Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex

Ferguson, Brielle R.; Gao, Wen-Jun

doi:10.1016/j.biopsych.2017.11.033

Cited by 186Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex

Open access

Ferguson, Brielle R., Gao, Wen-Jun·2018·Biological Psychiatry

DOI 10.1016/j.biopsych.2017.11.033PMC PMC5862785

Open this paper in CoChat — free account

Abstract

Background The mediodorsal thalamus plays a critical role in cognition through its extensive innervation of the medial prefrontal cortex (mPFC), but how the two structures cooperate at the single-cell level to generate associated cognitive functions and other mPFC-dependent behaviors remains elusive. Maintaining the proper balance between excitation and inhibition (E/I balance) is of principal importance for organizing cortical activity. Furthermore, the PFC E/I balance has been implicated in successful execution of multiple PFC-dependent behaviors in both animal research and the context of human psychiatric disorders.Methods Here, we used a pharmacogenetic strategy to decrease mediodorsal thalamic activity in adult male rats and evaluated the consequences for E/I balance in PFC pyramidal neurons as well as cognition, social interaction, and anxiety.Results We found that dampening mediodorsal thalamic activity caused significant reductions in gamma-aminobutyric acidergic signaling and increased E/I balance in the mPFC and was concomitant with abnormalities in these behaviors. Furthermore, by selectively activating parvalbumin interneurons in the mPFC with a novel pharmacogenetic approach, we restored gamma-aminobutyric acidergic signaling and E/I balance as well as ameliorated all behavioral impairments.Conclusions These findings underscore the importance of thalamocortical activation of mPFC gamma-aminobutyric acidergic interneurons in a broad range of mPFC-dependent behaviors. Furthermore, they highlight this circuitry as a platform for therapeutic investigation in psychiatric diseases that involve impairments in PFC-dependent behaviors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2017.11.033

