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.024 · Cited by 353 · see citing works
ERK2: a logical AND gate critical for drug-induced plasticity?
Girault, J., Valjent, E., Caboche, J., & Hervé, D. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.08.012 · Cited by 348 · see citing works
Food Craving and Food “Addiction”
Rogers, P. J., & Smit, H. J. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00197-0 · Cited by 347 · see citing works
Neuroplasticity Mediated by Altered Gene Expression
McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works
Decreased brain reward produced by ethanol withdrawal
Schulteis, G., Markou, A., Cole, M., & Koob, G. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5880 · Cited by 345 · see citing works
Dopaminergic Modulation of Risk-Based Decision Making
Onge, J. R. S., & Floresco, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.121 · Cited by 337 · see citing works
Repeated social-defeat stress, cocaine or morphine
Covington, H. E., & Miczek, K. A. (2001) · Psychopharmacology · doi:10.1007/s002130100858 · Cited by 326 · see citing works
Antidepressant effects of exercise: Evidence for an adult-neurogenesis hypothesis?
Ernst, C., Olson, A. K., Pinel, J. P. J., Lam, R. W., & Christie, B. R. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0610 · Cited by 322 · see citing works
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318 · see citing works
Evidence That Separate Neural Circuits in the Nucleus Accumbens Encode Cocaine Versus “Natural” (Water and Food) Reward
Carelli, R. M., Ijames, S. G., & Crumling, A. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04255.2000 · Cited by 310 · see citing works
Auditory cortical plasticity: a comparison with other sensory systems
Rauschecker, J. P. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01303-4 · Cited by 308 · see citing works
Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat
Davis, J. F., Tracy, A. L., Schurdak, J. D., Tschöp, M. H., Lipton, J. W., Clegg, D. J., & Benoit, S. C. (2008) · Behavioral Neuroscience · doi:10.1037/a0013111 · Cited by 307 · see citing works
Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons
Stuber, G. D., Klanker, M., de Ridder, B., Bowers, M. S., Joosten, R. N. J. M. A., Feenstra, M. G. P., & Bonci, A. (2008) · Science · doi:10.1126/science.1160873 · Cited by 307 · see citing works
Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders
Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300 · see citing works
Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the Vagus nerves
Komisaruk, B. R., Whipple, B., Crawford, A., Grimes, S., Liu, W.-C., Kalnin, A., & Mosier, K. (2004) · Brain Research · doi:10.1016/j.brainres.2004.07.029 · Cited by 296 · see citing works
Should the scope of addictive behaviors be broadened to include pathological gambling?
Petry, N. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01593.x · Cited by 295 · see citing works
Environmental enrichment decreases intravenous self-administration of amphetamine in female and male rats
Bardo, M. T., Klebaur, J. E., Valone, J. M., & Deaton, C. (2001) · Psychopharmacology · doi:10.1007/s002130100720 · Cited by 292 · see citing works
The role of CRF and CRF-related peptides in the dark side of addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.008 · Cited by 290 · see citing works
Acute and Chronic Cocaine-Induced Potentiation of Synaptic Strength in the Ventral Tegmental Area: Electrophysiological and Behavioral Correlates in Individual Rats
Borgland, S. L., Malenka, R. C., & Bonci, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1312-04.2004 · Cited by 289 · see citing works
Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism?
Spanagel, R., & Hölter, S. M. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.2.231 · Cited by 288 · see citing works
How visual stimuli activate dopaminergic neurons at short latency
Dommett, E., Coizet, V., Blaha, C. D., Martindale, J., Lefebvre, V., Walton, N., Mayhew, J. E. W., Overton, P. G., & Redgrave, P. (2005) · Science · doi:10.1126/science.1107026 · Cited by 285 · see citing works
A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine
Avena, N. M., & Hoebel, B. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00502-5 · Cited by 284 · see citing works
Burst activity of ventral tegmental dopamine neurons is elicited by sensory stimuli in the awake cat
Horvitz, J. C., Stewart, T., & Jacobs, B. L. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00265-5 · Cited by 283 · see citing works
Reversal of cocaine addiction by environmental enrichment
Solinas, M., Chauvet, C., Thiriet, N., Rawas, R. E., & Jaber, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806889105 · Cited by 281 · see citing works
Topiramate for the Treatment of Binge Eating Disorder Associated With Obesity: A Placebo-Controlled Study
McElroy, S. L., Hudson, J. I., Capece, J. A., Beyers, K., Fisher, A. C., & Rosenthal, N. R. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.008 · Cited by 279 · see citing works
Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
Porrino, L. J., Lyons, D., Smith, H. R., Daunais, J. B., & Nader, M. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5578-03.2004 · Cited by 276 · see citing works
Role of ERK in cocaine addiction
Lü, L., Koya, E., Zhai, H., Hope, B. T., & Shaham, Y. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.005 · Cited by 269 · see citing works
Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence
Koob, G. F., Stinus, L., Moal, M. L., & Bloom, F. E. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80022-3 · Cited by 268 · see citing works
Animal Behavior: An evolutionary approach
Balph, M. H. (1984) · The Auk · doi:10.2307/4086942 · Cited by 267 · see citing works
Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics.
