Fluorescence imaging of pathophysiological microenvironments

Near-infrared fluorophores for biomedical imaging

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Dysregulated pH: a perfect storm for cancer progression

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The FLARE™ Intraoperative Near-Infrared Fluorescence Imaging System: A First-in-Human Clinical Trial in Breast Cancer Sentinel Lymph Node Mapping

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Fluorescent bioimaging of pH: from design to applications

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A Self-Calibrating Bipartite Viscosity Sensor for Mitochondria

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A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells

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Functional synthetic probes for selective targeting and multi-analyte detection and imaging

Yue, Y., Huo, F., Cheng, F., Zhu, X., Mafireyi, T. J., Strongin, R. M., & Yin, C. (2019) · Chemical Society Reviews · doi:10.1039/c8cs01006d · Cited by 331 · see citing works

Recent progresses in fluorescent probes for detection of polarity

Xiao, H., Li, P., & Tang, B. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213582 · Cited by 290 · see citing works

Molecular imaging of the tumor microenvironment

Zhou, Z., & Lu, Z.-R. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.012 · Cited by 253 · see citing works

A Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing and Monitoring Viscosity in Live Cells and Tissues

Zhang, Y., Li, Z., Hu, W., & Liu, Z. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02678 · Cited by 243 · see citing works

Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

Hou, J., Yu, K., Sunwoo, K., Kim, W. Y., Koo, S., Wang, J., Ren, W. X., Wang, S., Yu, X., & Kim, J. S. (2020) · Chem · doi:10.1016/j.chempr.2019.12.005 · Cited by 211 · see citing works

Visualization of ONOO– and Viscosity in Drug-Induced Hepatotoxicity with Different Fluorescence Signals by a Sensitive Fluorescent Probe

Deng, Y., & Feng, G. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03199 · Cited by 202 · see citing works

Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

Li, S., Wang, P., Feng, W., et al. (2019) · Chemical Communications · doi:10.1039/c9cc08267k · Cited by 174 · see citing works

A near-infrared fluorescent probe reveals decreased mitochondrial polarity during mitophagy

Li, X., Li, X., & Ma, H. (2019) · Chemical Science · doi:10.1039/c9sc05505c · Cited by 164 · see citing works

An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo

Xiao, H., Li, P., Zhang, W., & Tang, B. (2015) · Chemical Science · doi:10.1039/c5sc04099j · Cited by 152 · see citing works

Rational design of a lipid-droplet-polarity based fluorescent probe for potential cancer diagnosis

Yin, J., Peng, M., Ma, Y., Guo, R., & Lin, W. (2018) · Chemical Communications · doi:10.1039/c8cc07398h · Cited by 144 · see citing works

Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations

Dou, K., Huang, W., Xiang, Y., Li, S., & Liu, Z. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00634 · Cited by 126 · see citing works

A ratiometric fluorescence probe for lysosomal polarity

Li, M., Fan, J., Li, H., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.044 · Cited by 125 · see citing works

A ratiometric two-photon probe for quantitative imaging of mitochondrial pH values

Sarkar, A. R., Heo, C. H., Xu, L., Lee, H. W., Si, H. Y., Byun, J. W., & Kim, H. M. (2015) · Chemical Science · doi:10.1039/c5sc03708e · Cited by 123 · see citing works

Lysosome targeting carbon dots-based fluorescent probe for monitoring pH changes in vitro and in vivo

Gao, P., Wang, J., Zheng, M. J., et al. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.122665 · Cited by 122 · see citing works

Noninvasive Cancer Diagnosis In Vivo Based on a Viscosity-Activated Near-Infrared Fluorescent Probe

Yin, J., Kong, X., & Lin, W. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03803 · Cited by 121 · see citing works

A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis

Fan, L., Wang, X., Ge, J., Li, F., Wang, X., Wang, J., Shuang, S., & Dong, C. (2019) · Chemical Communications · doi:10.1039/c9cc00962k · Cited by 111 · see citing works

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

Owyong, T. C., Subedi, P., Deng, J., Hinde, E., Paxman, J. J., White, J. M., Chen, W., Heras, B., Wong, W. W. H., & Hong, Y. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201914263 · Cited by 104 · see citing works

A mitochondria-targeted two-photon fluorogenic probe for the dual-imaging of viscosity and H 2 O 2 levels in Parkinson's disease models

Li, H., Xin, C., Zhang, G., Han, X., Qin, W., Zhang, C., Yu, C., Jing, S., Li, L., & Huang, W. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00576e · Cited by 94 · see citing works

In situ visualization of peroxisomal viscosity in the liver of mice with non-alcoholic fatty liver disease by near-infrared fluorescence and photoacoustic imaging

Zhou, Y., Li, P., Wang, X., Wu, C., Fan, N., Liu, X., Wu, L., Zhang, W., Zhang, W., Liu, Z., et al. (2020) · Chemical Science · doi:10.1039/d0sc02922j · Cited by 90 · see citing works

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Yan, K., Sedgwick, A. C., Zang, Y., Chen, G., He, X., Li, J. X., Yoon, J., & James, T. D. (2019) · Small Methods · doi:10.1002/smtd.201900013 · Cited by 87 · see citing works

A biotin-guided fluorescent probe for dual-mode imaging of viscosity in cancerous cells and tumor tissues

Ren, M., Xu, Q., Wang, S., Liu, L., & Kong, F. (2020) · Chemical Communications · doi:10.1039/d0cc05039c · Cited by 85 · see citing works

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Wu, L., Wang, Y., James, T. D., Jia, N., & Huang, C. (2018) · Chemical Communications · doi:10.1039/c8cc02330a · Cited by 80 · see citing works

Golgi Apparatus Polarity Indicates Depression-Like Behaviors of Mice Using in Vivo Fluorescence Imaging

Li, P., Guo, X., Bai, X., Wang, X., Ding, Q., Zhang, W., Zhang, W., & Tang, B. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04703 · Cited by 77 · see citing works

A simple benzothiazole-based mitochondrial-targeting fluorescent probe for visualizing and monitoring viscosity in living cell, lung organ tissue, and living mice

Tang, L., Zhou, L., Yan, X., Zhong, K., Gao, X. P., Liu, X., & Li, J. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108644 · Cited by 77 · see citing works

Two-photon dual-channel fluorogenic probe for in situ imaging the mitochondrial H2S/viscosity in the brain of drosophila Parkinson’s disease model

Fang, Z., Su, Z. A., Qin, W., et al. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.063 · Cited by 77 · see citing works

Towards a molecular understanding of arthritis

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Highly Sensitive Hill-Type Small-Molecule pH Probe That Recognizes the Reversed pH Gradient of Cancer Cells

Luo, X. L., Yang, H., Wang, H., Ye, Z., Zhou, Z., Gu, L., Chen, J., Xiao, Y., Liang, X., Qian, X. H., et al. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b00218 · Cited by 75 · see citing works

Pinpoint Diagnostic Kit for Heat Stroke by Monitoring Lysosomal pH

Wen, Y., Zhang, W., Liu, T., et al. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03612 · Cited by 74 · see citing works

Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

Yu, L., Zhang, J. F., Li, M., et al. (2020) · Chemical Communications · doi:10.1039/d0cc02943b · Cited by 69 · see citing works

Wide-Acidity-Range pH Fluorescence Probes for Evaluation of Acidification in Mitochondria and Digestive Tract Mucosa

Chen, G., Fu, Q., Yu, F., Ren, R., Liu, Y., Cao, Z., Li, G., Zhao, X., Chen, L., Wang, H., et al. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02164 · Cited by 63 · see citing works

A photostable Si-rhodamine-based near-infrared fluorescent probe for monitoring lysosomal pH during heat stroke

Mao, G., Liang, Z., Gao, G.-Q., Wang, Y., Guo, X., Su, L., Zhang, H., Ma, Q., & Zhang, G. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.09.053 · Cited by 59 · see citing works

Recent advances in fluorescent probes for extracellular pH detection and imaging

Chen, Y. (2020) · Analytical Biochemistry · doi:10.1016/j.ab.2020.113900 · Cited by 58 · see citing works

pH Switchable Nanoassembly for Imaging a Broad Range of Malignant Tumors

Liu, Y., Qu, Z., Cao, H., Sun, H., Gao, Y., & Jiang, X. (2017) · ACS Nano · doi:10.1021/acsnano.7b06483 · Cited by 52 · see citing works

A red-emitting fluorescent probe for mitochondria-target microviscosity in living cells and blood viscosity detection in hyperglycemia mice

Zhu, L., Fu, M., Yin, B., Wang, L., Chen, Y., & Zhu, Q. X. (2019) · Dyes and Pigments · doi:10.1016/j.dyepig.2019.107859 · Cited by 50 · see citing works

A pH-sensitive near-infrared fluorescent probe with alkaline p K a for chronic wound monitoring in diabetic mice

Mai, H., Wang, Y., Li, S., et al. (2019) · Chemical Communications · doi:10.1039/c9cc02289a · Cited by 46 · see citing works

Development of an endoplasmic reticulum-targeting fluorescent probe for the imaging of polarity in living cells and tissues

Song, W., Dong, B., Lu, Y., et al. (2019) · New Journal of Chemistry · doi:10.1039/c9nj02666e · Cited by 46 · see citing works

Tracking lysosomal polarity variation in inflamed, obese, and cancer mice guided by a fluorescence sensing strategy

Yin, J., Peng, M., & Lin, W. (2019) · Chemical Communications · doi:10.1039/c9cc04739e · Cited by 45 · see citing works

Self-assembled amphiphilic fluorescent probe: detecting pH-fluctuations within cancer cells and tumour tissues

Kim, S. Y., Podder, A., Lee, H., Cho, Y.-J., Han, E. H., Khatun, S., Sessler, J. L., Hong, K. S., & Bhuniya, S. (2020) · Chemical Science · doi:10.1039/d0sc03795h · Cited by 45 · see citing works

Lysosomal polarity increases with aging as revealed by a lysosome-targetable near-infrared fluorescent probe

Shi, D., Hu, L., Li, X., Liu, W., Gao, Y. J., Li, X., Jiang, B., Xia, C., Guo, Y., & Li, J. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128302 · Cited by 44 · see citing works

Design strategy for germanium-rhodamine based pH-activatable near-infrared fluorescence probes suitable for biological applications

Koide, Y., Kojima, R., Hanaoka, K., Numasawa, K., Komatsu, T., Nagano, T., Kobayashi, H., & Urano, Y. (2019) · Communications Chemistry · doi:10.1038/s42004-019-0194-4 · Cited by 41 · see citing works

Hypoxia-responsive fluorescent nanoprobe for imaging and cancer therapy

Chen, S., Liu, J., Li, Y., Wu, X., Yuan, Q., Yang, R., & Zheng, J. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116010 · Cited by 23 · see citing works

A unique polarity-sensitive photothermal sensitizer revealing down-regulated mitochondrial polarity during photo-induced cell death

Liu, C., Tian, M., & Lin, W. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb02233c · Cited by 22 · see citing works

Polarity-activated super-resolution imaging probe for the formation and morphology of amyloid fibrils

Lv, Z., Li, L., Man, Z., Xu, Z., Cui, H., Zhan, R., He, Q., Zheng, L., & Fu, H. (2020) · Nano Research · doi:10.1007/s12274-020-2899-1 · Cited by 18 · see citing works

Correction: Functional synthetic probes for selective targeting and multi-analyte detection and imaging

Yue, Y., Huo, F., Cheng, F., et al. (2019) · Chemical Society Reviews · doi:10.1039/c9cs90059d · Cited by 11 · see citing works

Revealing Minor pH Changes of Mitochondria by a Highly Sensitive Molecular Fluorescent Probe

Yuan, J., Peng, R., Cheng, D., et al. (2021) · Chemistry - An Asian Journal · doi:10.1002/asia.202001350 · Cited by 10 · see citing works

Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Li, H., Kim, Y., Jung, H., Hyun, J. Y., & Shin, I. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00722c · Cited by 356 · see citing works

Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

Wang, L., Li, N., Wang, W., Mei, A., Shao, J., Wang, W., & Dong, X. (2024) · ACS Nano · doi:10.1021/acsnano.3c12316 · Cited by 127 · see citing works

Near-infrared fluorescent Aza-BODIPY dyes: Rational structural design and biomedical imaging

Zhao, B., Liao, L., Zhu, Y., Hu, Z., & Wu, F. (2023) · Journal of Luminescence · doi:10.1016/j.jlumin.2023.120099 · Cited by 31 · see citing works

Organic small-molecule NIR-II fluorophores for tumor phototheranostics

Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works

Mining Chinese Polarity Shifters

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GaN Polarity and Its Measurement and Application

Liu, B. (2002) · Bandaoti guangdian

Polarity Fluctuation Inhibition by Memory in Collective Cell Motion

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A Study on the Fluorescence Properties of Fluorescent Dyes on Polyester Fibrics

Wei, Z. C. (2004) · Dyestuffs and coloration

Polarity Items

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