The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer's disease
Abstract
The delivery of drugs across the blood–brain barrier (BBB) effectively and safely is one of the major challenges in the treatment of neurodegenerative diseases.
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In the citing paper
“In combination with ultrasound, this system could accumulate in the brain and promote drug delivery because of the transient opening of the BBB.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [224]
In the citing paper
“Qc@SNPs-MB effectively treated Alzheimer’s disease by protecting nerve cells and reducing endoplasmic reticulum stress which comes from oxidative stress, inflammatory response, calcium homeostasis imbalance, and neuronal apoptosis.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [224]
Citations
Cites
Endoplasmic reticulum stress: cell life and death decisions
Xu, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26373 · Cited by 2,291
From endoplasmic-reticulum stress to the inflammatory response
Zhang, K., & Kaufman, R. J. (2008) · Nature · doi:10.1038/nature07203 · Cited by 2,010
Redox- and non-redox-metal-induced formation of free radicals and their role in human disease
Valko, M., Jomová, K., Rhodes, C. J., Kuča, K., & Musílek, K. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1579-5 · Cited by 1,062
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
Hetz, C., & Mollereau, B. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3689 · Cited by 684
Bioinorganic Chemistry of Alzheimer’s Disease
Kepp, K. P. (2012) · Chemical Reviews · doi:10.1021/cr300009x · Cited by 683
Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626
Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 612
Ai, X., Ho, C. J. H., Aw, J., Attia, A. B. E., Mu, J., Wang, Y., Wang, X., Wang, Y., Liu, X., Chen, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10432 · Cited by 432
Self-citationRecent advances in nanomaterial-based synergistic combination cancer immunotherapy
Sang, W., Zhang, Z., Dai, Y., & Chen, X. S. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00896e · Cited by 409
Self-citation
Research works printed but not linked: 1
- Kuehn, 2018, J. Am. Med. Assoc., 320, 1851
Cited by
Sorted by citations
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
Self-citationWang, J., Li, Z., Pan, M., Fiaz, M., Hao, Y., Yan, Y., Sun, L., & Yan, F. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114539 · Cited by 161
Applications of focused ultrasound-mediated blood-brain barrier opening
Gorick, C. M., Breza, V. R., Nowak, K. M., Cheng, V. W. T., Fisher, D. G., Debski, A. C., Hoch, M. R., Demir, Z. E. F., Tran, N. M., Schwartz, M. R., et al. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114583 · Cited by 144
Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery
Shakya, G., Cattaneo, M., Guerriero, G., Prasanna, A., Fiorini, S., & Supponen, O. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115178 · Cited by 139
Poudel, P., & Park, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040835 · Cited by 124
Metadata
- Authors
- Liu, Y., Gong, Y., Xie, W., Huang, A., Yuan, X., Zhou, H., Zhu, X., Chen, X., Liu, J., Liu, J., & Qin, X.
- Affiliations
- Jinan University (CN)
- College of Pharmacy
- Corresponding author
- Liu, Jie
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 12
- Issue
- 11
- Pages
- 6498-6511
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W3003203987
- Cited by
- 123
- References
- 52
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 22 · 2023: 15 · 2022: 25 · 2021: 16 · 2020: 7
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81803027, 21877051, 21701034)
- Natural Science Foundation of Guangdong Province (2018A030310628)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- microbubbles, focused ultrasound, blood-brain barrier, sonoporation, quercetin, sulfur nanoparticles, Alzheimer's disease, endoplasmic reticulum stress, brain drug delivery, neuroprotection, oxidative stress, memory impairment, neuroinflammation, calcium homeostasis
- MeSH terms
- Ultrasonic Waves, Alzheimer Disease, Animals, Blood-Brain Barrier, Cell Line, Disease Models, Animal, Humans, Quercetin, Drug Delivery Systems, Microbubbles, Mice, Nanoparticles, Endoplasmic Reticulum Stress
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