Shippenberg, T. S., & Heidbreder, C. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09578-3 · Cited by 263 · see citing works
Neuroplasticity of Dopamine Circuits After Exercise: Implications for Central Fatigue
Foley, T. E., & Fleshner, M. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8032-3 · Cited by 261 · see citing works
Mind versus metabolism in the control of food intake and energy balance
Berthoud, H. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.034 · Cited by 259 · see citing works
Prevention and treatment of drug addiction by environmental enrichment
Solinas, M., Thiriet, N., Chauvet, C., & Jaber, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.002 · Cited by 256 · see citing works
Opiate-like effects of sugar on gene expression in reward areas of the rat brain
Spangler, R., Wittkowski, K. M., Goddard, N. L., Avena, N. M., Hoebel, B. G., & LEIBOWITZ, S. F. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.02.013 · Cited by 255 · see citing works
A concurrently available nondrug reinforcer prevents the acquisition or decreases the maintenance of cocaine-reinforced behavior
Carroll, M. E., Lac, S. T., & Nygaard, S. L. (1989) · Psychopharmacology · doi:10.1007/bf00443407 · Cited by 251 · see citing works
Gender differences in the mesocorticolimbic system during computer game-play
Hoeft, F., Watson, C., Kesler, S. R., Bettinger, K. E., & Reiss, A. L. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.11.010 · Cited by 250 · see citing works
What do female rats like about sex? Paced mating
Paredes, R. G., & Vazquez, B. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00087-x · Cited by 247 · see citing works
Neural signals in the monkey ventral striatum related to motivation for juice and cocaine rewards
Bowman, E. M., Aigner, T. G., & Richmond, B. J. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.3.1061 · Cited by 246 · see citing works
ΔFosB: a molecular mediator of long-term neural and behavioral plasticity1Published on the World Wide Web on 27 November 1998.1
Nestler, E. J., Kelz, M. B., & Chen, J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01191-3 · Cited by 246 · see citing works
Compulsive Buying
Lejoyeux, M., & Weinstein, A. M. (2010) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2010.493590 · Cited by 242 · see citing works
Reduction of Adult Hippocampal Neurogenesis Confers Vulnerability in an Animal Model of Cocaine Addiction
Noonan, M. A., Bulin, S. E., Fuller, D. C., & Eisch, A. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4256-09.2010 · Cited by 236 · see citing works
Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty
Rebec, G. V., Christensen, J. R. C., Guerra, C., & Bardo, M. T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01004-4 · Cited by 235 · see citing works
Striatal dopamine turnover during treadmill running in the rat: Relation to the speed of running
Hattori, S., Naoi, M., & Nishino, H. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90214-3 · Cited by 234 · see citing works
Brain substrates for increased drug seeking during protracted withdrawal
Aston‐Jones, G., & Harris, G. C. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.020 · Cited by 233 · see citing works
Repeated cocaine administration upregulates K and μ, but not δ, opioid receptors
Unterwald, E. M., Rubenfeld, J. M., & Kreek, M. J. (1994) · Neuroreport · doi:10.1097/00001756-199408150-00018 · Cited by 230 · see citing works
Insight Into the Relationship Between Impulsivity and Substance Abuse From Studies Using Animal Models
Winstanley, C. A., Olausson, P., Taylor, J. R., & Jentsch, J. D. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01215.x · Cited by 229 · see citing works
Role of ventral medial prefrontal cortex in incubation of cocaine craving
Koya, E., Uejima, J. L., Wihbey, K. A., Bossert, J. M., Hope, B. T., & Shaham, Y. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.022 · Cited by 229 · see citing works
Taste, experience, and feeding.
(1990) · American Psychological Association eBooks · doi:10.1037/10075-000 · Cited by 227 · see citing works
Delta FosB regulates wheel running.