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Dampening thalamic activity causes reductions of GABA signaling in mPFC and abnormalities in cognition and social interaction, ameliorated by activating mPFC PV+ interneurons.
“Dampening thalamic activity causes significant reductions of GABA signaling in the mPFC and concomitant abnormalities in cognition and social interaction, which is ameliorated by selectively activating mPFC PV+ interneurons 34.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [34]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454 · see citing works
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works
DREADDs for neuroscientists
Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742 · see citing works
How Inhibition Shapes Cortical Activity
Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678 · see citing works
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · cited 1× · see citing works
“To measure sociability and social novelty, animals were tested in a threechamber paradigm (27).”
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527 · see citing works
Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat
Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421 · see citing works
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · see citing works
GABA A ‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244 · see citing works
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Lewis, D. A., Curley, A. A., Glausier, J. R., & Volk, D. W. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.004 · Cited by 1,071 · see citing works
Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders
Nelson, S. B., & Valakh, V. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.033 · Cited by 1,001 · see citing works
Thalamic amplification of cortical connectivity sustains attentional control
Schmitt, L. I., Wimmer, R. D., Nakajima, M., Happ, M., Mofakham, S., & Halassa, M. M. (2017) · Nature · doi:10.1038/nature22073 · Cited by 663 · see citing works
Thalamic Relay Functions and Their Role in Corticocortical Communication
Guillery, R. W., & Sherman, S. M. (2002) · Neuron · doi:10.1016/s0896-6273(01)00582-7 · Cited by 637 · see citing works
Involvement of the Prelimbic–Infralimbic Areas of the Rodent Prefrontal Cortex in Behavioral Flexibility for Place and Response Learning
Ragozzino, M. E., Detrick, S., & Kesner, R. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04585.1999 · Cited by 553 · see citing works
Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex
Chudasama, Y., & Robbins, T. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08771.2003 · Cited by 543 · see citing works
Thalamic control of sensory selection in divided attention
Wimmer, R. D., Schmitt, L. I., Davidson, T. J., Nakajima, M., Deisseroth, K., & Halassa, M. M. (2015) · Nature · doi:10.1038/nature15398 · Cited by 530 · see citing works
Behavioral phenotypes of Disc1 missense mutations in mice
Clapcote, S. J., Lipina, T. V., Millar, J. K., Mackie, S., Christie, S., Ogawa, F., Lerch, J. P., Trimble, K., Uchiyama, M., Sakuraba, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.015 · Cited by 526 · see citing works
Thalamic projections sustain prefrontal activity during working memory maintenance
Bolkan, S. S., Stujenske, J. M., Parnaudeau, S., Spellman, T., Rauffenbart, C., Abbas, A. I., Harris, A. Z., Gordon, J. A., & Kellendonk, C. (2017) · Nature Neuroscience · doi:10.1038/nn.4568 · Cited by 521 · see citing works
Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516 · see citing works
Interlaminar Connections in the Neocortex
Thomson, A. M. (2002) · Cerebral Cortex · doi:10.1093/cercor/13.1.5 · Cited by 468 · see citing works
GABA system dysfunction in autism and related disorders: From synapse to symptoms
Coghlan, S., Horder, J., Inkster, B., Méndez, M. A., Murphy, D., & Nutt, D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.005 · Cited by 437 · see citing works
Destruction and Creation of Spatial Tuning by Disinhibition: GABAABlockade of Prefrontal Cortical Neurons Engaged by Working Memory
Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00485.2000 · Cited by 407 · see citing works
Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory
Wang, X.-J., Tegner, J. N., Constantinidis, C., & Goldman‐Rakic, P. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305337101 · Cited by 405 · see citing works
Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition
Parnaudeau, S., O’Neill, P.-K., Bolkan, S. S., Ward, R. D., Abbas, A. I., Roth, B. L., Balsam, P. D., Gordon, J. A., & Kellendonk, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.038 · Cited by 387 · see citing works
Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking
Mahler, S. V., Vazey, E. M., Beckley, J. T., Keistler, C., McGlinchey, E. M., Kaufling, J., Wilson, S. P., Deisseroth, K. A., Woodward, J. J., & Aston‐Jones, G. (2014) · Nature Neuroscience · doi:10.1038/nn.3664 · Cited by 344 · see citing works
Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice
Cho, K. K. A., Hoch, R., Lee, A. T., Patel, T., Rubenstein, J. L. R., & Sohal, V. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.019 · Cited by 329 · see citing works
Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice
Selimbeyoglu, A., Kim, C. K., Inoue, M., Lee, S. Y., Hong, A. S. O., Kauvar, I., Ramakrishnan, C., Fenno, L. E., Davidson, T. J., Wright, M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah6733 · Cited by 326 · see citing works
Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model
Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs370 · Cited by 255 · see citing works
Prefrontal cortex and hippocampus subserve different components of working memory in ratsPreprint
Yoon, T., Okada, J., Jung, M. W., & Kim, J. J. (2008) · Learning & Memory · doi:10.1101/lm.850808 · Cited by 252 · see citing works
Different glutamate receptor channels mediate fast excitatory synaptic currents in inhibitory and excitatory cortical neurons
Hestrin, S. (1993) · Neuron · doi:10.1016/0896-6273(93)90221-c · Cited by 238 · see citing works
Thalamic-Prefrontal Cortical-Ventral Striatal Circuitry Mediates Dissociable Components of Strategy Set Shifting
Block, A. E., Dhanji, H., Thompson-Tardif, S. F., & Floresco, S. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl073 · Cited by 215 · see citing works
Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform
Lavoie, A. M., Tingey, J., Harrison, N. L., Pritchett, D. B., & Twyman, R. E. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78280-8 · Cited by 205 · see citing works
Prefrontal Cortex and Working Memory for Spatial Response, Spatial Location, and Visual Object Information in the Rat
Kesner, R. P., Hunt, M. E., Williams, J. M., & Long, J. M. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.2.311 · Cited by 201 · see citing works
Activation of a Cortical Column by a Thalamocortical Impulse
Swadlow, H. A., Gusev, A. G., & Bezdudnaya, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07766.2002 · Cited by 183 · see citing works
Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing
DeNardo, L. A., Berns, D. S., DeLoach, K. E., & Luo, L. (2015) · Nature Neuroscience · doi:10.1038/nn.4131 · Cited by 173 · see citing works
Gating of Hippocampal-Evoked Activity in Prefrontal Cortical Neurons by Inputs from the Mediodorsal Thalamus and Ventral Tegmental Area
Floresco, S., & Grace, A. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03930.2003 · Cited by 156 · see citing works
Mediodorsal Thalamus Hypofunction Impairs Flexible Goal-Directed Behavior
Parnaudeau, S., Taylor, K., Bolkan, S., Ward, R. D., Balsam, P., & Kellendonk, C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.020 · Cited by 156 · see citing works
Properties of Excitatory Synaptic Responses in Fast-spiking Interneurons and Pyramidal Cells from Monkey and Rat Prefrontal Cortex
Povysheva, N. V., González‐Burgos, G., Zaitsev, A. V., Kröner, S., Barrionuevo, G., Lewis, D. A., & Krimer, L. S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj002 · Cited by 145 · see citing works
G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain
Ponce, A., Bueno, E., Kentros, C. G., de Miera, E. V., Chow, A., Hillman, D. E., Chen, S., Zhu, L., Wu, M., Wu, X., et al. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01990.1996 · Cited by 140 · see citing works
Indiplon Is a High-Affinity Positive Allosteric Modulator with Selectivity for α1 Subunit-Containing GABAA Receptors
Petroski, R. E., Pomeroy, J. E., Das, R., Bowman, H., Yang, W., Chen, A. P., & Foster, A. C. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096701 · Cited by 118 · see citing works
Short promoters in viral vectors drive selective expression in mammalian inhibitory neurons, but do not restrict activity to specific inhibitory cell-types
Nathanson, J. L. (2009) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.019.2009 · Cited by 111 · see citing works
Delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in Japanese macaque monkeys
Sawaguchi, T., Matsumura, M., & Kubota, K. (1989) · Experimental Brain Research · doi:10.1007/bf00249897 · Cited by 109 · see citing works
Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia
Hoftman, G. D., Datta, D., & Lewis, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.022 · Cited by 109 · see citing works
Target-Specific Properties of Thalamocortical Synapses onto Layer 4 of Mouse Primary Visual Cortex
Kloc, M., & Maffei, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2595-14.2014 · Cited by 99 · see citing works
Schizophrenia-Like Attentional Deficits Following Blockade of Prefrontal Cortex GABAA Receptors
Paine, T. A., Slipp, L. E., & Carlezon, W. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.51 · Cited by 83 · see citing works
Pre‐synaptic GABAB receptors inhibit glutamate release through GIRK channels in rat cerebral cortex
Ladera, C., Godino, M. D. C., Cabañero, M. J., Torres, M., Watanabe, M., Luján, R., & Sánchez‐Prieto, J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05712.x · Cited by 81 · see citing works
Mediodorsal thalamic afferents to layer III of the rat prefrontal cortex: Synaptic relationships to subclasses of interneurons
Rotaru, D. C., Barrionuevo, G., & Sesack, S. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20661 · Cited by 81 · see citing works
The Magnocellular Mediodorsal Thalamus is Necessary for Memory Acquisition, But Not Retrieval
Mitchell, A. S., & Gaffan, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4922-07.2008 · Cited by 72 · see citing works
Receptor system response kinetics reveal functional subtypes of native murine and recombinant human GABAA receptors
McClellan, A. M. L., & Twyman, R. E. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.711ab.x · Cited by 69 · see citing works
Prefrontal Cortical GABA Modulation of Spatial Reference and Working Memory
Auger, M. L., & Floresco, S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu013 · Cited by 66 · see citing works
Mediodorsal thalamic lesions impair “Reference” and “working” memory in rats
Stokes, K. A., & Best, P. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90111-g · Cited by 62 · see citing works
Prefrontal cortical microcircuits bind perception to executive control
Opriș, I. C., Santos, L. M., Gerhardt, G. A., Song, D. B., Berger, T. W., Hampson, R. E., & Deadwyler, S. A. (2013) · Scientific Reports · doi:10.1038/srep02285 · Cited by 56 · see citing works
Thalamocortical synapses between axons from the mediodorsal thalamic nucleus and pyramidal cells in the prelimbic cortex of the rat
Kuroda, M., Murakami, K., Kishi, K., & Price, J. L. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903560110 · Cited by 45 · see citing works
Direct synaptic connections between thalamocortical axon terminals from the mediodorsal thalamic nucleus (MD) and corticothalamic neurons to MD in the prefrontal cortex
Kuroda, M., Murakami, K., Oda, S., Shinkai, M., & Kishi, K. (1993) · Brain Research · doi:10.1016/0006-8993(93)91683-j · Cited by 44 · see citing works
Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks
Roux, N. L., Amar, M., Moreau, A. W., Baux, G., & Fossier, P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06288.x · Cited by 39 · see citing works
Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and γ‐aminobutyric acidergic cortical cells in the prelimbic cortex of the rat
Kuroda, M., Yokofujita, J., Oda, S., & Price, J. L. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20249 · Cited by 36 · see citing works
Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and layer III pyramidal cells in the prelimbic cortex of the rat
Kuroda, M., Ojima, H., Igarashi, H., Murakami, K., Okada, A., & Shinkai, M. (1996) · Brain Research · doi:10.1016/0006-8993(95)01438-1 · Cited by 19 · see citing works

