Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration
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various strategies to overcome major obstacles such as insufficient mechanical property and uncontrollable degradation. This review presents the research status of GelMA, its structure and function, GelMA-based biomaterials and the development of methods along with their existing challenges.
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Scaffolds in bone regenerative medicine with rich functional properties serve as a solution.
“In this context, the usage of scaffolds in bone regenerative medicine with rich functional properties serves as a solution [5].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [5]
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3D printing of polymer matrix composites: A review and prospective
Wang, X., Jiang, M., Zhou, Z., Gou, J., & Hui, D. (2016) · Composites Part B Engineering · doi:10.1016/j.compositesb.2016.11.034 · Cited by 3,341 · see citing works
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146 · see citing works
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377 · see citing works
Recent advances in bone tissue engineering scaffolds
Bose, S., Roy, M., & Bandyopadhyay, A. K. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.07.005 · Cited by 2,217 · see citing works
Wang, X., Xu, S., Zhou, S., Xu, W., Leary, M., Choong, P., Qian, M., Brandt, M., & Xie, Y. M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.012 · Cited by 2,138 · see citing works
Self-citationBiomaterials for bone tissue engineering
Stevens, M. M. (2008) · Materials Today · doi:10.1016/s1369-7021(08)70086-5 · Cited by 1,200 · see citing works
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949 · see citing works
Direct 3D bioprinting of perfusable vascular constructs using a blend bioink
Jia, W., Gungor-Ozkerim, P. S., Zhang, Y. S., Yue, K., Zhu, K., Liu, W., Pi, Q., Byambaa, B., Dokmeci, M. R., Shin, S. R., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.038 · Cited by 922 · see citing works
Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low‐Viscosity Bioink
Colosi, C., Shin, S. R., Manoharan, V., Massa, S., Costantini, M., Barbetta, A., Dokmeci, M. R., Dentini, M., & Khademhosseini, A. (2016) · Advanced Materials · doi:10.1002/adma.201503310 · Cited by 863 · see citing works
Implant biomaterials: A comprehensive review
Saini, M. (2015) · World Journal of Clinical Cases · doi:10.12998/wjcc.v3.i1.52 · Cited by 845 · see citing works
Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering
Zhao, X., Lang, Q., Yildirimer, L., Lin, Z. Y., Cui, W., Annabi, N., Ng, K. W., Dokmeci, M. R., Ghaemmaghami, A. M., & Khademhosseini, A. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500005 · Cited by 839 · see citing works
The roles of vascular endothelial growth factor in bone repair and regeneration
Hu, K., & Olsen, B. R. (2016) · Bone · doi:10.1016/j.bone.2016.06.013 · Cited by 678 · see citing works
Bioactive Nanoengineered Hydrogels for Bone Tissue Engineering: A Growth-Factor-Free Approach
Xavier, J. R., Thakur, T., Desai, P. B., Jaiswal, M. K., Sears, N., Cosgriff‐Hernandez, E., Kaunas, R. R., & Gaharwar, A. K. (2015) · ACS Nano · doi:10.1021/nn507488s · Cited by 653 · see citing works
Stimuli-responsive bio-based polymeric systems and their applications
Gao, S., Tang, G., Hua, D., Xiong, R., Han, J., Jiang, S., Zhang, Q., & Huang, C. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb02491j · Cited by 614 · see citing works
Yin, J., Yan, M., Wang, Y., Fu, J., & Suo, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b16059 · Cited by 602 · see citing works
Das, S., Pati, F., Choi, Y., Rijal, G., Shim, J., Kim, S. W., Ray, A. R., Cho, D., & Ghosh, S. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.09.023 · Cited by 557 · see citing works
Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering
Liu, X., Callahan, L. A. S., Hu, J., & Ma, P. X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.068 · Cited by 540 · see citing works
Nanomaterials and bone regeneration
