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Cited by 144Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Applications of focused ultrasound-mediated blood-brain barrier opening

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Gorick, Catherine M., Breza, Victoria R., Nowak, Katherine M., Cheng, Vinton W.T., Fisher, Delaney G., Debski, Anna C., Hoch, Matthew R., Demir, Zehra E.F. +4 more·2022·Advanced Drug Delivery Reviews
DOI 10.1016/j.addr.2022.114583PMC PMC9712235
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Abstract

The blood brain barrier (BBB) plays a critically important role in the regulation of central nervous system (CNS) homeostasis, but also represents a major limitation to treatments of brain pathologies. In recent years, focused ultrasound (FUS) in conjunction with gas-filled microbubble contrast agents has emerged as a powerful tool for transiently and non-invasively disrupting the BBB in a targeted and image-guided manner, allowing for localized delivery of drugs, genes, or other therapeutic agents. Beyond the delivery of known therapeutics, FUS-mediated BBB opening also demonstrates the potential for use in neuromodulation and the stimulation of a range of cell- and tissue-level physiological responses that may prove beneficial in disease contexts. Clinical trials investigating the safety and efficacy of FUS-mediated BBB opening are well underway, and offer promising non-surgical approaches to treatment of devastating pathologies. This article reviews a range of pre-clinical and clinical studies demonstrating the tremendous potential of FUS to fundamentally change the paradigm of treatment for CNS diseases.

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  • Gas-filled microbubbles with ultrasound open BBB in image-guided and targeted manner, ensuring local drug delivery.

    “gas-filled microbubble has emerged as a contrast agent in conjunction with ultrasound for opening the BBB in an image-guided and targeted manner, ensuring the local delivery of drugs.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [223]

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Cited by

Sorted by citations

Authors
Gorick, C. M., Breza, V. R., Nowak, K. M., Cheng, V. W. T., Fisher, D. G., Debski, A. C., Hoch, M. R., Demir, Z. E. F., Tran, N. M., Schwartz, M. R., Sheybani, N. D., & Price, R. J.
Affiliations
  • University of Virginia (US)
  • University of Leeds (GB)
Corresponding author
Price, Richard J.
ORCID
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2022-12
Volume
191
Pages
114583
ISSN
0169-409X (ISSN-L)
DOI
10.1016/j.addr.2022.114583
PMC
PMC9712235
OpenAlex
W4306804981
Cited by
144
References
6
Citations by year
2026: 42 · 2025: 41 · 2024: 41 · 2023: 20
FWCI
2.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • National Institutes of Health (R01EB030744, R21NS118278)
  • National Institutes of Health Office of the Director (DP5OD031846)
  • National Institute of Neurological Disorders and Stroke (R01NS111102)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB030409)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
focused ultrasound, blood-brain barrier opening, microbubbles, gene delivery, neuromodulation, neuropathology, image-guided therapy
MeSH terms
Biological Transport, Blood-Brain Barrier, Contrast Media, Humans, Magnetic Resonance Imaging, Drug Delivery Systems, Microbubbles

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