Flagged first, then by citations

Sorted by citations

PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders
Ferguson, B. R., & Gao, W.-J. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00037 · Cited by 594 · see citing works
Self-citation
Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications
Yan, Z., & Rein, B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01092-3 · Cited by 300 · see citing works
Thalamic regulation of switching between cortical representations enables cognitive flexibility
Rikhye, R. V., Gilra, A., & Halassa, M. M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0269-z · Cited by 302 · see citing works
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice
Guo, B., Chen, J., Chen, Q., Ren, K., Feng, D., Mao, H., Yao, H., Yang, J., Liu, H., Liu, Y., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0445-9 · Cited by 287 · see citing works
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Jiang, C.-C., Lin, L., Long, S., Ke, X., Fukunaga, K., Lu, Y., & Han, F. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01081-0 · Cited by 272 · see citing works
Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition
Page, C. E., & Coutellier, L. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.024 · Cited by 213 · see citing works
A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex
Xu, H., Liu, L., Tian, Y., Wang, J., Li, J., Zheng, J., Zhao, H., He, M., Xu, T.-L., Duan, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.026 · Cited by 181 · see citing works
Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations
Jaramillo, J., Mejías, J. F., & Wang, X. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.023 · Cited by 160 · see citing works
PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment
Coley, A. A., & Gao, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-45971-w · Cited by 139 · see citing works
Self-citation
Thalamic circuits for independent control of prefrontal signal and noise
Mukherjee, A., Lam, N. H., Wimmer, R. D., & Halassa, M. M. (2021) · Nature · doi:10.1038/s41586-021-04056-3 · Cited by 128 · see citing works
A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms
Liu, Y., Ouyang, P., Zheng, Y., Mi, L., Zhao, J., Ning, Y., & Guo, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.664535 · Cited by 129 · see citing works
Ventral Hippocampal-Prefrontal Interaction Affects Social Behavior via Parvalbumin Positive Neurons in the Medial Prefrontal Cortex
Sun, Q., Li, X., Li, A., Zhang, J., Ding, Z., Gong, H., & Luo, Q. (2020) · iScience · doi:10.1016/j.isci.2020.100894 · Cited by 105 · see citing works
Cell type–differential modulation of prefrontal cortical GABAergic interneurons on low gamma rhythm and social interaction
Liu, L., Xu, H., Wang, J., Li, J., Tian, Y., Zheng, J., He, M., Xu, T., Wu, Z., Li, W., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay4073 · Cited by 81 · see citing works
Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction
Gao, W., Yang, S.-S., Mack, N. R., & Chamberlin, L. A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01196-w · Cited by 70 · see citing works
Self-citation
Thalamocortical interactions in cognition and disease: The mediodorsal and anterior thalamic nuclei
Perry, B. A. L., Lomi, E., & Mitchell, A. S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.032 · Cited by 62 · see citing works
A high-fat high-sugar diet in adolescent rats impairs social memory and alters chemical markers characteristic of atypical neuroplasticity and parvalbumin interneuron depletion in the medial prefrontal cortex
Reichelt, A. C., Gibson, G. D., Abbott, K. N., & Hare, D. J. (2019) · Food & Function · doi:10.1039/c8fo02118j · Cited by 65 · see citing works
Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice
Li, J., Wu, X., Zhao, L.-J., Sun, H.-X., Hong, J., Wu, F.-L., Chen, S., Chen, T., Li, H., Dong, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38264-4 · Cited by 63 · see citing works
Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex
Harkness, J. H., Gonzalez, A. E., Bushana, P. N., Jorgensen, E. T., Hegarty, D. M., Nardo, A. A. D., Prochiantz, A., Wisor, J. P., Aicher, S. A., Brown, T. E., et al. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02229-4 · Cited by 51 · see citing works
Schizophrenia, the gut microbiota, and new opportunities from optogenetic manipulations of the gut-brain axis
Patrono, E., Svoboda, J., & Stuchlı́k, A. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00180-2 · Cited by 55 · see citing works
Nests of dividing neuroblasts sustain interneuron production for the developing human brain
Paredes, M. F., Mora, C., Flores-Ramirez, Q., Cebrián‐Silla, A., Dosso, A. D., Larimer, P., Chen, J., Kang, G., González-Granero, S., Garcia, E., et al. (2022) · Science · doi:10.1126/science.abk2346 · Cited by 50 · see citing works
GABAergic System Dysfunction and Challenges in Schizophrenia Research
Jahangir, M., Zhou, J., Lang, B., & Wang, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663854 · Cited by 52 · see citing works
Medial prefrontal cortical control of reward‐ and aversion‐based behavioral output: Bottom‐up modulation
Pastor, V. E., & Medina, J. H. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15168 · Cited by 48 · see citing works
Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse
Mukherjee, A., Bajwa, N., Lam, N. H., Porrero, C., Clascá, F., & Halassa, M. M. (2020) · eLife · doi:10.7554/elife.62554 · Cited by 49 · see citing works
Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence
Huang, Y., Jiang, H., Zheng, Q., Fok, A. H. K., Li, X., Lau, C. G., & Lai, C. S. W. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01005-w · Cited by 47 · see citing works
Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder
Markopoulos, A., Inserra, A., De Gregorio, D., & Gobbi, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.749068 · Cited by 46 · see citing works
Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action
Millan, M. J. (2022) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253221105128 · Cited by 44 · see citing works
Novel pharmacological targets for GABAergic dysfunction in ADHD
Ferranti, A. S., Luessen, D. J., & Niswender, C. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109897 · Cited by 43 · see citing works
