The axo-myelinic synapse
Abstract
Axons have evolved to acquire myelination, enabling denser packing and speedier transmission. Although myelin is considered a passive insulator, recent reports suggest a more dynamic role. Axons, in turn, are endowed with neurotransmitter release and uptake systems along their trunks. Based on these observations, I argue that there may exist a new type of chemical synapse between axon and myelin, one that supports activity-dependent communication between the two. This raises intriguing possibilities of dynamic fine-tuning of the myelin sheath even in adulthood, efficient recruitment of resources for myelin maintenance and bi-directional signaling, whereby the axon informs its myelinating cell of its metabolic needs proportionally to the electrical traffic it is transmitting. This would also have implications for de- and dysmyelinating diseases should this axo-myelinic synapse become dysfunctional.
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Oligodendroglial NMDA receptors are localized in specialized microdomains of myelinating processes and also face the periaxonal space.
“Oligodendroglial NMDA receptors are localized in specialized microdomains of myelinating processes”
From Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism (2016) · cites this paper as Stys, 2011
Cites
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544 · see citing works
Training induces changes in white-matter architecture
Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2412 · Cited by 1,508 · see citing works
Structural maturation of neural pathways in children and adolescents: in vivo study
Paus, T., Zijdenbos, A., Worsley, K., Collins, D. L., Blumenthal, J., Giedd, J. N., Rapoport, J. L., & Evans, A. C. (1999) · Science · doi:10.1126/science.283.5409.1908 · Cited by 1,322 · see citing works
Extensive piano practicing has regionally specific effects on white matter development
Bengtsson, S. L., Nagy, Z., Skare, S., Forsman, L., Forssberg, H., & Ullén, F. (2005) · Nature Neuroscience · doi:10.1038/nn1516 · Cited by 1,193 · see citing works
A theory of the effects of fibre size in medullated nerve
Rushton, W. A. H. (1951) · The Journal of Physiology · doi:10.1113/jphysiol.1951.sp004655 · Cited by 1,075 · see citing works
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062 · see citing works
Myelination and support of axonal integrity by glia
Nave, K.-A. (2010) · Nature · doi:10.1038/nature09614 · Cited by 1,062 · see citing works
Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L. W., Lai, C., Schwab, M. H., & Nave, K. (2004) · Science · doi:10.1126/science.1095862 · Cited by 940 · see citing works
Molecular Background of Leak K + Currents: Two-Pore Domain Potassium Channels
Enyedi, P., & Czirják, G. (2010) · Physiological Reviews · doi:10.1152/physrev.00029.2009 · Cited by 871 · see citing works
Purinergic signalling in neuron–glia interactions
Fields, R. D., & Burnstock, G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1928 · Cited by 852 · see citing works
Nonvesicular release of neurotransmitter
Attwell, D., Barbour, B., & Szatkowski, M. S. (1993) · Neuron · doi:10.1016/0896-6273(93)90145-h · Cited by 840 · see citing works
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773 · see citing works
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
Chatterton, J. E., Awobuluyi, M., Premkumar, L. S., Takahashi, H., Talantova, M. V., Shin, Y., Cui, J., Tu, S., Sevarino, K. A., Nakanishi, N., et al. (2002) · Nature · doi:10.1038/nature715 · Cited by 695 · see citing works
Astrocytes promote myelination in response to electrical impulses
Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689 · see citing works
Induction of myelination in the central nervous system by electrical activity
Demerens, C., Stankoff, B., Logak, M., Anglade, P., Allinquant, B., Couraud, F., Zalc, B., & Lubetzki, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9887 · Cited by 678 · see citing works
Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons
Barres, B. A., & Raff, M. C. (1993) · Nature · doi:10.1038/361258a0 · Cited by 673 · see citing works
Regulation of oligodendrocyte differentiation and myelination
Emery, B. (2010) · Science · doi:10.1126/science.1190927 · Cited by 653 · see citing works
Myelination and the trophic support of long axons
Nave, K.-A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2797 · Cited by 648 · see citing works
Debanne, D., Campanac, E., Bialowas, A., Carlier, E., & Alcaraz, G. (2011) · Physiological Reviews · doi:10.1152/physrev.00048.2009 · Cited by 590 · see citing works
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
Salter, M. G., & Fern, R. F. (2005) · Nature · doi:10.1038/nature04301 · Cited by 556 · see citing works
Sodium-Calcium Exchange: A Molecular Perspective
Philipson, K. D., & Nicoll, D. A. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.111 · Cited by 540 · see citing works
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
Micu, I., Jiang, Q., Coderre, E., Ridsdale, A., Zhang, L., Woulfe, J., Yin, X., Trapp, B. D., McRory, J. E., Rehak, R., et al. (2005) · Nature · doi:10.1038/nature04474 · Cited by 504 · see citing works
Electron microscopy of oligodendroglia in severe mental illness
Uranova, N., Orlovskaya, D., Vikhreva, O., Zimina, I., Kolomeets, N., Vostrikov, V., & Rachmanova, V. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00528-7 · Cited by 495 · see citing works
Rapid Conduction and the Evolution of Giant Axons and Myelinated Fibers
Hartline, D. K., & Colman, D. R. (2007) · Current Biology · doi:10.1016/j.cub.2006.11.042 · Cited by 478 · see citing works
Vesicular release of glutamate from unmyelinated axons in white matter
Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 476 · see citing works
Vesicular glutamate release from axons in white matter
Kukley, M., Capetillo‐Zarate, E., & Dietrich, D. (2007) · Nature Neuroscience · doi:10.1038/nn1850 · Cited by 460 · see citing works