Werme, M., Messer, C. J., Olson, L., Gilden, L., Thorén, P., Nestler, E. J., & Brené, S. (2002) · PubMed Central · doi:10.1523/jneurosci.22-18-08133.2002 · Cited by 224 · see citing works
The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia
Deutch, A. Y. (1992) · Springer eBooks · doi:10.1007/978-3-7091-9211-5_5 · Cited by 221 · see citing works
Microdialysis Studies of Brain Norepinephrine, Serotonin, and Dopamine Release During Ingestive Behavior Theoretical and Clinical Implicationsa
HOEBEL, B. G., HERNANDEZ, L., SCHWARTZ, D. H., MARK, G. P., & HUNTER, G. A. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb53242.x · Cited by 220 · see citing works
Sexual addiction: Many conceptions, minimal data
Gold, S. N., & Heffner, C. L. (1998) · Clinical Psychology Review · doi:10.1016/s0272-7358(97)00051-2 · Cited by 215 · see citing works
Sugar-dependent rats show enhanced responding for sugar after abstinence: Evidence of a sugar deprivation effect
Avena, N. M., Long, K. A., & Hoebel, B. G. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.12.016 · Cited by 215 · see citing works
kappa-Opioid receptor signaling and brain reward function
Bruijnzeel, A. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.008 · Cited by 214 · see citing works
Wheel-running attenuates intravenous cocaine self-administration in rats Sex differences
Cosgrove, K. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00853-5 · Cited by 213 · see citing works
Food addiction: true or false?
Corsica, J. A., & Pelchat, M. L. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328336528d · Cited by 209 · see citing works
Behavioral sensitization is accompanied by an enhancement in amphetamine-stimulated dopamine release from striatal tissue in vitro
Robinson, T. E., & Becker, J. B. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90478-2 · Cited by 207 · see citing works
Effects of Cocaine Self-administration on Striatal Dopamine Systems in Rhesus Monkeys Initial and Chronic Exposure
Nader, M. A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00427-4 · Cited by 206 · see citing works
Development of an Alcohol-Deprivation Effect in Rats
Sinclair, J. D., & Senter, R. J. (1968) · Quarterly Journal of Studies on Alcohol · doi:10.15288/qjsa.1968.29.863 · Cited by 204 · see citing works
Early Environmental Enrichment Moderates the Behavioral and Synaptic Phenotype of MeCP2 Null Mice
Lonetti, G., Angelucci, A., Morando, L., Boggio, E. M., Giustetto, M., & Pizzorusso, T. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.022 · Cited by 201 · see citing works
Neurotransmitters and prefrontal cortex–limbic system interactions: implications for plasticity and psychiatric disorders
Arco, A. D., & Mora, F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0243-8 · Cited by 201 · see citing works
Risk of Becoming Cocaine Dependent: Epidemiological Estimates for the United States, 2000–2001
O’Brien, M. S., & Anthony, J. C. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300681 · Cited by 198 · see citing works
Regional Brain Dopamine Metabolism: A Marker for the Speed, Direction, and Posture of Moving Animals
Freed, C. R., & Yamamoto, B. K. (1985) · Science · doi:10.1126/science.4012312 · Cited by 195 · see citing works
Neurobehavioral effects of environmental enrichment and drug abuse vulnerability
Stairs, D. J., & Bardo, M. T. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.01.016 · Cited by 193 · see citing works
Shared brain vulnerabilities open the way for nonsubstance addictions: Carving addiction at a new joint?
Frascella, J., Potenza, M. N., Brown, L. L., & Childress, A. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05420.x · Cited by 191 · see citing works
Cocaine Is Low on the Value Ladder of Rats: Possible Evidence for Resilience to Addiction
Cantin, L., Lenoir, M., Augier, E., Vanhille, N., Dubreucq, S., Serre, F., Vouillac‐Mendoza, C., & Ahmed, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011592 · Cited by 190 · see citing works
Decreases in Dietary Preference Produce Increased Emotionality and Risk for Dietary Relapse
Teegarden, S. L., & Bale, T. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.032 · Cited by 188 · see citing works
Rat Brain: Effects of Environmental Enrichment on Wet and Dry Weights
Bennett, E. L., Rosenzweig, M. R., & Diamond, M. C. (1969) · Science · doi:10.1126/science.163.3869.825 · Cited by 186 · see citing works
Increased extracellular dopamine in the nucleus accumbens and striatum of the female rat during paced copulatory behavior.