Prefrontal GABAergic Interneurons Gate Long-Range Afferents to Regulate Prefrontal Cortex-Associated Complex Behaviors
Yang, S.-S., Mack, N. R., Shu, Y., & Gao, W. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.716408 · Cited by 41 · see citing works
Self-citation
Cerebellar Dysfunction in Autism Spectrum Disorders: Deriving Mechanistic Insights from an Internal Model Framework
Kelly, E., Escamilla, C. O., & Tsai, P. T. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.012 · Cited by 43 · see citing works
Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia
Benoit, L., Canetta, S., & Kellendonk, C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.03.004 · Cited by 46 · see citing works
Differential Rearrangement of Excitatory Inputs to the Medial Prefrontal Cortex in Chronic Pain Models
Jefferson, T. S., Kelly, C. J., & Martina, M. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.791043 · Cited by 41 · see citing works
Brain-wide electrical dynamics encode individual appetitive social behavior
Mague, S. D., Talbot, A., Blount, C., Walder-Christensen, K. K., Duffney, L. J., Adamson, E., Bey, A. L., Ndubuizu, N., Thomas, G. E., Hughes, D. N., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.016 · Cited by 46 · see citing works
VIP-expressing interneurons in the anterior insular cortex contribute to sensory processing to regulate adaptive behavior
Ramos-Prats, A., Paradiso, E., Castaldi, F., Sadeghi, M., Mir, M. Y., Hörtnagl, H., Göbel, G., & Ferraguti, F. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110893 · Cited by 38 · see citing works
Prenatal sevoflurane exposure causes neuronal excitatory/inhibitory imbalance in the prefrontal cortex and neurofunctional abnormality in rats
Zhao, T., Chen, Y., Sun, Z., Shi, Z., Qin, J., Lu, J., Li, C., Ma, D., Zhou, L., & Song, X. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105121 · Cited by 38 · see citing works
Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors
Zhang, L., Qin, Z., Ricke, K. M., Cruz, S. A., Stewart, A. F. R., & Chen, H. (2020) · Nature Communications · doi:10.1038/s41467-020-14813-z · Cited by 38 · see citing works
Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
Kato, T., Fujimori-Tonou, N., Mizukami, H., Ozawa, K., Fujisawa, S., & Kato, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-52984-y · Cited by 36 · see citing works
Time-sensitive changes in the maternal brain and their influence on mother-child attachment
Nehls, S., Losse, E. M., Enzensberger, C., Frodl, T., & Chechko, N. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02805-2 · Cited by 36 · see citing works
Prefrontal PV interneurons facilitate attention and are linked to attentional dysfunction in a mouse model of absence epilepsy
Ferguson, B. R., Glick, C., & Huguenard, J. R. (2023) · eLife · doi:10.7554/elife.78349 · Cited by 29 · see citing works
Self-citation
PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex
McEachern, E., Coley, A. A., Yang, S.-S., & Gao, W. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108277 · Cited by 34 · see citing works
Self-citation
A phylogenetically-conserved axis of thalamocortical connectivity in the human brain
Oldham, S., & Ball, G. (2023) · Nature Communications · doi:10.1038/s41467-023-41722-8 · Cited by 34 · see citing works
Astrocyte Activation in the ACC Contributes to Comorbid Anxiety in Chronic Inflammatory Pain and Involves in The Excitation-Inhibition Imbalance
Wei, N., Guo, Z., Qiu, M., Ye, R., Shao, X., Liang, Y., Liu, B., Fang, J., Fang, J., & Du, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04027-5 · Cited by 34 · see citing works
Early Life Stress Induces Different Behaviors in Adolescence and Adulthood May Related With Abnormal Medial Prefrontal Cortex Excitation/Inhibition Balance
Chen, Y., Zheng, Y., Yan, J., Zhu, C., Zeng, X., Zheng, S., Li, W., Yao, L., Xia, Y., Su, W.-W., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.720286 · Cited by 32 · see citing works
Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review
Parrella, N.-F., Hill, A. T., Dipnall, L. M., Loke, Y. J., Enticott, P. G., & Ford, T. C. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.11.014 · Cited by 32 · see citing works
Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress
Luo, Z., Chen, J., Dai, Y., So, K., & Zhang, L. (2023) · Communications Biology · doi:10.1038/s42003-023-05003-w · Cited by 29 · see citing works
erbb4 Deficits in Chandelier Cells of the Medial Prefrontal Cortex Confer Cognitive Dysfunctions: Implications for Schizophrenia
Yang, J., Shen, C.-J., Chen, X.-J., Kong, Y., Liu, Y.-S., Li, X., Chen, Z., Gao, T., & Li, X. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy316 · Cited by 28 · see citing works
The impact of maternal immune activation on GABAergic interneuron development: A systematic review of rodent studies and their translational implications
Gillespie, B., Panthi, S., Sundram, S., & Hill, R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105488 · Cited by 30 · see citing works
Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice
Shi, P., Nie, J., Liu, H., Li, Y., Lu, X., Shen, X., Ge, F., Yuan, T., & Guan, X. (2019) · The FASEB Journal · doi:10.1096/fj.201802192rr · Cited by 28 · see citing works
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
Zhang, Y.-M., Zong, H.-C., Qi, Y.-B., Chang, L.-L., Gao, Y.-N., Zhou, T., Yin, T., Liu, M., Pan, K.-J., Chen, W.-G., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02283-w · Cited by 27 · see citing works
Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice
Botterill, J. J., Khlaifia, A., Appings, R., Wilkin, J., Violi, F., Premachandran, H., Cruz-Sanchez, A., Canella, A. E., Patel, A. V., Zaidi, S. D., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01795-5 · Cited by 26 · see citing works
Change in serotonergic modulation contributes to the synaptic imbalance of neuronal circuit at the prefrontal cortex in the 15q11-13 duplication mouse model of autism
Saitow, F., Takumi, T., & Suzuki, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107931 · Cited by 27 · see citing works
The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia
Mukherjee, A., & Halassa, M. M. (2022) · The Neuroscientist · doi:10.1177/10738584221112861 · Cited by 25 · see citing works
Synaptic inhibition in the neocortex: Orchestration and computation through canonical circuits and variations on the theme