Gong, T., Xie, J., Liao, J., Zhang, T., Lin, S., & Lin, Y. (2015) · Bone Research · doi:10.1038/boneres.2015.29 · Cited by 538 · see citing works
Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis
Shirahama, H., Lee, B. H., Tan, L. P., & Cho, N. (2016) · Scientific Reports · doi:10.1038/srep31036 · Cited by 477 · see citing works
Zhao, X., Liu, S., Yildirimer, L., Zhao, H., Ding, R., Wang, H., Cui, W., & Weitz, D. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504943 · Cited by 426 · see citing works
Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue
Byambaa, B., Annabi, N., Yue, K., Santiago, G. T., Álvarez, M. M., Jia, W., Kazemzadeh‐Narbat, M., Shin, S. R., Tamayol, A., & Khademhosseini, A. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700015 · Cited by 396 · see citing works
Enhanced bone regeneration with a gold nanoparticle–hydrogel complex
Heo, D. N., Ko, W., Bae, M. S., Lee, J. B., Lee, D.-W., Byun, W., Lee, C. H., Kim, E.-C., Jung, B., & Kwon, I. K. (2014) · Journal of Materials Chemistry B · doi:10.1039/c3tb21246g · Cited by 290 · see citing works
Huang, K., Wu, J., & Gu, Z. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b21179 · Cited by 273 · see citing works
Self-citationCheng, H., Yue, K., Kazemzadeh‐Narbat, M., Liu, Y., Khalilpour, A., Li, B., Zhang, Y. S., Annabi, N., & Khademhosseini, A. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16779 · Cited by 263 · see citing works
Hoch, E., Hirth, T., Tovar, G. E. M., & Borchers, K. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20745e · Cited by 256 · see citing works
Hoch, E., Schuh, C., Hirth, T., Tovar, G. E. M., & Borchers, K. (2012) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-012-4731-2 · Cited by 254 · see citing works
3D printing of complex GelMA-based scaffolds with nanoclay
Gao, Q., Niu, X., Shao, L., Zhou, L., Lin, Z., Sun, A., Fu, J., Chen, Z., Hu, J. P., Liu, Y., et al. (2019) · Biofabrication · doi:10.1088/1758-5090/ab0cf6 · Cited by 245 · see citing works
Synthesis and Characterization of Types A and B Gelatin Methacryloyl for Bioink Applications
Lee, B., Lum, N., Seow, L., Lim, P., & Tan, L. P. (2016) · Materials · doi:10.3390/ma9100797 · Cited by 243 · see citing works
Mechanically Stiff Nanocomposite Hydrogels at Ultralow Nanoparticle Content
Jaiswal, M. K., Xavier, J. R., Carrow, J. K., Desai, P. B., Alge, D. L., & Gaharwar, A. K. (2015) · ACS Nano · doi:10.1021/acsnano.5b03918 · Cited by 236 · see citing works
3D Culture of Chondrocytes in Gelatin Hydrogels with Different Stiffness
Li, X., Chen, S., Li, J., Wang, X., Zhang, J., Kawazoe, N., & Chen, G. (2016) · Polymers · doi:10.3390/polym8080269 · Cited by 234 · see citing works
Tissue engineering strategies for promoting vascularized bone regeneration
Almubarak, S. M., Nethercott, H. E., Freeberg, M., Beaudon, C., Jha, A. K., Jackson, W. M., Marcucio, R., Miclau, T., Healy, K. E., & Bahney, C. S. (2015) · Bone · doi:10.1016/j.bone.2015.11.011 · Cited by 200 · see citing works
Visser, J., Gawlitta, D., Benders, K. E. M., Toma, S. M. H., Pouran, B., van Weeren, P. R., Dhert, W. J. A., & Malda, J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.020 · Cited by 188 · see citing works
Zhou, X., Nowicki, M. A., Cui, H., Zhu, W., Fang, X., Miao, S., Lee, S., Keidar, M., & Zhang, L. G. (2017) · Carbon · doi:10.1016/j.carbon.2017.02.049 · Cited by 186 · see citing works
Gelatin methacrylate scaffold for bone tissue engineering: The influence of polymer concentration
Celikkin, N., Mastrogiacomo, S., Jaroszewicz, J., Walboomers, X. F., & Święszkowski, W. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36226 · Cited by 183 · see citing works
Paul, A., Manoharan, V., Krafft, D., Assmann, A., Uquillas, J. A., Shin, S. R., Hasan, A., Hussain, M. A., Memić, A., Gaharwar, A. K., et al. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02745d · Cited by 178 · see citing works
Click‐Crosslinked Injectable Gelatin Hydrogels
Koshy, S. T., Desai, R. M., Joly, P., Li, J., Bagrodia, R. K., Lewin, S. A., Joshi, N. S., & Mooney, D. J. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500757 · Cited by 173 · see citing works
Inorganic Strengthened Hydrogel Membrane as Regenerative Periosteum
