Plasticity in designing PROTACs for selective and potent degradation of HDAC6

Development and Applications of CRISPR-Cas9 for Genome Engineering

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Erasers of Histone Acetylation: The Histone Deacetylase EnzymesPreprint

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

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Targeted protein degradation by PROTACs

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Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR

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HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

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Histone deacetylases and cancer

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Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes

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Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

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PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies

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Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

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Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy

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Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK)

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Histone Deacetylase 6 in Health and Disease

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The ins and outs of tubulin acetylation: More than just a post-translational modification?

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Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

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Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity

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Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One

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Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference

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HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases

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Developing potent PROTACs tools for selective degradation of HDAC6 protein

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Pretreatment advanced lung cancer inflammation index ( ALI ) for predicting early progression in nivolumab‐treated patients with advanced non–small cell lung cancer

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Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies

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Proteolysis-Targeting Chimeras: Harnessing the Ubiquitin-Proteasome System to Induce Degradation of Specific Target Proteins

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Current strategies for the design of PROTAC linkers: a critical review

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Proteolysis-targeting chimeras (PROTACs) in cancer therapy

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Targeted protein degradation: advances in drug discovery and clinical practice

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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy

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PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)

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PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

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Targeting histone deacetylases for cancer therapy: Trends and challenges

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Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives

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Developments of CRBN-based PROTACs as potential therapeutic agents

Wang, C., Zhang, Y., Wu, Y., & Xing, D. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113749 · Cited by 152 · see citing works

Characteristic roadmap of linker governs the rational design of PROTACs

Dong, Y., Ma, T., Xu, T., Feng, Z., Li, Y., Song, L., Yao, X., Ashby, C. R., & Hao, G.-F. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.04.007 · Cited by 146 · see citing works

Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies

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Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs

Xiao, Y., Wang, J., Zhao, L., Chen, X., Zheng, G., Zhang, X., & Liao, D. (2020) · Chemical Communications · doi:10.1039/d0cc03243c · Cited by 130 · see citing works

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

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Strategies for designing proteolysis targeting chimaeras (PROTACs)

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A bibliometric analysis of PROTAC from 2001 to 2021

Li, D., Yu, D., Li, Y., & Yang, R. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114838 · Cited by 122 · see citing works

Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase

Yang, K., Wu, H., Zhang, Z., Leisten, E. D., Nie, X., Liu, B., Wen, Z., Zhang, J., Cunningham, M. D., & Tang, W. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.0c00046 · Cited by 124 · see citing works

Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1

Hu, M., Zhou, W., Wang, Y., Yao, D., Ye, T., Yao, Y., Chen, B., Liu, G., Yang, X., Wang, W., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.02.010 · Cited by 114 · see citing works

HDAC-targeting epigenetic modulators for cancer immunotherapy

Cheng, B., Pan, W., Xiao, Y., Ding, Z., Zhou, Y., Fei, X., Liu, J., Su, Z., Peng, X., & Chen, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116129 · Cited by 115 · see citing works

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

Luo, G., Li, Z., Lin, X., Li, X., Chen, Y., Xi, K., Xiao, M., Wei, H., Zhu, L., & Xiang, H. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.001 · Cited by 83 · see citing works

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

Peng, X., Hu, Z., Zeng, L., Zhang, M., Xu, C., Lu, B., Tao, C., Chen, W., Hou, W., Cheng, K., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.003 · Cited by 85 · see citing works

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors

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HDAC Inhibitors: Innovative Strategies for Their Design and Applications

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Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity

Sinatra, L., Yang, J. C., Schliehe‐Diecks, J., Dienstbier, N., Vogt, M., Gebing, P., Bachmann, L. M., Sönnichsen, M., Lenz, T., Stühler, K., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01659 · Cited by 74 · see citing works

Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6

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PROTACs: A novel strategy for cancer drug discovery and development

Han, X., & Sun, Y. (2023) · MedComm · doi:10.1002/mco2.290 · Cited by 67 · see citing works

Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention

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Recent Advances of Degradation Technologies Based on PROTAC Mechanism

Xiao, M., Zhao, J., Wang, Q., Liu, J., & Ma, L. (2022) · Biomolecules · doi:10.3390/biom12091257 · Cited by 66 · see citing works

Journey of PROTAC: From Bench to Clinical Trial and Beyond

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Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation

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Discovery of a PROTAC targeting ALK with in vivo activity

Yan, G., Zhong, X.-X., Lin, Y., Pu, C., Shan, H., Lan, S., Zhou, M., Hou, X., Yang, J., & Li, R. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.113150 · Cited by 59 · see citing works