Lourenço, J., Koukouli, F., & Bacci, A. (2020) · Cortex · doi:10.1016/j.cortex.2020.08.015 · Cited by 22 · see citing works
Pharmacogenetic activation of parvalbumin interneurons in the prefrontal cortex rescues cognitive deficits induced by adolescent MK801 administration
Chamberlin, L. A., Yang, S.-S., McEachern, E., Lucas, J. T. M., McLeod, O. W., Rolland, C. A., Mack, N. R., Ferguson, B. R., & Gao, W. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01576-6 · Cited by 25 · see citing works
Self-citation
Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
Arime, Y., Saitoh, Y., Ishikawa, M., Kamiyoshihara, C., Uchida, Y., Fujii, K., Takao, K., Akiyama, K., & Ohkawa, N. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01769-z · Cited by 25 · see citing works
Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors
Li, F., Zheng, X., Wang, H., Meng, L., Chen, M., Hui, Y., Liu, D., Li, Y., Xie, K., Zhang, J., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01829-y · Cited by 24 · see citing works
Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in Disc1 Locus Impairment Mice
Delevich, K. M., Jaaro-Peled, H., Penzo, M. A., Sawa, A., & Li, B. (2020) · eNeuro · doi:10.1523/eneuro.0496-19.2020 · Cited by 25 · see citing works
Molecular and Circuit Architecture of Social HierarchyPreprint
Nelson, A. C., Kapoor, V., Vaughn, E., Gnanasegaram, J. A., Rubinstein, N. D., Murthy, V. N., & Dulac, C. G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/838664 · Cited by 24 · see citing works
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
Qi, C., Sima, W., Mao, H., Hu, E., Ge, J., Deng, M., Chen, A., Ye, W., Xue, Q., Wang, W., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59473-z · Cited by 26 · see citing works
Prenatal expression of d-aspartate oxidase causes early cerebral d-aspartate depletion and influences brain morphology and cognitive functions at adulthood
Rosa, A. D., Mastrostefano, F., Maio, A. D., Nuzzo, T., Saitoh, Y., Katane, M., Isidori, A. M., Caputo, V., Marotta, P., Falco, G., et al. (2020) · Amino Acids · doi:10.1007/s00726-020-02839-y · Cited by 23 · see citing works
Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry
Dannenhoffer, C. A., Robertson, M. M., Macht, V. A., Mooney, S. M., Boettiger, C. A., & Robinson, D. L. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.07.004 · Cited by 23 · see citing works
Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype‐specific signatures, clinical correlates, and practical relevance
McKenna, M. C., Lope, J., Bede, P., & Tan, E. L. (2023) · Brain and Behavior · doi:10.1002/brb3.2881 · Cited by 23 · see citing works
Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus
Ren, P., Wang, J.-Y., Chen, H., Wang, Y., Cui, L.-Y., Duan, J.-Y., Guo, W.-Z., Zhao, Y., & Li, Y. (2024) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2024.02.003 · Cited by 23 · see citing works
Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure
Kiffer, F. C., Luitel, K., Tran, F. H., Patel, R., Guzman, C. S., Soler, I., Xiao, R., Shay, J. W., Yun, S., & Eisch, A. J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113677 · Cited by 23 · see citing works
Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study
Tang, S., Xu, S., Waddell, J., Zhu, W., Gullapalli, R. P., & Mooney, S. M. (2019) · Developmental Neuroscience · doi:10.1159/000499183 · Cited by 22 · see citing works
Targeting the Neuronal Activity of Prefrontal Cortex: New Directions for the Therapy of Depression
Zhou, X., Bao, W.-D., Liu, D., & Zhu, L. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191101124017 · Cited by 22 · see citing works
Repeated methamphetamine administration produces cognitive deficits through augmentation of GABAergic synaptic transmission in the prefrontal cortex
Armenta-Reséndiz, M., Assali, A., Tsvetkov, E., Cowan, C. W., & Lavı́n, A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01371-9 · Cited by 23 · see citing works
Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies
Mack, N. R., Bouras, N. N., & Gao, W. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.03.008 · Cited by 24 · see citing works
Self-citation
Lack of synaptic protein, calsyntenin‐2, impairs morphology of synaptic complexes in mice
Ranneva, S. V., Maksimov, V. F., Korostyshevskaja, I. M., & Lipina, T. V. (2019) · Synapse · doi:10.1002/syn.22132 · Cited by 22 · see citing works
Mediodorsal Thalamus Contributes to the Timing of Instrumental Actions
Lusk, N. A., Meck, W. H., & Yin, H. H. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0695-20.2020 · Cited by 21 · see citing works
Food Restriction Engages Prefrontal Corticostriatal Cells and Local Microcircuitry to Drive the Decision to Run versus Conserve Energy
Santiago, A. N., Makowicz, E. A., Du, M., & Aoki, C. J. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa394 · Cited by 21 · see citing works
Improvements in gait and balance in patients with multiple sclerosis after treatment with coconut oil and epigallocatechin gallate. A pilot study
Cuerda‐Ballester, M., Proaño, B., Alarcón-Jiménez, J., de Bernardo, N., Villarón-Casales, C., Lajara-Romance, J. M., & Ortí, J. E. D. L. R. (2023) · Food & Function · doi:10.1039/d2fo02207a · Cited by 21 · see citing works
GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders
Hughes, H., Brady, L. J., & Schoonover, K. E. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1440834 · Cited by 20 · see citing works
Machine learning: assessing neurovascular signals in the prefrontal cortex with non-invasive bimodal electro-optical neuroimaging in opiate addiction
Ieong, H. F.-H., Gao, F. Q., & Yuan, Z. (2019) · Scientific Reports · doi:10.1038/s41598-019-54316-6 · Cited by 21 · see citing works
The Optogenetic Revolution in Cerebellar Investigations
Prestori, F., Montagna, I., D'Angelo, E. U., & Mapelli, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072494 · Cited by 20 · see citing works
Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction
Thomson, D. M., Mitchell, E. J., Openshaw, R. L., Pratt, J. A., & MORRIS, B. J. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211032439 · Cited by 20 · see citing works
The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero
Skorput, A. G. J., Lee, S. M., Yeh, P. W. L., & Yeh, H. H. (2019) · eLife · doi:10.7554/elife.48648 · Cited by 19 · see citing works