Xin, T., Gu, Y., Cheng, R., Tang, J., Sun, Z., Cui, W., & Chen, L. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b13167 · Cited by 169 · see citing works
Quantification of Substitution of Gelatin Methacryloyl: Best Practice and Current Pitfalls
Claaßen, C., Claaßen, M. H., Truffault, V., Rebers, L., Tovar, G. E. M., Borchers, K., & Southan, A. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01221 · Cited by 168 · see citing works
Microfluidic Spinning of Cell‐Responsive Grooved Microfibers
Shi, X., Ostrovidov, S., Zhao, Y., Liang, X., Kasuya, M., Kurihara, K., Nakajima, K., Bae, H., Wu, H., & Khademhosseini, A. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201404531 · Cited by 163 · see citing works
Mredha, M. T. I., Kitamura, N., Nonoyama, T., Wada, S., Goto, K., Zhang, X., Nakajima, T., Kurokawa, T., Takagi, Y., Yasuda, K., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.005 · Cited by 161 · see citing works
A review of hydrogel use in fracture healing and bone regeneration
Gibbs, D., Black, C. R. M., Dawson, J. I., & Oreffo, R. O. C. (2014) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1968 · Cited by 156 · see citing works
The scaffold microenvironment for stem cell based bone tissue engineering
Hao, Z., Song, Z., Huang, J. C., Huang, K., Panetta, A., Gu, Z., & Wu, J. (2017) · Biomaterials Science · doi:10.1039/c7bm00146k · Cited by 154 · see citing works
Self-citationHeo, D. N., Castro, N. J., Lee, S., Noh, H., Zhu, W., & Zhang, L. G. (2017) · Nanoscale · doi:10.1039/c6nr09652b · Cited by 152 · see citing works
Zuo, Y., Liu, X., Wei, D., Sun, J., Xiao, W., Zhao, H., Guo, L., Wei, Q., Fan, H., & Zhang, X. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01433 · Cited by 150 · see citing works
Analysis of anisotropic viscoelastoplastic properties of cortical bone tissues
Abdelwahab, A. A., Alam, K., & Silberschmidt, V. V. (2010) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2010.10.001 · Cited by 148 · see citing works
Cheng, H., Chabok, R., Guan, X., Chawla, A., Li, Y., Khademhosseini, A., & Jang, H. L. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.01.016 · Cited by 132 · see citing works
Huang, A., Peng, X., Geng, L., Zhang, L., Huang, K., Chen, B., Gu, Z., & Kuang, T. (2018) · Polymer Testing · doi:10.1016/j.polymertesting.2018.08.027 · Cited by 106 · see citing works
Self-citationPhotocrosslinkable and elastomeric hydrogels for bone regeneration
Thakur, T., Xavier, J. R., Cross, L., Jaiswal, M. K., Mondragón, E., Kaunas, R. R., & Gaharwar, A. K. (2015) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35621 · Cited by 97 · see citing works
Engineering Photocrosslinkable Bicomponent Hydrogel Constructs for Creating 3D Vascularized Bone
Kazemzadeh‐Narbat, M., Rouwkema, J., Annabi, N., Cheng, H., Ghaderi, M., Cha, B., Aparnathi, M. K., Khalilpour, A., Byambaa, B., Jabbari, E., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601122 · Cited by 73 · see citing works
Xu, H., Jiang, S., Ding, C., Zhu, Y., Li, J., & Hou, H. (2017) · Materials Letters · doi:10.1016/j.matlet.2017.05.019 · Cited by 67 · see citing works
Parthiban, S. P., Rana, D., Jabbari, E., Benkirane-Jessel, N., & Ramalingam, M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.046 · Cited by 64 · see citing works
Porous Particle-Reinforced Bioactive Gelatin Scaffold for Large Segmental Bone Defect Repairing
Cui, Y., Zhu, T., Li, A., Liu, B., Cui, Z., Qiao, Y., Tian, Y., & Qiu, D. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19010 · Cited by 64 · see citing works
Gu, Z., Xie, H., Li, L., Zhang, X., Liu, F., & Yu, X. (2013) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-013-4891-8 · Cited by 63 · see citing works
Self-citationHybrid hydrogels with high strength and biocompatibility for bone regeneration
Zheng, Y., Huang, K., You, X., Huang, B., Wu, J., & Gu, Z. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.07.017 · Cited by 52 · see citing works
Self-citationSamorezov, J. E., Headley, E. B., Everett, C. R., & Alsberg, E. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35668 · Cited by 49 · see citing works
