Roles of white matter in central nervous system pathophysiologies
Open accessAbstract
The phylogenetic enlargement of cerebral cortex culminating in the human brain imposed greater communication needs that have been met by the massive expansion of WM (white matter). Damage to WM alters brain function, and numerous neurological diseases feature WM involvement. In the current review, we discuss the major features of WM, the contributions of WM compromise to brain pathophysiology, and some of the mechanisms mediating WM injury. We will emphasize the newly appreciated importance of neurotransmitter signalling in WM, particularly glutamate and ATP signalling, to understanding both normal and abnormal brain functions. A deeper understanding of the mechanisms leading to WM damage will generate much-needed insights for developing therapies for acute and chronic diseases with WM involvement.
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Loss of myelin slows axon potential transmission and threatens axon integrity, leading to axonal loss.
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From The Pathobiology of Vascular Dementia (2013) · cites this paper as Matute and Ransom, 2012
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From The Pathobiology of Vascular Dementia (2013) · cites this paper as Matute and Ransom, 2012
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From The Pathobiology of Vascular Dementia (2013) · cites this paper as Matute and Ransom, 2012
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Ouardouz, M., Coderre, E., Basak, A., Chen, A. A., Zamponi, G. W., Hameed, S., Rehak, R., Yin, X., Trapp, B. D., & Stys, P. K. (2009) · Annals of Neurology · doi:10.1002/ana.21533 · Cited by 107 · see citing works
Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors
Ouardouz, M., Coderre, E., Zamponi, G. W., Hameed, S., Yin, X., Trapp, B. D., & Stys, P. K. (2009) · Annals of Neurology · doi:10.1002/ana.21539 · Cited by 104 · see citing works
Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron–glia signaling
Fields, R. D. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.02.009 · Cited by 103 · see citing works
Ruiz, A., Matute, C., & Alberdi, E. M. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.31 · Cited by 102 · see citing works
Self-citationThe Behavioral Neurology Of White Matter
Filley, C. M. (2001) · doi:10.1093/oso/9780195135619.001.0001 · Cited by 97 · see citing works
Activation of Kainate Receptors Sensitizes Oligodendrocytes to Complement Attack
Alberdi, E. M., Sánchez‐Gómez, M. V., Torre, I., Domercq, M., Pérez‐Samartín, A., Pérez‐Cerdá, F., & Matute, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3780-05.2006 · Cited by 93 · see citing works
Self-citationMelani, A., Cipriani, S., Vannucchi, M. G., Nosi, D., Donati, C., Bruni, P., Giovannini, M. G., & Pedata, F. (2009) · Brain · doi:10.1093/brain/awp076 · Cited by 91 · see citing works
Longuemare, M. C., Rose, C. R., Farrell, K., Ransom, B. R., Waxman, S. G., & Swanson, R. A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00152-9 · Cited by 90 · see citing works
Self-citationGlutamatergic signaling in the brain's white matter
Bakiri, Y., Burzomato, V., Frugier, G., Hamilton, N. B., Káradóttir, R. T., & Attwell, D. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.015 · Cited by 83 · see citing works
Calcium dyshomeostasis in white matter pathology
Matute, C. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.12.004 · Cited by 81 · see citing works
Self-citationPak, K. J., Chan, S. L., & Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:1:53 · Cited by 77 · see citing works
Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo.
Jantaratnotai, N., Ryu, J. K., Kim, S. U., & McLarnon, J. G. (2003) · PubMed · doi:10.1097/00001756-200308060-00005 · Cited by 71 · see citing works
Friedle, S. A., Curet, M., & Watters, J. J. (2009) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488910789753530 · Cited by 71 · see citing works
The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells
Madry, C., Haglerød, C., & Attwell, D. (2010) · Brain · doi:10.1093/brain/awq284 · Cited by 62 · see citing works
Wang, L., Cai, W., Chen, P., Deng, Q., & Cong-min, Z. (2008) · Glia · doi:10.1002/glia.20758 · Cited by 61 · see citing works
Sánchez‐Gómez, M. V., Alberdi, E. M., Pérez‐Navarro, E., Alberch, J., & Matute, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5578-10.2011 · Cited by 60 · see citing works
Self-citationPampliega, O., Domercq, M., Villoslada, P., Sepulcre, J., Antigüedad, A. R., & Matute, C. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.01.011 · Cited by 58 · see citing works
Self-citationLepore, A. C., O'donnell, J., Kim, A. S., Yang, E. J., Tuteja, A., Haidet-Phillips, A. M., O’Banion, C. P., & Maragakis, N. J. (2011) · Glia · doi:10.1002/glia.21241 · Cited by 57 · see citing works
Fern, R. F., Waxman, S. G., & Ransom, B. R. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.6.2609 · Cited by 57 · see citing works
Self-citationGlutamate receptor‐mediated ischemic injury of premyelinated central axons
Alix, J. J. P., & Fern, R. F. (2009) · Annals of Neurology · doi:10.1002/ana.21767 · Cited by 55 · see citing works
The Curious Case of NG2 Cells: Transient Trend or Game Changer?
