Molecular heterogeneity of aggrecan-based perineuronal nets around five subclasses of parvalbumin-expressing neurons in the mouse hippocampus.
Abstract
Subsets of GABAergic neurons are surrounded by perineuronal nets (PNNs), which play a critical role in the regulation of neural plasticity and neuroprotection. Although the plant lectin Wisteria floribunda agglutinin (WFA) has been commonly used to label PNNs, WFA only detects N-acetyl-d-galactosamine on aggrecan, a member of the lectican family. In this study, we used WFA and the antibody against the core protein of aggrecan (ACAN) to investigate the molecular heterogeneity of aggrecan-based PNNs around five subclasses of parvalbumin-expressing (PV+) γ-aminobutyric acid (GABA)ergic neurons in the CA1 and CA3 regions of the mouse hippocampus. The vast majority of ACAN+ PNNs were colocalized with WFA in the stratum pyramidale, whereas a substantial population of ACAN+ PNNs lacked WFA labeling in the stratum oriens. We then defined the subclasses of PV+ neurons based on their cellular locations, molecular expression, and septal projection. Like the WFA+ PNNs, ACAN+ PNNs surrounded PV+ basket cells and bistratified cells but not axo-axonic cells. Unlike the WFA+ PNNs, ACAN+ PNNs frequently surrounded PV+ oriens-lacunosum moleculare cells and hippocampo-septal cells. Interestingly, the relative densities of GABAergic synapses were higher around PV+ neurons with ACAN+ PNNs than around those without ACAN+ PNNs. Degradation of WFA+ PNNs by chondroitinase ABC did not affect the GABAergic synaptic densities around PV+ neurons. Our findings suggest that the molecular composition of aggrecan-based PNNs around PV+ neurons may differ in a subclass-specific manner, and also might help determine the functional involvement of PNNs in the regulation of GABAergic synapses around PV+ neurons in the hippocampus. J. Comp. Neurol. 525:1234-1249, 2017. © 2016 Wiley Periodicals, Inc.
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PNNs are heterogeneous structures.
“PNNs are heterogeneous structures (Ueno et al., 2017b; Yamada and Jinno, 2017; Irvine and Kwok, 2018)”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Yamada and Jinno, 2017
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- Authors
- Yamada, J., & Jinno, S.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Jinno, Shozo
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2016-11-21
- Volume
- 525
- Issue
- 5
- Pages
- 1234-1249
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2531096100
- Cited by
- 59
- References
- 72
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 12 · 2017: 9
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fuji Foundation for Protein Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- perineuronal nets, aggrecan, parvalbumin neurons, GABAergic neurons, hippocampus, basket cells, axo-axonic cells, Wisteria floribunda agglutinin, GABAergic synapses, chondroitinase ABC, molecular heterogeneity, CA1, CA3
- MeSH terms
- Animals, Extracellular Matrix, Hippocampus, Immunohistochemistry, Male, Mice, Inbred C57BL, Parvalbumins, Mice, Aggrecans, GABAergic Neurons
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