Porrelli, D., Travan, A., Turco, G., Marsich, E., Borgogna, M., Paoletti, S., & Donati, I. (2015) · Macromolecular Materials and Engineering · doi:10.1002/mame.201500055 · Cited by 35 · see citing works
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Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
Kurian, A. G., Singh, R. K., Patel, K. D., Lee, J., & Kim, H. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.027 · Cited by 450 · see citing works
Lv, B., Lu, L., Hu, L., Peng, C., Hu, Y., Xie, X., Dai, G., Mi, B., Liu, X., & Liu, G. (2023) · Theranostics · doi:10.7150/thno.80615 · Cited by 190 · see citing works
Self-citation3D Bioprinting of Methylcellulose/Gelatin-Methacryloyl (MC/GelMA) Bioink with High Shape Integrity
Rastin, H., Ormsby, R. T., Atkins, G. J., & Lošić, D. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00169 · Cited by 159 · see citing works
Microfluidic Formulation of Topological Hydrogels for Microtissue Engineering
Rojek, K. O., Ćwiklińska, M., Kuczak, J., & Guzowski, J. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00798 · Cited by 150 · see citing works
Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent
Mahdavi, S. S., Abdekhodaie, M. J., Kumar, H., Mashayekhan, S., Baradaran‐Rafii, A., & Kim, K. (2020) · Annals of Biomedical Engineering · doi:10.1007/s10439-020-02537-6 · Cited by 146 · see citing works
Stem cell-laden injectable hydrogel microspheres for cancellous bone regeneration
Wu, J., Li, G., Ye, T., Lu, G., Li, R., Deng, L., Wang, L., Cai, M., & Cui, W. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124715 · Cited by 139 · see citing works
Biomedical application of photo-crosslinked gelatin hydrogels
Xiang, L., & Cui, W. (2021) · Journal of Leather Science and Engineering · doi:10.1186/s42825-020-00043-y · Cited by 132 · see citing works
Mamidi, N., Ijadi, F., & Norahan, M. H. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.3c00279 · Cited by 115 · see citing works
Zhang, Y., Chen, H., & Li, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.171 · Cited by 114 · see citing works
Li, Z., Li, S., Jin, Y., Ha, Y., Zhang, Q., Zhou, X., & He, C. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119469 · Cited by 112 · see citing works
Nanoscale β-TCP-Laden GelMA/PCL Composite Membrane for Guided Bone Regeneration
Mahmoud, A. H., Han, Y., Dal‐Fabbro, R., Daghrery, A., Xu, J., Kaigler, D., Bhaduri, S. B., Malda, J., & Bottino, M. C. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c03059 · Cited by 86 · see citing works
Jia, X., Fan, X., Chen, C., Lu, Q., Zhou, H., Zhao, Y., Wang, X., Han, S., Ouyang, L., Yan, H., et al. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.3c01021 · Cited by 85 · see citing works
Injectable, Antibacterial, and Hemostatic Tissue Sealant Hydrogels
Haghniaz, R., Montazerian, H., Rabbani, A., Baidya, A., Usui, B., Zhu, Y., Tavafoghi, M., Wahid, F., Kim, H., Sheikhi, A., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301551 · Cited by 73 · see citing works
Fibrous Polymer-Based Composites Obtained by Electrospinning for Bone Tissue Engineering
Peranidze, K., Safronova, T. V., & Кильдеева, Н. Р. (2021) · Polymers · doi:10.3390/polym14010096 · Cited by 62 · see citing works
Li, Y.-C. E., Jodat, Y. A., Samanipour, R., Zorzi, G., Zhu, K., Hirano, M., Chang, K., Arnaout, A., Hassan, S., Matharu, N., et al. (2021) · Biofabrication · doi:10.1088/1758-5090/abc1be · Cited by 61 · see citing works
Baghban, S. A., Ebrahimi, M., Bagheri‐Khoulenjani, S., & Khorasani, M. (2021) · RSC Advances · doi:10.1039/d1ra01269j · Cited by 61 · see citing works
Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57 · see citing works
Biopolymer-based self-healing hydrogels: A short review
Wang, X., Zhang, H. J., Yang, Y., Chen, Y. M., Zhu, X., & You, X. (2023) · Giant · doi:10.1016/j.giant.2023.100188 · Cited by 53 · see citing works
Liu, C., Dai, T., Wu, X., Ma, J., Liu, J., Wu, S., Yang, L., & Zhao, H. (2022) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2022.07.011 · Cited by 50 · see citing works
Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional In Vitro Bone Model