Parvalbumin neurons mediate neurological phenotypes of anti-NMDAR encephalitis
Feng, Y.-F., Zeng, Z.-K., Ni, Y., Hu, Y., Yang, K., Cai, F., Zhou, Q., Chen, M., Zhu, X., Chen, S., et al. (2025) · Brain · doi:10.1093/brain/awae374 · Cited by 18 · see citing works
Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice
Anacker, A. M. J., Moran, J., Santarelli, S., Forsberg, C. G., Rogers, T. D., Stanwood, G. D., Hall, B. J., Delpire, E. J., Veenstra-VanderWeele, J. M., & Saxe, M. (2019) · Autism Research · doi:10.1002/aur.2098 · Cited by 17 · see citing works
Prefrontal cortex astrocytes modulate distinct neuronal populations to control anxiety-like behavior
Kim, E., Du, H., Tan, Y., Brown, B. L., Chang, Y., Castro, B. D., Sweedler, J. V., & Yu, X. (2025) · Nature Communications · doi:10.1038/s41467-025-63131-9 · Cited by 18 · see citing works
Adolescent Δ9-Tetrahydrocannabinol Exposure Selectively Impairs Working Memory but Not Several Other mPFC-Mediated Behaviors
Chen, H.-T., & Mackie, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.576214 · Cited by 17 · see citing works
Neurophysiological basis of the N400 deflection, from Mismatch Negativity to Semantic Prediction Potentials and late positive components
Almeida, V. N. (2021) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2021.06.001 · Cited by 17 · see citing works
Prefrontal Cortical Control of Anxiety: Recent Advances
Mack, N. R., Deng, S., Yang, S.-S., Shu, Y., & Gao, W. (2022) · The Neuroscientist · doi:10.1177/10738584211069071 · Cited by 14 · see citing works
Self-citation
Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility
Zhang, X., Mukherjee, A., Halassa, M. M., & Chen, Z. S. (2025) · Nature Communications · doi:10.1038/s41467-025-58011-1 · Cited by 17 · see citing works
The autism-associated loss of δ-catenin functions disrupts social behavior
Mendez-Vazquez, H., Roach, R. L., Nip, K., Chanda, S., Sathler, M. F., Garver, T., Danzman, R. A., Moseley, M. C., Roberts, J. P., Koch, O. N., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300773120 · Cited by 14 · see citing works
Accelerated social representational drift in the nucleus accumbens in a model of autismPreprint
Zhao, P., Chen, X., Bellafard, A., Murugesan, A., Quan, J. J., Aharoni, D. B., & Golshani, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.05.552133 · Cited by 15 · see citing works
Connecting Neurobiological Features with Interregional Dysconnectivity in Social-Cognitive Impairments of Schizophrenia
Adraoui, F. W., Douw, L., Martens, G. J. M., & Maas, D. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097680 · Cited by 14 · see citing works
MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV+ interneurons or forebrain pyramidal cells
Sokolenko, E., Nithianantharajah, J., & Jones, N. C. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108103 · Cited by 14 · see citing works
Cognitive outcome is related to functional thalamo-cortical connectivity after paediatric stroke
Steiner, L., Federspiel, A., Slavova, N., Wiest, R., Grunt, S., Steinlin, M. I., & Everts, R. (2022) · Brain Communications · doi:10.1093/braincomms/fcac110 · Cited by 13 · see citing works
Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice
Ma, Y., Yang, C., Zhang, C., Sun, Y., Yao, X., Liu, X., Li, X., Wang, H., Wang, H., Wang, T., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02845-6 · Cited by 13 · see citing works
Environmental exposure to 17β-trenbolone during adolescence inhibits social interaction in male mice
Zhang, S., Jiao, Z., Zhao, X. J., Sun, M., & Feng, X. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117710 · Cited by 13 · see citing works
From Hyposociability to Hypersociability—The Effects of PSD-95 Deficiency on the Dysfunctional Development of Social Behavior
Gao, W., & Mack, N. R. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.618397 · Cited by 13 · see citing works
Self-citation
Role of Medial Prefrontal Cortical Neurons and Oxytocin Modulation in the Establishment of Social Buffering
Jung, T., Jang, M., & Noh, J. (2021) · Experimental Neurobiology · doi:10.5607/en20038 · Cited by 12 · see citing works
Decreased grey matter volume in dorsolateral prefrontal cortex and thalamus accompanied by compensatory increases in middle cingulate gyrus of premature ejaculation patients
Gao, S., Chen, J., Liu, J., Guan, Y., Liu, R., Yang, J., & Yang, X. (2023) · Andrology · doi:10.1111/andr.13547 · Cited by 12 · see citing works
Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex
Martinez, C. A., Pantazopoulos, H., Gisabella, B., Stephens, E. T., Garteiser, J., & Arco, A. D. (2024) · Scientific Reports · doi:10.1038/s41598-024-57599-6 · Cited by 11 · see citing works
Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder
Tseng, H., Wu, C. Y., Chang, H. H., Lu, T., Chang, W. H., Hsu, C., Lin, R.-Y., Yeh, D.-R., Shaw, F.-Z., Yang, Y. K., et al. (2024) · Psychological Medicine · doi:10.1017/s0033291724001326 · Cited by 12 · see citing works
Molecular and neural control of social hierarchy by a forebrain-thalamocortical circuit
Nelson, A. C., Kapoor, V., Vaughn, E., Gnanasegaram, J. A., Rubinstein, N. D., Talay, M., Murthy, V. N., & Dulac, C. G. (2025) · Cell · doi:10.1016/j.cell.2025.07.024 · Cited by 35 · see citing works
Cortical dopamine D5 receptors regulate neuronal circuit oscillatory activity and memory in rats
Albeely, A. M., Nolan, C. J., Rasmussen, D. J., Bailey, C. D. C., & Perreault, M. L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14210 · Cited by 11 · see citing works
The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice
Chehrazi, P., Lee, K. K. Y., Lavertu-Jolin, M., Abbasnejad, Z., Carreño-Muñoz, M. I., Chattopadhyaya, B., & Cristo, G. D. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.04.019 · Cited by 14 · see citing works
Pathway-specific inhibition of critical projections from the mediodorsal thalamus to the frontal cortex controls kindled seizures
Wicker, E., Hyder, S. K., & Forcelli, P. A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102286 · Cited by 11 · see citing works
mGlu1-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice
Luessen, D. J., Gallinger, I. M., Ferranti, A. S., Foster, D. J., Melancon, B. J., Lindsley, C. W., Niswender, C. M., & Conn, P. J. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01350-0 · Cited by 11 · see citing works