Development of the first non-hydroxamate selective HDAC6 degraders

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HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation

Xiao, Y., Hale, S. M., Awasthee, N., Meng, C., Zhang, X., Liu, Y., Ding, H., Huo, Z., Lv, D., Zhang, W., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.010 · Cited by 54 · see citing works

Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer

Pu, C., Tong, Y., Liu, Y., Lan, S., Wang, S., Yan, G., Zhang, H., Luo, D., Ma, X., Yu, S., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114321 · Cited by 50 · see citing works

Discovery of pomalidomide-based PROTACs for selective degradation of histone deacetylase 8

Sun, Z., Deng, B., Yang, Z., Mai, R., Huang, J., Ma, Z., Chen, T., & Chen, J. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114544 · Cited by 46 · see citing works

Bifunctional HDAC Therapeutics: One Drug to Rule Them All?

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Small molecules targeting HDAC6 for cancer treatment: Current progress and novel strategies

Huang, Z., Li, L., Cheng, B., & Li, D. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117218 · Cited by 45 · see citing works

The application of PROTAC in HDAC

Chen, S., Zheng, Y., Liang, B., Yin, Y., Yao, J., Wang, Q., Liu, Y., & Neamati, N. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115746 · Cited by 43 · see citing works

Degraders in epigenetic therapy: PROTACs and beyond

Dai, X., Ji, S., Fu, M., Liu, G.-Z., Liu, H., Wang, S., Shen, L., Wang, N., Herdewijn, P. A., Zheng, Y., et al. (2024) · Theranostics · doi:10.7150/thno.92526 · Cited by 44 · see citing works

Advancements in Hydrazide-Based HDAC Inhibitors: A Review of Recent Developments and Therapeutic Potential

Raucci, A., Zwergel, C., Valente, S., & Mai, A. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01677 · Cited by 41 · see citing works

Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release

Bockstiegel, J., Wurnig, S. L., Engelhardt, J., Enns, J., Hansen, F. K., & Weindl, G. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115693 · Cited by 40 · see citing works

PROTACs in Epigenetic Cancer Therapy: Current Status and Future Opportunities

Liu, X., Wang, A., Shi, Y., Dai, M., Liu, M., & Cai, H. (2023) · Molecules · doi:10.3390/molecules28031217 · Cited by 38 · see citing works

Designing HDAC-PROTACs: Lessons Learned So Far

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PROTAC: targeted drug strategy. Principles and limitations

Koroleva, O. A., Dutikova, Y. V., Trubnikov, A. V., Zenov, F. A., Manasova, E. V., Shtil, A. A., & Kurkin, A. V. (2022) · Russian Chemical Bulletin · doi:10.1007/s11172-022-3659-z · Cited by 38 · see citing works

HDAC6—An Emerging Target Against Chronic Myeloid Leukemia?

Losson, H., Schnekenburger, M., Dicato, M. A., & Diederich, M. F. (2020) · Cancers · doi:10.3390/cancers12020318 · Cited by 32 · see citing works

Designing an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells

Liu, Y., Zhen, Y., Wang, G., Yang, G., Fu, L., Liu, B., & Ouyang, L. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112505 · Cited by 34 · see citing works

Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer’s disease

Li, Y., Lin, S., Gu, Z., Chen, L., & He, B. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.129015 · Cited by 33 · see citing works

Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease

Li, Y., Gu, Z., Lin, S., Chen, L., Dzreyan, V., Eid, M., Demyanenko, S. V., & He, B. (2022) · Brain Sciences · doi:10.3390/brainsci12050672 · Cited by 31 · see citing works

Progress of small molecules for targeted protein degradation: PROTACs and other technologies

Zhao, H., Xin, M., & Zhang, S. (2023) · Drug Development Research · doi:10.1002/ddr.22026 · Cited by 31 · see citing works

Current strategies for improving limitations of proteolysis targeting chimeras

Pu, C., Wang, S., Liu, L., Feng, Z., Zhang, H., Gong, Q., Sun, Y., Guo, Y., & Li, R. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.107927 · Cited by 29 · see citing works

Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization

Shan, Y., Si, R., Wang, J., Zhang, Q., Li, J., Ma, Y., & Zhang, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112654 · Cited by 29 · see citing works

Small-Molecule PROTACs for Cancer Immunotherapy

Liu, Z., Zhang, Y., Xiang, Y., & Kang, X. (2022) · Molecules · doi:10.3390/molecules27175439 · Cited by 29 · see citing works

Progress of proteolysis-targeting chimeras (PROTACs) delivery system in tumor treatment