Romero-López, M., Li, Z. A., Rhee, C., Maruyama, M., Pajarinen, J., O’Donnell, B. T., Lin, T., Lo, C.-W., Hanlon, J., Dubowitz, R., et al. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0041 · Cited by 48 · see citing works
Injectable antibacterial Ag-HA/ GelMA hydrogel for bone tissue engineering
Wang, J., Wang, X., Liang, Z., Lan, W., Wei, Y., Hu, Y., Wang, L., Lei, Q., & Huang, D. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1219460 · Cited by 45 · see citing works
Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair
Feng, Y., Guo, W., Hu, L., Yi, X., & Tang, F. (2022) · Polymers · doi:10.3390/polym14224906 · Cited by 45 · see citing works
Wang, Y., Wu, H., Pan, Y., Xiao, Y., Chen, Y., Yang, S., Wang, J., Feng, W., Hu, C., Niu, X.-K., et al. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf025 · Cited by 44 · see citing works
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Phogat, K., Ghosh, S. B., & Bandyopadhyay‐Ghosh, S. (2022) · Journal of Applied Polymer Science · doi:10.1002/app.53362 · Cited by 43 · see citing works
The Role of Natural Hydrogels in Enhancing Wound Healing: From Biomaterials to Bioactive Therapies
Pintilei, P. S., Binaymotlagh, R., Chronopoulou, L., & Palocci, C. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17101243 · Cited by 43 · see citing works
Application of photo-crosslinkable gelatin methacryloyl in wound healing
Zhang, J., Liu, C., Li, X., Liu, Z., & Zhang, Z. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1303709 · Cited by 41 · see citing works
An insight into cell-laden 3D-printed constructs for bone tissue engineering
Swetha, S. V., Lavanya, K., Sruthi, R., & Selvamurugan, N. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb02019b · Cited by 37 · see citing works
Krishna, D. V., & Sankar, M. R. (2023) · Materials Today Communications · doi:10.1016/j.mtcomm.2023.105696 · Cited by 37 · see citing works
Al-Sudani, B. T., Salehi, S., Kamil, M. M., Al‐Musawi, M. H., Valizadeh, H., Mirhaj, M., Sharifianjazi, M., Shahriari‐Khalaji, M., Sattar, M., Sharifianjazi, F., et al. (2024) · Journal of Polymers and the Environment · doi:10.1007/s10924-024-03324-3 · Cited by 36 · see citing works
Herrera-Ruiz, A., Tovar, B. B., García, R. G., Tamez, M. F. L., & Mamidi, N. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122645 · Cited by 35 · see citing works
Exploring 4D printing of smart materials for regenerative medicine applications
Alanazi, B. N., Ahmed, H. A., Alharbi, N. S., Ebrahim, N. A. A., & Soliman, S. M. A. (2025) · RSC Advances · doi:10.1039/d5ra04410c · Cited by 34 · see citing works
Yang, J., Yuan, K., Zhang, T., Zhou, S., Li, W., Chen, Z., & Wang, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203105 · Cited by 32 · see citing works
Jin, M., Sun, N., Weng, W., Sang, Z., Liu, T., Xia, W., Wang, S., Sun, X., Wang, T., Li, H., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124820 · Cited by 31 · see citing works
Guo, Y., Liu, Y., Zhang, Z., Zhang, X., Xu, J. K., Zhang, R., Chen, G., Zhu, L., & Zhu, M. (2025) · Advanced Materials · doi:10.1002/adma.202414877 · Cited by 31 · see citing works
Rational design of viscoelastic hydrogels for periodontal ligament remodeling and repair
Zhang, S., Liu, J., Feng, F., Jia, Y., Xu, F., Wei, Z., & Zhang, M. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.12.017 · Cited by 29 · see citing works
Codrea, C. I., Baykara, D., Mitran, R., Koyuncu, A. C. Ç., Gündüz, O., & Ficai, A. (2024) · Polymers · doi:10.3390/polym16131932 · Cited by 29 · see citing works
Jamshidifar, E., Esfandyari‐Manesh, M., Motasadizadeh, H., Naderizadeh, S., Yourdkhani, A., Samadi, N., & Dinarvand, R. (2022) · Journal of Materials Science · doi:10.1007/s10853-022-07456-6 · Cited by 29 · see citing works
Yang, M., Cheng, Y.-T., Tsai, H., Darge, H. F., Huang, C., & Lin, S. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213504 · Cited by 28 · see citing works
Liu, X., Hu, H., Ma, J., & Wang, B. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123480 · Cited by 27 · see citing works
Heinemann, C., Buchner, F., Lee, P. S., Bernhardt, A., Kruppke, B., Wiesmann, H., & Hintze, V. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14060317 · Cited by 26 · see citing works