Mangin, J., & Gallo, V. (2011) · ASN NEURO · doi:10.1042/an20110001 · Cited by 55 · see citing works
Stys, P. K. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.004 · Cited by 51 · see citing works
Had‐Aissouni, L. (2011) · Amino Acids · doi:10.1007/s00726-011-0863-9 · Cited by 50 · see citing works
Alix, J. J. P., DOLPHIN, A. C., & Fern, R. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.155077 · Cited by 50 · see citing works
Malva, J. O., Silva, A. P., & Cunha, R. A. (2003) · Neurochemical Research · doi:10.1023/a:1025618324593 · Cited by 49 · see citing works
Magnetic resonance imaging in dementia: a study of brain white matter changes
Bronge, L. (2002) · Acta Radiologica · doi:10.1034/j.1600-0455.43.s.428.1.x · Cited by 49 · see citing works
Glia as transmitter sources and sensors in health and disease
Domingues, A. M. D. J., Taylor, M., & Fern, R. F. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.03.024 · Cited by 47 · see citing works
Axon–glia synapses are highly vulnerable to white matter injury in the developing brain
Shen, Y., Liu, X., Pleasure, D., & Deng, W. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22722 · Cited by 44 · see citing works
Neuroglial interactions mediated by purinergic signalling in the pathophysiology of CNS disorders
Matute, C., & Cavaliere, F. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.02.011 · Cited by 41 · see citing works
Self-citationEvidence for physiologically active axonal adenosine receptors in the rat corpus callosum
Swanson, T. H., Krahl, S. E., Liu, Y.-Z., Drazba, J. A., & Rivkees, S. A. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01323-1 · Cited by 37 · see citing works
Anaerobic Function of CNS White Matter Declines with Age
Hamner, M. A., Möller, T., & Ransom, B. R. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.216 · Cited by 32 · see citing works
Self-citationNikolaeva, M. A., Richard, S., Mouihate, A., & Stys, P. K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5729-08.2009 · Cited by 19 · see citing works
Constantinou, S., & Fern, R. F. (2009) · Glia · doi:10.1002/glia.20839 · Cited by 18 · see citing works
Ransom, B. R., & Baltan, S. (2009) · Annals of Neurology · doi:10.1002/ana.21659 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Kettenmann H Ransom BR Neuroglia, Oxford University Press, Oxford. 2005
Cited by
Sorted by citations
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works
“The resulting accumulation of intracellular Na+ reverses the operation of the Na+/ Ca2+ exchanger, resulting in intracellular Ca2+ accumulation (Matute and Ransom, 2012; Stys et al., 1992).”
Influential
- Authors
- Matute, C., & Ransom, B. R.
- Affiliations
- University of the Basque Country (ES)
- University of Washington (US)
- Corresponding author
- Matute, Carlos
- Venue
- ASN Neuro
- Publisher
- Informa UK Limited
- Published
- 2012-02
- Volume
- 4
- Issue
- 2
- ISSN
- 1759-0914 (ISSN-L)
- PMC
- PMC3310305
- OpenAlex
- W1991530671
- Cited by
- 70
- References
- 133
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- ASN NEURO (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Eusko Jaurlaritza
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- white matter, white matter injury, glutamate signalling, ATP signalling, neurotransmitter signalling, neurological disorders, brain injury mechanisms, cerebral cortex evolution
- MeSH terms
- Adenosine Triphosphate, Animals, Axons, Central Nervous System Diseases, Humans, Nerve Fibers, Myelinated, Neuroglia, Signal Transduction, Neurotransmitter Agents, Glutamic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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