Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer's disease

Endoplasmic reticulum stress: cell life and death decisions

Xu, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26373 · Cited by 2,291

From endoplasmic-reticulum stress to the inflammatory response

Zhang, K., & Kaufman, R. J. (2008) · Nature · doi:10.1038/nature07203 · Cited by 2,010

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

Valko, M., Jomová, K., Rhodes, C. J., Kuča, K., & Musílek, K. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1579-5 · Cited by 1,062

Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

Hetz, C., & Mollereau, B. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3689 · Cited by 684

Bioinorganic Chemistry of Alzheimer’s Disease

Kepp, K. P. (2012) · Chemical Reviews · doi:10.1021/cr300009x · Cited by 683

Alzheimer's Disease: From Pathology to Therapeutic Approaches

Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 612

In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

Ai, X., Ho, C. J. H., Aw, J., Attia, A. B. E., Mu, J., Wang, Y., Wang, X., Wang, Y., Liu, X., Chen, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10432 · Cited by 432

Recent advances in nanomaterial-based synergistic combination cancer immunotherapy

Sang, W., Zhang, Z., Dai, Y., & Chen, X. S. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00896e · Cited by 409

In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging

Huynh, E., Leung, B. Y. C., Helfield, B. L., Shakiba, M., Gandier, J., Jin, C. S., Master, E. R., Wilson, B. C., Goertz, D. E., & Zheng, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.25 · Cited by 364

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

Agrawal, M., Ajazuddin, Tripathi, D. K., Saraf, S., Saraf, S., Antimisiaris, S. G., Mourtas, S., Hammarlund-Udenaes, M., & Alexander, A. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.019 · Cited by 356

Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice

Zhang, C., Xu, W., Zheng, X., Shao, X., Liu, Q., Zhang, Q., & Qian, Y. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.063 · Cited by 266

Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

Gao, N., Sun, H., Dong, K., Ren, J., Duan, T., Xu, C., & Qu, X. (2014) · Nature Communications · doi:10.1038/ncomms4422 · Cited by 263

Dual-Enzyme Characteristics of Polyvinylpyrrolidone-Capped Iridium Nanoparticles and Their Cellular Protective Effect against H2O2-Induced Oxidative Damage

Su, H., Liu, D., Zhao, M. L., Hu, W.-L., Xue, S.-S., Cao, Q., Le, X., Ji, L., & Mao, Z. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01271 · Cited by 207

Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease

Zhang, L., Zhao, P., Yue, C., Jin, Z., Liu, Q., Du, X., & He, Q. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.037 · Cited by 196

Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice

Liu, Y., An, S., Li, J., Kuang, Y., He, X., Guo, Y., Ma, H., Zhang, Y., Ji, B., & Jiang, C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.060 · Cited by 191

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

Nisbet, R. M., Van der Jeugd, A., Leinenga, G., Evans, H. T., Janowicz, P. W., & Götz, J. (2017) · Brain · doi:10.1093/brain/awx052 · Cited by 187

The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease

Savelieff, M. G., DeToma, A. S., Derrick, J. S., & Lim, M. H. (2014) · Accounts of Chemical Research · doi:10.1021/ar500152x · Cited by 174

Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice

Zhao, Y., Cai, J., Liu, Z., Li, Y., Zheng, C., Zheng, Y., Chen, Q., Chen, H., Ma, F., An, Y., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03644 · Cited by 166

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

Li, M. C., Howson, S. E., Dong, K., Gao, N., Ren, J., Scott, P., & Qu, X. (2014) · Journal of the American Chemical Society · doi:10.1021/ja502789e · Cited by 163

Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles

Fokong, S., Theek, B., Wu, Z., Koczera, P., Appold, L. C., Jorge, S., Resch‐Genger, U., van Zandvoort, M. A. M. J., Storm, G., Kiessling, F. M., et al. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.007 · Cited by 158

Enzyme‐Responsive Cell‐Penetrating Peptide Conjugated Mesoporous Silica Quantum Dot Nanocarriers for Controlled Release of Nucleus‐Targeted Drug Molecules and Real‐Time Intracellular Fluorescence Imaging of Tumor Cells

Li, J., Liu, F., Shao, Q., Min, Y., Costa, M., Yeow, E. K. L., & Xing, B. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300613 · Cited by 157

Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation

Lammers, T., Koczera, P., Fokong, S., Gremse, F., Ehling, J., Vogt, M., Pich, A., Storm, G., van Zandvoort, M., & Kiessling, F. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201401199 · Cited by 156

Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery

Cochran, M. C., Eisenbrey, J., Ouma, R. O., Soulen, M., & Wheatley, M. (2011) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2011.05.030 · Cited by 149

Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease

Sun, J., Wei, C., Liu, Y., Xie, W., Xu, M., Zhou, H., & Liu, J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.12.027 · Cited by 132

Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities

Yang, G., Zhou, D., Pan, Z., Yang, J., Zhang, D., Cao, Q., Ji, L., & Mao, Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119280 · Cited by 128

Chirality-Selected Chemical Modulation of Amyloid Aggregation

Gao, N., Du, Z., Guan, Y., Dong, K., Ren, J., & Qu, X. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b12537 · Cited by 126

Polyoxometalate-based nanozyme: Design of a multifunctional enzyme for multi-faceted treatment of Alzheimer’s disease

Gao, N., Dong, K., Zhao, A., Sun, H., Wang, Y., Ren, J., & Qu, X. (2016) · Nano Research · doi:10.1007/s12274-016-1000-6 · Cited by 120

Molybdenum Disulfide Nanoparticles as Multifunctional Inhibitors against Alzheimer’s Disease

Han, Q., Cai, S., Yang, L., Wang, X., Cui, Q., Yang, R., & Wang, C. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03816 · Cited by 118

Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2

Hiroi, T., Wei, H., Hough, C. J., Leeds, P. R., & Chuang, D. M. (2005) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500296 · Cited by 102

Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery

Fan, C., Ting, C.-Y., Chang, Y., Wei, K., Liu, H.-L., & Yeh, C. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.12.026 · Cited by 96

Sulfur Nanoparticles Synthesis and Characterization from H2S Gas, Using Novel Biodegradable Iron Chelates in W/O Microemulsion

Deshpande, A. S., Khomane, R. B., Vaidya, B. K., Joshi, R. M., Harle, A. S., & Kulkarni, B. D. (2008) · Nanoscale Research Letters · doi:10.1007/s11671-008-9140-6 · Cited by 96

Penetrating the Blood–Brain Barrier: Promise of Novel Nanoplatforms and Delivery Vehicles

Ali, I., & Chen, X. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b05341 · Cited by 93

Multifunctional carbon dots as a therapeutic nanoagent for modulating Cu( ii )-mediated β-amyloid aggregation

Chung, Y. J., Lee, B. I., & Park, C. B. (2019) · Nanoscale · doi:10.1039/c9nr00473d · Cited by 88

Near‐Infrared Activated Black Phosphorus as a Nontoxic Photo‐Oxidant for Alzheimer's Amyloid‑β Peptide

Li, Y., Du, Z., Liu, X., Ma, M., Yu, D., Lu, Y., Ren, J., & Qu, X. (2019) · Small · doi:10.1002/smll.201901116 · Cited by 86

Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors

Chang, E.-L., Ting, C.-Y., Hsu, P.-H., Lin, Y., Liao, E., Huang, C.-Y., Chang, Y., Chan, H., Chiang, C., Liu, H.-L., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.010 · Cited by 84

Gold Nanocage‐Based Dual Responsive “Caged Metal Chelator” Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease

Shi, P., Li, M., Ren, J., & Qu, X. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201301015 · Cited by 82

Rattle‐Structured Upconversion Nanoparticles for Near‐IR‐Induced Suppression of Alzheimer's β‐Amyloid Aggregation

Kuk, S. K., Lee, B. I., Lee, J., & Park, C. B. (2017) · Small · doi:10.1002/smll.201603139 · Cited by 79

Metal-involved theranostics: An emerging strategy for fighting Alzheimer’s disease

Wang, X., Wang, X., & Guo, Z. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.03.010 · Cited by 72

Ultrasound-Excited Protoporphyrin IX-Modified Multifunctional Nanoparticles as a Strong Inhibitor of Tau Phosphorylation and β-Amyloid Aggregation

Xu, M., Zhou, H., Liu, Y., Sun, J., Xie, W., Zhao, P., & Liu, J. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b08230 · Cited by 65

Codelivery of Plasmid and Curcumin with Mesoporous Silica Nanoparticles for Promoting Neurite Outgrowth

Cheng, C.-S., Liu, T., Chien, F., Mou, C., Wu, S., & Chen, Y. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b02797 · Cited by 63

Quercetin reduces eIF2α phosphorylation by GADD34 induction

Hayakawa, M., Itoh, M., Ohta, K., Li, S., Ueda, M., Wang, M.-X., Nishida, E., Islam, S., Suzuki, C., Ohzawa, K., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.006 · Cited by 52

Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative

Zhu, Z., Yang, T., Zhang, L., Liu, L., Yin, E., Zhang, C., Guo, Z., Chen, X., & Wang, X. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.052 · Cited by 44

A Near‐Infrared Responsive Drug Sequential Release System for Better Eradicating Amyloid Aggregates

Ma, M., Gao, N., Sun, Y., Ren, J., & Qu, X. (2017) · Small · doi:10.1002/smll.201701817 · Cited by 38

Sulfur Nanoparticles with Novel Morphologies Coupled with Brain-Targeting Peptides RVG as a New Type of Inhibitor Against Metal-Induced Aβ Aggregation

Sun, J., Xie, W., Zhu, X., Xu, M., & Liu, J. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00312 · Cited by 32

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors

Kwak, J. H., Yang, Z., Yoon, B., He, Y., Uhm, S., Shin, H., Lee, B. H., Yoo, Y. C., Lee, K., Han, S.-Y., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.045 · Cited by 31

Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis?

Langa, K. M., & Burke, J. F. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.2629 · Cited by 30

Increased delivery of TAT across an endothelial monolayer following ischemic injury

Simon, M. J., Kang, W. H., Gao, S., Banta, S., & Morrison, B. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.09.029 · Cited by 26

Nanotherapeutic Strategies for the Treatment of Alzheimer's Disease

Gu, X. Q., Chen, H., & Gao, X. (2015) · Therapeutic Delivery · doi:10.4155/tde.14.97 · Cited by 15

Antibiotic Resistance Challenge

Kuehn, B. M. (2018) · JAMA · doi:10.1001/jama.2018.16587 · Cited by 13

Coordinating Organismal Physiology Through the Unfolded Protein Response

Wiseman, R., & Haynes, C. M. (2018) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-319-78530-1 · Cited by 3

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906

Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases

Wang, J., Li, Z., Pan, M., Fiaz, M., Hao, Y., Yan, Y., Sun, L., & Yan, F. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114539 · Cited by 161

Applications of focused ultrasound-mediated blood-brain barrier opening

Gorick, C. M., Breza, V. R., Nowak, K. M., Cheng, V. W. T., Fisher, D. G., Debski, A. C., Hoch, M. R., Demir, Z. E. F., Tran, N. M., Schwartz, M. R., et al. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114583 · Cited by 144

Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery

Shakya, G., Cattaneo, M., Guerriero, G., Prasanna, A., Fiorini, S., & Supponen, O. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115178 · Cited by 139

Recent Advances in the Treatment of Alzheimer’s Disease Using Nanoparticle-Based Drug Delivery Systems

Poudel, P., & Park, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040835 · Cited by 124

Intracerebral drug delivery using microbubble/nanodroplet-assisted ultrasound to address neurodegenerative diseases

Ea, K., Taulier, N., Contino-Pepin, C., Urbach, W., Desgranges, S., Blasco, H., Ojaimi, Y. A., Corcia, P., Vourc’h, P., & Escoffre, J. (2025) · Journal of Clinical and Translational Research · doi:10.36922/jctr.24.00061 · Cited by 3

Microbubbles-based drug delivery for antiAlzheimer's drugs

Patel, M. B., Prajapati, B. G., & Yadav, M. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13205-6.00006-6 · Cited by 3

Methylene Blue Delivery Mediated by Focused Ultrasound-Induced Blood–Brain Barrier Disruption Reduces Neural Damage and Amyloid-Beta Plaques by AQP-4 Upregulation

Choi, H. J., Han, M., Jung, B., Hong, Y.-R., Shin, S., Lim, S., Lee, E., Kim, Y. K., & Park, J. (2022) · Biomedicines · doi:10.3390/biomedicines10123191 · Cited by 12

Ultrasound-mediated drug delivery to the brain: principles, progress and prospects

Dasgupta, A., Liu, M., Ojha, T., Storm, G., Kiessling, F. M., & Lammers, T. (2016) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2016.07.007 · Cited by 161

Recent Progress of the Treatment of Alzheimer's Disease Using Low- frequency Ultrasound Combined with Microbubbles

Gaosh, C. (2015) · Progress in Biomedical Engineering