Eggshell Microparticle Reinforced Scaffolds for Regeneration of Critical Sized Cranial Defects
Wu, X., Gauntlett, O. C., Zhang, T., Suvarnapathaki, S., McCarthy, C., Wu, B., & Camci‐Unal, G. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c19884 · Cited by 25 · see citing works
Cell Scaffolds for Bone Tissue Engineering
Iijima, K., & Otsuka, H. (2020) · Bioengineering · doi:10.3390/bioengineering7040119 · Cited by 23 · see citing works
Wang, L., Li, M., Li, X., Liu, J., Mao, Y., & Tang, K. (2020) · Macromolecular Materials and Engineering · doi:10.1002/mame.202000188 · Cited by 23 · see citing works
Viscoelastic and phototunable GelMA-alginate hydrogels for 3D cell culture
Tansık, G., & Stowers, R. S. (2024) · MRS Advances · doi:10.1557/s43580-024-00815-2 · Cited by 26 · see citing works
Visible light-induced 3D bioprinted injectable scaffold for minimally invasive tissue regeneration
Tilton, M., Camilleri, E. T., Potes, M. D. A., Gaihre, B., Liu, X., Lucien, F., Elder, B. D., & Lu, L. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213539 · Cited by 21 · see citing works
A Macroporous Cryogel with Enhanced Mechanical Properties for Osteochondral Regeneration In vivo
Wu, X., Yang, J. J., Wu, F., Cao, W., Zhou, T., Wang, Z., Tu, C., Gou, Z., Zhang, L., & Gao, C. (2022) · Chinese Journal of Polymer Science · doi:10.1007/s10118-022-2835-9 · Cited by 20 · see citing works
Kim, S.-Y., Choi, A., Park, J.-E., Jang, Y., & Lee, M. (2022) · Polymers · doi:10.3390/polym14235317 · Cited by 20 · see citing works
Si, X., Zhang, Q., Ning, B., Qiang, L., Li, Q., Liu, Y., Fan, M., Shan, J., Shen, G., Lin, Z., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152463 · Cited by 19 · see citing works
Xiu, H., Yang, K., Li, D., Lai, H., Zhu, Z., Jiang, D., Yan, J., Shi, C., Pan, S., Yin, Z., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403205 · Cited by 18 · see citing works
Liu, S., Chen, G., Chen, Z., Wang, F., & Lv, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146485 · Cited by 21 · see citing works
Cardoso, L. M., de Carvalho, A. B. G., Anselmi, C., Mahmoud, A. H., Dal‐Fabbro, R., Basso, F. G., & Bottino, M. C. (2024) · Dental Materials · doi:10.1016/j.dental.2024.06.019 · Cited by 18 · see citing works
Wang, W., Zhu, Y., Li, J., Geng, T., Jia, J., Wang, X., Yuan, C., & Wang, P. (2023) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.0180 · Cited by 17 · see citing works
Pablos, J. L., Jiménez‐Holguín, J., Sánchez‐Salcedo, S., Salinas, A. J., Corrales, T., & Vallet‐Regí, M. (2023) · Gels · doi:10.3390/gels9050403 · Cited by 17 · see citing works
Chen, Y., Chen, Y., Han, T., Xie, Z., Yang, Y., Chen, S., & Wang, C. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37589 · Cited by 17 · see citing works
Lv, N., Zhou, Z., Hong, L., Li, H., Liu, M., & Qian, Z. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1389397 · Cited by 17 · see citing works
Cernencu, A. I., Vlăsceanu, G. M., Serafim, A., Pîrcălăbioru, G. G., & Ioniţă, M. (2023) · RSC Advances · doi:10.1039/d3ra02786d · Cited by 16 · see citing works
Biopolysaccharides: Properties and Applications
Tunçer, S. (2021) · Polysaccharides · doi:10.1002/9781119711414.ch6 · Cited by 16 · see citing works
Recent Advances in Gelatin Methacryloyl Hydrogels for Bone Regeneration
Guo, J., Meng, L., Wang, H., Zhao, K., Ding, Q., & Sun, L. J. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c02701 · Cited by 16 · see citing works
Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis
Wang, Y., Peng, Z., Zhang, D., & Song, D. (2023) · Gels · doi:10.3390/gels9040302 · Cited by 15 · see citing works
Sedek, E. M., Kamoun, E. A., El‐Deeb, N. M., Abdelkader, S., Fahmy, A. E., Nouh, S. R., & Khalil, N. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03236-z · Cited by 14 · see citing works
Yourdkhani, A., Esfandyari‐Manesh, M., Ranjbaran, P., & Dinarvand, R. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105345 · Cited by 14 · see citing works
Application of hydrogel microneedles in the oral cavity
He, Y., He, D., Fan, L., Ren, S., Wang, L., & Sun, J. (2024) · Biopolymers · doi:10.1002/bip.23573 · Cited by 14 · see citing works
Zaki-Germi, S., Afshar, D., Akbari, A., & Nikfarjam, N. (2025) · Composites Science and Technology · doi:10.1016/j.compscitech.2025.111059 · Cited by 13 · see citing works
Ke, D., Yu, J., Liu, P., Niu, C., & Yang, X. (2022) · Materialia · doi:10.1016/j.mtla.2022.101339 · Cited by 13 · see citing works
Gundu, S., Sahi, A. K., Varshney, N., Varghese, J., Vishwakarma, N. K., & Mahto, S. K. (2022) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2022.2101415 · Cited by 13 · see citing works
The current status of nano-hydrogel preparations for osteochondral repair: Systematic Review
Amhare, A. F., Qiao, L., Deng, H., Lin, J., Wang, J., Wang, W., & Han, J. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1611522 · Cited by 12 · see citing works
Adhikari, B., Stinson, B. S., Osmond, M. J., Pantcheva, M. B., & Krebs, M. D. (2021) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.1c02828 · Cited by 12 · see citing works
Dehli, F., Schless, O., Kaliske, [. M., Potthof, I., Taoum, A., Fuest, M., & Campos, D. F. D. (2025) · Materials Advances · doi:10.1039/d5ma00076a · Cited by 11 · see citing works
Lee, D., Park, J., Seo, Y.-W., Jin, X., Hong, J., Bhattacharyya, A., Noh, I., & Choi, S. (2023) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2203220161 · Cited by 11 · see citing works
Jiang, J., Cai, C., Li, S., Xiong, Y., Liu, C., Shu, Z., Yang, J., Zheng, M., Tang, T., Liu, W., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.163133 · Cited by 11 · see citing works
Torres, Y., Begines, B., Beltrán, A. M., & Boccaccini, A. R. (2021) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2021.127366 · Cited by 11 · see citing works
Zhang, X., Wang, W., Chen, J., & Lai, M. (2022) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2022.2155780 · Cited by 11 · see citing works
3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review
Enbergs, S., Spinnen, J., Dehne, T., & Sittinger, M. (2023) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1155/2023/3901448 · Cited by 11 · see citing works
Triaxial bioprinting large-size vascularized constructs with nutrient channels
Zhang, J., Suttapreyasri, S., Leethanakul, C., & Samruajbenjakun, B. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acf25a · Cited by 10 · see citing works
Precision and customization in regenerative medicine: The role of coaxial 3D printing
Cheng, S., Wei, J., Liu, S., Liu, J., Luo, X., Lan, Y., Dong, M., Zhou, L., Huang, W., Chen, Z., et al. (2025) · Biomedical Technology · doi:10.1016/j.bmt.2025.100115 · Cited by 10 · see citing works
Yamaguchi, S., Akeda, K., Shintani, S. A., Sudo, A., & Matsushita, T. (2022) · Coatings · doi:10.3390/coatings12020139 · Cited by 10 · see citing works
Biological Functions of Macromolecular Protein Hydrogels in Constructing Osteogenic Microenvironment
Wang, Y., Lv, H., Ren, S., Zhang, J., Liu, X., Chen, S., Zhai, J., & Zhou, Y. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00910 · Cited by 9 · see citing works
Mi, B., Zhang, J., Meng, H., Xu, Y., Xie, J., Hao, D., & Shan, L. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150714 · Cited by 9 · see citing works
Necolau, M. I., Ioniţă, M., & Pandele, A. M. (2025) · Polymers · doi:10.3390/polym17091212 · Cited by 10 · see citing works
Abtahi, M., Khorasani, S. N., Khalili, S., Hafezi, M., Sattari‐Najafabadi, M., Chahi, M., & Neisiany, R. E. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143845 · Cited by 9 · see citing works
Lipari, S., Marfoglia, A., Sorrentino, G., Cazalbou, S., Pilloux, L., Sacco, P., & Donati, I. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c00518 · Cited by 9 · see citing works
Fernandes, P. D., Silva, F. C., Magalhães, F. D., Pereira, R. F., Santos, S. G., & Pinto, A. M. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.11.043 · Cited by 9 · see citing works
Hassanzadeh, P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119400 · Cited by 9 · see citing works
Bedir, T., Baykara, D., Şahin, A., Şenel, İ., Kaya, E., Tinaz, G. B., Gündüz, O., & Üstündağ, C. B. (2024) · Macromolecular Materials and Engineering · doi:10.1002/mame.202400199 · Cited by 8 · see citing works
Optimised GelMA/Tragacanth gum hydrogel loaded with vanillic acid for biomedical applications