Medial Prefrontal Cortex Excitation/Inhibition Balance and Schizophrenia-like Behaviors Regulated by Thalamic Inputs to Interneurons
Fan, Z., & Hu, H. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.005 · Cited by 7 · see citing works
The Mediodorsal Thalamus: An Essential Partner of the Prefrontal Cortex for Cognition
Parnaudeau, S., Bolkan, S. S., & Kellendonk, C. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.008 · Cited by 283 · see citing works
Central thalamic inactivation impairs the expression of action‐ and outcome‐related responses of medial prefrontal cortex neurons in the rat
Francoeur, M. J., Wormwood, B. A., Gibson, B. M., & Mair, R. G. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14350 · Cited by 9 · see citing works
Modulating excitation of the mediodorsal thalamus rescues dysfunction after administration of MK-801 in rats
Chen, P., Hu, H., Wang, M., Li, R., Wei, J., Wang, M., Tan, T., & Yu, Y. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149532 · Cited by 2 · see citing works
The influence of central thalamus on coding properties of prefrontal cortex
Wormwood, B. A. (2015) · University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)

Authors: Ferguson, B. R., & Gao, W.-J.
Affiliations: Drexel University (US)
Corresponding author: Gao, Wen-Jun
ORCID: Ferguson, Brielle R.
Gao, Wen-Jun
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2018-04
Volume: 83
Issue: 8
Pages: 657-669
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2017.11.033
PMC: PMC5862785
OpenAlex: W2774489697
Cited by: 186
References: 59
Citations by year: 2026: 24 · 2025: 26 · 2024: 27 · 2023: 26 · 2022: 18 · 2021: 24 · 2020: 19 · 2019: 17 · 2018: 5
FWCI: 5.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health/National Institute of Mental Health (F31MH111361, R01MH085666, R21MH111609)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: mediodorsal thalamus, medial prefrontal cortex, excitation-inhibition balance, GABAergic neurotransmission, parvalbumin interneurons, thalamocortical circuits, cognition, social behavior, anxiety, pyramidal neurons, mental illness
MeSH terms: Animals, Behavior, Animal, Cognition, gamma-Aminobutyric Acid, Interneurons, Male, Pharmacogenetics, Social Behavior, Signal Transduction, Rats, Sprague-Dawley, Prefrontal Cortex, Patch-Clamp Techniques, GABA Agents, Excitatory Postsynaptic Potentials, Mediodorsal Thalamic Nucleus, Rats, Inhibitory Postsynaptic Potentials, GABAergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks