Cited by 20Ultrasound and Hyperthermia ApplicationsAlzheimer's disease research and treatmentsBarrier Structure and Function Studies

A comprehensive review of advanced focused ultrasound (FUS) microbubbles-mediated treatment of Alzheimer’s disease

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Rouhi, Nadiyeh, Chakeri, Zahra, Ghorbani Nejad, Behnam, Rahimzadegan, Milad, Rafi Khezri, Mohammad, Kamali, Hossein, Nosrati, Rahim·2024·Heliyon

Abstract

Alzheimer's disease (AD) is characterized by progressive neurodegeneration, memory loss, and cognitive impairment leading to dementia and death. The blood-brain barrier (BBB) prevents the delivery of drugs into the brain, which can limit their therapeutic potential in the treatment of AD. Therefore, there is a need to develop new approaches to bypass the BBB for appropriate treatment of AD. Recently, focused ultrasound (FUS) has been shown to disrupt the BBB, allowing therapeutic agents to penetrate the brain. In addition, microbubbles (MBs) as lipophilic carriers can penetrate across the BBB and deliver the active drug into the brain tissue. Therefore, combined with FUS, the drug-encapsulated MBs can pass through the ultrasound-disrupted zone of the BBB and diffuse into the brain tissue. This review provides clear and concise statements on the recent advances of the various FUS-mediated MBs-based carriers developed for delivering AD-related drugs. In addition, the sonogenetics-based FUS/MBs approaches for the treatment of AD are highlighted. The future perspectives and challenges of ultrasound-based MBs drug delivery in AD are then discussed.

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Research works printed but not linked: 3

  1. [74]Wasielewska J.M. White A.R. Focused ultrasound-mediated drug delivery in humans–a path towards translation in neurodegenerative diseases Pharm. Res. (N. Y.) 39 2022 427 439 PMC8986691 35257286
  2. [117]Shi Q. Sun T. Zhang Y. Power C. Hoesch C. Antonelli S. Schroeder M.K. Caldarone B.J. Taudte N. Schenk M. Ultrasound-mediated blood-brain barrier disruption improves anti-pyroglutamate 3 Aβ antibody efficacy and enhances phagocyte infiltration into brain in aged Alzheimer’s disease-like mice bioRxiv 2021
  3. [120]Yang Y. Pacia C.P. Ye D. Zhu L. Baek H. Yue Y. Yuan J. Miller M.J. Cui J. Culver J.P. Sonogenetics for noninvasive and cellular-level neuromodulation in rodent brain bioRxiv 2020

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Authors
Rouhi, N., Chakeri, Z., Ghorbani Nejad, B., Rahimzadegan, M., Rafi Khezri, M., Kamali, H., & Nosrati, R.
Affiliations
  • University of Mississippi Medical Center (US)
  • University of Washington (US)
  • Shahid Beheshti University of Medical Sciences (IR)
  • Mashhad University of Medical Sciences (IR)
  • Guilan University of Medical Sciences (IR)
Corresponding author
  • Rouhi, Nadiyeh
  • Kamali, Hossein
  • Nosrati, Rahim
Venue
Heliyon
Publisher
Elsevier BV
Published
2024-09
Volume
10
Issue
18
Pages
e37533
ISSN
2405-8440 (ISSN-L)
OpenAlex
W4402299006
Cited by
20
References
185
Citations by year
2026: 10 · 2025: 9 · 2024: 1
FWCI
0.72
Type
journal article
Language
en
Open access
Locations
  • Heliyon (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Georgetown University
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
Alzheimer's disease, focused ultrasound, microbubbles, blood-brain barrier disruption, brain drug delivery, sonogenetics, neurodegeneration

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