Golshirazi, A., Labbaf, S., & Varshosaz, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143535 · Cited by 8 · see citing works
A Hybrid Scaffold Induces Chondrogenic Differentiation and Enhances In Vivo Cartilage Regeneration
Zhao, J., Yan, Z., Ding, Y., Dai, Y., Feng, Z., Li, Z., Ma, L., Diao, N., Guo, A., & Yin, H. (2024) · Tissue Engineering Part A · doi:10.1089/ten.tea.2023.0344 · Cited by 7 · see citing works
Du, Y., Chen, M., Jiang, J., Wang, L., Wu, G., & Feng, J. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14100513 · Cited by 6 · see citing works
Inorganic/Biopolymers Hybrid Hydrogels Dual Cross-Linked for Bone Tissue Regeneration
Cernencu, A. I., Dinu, A. I., Dinescu, S., Trusca, R. D., Istodorescu, M., Lungu, A., Stancu, I., & Iovu, H. (2022) · Gels · doi:10.3390/gels8120762 · Cited by 6 · see citing works
Xu, Q. F., Bai, Y., Li, S., Hou, W., Hao, Y., Yang, R., Li, X., & Zhang, X. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1372636 · Cited by 5 · see citing works
Fiorelli, E., Scioli, M. G., Terriaca, S., Haq, A. U., Storti, G., Madaghiele, M., Palumbo, V., Pashaj, E., Matteis, F. D., Ribuffo, D., et al. (2024) · Bioengineering · doi:10.3390/bioengineering11090920 · Cited by 4 · see citing works
Bone powder-laden hydrogel scaffolds in bone tissue engineering
Shen, X., Zhu, D., Hu, H., Su, L., Wu, G., Forouzanfar, T., Yang, G., & Jiang, Z. (2025) · Biomaterials Science · doi:10.1039/d5bm00962f · Cited by 3 · see citing works
Salvati, M., Tiberio, F., Giacon, N., Augello, A., Tamburrini, G., Pietro, L. D., Vita, A., Tosi, D. D., Perini, G., Canini, G., et al. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbaf115 · Cited by 3 · see citing works
Exosomes in osteoporosis: regulatory mechanisms and clinical applications
Shuai, Q., Tian, J., Yang, W., & Huang, S. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1792752 · Cited by 4 · see citing works
Tommasino, C., Sardo, C., Guidone, A., Raucci, M. G., Mariano, A., Soriente, A., Aquino, R. P., Wylie, M. P., Auriemma, G., & Lamprou, D. A. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01262g · Cited by 3 · see citing works
Wang, J., Qi, X., Zhou, Y., Wang, G., Yang, Y., Jiang, T., Yu, L., Wang, S., & Zhang, W. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1183594 · Cited by 3 · see citing works
Tang, J., Zuo, Z., Cao, Q., Yao, Y., & Liu, T. (2025) · Macromolecules · doi:10.1021/acs.macromol.4c02647 · Cited by 2 · see citing works
Thakur, A., Sharma, R., Sharma, R., & Devi, A. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10455-8 · Cited by 2 · see citing works
Tuning the structure and properties of cell-embedded gelatin hydrogels for tumor organoids
de Souza, S. O. L., de Oliveira, S. M., Lehman, C. P., da Silva, M. C., Silva, L. M., & Oréfice, R. L. (2023) · Polímeros · doi:10.1590/0104-1428.20220024 · Cited by 2 · see citing works
Shen, G., Si, X., Qiang, L., Liu, Y., Yin, Z., Shan, J., & Zheng, P. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168275 · Cited by 1 · see citing works
Tao, Y., Chen, Y., Wang, Q., Deng, Q., & He, B. (2026) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2026.139648 · Cited by 1 · see citing works
- Authors
- Dong, Z., Yuan, Q., Huang, K., Xu, W., Liu, G., & Gu, Z.
- Affiliations
- Quzhou University (CN)
- Sun Yat-sen University (CN)
- Corresponding author
- Liu, Guiting
- Gu, Zhipeng
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 9
- Issue
- 31
- Pages
- 17737-17744
- ISSN
- 2046-2069 (ISSN-L)
- PMC
- PMC9064644
- OpenAlex
- W2948473358
- Cited by
- 123
- References
- 56
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 18 · 2023: 27 · 2022: 19 · 2021: 9 · 2020: 8
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- RSC Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (5150030109)
- Fundamental Research Funds for the Central Universities (ln18lgpy58)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- gelatin methacryloyl, bone regeneration, biomaterials, mechanical properties, controlled degradation, hydrogels, tissue engineering scaffolds
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