Fan, L., Tong, W., Wei, A., & Mu, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133680 · Cited by 28 · see citing works

Advances in the Design and Development of PROTAC-mediated HDAC Degradation

Rodrigues, D. A., Roe, A. J., Griffith, D. M., & Chonghaile, T. N. (2021) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026621666211015092047 · Cited by 24 · see citing works

Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury

Xia, K., Qiu, T., Jian, Y., Liu, H., Chen, H., Liu, X., Chen, Z., & Wang, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115128 · Cited by 25 · see citing works

PROTAC chemical probes for histone deacetylase enzymes

Patel, U., Smalley, J. P., & Hodgkinson, J. T. (2023) · RSC Chemical Biology · doi:10.1039/d3cb00105a · Cited by 24 · see citing works

Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC

Cao, J., Zhao, W., Zhao, C., Liu, Q., Li, S., Zhang, G., Chou, C. J., & Zhang, Y. (2020) · Molecules · doi:10.3390/molecules25214991 · Cited by 24 · see citing works

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer

Vuletić, A. M., Martinović, K. M., & Spasić, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010054 · Cited by 24 · see citing works

Rational Proteolysis Targeting Chimera Design Driven by Molecular Modeling and Machine Learning

Tan, S., Chen, Z., Lu, R., Liu, H., & Yao, X. (2025) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.70013 · Cited by 23 · see citing works

Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)

Tomaselli, D., Mautone, N., Mai, A., & Rotili, D. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112750 · Cited by 21 · see citing works

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy: screening, synthesis, and biological evaluation

Geurs, S., Clarisse, D., Baele, F., Franceus, J., Desmet, T., Bosscher, K. D., & D’hooghe, M. (2022) · Chemical Communications · doi:10.1039/d2cc01550a · Cited by 20 · see citing works

Recent Advances in Small Molecular Modulators Targeting Histone Deacetylase 6

Xiao, Y., & Zhang, X. (2020) · Future Drug Discovery · doi:10.4155/fdd-2020-0023 · Cited by 20 · see citing works

Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands

Lu, Y., Sun, D., Xiao, D., Shao, Y.-Y., Su, M., Zhou, Y., Li, J. X., Zhu, S., & Lu, W. P. (2021) · Molecules · doi:10.3390/molecules26237241 · Cited by 20 · see citing works

Targeting micro-environmental pathways by PROTACs as a therapeutic strategy

Liu, J., Peng, Y., Inuzuka, H., & Wei, W. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.07.001 · Cited by 20 · see citing works

Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders

Feller, F., Honin, I., Miranda, M., Weber, H. B., Henze, S., Hanl, M., & Hansen, F. K. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02569 · Cited by 19 · see citing works

Design and pharmaceutical applications of proteolysis-targeting chimeric molecules

Liang, Y., Nandakumar, K. S., & Cheng, K. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114211 · Cited by 16 · see citing works

Exploring the landscape of post-translational modification in drug discovery

Cao, Y., Yu, T., Zhu, Z., Zhang, Y., Sun, S., Li, N., Gu, C., & Yang, Y. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108749 · Cited by 15 · see citing works

Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy

Zhang, H., Zhang, Y., Feng, Z., Shuai, M., Ma, X., Wang, S., Yu, S., Deng, R., Luo, D., Shi, J., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02259 · Cited by 15 · see citing works

PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance

Giardina, S. F., Valdambrini, E., Warren, J. D., & Barany, F. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009621666210203110857 · Cited by 14 · see citing works

Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo

Yang, H., Qin, J., Pei, Y., Guan, S., Zhao, M., Wang, Y., Yao, Y., Duan, Y., & Sun, M. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116067 · Cited by 14 · see citing works

Cereblon: promise and challenges for combating human diseases

Kim, H. K., Seol, J. E., Ahn, S. W., Jeon, S., Park, C., & Han, J. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02624-0 · Cited by 14 · see citing works

Chimera induced protein degradation: PROTACs and beyond

Yin, L., & Hu, Q. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112494 · Cited by 14 · see citing works

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3Preprint

Roatsch, M., Vogelmann, A., Herp, D., Jung, M., & Olsen, C. A. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12416303.v1 · Cited by 14 · see citing works

Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy

Carelock, M. E., Master, R. P., Kim, M., Jin, Z., Wang, L. A., Maharjan, C. K., Hua, N., De, U., Kolb, R. H., Xiao, Y., et al. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad019 · Cited by 13 · see citing works

The Role of HDAC6 in Glioblastoma Multiforme: A New Avenue to Therapeutic Interventions?

Spallotta, F., & Illi, B. (2024) · Biomedicines · doi:10.3390/biomedicines12112631 · Cited by 12 · see citing works

Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders

Zhai, S., Honin, I., Schäker‐Hübner, L., Hanl, M., Jacobi, L., Dressler, F., Pieńkowska, D. E., König, P., Gerhartz, J., Voget, R., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00674 · Cited by 11 · see citing works

Targeting reversible post-translational modifications with PROTACs: a focus on enzymes modifying protein lysine and arginine residues

Pichlak, M., Sobierajski, T., Błażewska, K. M., & Gendaszewska‐Darmach, E. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2254012 · Cited by 10 · see citing works

Epigenetic therapy meets targeted protein degradation: HDAC-PROTACs in cancer treatment

Hussain, M. S., Zhang, L., Rana, A. J., Maqbool, M., Ashique, S., Khan, Y., Jakhmola, V., Hanbashi, A., Mawkili, W., & Khan, G. (2025) · Future Medicinal Chemistry · doi:10.1080/17568919.2025.2533113 · Cited by 9 · see citing works

PROTACs targeting epigenetic proteins

Zhang, C., He, Y., Sun, X., Wei, W., Liu, Y., & Rao, Y. (2023) · Acta Materia Medica · doi:10.15212/amm-2023-0039 · Cited by 11 · see citing works

PROTAC‐Based HDAC Degradation: A Paradigm Shift in Targeted Epigenetic Therapies

Himaja, A., Halder, D., Banerjee, S., Biswas, S., Adhikari, N., & Ghosh, B. (2025) · ChemMedChem · doi:10.1002/cmdc.202500203 · Cited by 9 · see citing works

Histone deacetylase 6: a potential therapeutic target for drug development

Li, Z., Zhu, H., Wang, X., Zhang, L., & Zhang, L. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108932 · Cited by 7 · see citing works

Developing PROteolysis TArgeting Chimeras (PROTACs) for hematologic malignancies

Wu, Y., Zhang, J., Zhu, X., & Zhang, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215808 · Cited by 7 · see citing works

Proteasomal Degradation of Zn-Dependent Hdacs: The E3-Ligases Implicated and the Designed Protacs That Enable Degradation

Márquez-Cantudo, L., Ramos, A., Coderch, C., & de Pascual‐Teresa, B. (2021) · Molecules · doi:10.3390/molecules26185606 · Cited by 7 · see citing works

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3Preprint

Roatsch, M., Vogelmann, A., Herp, D., Jung, M., & Olsen, C. A. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12416303 · Cited by 6 · see citing works

Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor

Cursaro, I., Ciccone, V., Tudino, V., Papulino, C., Scalvini, L., Donnini, S., Morbidelli, L., Bini, L., Landi, C., Contri, C., et al. (2025) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2025.100276 · Cited by 5 · see citing works

HDAC6 mediates tumorigenesis during mitosis and the development of targeted deactivating agents

Peng, J., Liu, H., Liu, Y., Liu, J., Zhao, Q., Liu, W., Niu, H., Xue, H., Sun, J., & Wu, J. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107818 · Cited by 5 · see citing works

Solid-phase synthesis of cereblon-recruiting selective histone deacetylase 6 degraders (HDAC6 PROTACs) with anti-leukemic activityPreprint

Sinatra, L., Yang, J., Schliehe‐Diecks, J., Dienstbier, N., Vogt, M., Gebing, P., Bachmann, L. M., Sönnichsen, M., Lenz, T., Stühler, K., et al. (2022) · ChemRxiv · doi:10.26434/chemrxiv-2022-dntx4-v2 · Cited by 5 · see citing works

Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation

Lin, C., Hsu, J., Hsu, Y., Fan, K.-C., Wu, S., Lin, M., Guh, J., & Yu, C. (2025) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2025.2468355 · Cited by 3 · see citing works

Prospects and advances of PROTAC in the treatment of hematologic malignancies

Wang, X., Zhang, M., & Mei, H. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00759-3 · Cited by 3 · see citing works

Unlocking the therapeutic potential of HDAC inhibitors in colorectal cancer: Mechanisms, efficacy, and future perspectives

Wen, Y., Yang, C., Ye, Y., Shen, Z., & Wang, C. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104920 · Cited by 3 · see citing works

Recent Innovative Advances in the Discovery of Selective HDAC6 Inhibitors

Tavares, M. T., & Shen, S. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0040 · Cited by 3 · see citing works

