A comprehensive review of advanced focused ultrasound (FUS) microbubbles-mediated treatment of Alzheimer’s disease
Open accessAbstract
Alzheimer's disease (AD) is characterized by progressive neurodegeneration, memory loss, and cognitive impairment leading to dementia and death. The blood-brain barrier (BBB) prevents the delivery of drugs into the brain, which can limit their therapeutic potential in the treatment of AD. Therefore, there is a need to develop new approaches to bypass the BBB for appropriate treatment of AD. Recently, focused ultrasound (FUS) has been shown to disrupt the BBB, allowing therapeutic agents to penetrate the brain. In addition, microbubbles (MBs) as lipophilic carriers can penetrate across the BBB and deliver the active drug into the brain tissue. Therefore, combined with FUS, the drug-encapsulated MBs can pass through the ultrasound-disrupted zone of the BBB and diffuse into the brain tissue. This review provides clear and concise statements on the recent advances of the various FUS-mediated MBs-based carriers developed for delivering AD-related drugs. In addition, the sonogenetics-based FUS/MBs approaches for the treatment of AD are highlighted. The future perspectives and challenges of ultrasound-based MBs drug delivery in AD are then discussed.
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FUS is a safe, non-invasive, and reversible technique capable of temporarily disrupting the BBB.
“FUS is a safe, non-invasive, and reversible technique capable of temporarily disrupting the BBB.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [79]
Effective BBB opening requires combining FUS with systemically administered MBs.
“However, effective BBB opening requires combining FUS with systemically administered MBs.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [79]
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Advances in therapeutic hybrid neuromodulation for Parkinson’s disease
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Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
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InfluentialNano-phyto formulations for overcoming drug resistance in brain cancer: A translational roadmap
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Emerging hydrogel platforms for disease modeling, diagnosis, and imaging of Alzheimer's disease
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- Authors
- Rouhi, N., Chakeri, Z., Ghorbani Nejad, B., Rahimzadegan, M., Rafi Khezri, M., Kamali, H., & Nosrati, R.
- Affiliations
- University of Mississippi Medical Center (US)
- University of Washington (US)
- Shahid Beheshti University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Guilan University of Medical Sciences (IR)
- Corresponding author
- Rouhi, Nadiyeh
- Kamali, Hossein
- Nosrati, Rahim
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2024-09
- Volume
- 10
- Issue
- 18
- Pages
- e37533
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC11416559
- OpenAlex
- W4402299006
- Cited by
- 20
- References
- 185
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Georgetown University
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Alzheimer's disease, focused ultrasound, microbubbles, blood-brain barrier disruption, brain drug delivery, sonogenetics, neurodegeneration
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