Mermelstein, P. G., & Becker, J. B. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.2.354 · Cited by 186 · see citing works
Changes in ??-Endorphin Levels in Response to Aerobic and Anaerobic Exercise
Schwarz, L., & Kindermann, W. (1992) · Sports Medicine · doi:10.2165/00007256-199213010-00003 · Cited by 185 · see citing works
Transient increases in catecholaminergic activity in medial prefrontal cortex and nucleus accumbens shell during novelty
Rebec, G. V., Grabner, C. P., Johnson, M., Pierce, R. C., & Bardo, M. T. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00382-x · Cited by 184 · see citing works
Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. ‘natural’ reinforcement
Carelli, R. M. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00760-6 · Cited by 183 · see citing works
Sensory stimuli alter discharge rate of dopamine (DA) neurons: evidence for two functional types of DA cells in the substantia nigra
Chiodo, L. A., Antelman, S. M., Caggiula, A. R., & Lineberry, C. G. (1980) · Brain Research · doi:10.1016/0006-8993(80)90366-2 · Cited by 179 · see citing works
Opposite Effects of Amphetamine Self-administration Experience on Dendritic Spines in the Medial and Orbital Prefrontal Cortex
Crombag, H. S. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh136 · Cited by 178 · see citing works
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area
Mameli, M., Bellone, C., Brown, M. T. C., & Lüscher, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2763 · Cited by 177 · see citing works
Environmental Enrichment Produces a Behavioral Phenotype Mediated by Low Cyclic Adenosine Monophosphate Response Element Binding (CREB) Activity in the Nucleus Accumbens
Green, T. A., Alibhai, I. N., Roybal, C. N., Winstanley, C. A., Theobald, D. E. H., Birnbaum, S. G., Graham, A., Unterberg, S., Graham, D. L., Vialou, V., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.022 · Cited by 177 · see citing works
Phasic dopamine release in appetitive behaviors and drug addiction
Wanat, M., Willuhn, I., Clark, J., & Phillips, P. (2009) · Current Drug Abuse Reviewse · doi:10.2174/1874473710902020195 · Cited by 177 · see citing works
Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine
Solinas, M., Thiriet, N., Rawas, R. E., Lardeux, V., & Jaber, M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.51 · Cited by 175 · see citing works
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex
Smith, G. B., Heynen, A. J., & Bear, M. F. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0198 · Cited by 175 · see citing works
Reward systems and food intake: role of opioids
Gosnell, B. A., & Levine, A. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.73 · Cited by 173 · see citing works
Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia
Avena, N. M., & Hoebel, B. G. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01050-x · Cited by 170 · see citing works
Facilitation of Sexual Behavior and Enhanced Dopamine Efflux in the Nucleus Accumbens of Male Rats afterd-Amphetamine-Induced Behavioral Sensitization
Fiorino, D. F., & Phillips, A. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00456.1999 · Cited by 170 · see citing works

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(APA) APA DSM-5 Proposed Revisions Include New Category of Addiction and Related Disorders 2010 [Press Release]. Retrieved from http://wwwdsm5org/newsroom/pages/pressreleasesaspx
American Psychiatric Association A DSM-5 Proposed Revisions Include New Category of Addiction and Related Disorders 2010 [Press Release]. Retrieved from http://wwwdsm5org/newsroom/pages/pressreleasesaspx
Nair SG Adams-Deutsch T Epstein DH Shaham Y The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking Prog Neurobiol 2009b PMC2745723 19497349
van Praag H Kempermann G Gage FH Neural consequences of environmental enrichment Nat Rev Neurosci 2000b 1 191 198 11257907

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Authors: Olsen, C. M.
Affiliations: Vanderbilt University (US)
Corresponding author: Olsen, Christopher M.
ORCID: Olsen, Christopher M.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2011-12
Volume: 61
Issue: 7
Pages: 1109-1122
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.03.010
PMC: PMC3139704
OpenAlex: W2045365443
Cited by: 339
References: 354
Citations by year: 2026: 9 · 2025: 19 · 2024: 18 · 2023: 12 · 2022: 32 · 2021: 26 · 2020: 64 · 2019: 20 · 2018: 20 · 2017: 22 · 2016: 23 · 2015: 18 · 2014: 33 · 2013: 9 · 2012: 10
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (R00DA026994, DA026994, K99DA026994)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: behavioral addiction, natural reward, neuroplasticity, drug addiction, reward processing, compulsive behavior, craving, relapse, gambling addiction, food addiction, sexual addiction, exercise addiction, compulsive buying, tolerance and withdrawal
MeSH terms: Animals, Brain, Exploratory Behavior, Food, Humans, Neuronal Plasticity, Neurons, Reinforcement, Psychology, Reward, Sexual Behavior, Sexual Behavior, Animal, Exercise, Behavior, Addictive

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