Targeted Protein Degradation by Proteolysis Targeting Chimeras

Du, W. (2022) · doi:10.1002/9781119627784.ch11 · Cited by 2 · see citing works

The Chicken HDAC4 Promoter and Its Regulation by MYC and HIF1A

Wang, Y., Kong, R., Xie, K., Wang, X., Wu, H., & Zhang, Y. (2024) · Genes · doi:10.3390/genes15121518 · Cited by 1 · see citing works

PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators

Periyasamy, S., Jarrett, T., Truong, J., & Skouta, R. (2026) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2026.2636394 · Cited by 1 · see citing works

Bifunctional proximity-inducing strategies for targeted and programmable post-translational modifications

Tanga, S., Das, P., Samoi, T. B., Hota, A., Karmakar, A., & Maji, B. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115874 · Cited by 1 · see citing works

Histone Deacetylase Meets Protein Degradation: Accelerating Anticancer Drug Discovery

Wang, J.-J., Gao, Y., Ji, X.-Q., Yin, J.-Y., Zhang, M., Wang, B., Liu, H., Feng, S., Wang, N., Lu, G., et al. (2026) · Medicinal Research Reviews · doi:10.1002/med.70052 · Cited by 2 · see citing works

Discovery of a Selective Histone Deacetylase 6 Degrader (HDAC6 PROTAC) with a Short and Rigid Linker Demonstrating Sustained Knockdown of HDAC6 In Vivo

Ripa, L., Cassani, C., Hughes, G. A., Ranieri, B., Ullah, V., Zambelloni, R., Andreasson, T., Collins, M., Lindberg, B., Llinàs, A., et al. (2026) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6c00086 · Cited by 1 · see citing works

Solid-phase synthesis of cereblon-recruiting selective histone deacetylase 6 degraders (HDAC6 PROTACs) with anti-leukemic activityPreprint

Sinatra, L., Yang, J., Schliehe‐Diecks, J., Dienstbier, N., Voigt, M., Gebing, P., Bachmann, L. M., Sönnichsen, M., Lenz, T., Stühler, K., et al. (2022) · ChemRxiv · doi:10.26434/chemrxiv-2022-dntx4

Solid-phase synthesis of cereblon-recruiting selective histone deacetylase 6 degraders (HDAC6 PROTACs) with anti-leukemic activityPreprint

Sinatra, L., Yang, J., Schliehe‐Diecks, J., Dienstbier, N., Vogt, M., Gebing, P., Bachmann, L. M., Sönnichsen, M., Lenz, T., Stühler, K., et al. (2022) · ChemRxiv · doi:10.26434/chemrxiv-2022-dntx4-v3

Targeted Protein Degradation of Metalloenzymes

O’Herin, C., & Cohen, S. M. (2025) · Wiley eBooks · doi:10.1002/0471266949.bmc303

Rapid Two-Step Multicomponent Synthesis and Structure-degradation Relationships of Selective HDAC6 PROTAC Degraders

Tsymliakov, M., Hanl, M., Enns, J., Zhai, S., Ferretti, E., König, P., Kousa, R., Tu, J., Steinebach, C., Gütschow, M., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c02045 · Cited by 1 · see citing works

Development of Ethyl-Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs

Stopper, D., Honin, I., Feller, F., & Hansen, F. K. (2025) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5c00033 · Cited by 14 · see citing works

Solid-phase synthesis of cereblon-recruiting selective histone deacetylase 6 degraders (HDAC6 PROTACs) with anti-leukemic activityPreprint

Sinatra, L., Yang, J., Schliehe‐Diecks, J., Dienstbier, N., Vogt, M., Gebing, P., Bachmann, L. M., Sönnichsen, M., Lenz, T., Stühler, K., et al. (2022) · ChemRxiv · doi:10.26434/chemrxiv-2022-dntx4-v2 · Cited by 5 · see citing works

Target engagement studies and kinetic live-cell degradation assays enable the systematic characterization of HDAC6 PROTACsPreprint

Hanl, M., Feller, F., Honin, I., Tan, K., Miranda, M., Schäker-Hübner, L., Bückreiß, N., Schiedel, M., Gütschow, M., Bendas, G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.31.646177

Discovery of a Selective Histone Deacetylase 6 Degrader (HDAC6 PROTAC) with a Short and Rigid Linker Demonstrating Sustained Knockdown of HDAC6 In Vivo

Ripa, L., Cassani, C., Hughes, G. A., Ranieri, B., Ullah, V., Zambelloni, R., Andreasson, T., Collins, M., Lindberg, B., Llinàs, A., et al. (2026) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6c00086 · Cited by 1 · see citing works