Matute, C., Torre, I., Pérez‐Cerdá, F., Pérez‐Samartín, A., Alberdi, E. M., Etxebarria, E., Arranz, A. M., Ravid, R., Antigüedad, A. R., Sánchez‐Gómez, M. V., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0579-07.2007 · Cited by 404 · see citing works
Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate
Rinholm, J. E., Hamilton, N. B., Kessaris, N., Richardson, W. D., Bergersen, L. H., & Attwell, D. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3516-10.2011 · Cited by 383 · see citing works
Barrett, E. F., & Barrett, J. N. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014064 · Cited by 375 · see citing works
Wender, R., Brown, A. M., Fern, R., Swanson, R. A., Farrell, K., & Ransom, B. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06804.2000 · Cited by 374 · see citing works
Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein
Milner, R. J., Lai, C., Nave, K., Lenoir, D., Ogata, J., & Sutcliffe, J. G. (1985) · Cell · doi:10.1016/0092-8674(85)90289-2 · Cited by 337 · see citing works
Myelin Proteomics: Molecular Anatomy of an Insulating Sheath
Jahn, O., Tenzer, S., & Werner, H. B. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8071-2 · Cited by 331 · see citing works
Rapid Ischemic Cell Death in Immature Oligodendrocytes: A Fatal Glutamate Release Feedback Loop
Fern, R. F., & Möller, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00034.2000 · Cited by 321 · see citing works
Li, S., & Stys, P. K. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01190.2000 · Cited by 307 · see citing works
Hodgkin, A. L. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005152 · Cited by 268 · see citing works
Response of Schwann Cells to Action Potentials in Development
Stevens, B. A., & Fields, R. D. (2000) · Science · doi:10.1126/science.287.5461.2267 · Cited by 267 · see citing works
Verkhratsky, A., & Kirchhoff, F. (2007) · The Neuroscientist · doi:10.1177/1073858406294270 · Cited by 265 · see citing works
White Matter Tractography in Bipolar Disorder and Schizophrenia
McIntosh, A. M., Maniega, S. M., Lymer, G. K. S., McKirdy, J. W., Hall, J., Sussmann, J. E., Bastin, M. E., Clayden, J. D., Johnstone, E. C., & Lawrie, S. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.026 · Cited by 259 · see citing works
Li, S., Mealing, G. A. R., Morley, P., & Stys, P. K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0002.1999 · Cited by 252 · see citing works
Court, F. A., Hendriks, W. T. J., MacGillavry, H. D., Álvarez, J., & van Minnen, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2429-08.2008 · Cited by 239 · see citing works
James, G., & Butt, A. M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01756-9 · Cited by 236 · see citing works
P2X7 receptors mediate ischemic damage to oligodendrocytes
Domercq, M., Perez‐Samartin, A., Aparicio, D., Alberdi, E., Pampliega, O., & Matute, C. (2010) · Glia · doi:10.1002/glia.20958 · Cited by 221 · see citing works
Verkhratsky, A., Krishtal, O., & Burnstock, G. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8063-2 · Cited by 218 · see citing works
Calcium signaling of glial cells along mammalian axons
Kriegler, S., & Chiu, S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04229.1993 · Cited by 203 · see citing works
Neuron-glia synapses in the brain
Bergles, D. E., Jabs, R., & Steinhäuser, C. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.12.003 · Cited by 199 · see citing works
Orthmann‐Murphy, J. L., Freidin, M. M., Fischer, E., Scherer, S. S., & Abrams, C. K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3395-07.2007 · Cited by 191 · see citing works
Pelizaeus-Merzbacher disease: Genetic and cellular pathogenesis
Garbern, J. Y. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6182-8 · Cited by 189 · see citing works
Energy transfer from astrocytes to axons: the role of CNS glycogen
Brown, A. M., Tekkök, S. B., & Ransom, B. R. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.11.005 · Cited by 186 · see citing works
Diffusion Tensor Imaging in Psychiatric Disorders
White, T. J. H., Nelson, M., & Lim, K. O. (2008) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e3181809f1e · Cited by 177 · see citing works
Influence of the NR3A subunit on NMDA receptor functions
Henson, M. A., Roberts, A. C., Pérez‐Otaño, I., & Philpot, B. D. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.004 · Cited by 170 · see citing works
Control of Myelination by Specific Patterns of Neural Impulses
Stevens, B., Tanner, S. L., & Fields, R. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09303.1998 · Cited by 170 · see citing works
Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, T. M., Schousboe, A., Waagepetersen, H. S., & Ransom, B. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20335 · Cited by 169 · see citing works
Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation
Stirling, D. P., & Stys, P. K. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.02.002 · Cited by 163 · see citing works
On the relation between fibre diameter and conduction velocity in myelinated nerve fibres
Ritchie, J. M. (1982) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1982.0092 · Cited by 161 · see citing works
Kirischuk, S., Scherer, J., Kettenmann, H., & Verkhratsky, A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020566 · Cited by 151 · see citing works
Glutamate and ATP signalling in white matter pathology
Matute, C. (2011) · Journal of Anatomy · doi:10.1111/j.1469-7580.2010.01339.x · Cited by 149 · see citing works
Diffusion tensor imaging in the early phase of schizophrenia: What have we learned?
Peters, B. D., Blaas, J., & de Haan, L. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.003 · Cited by 148 · see citing works
White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies
Heng, S., Song, A. W., & Sim, K. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0368-9 · Cited by 145 · see citing works
Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2‐glia
Hamilton, N. B., Vayro, S., Wigley, R., & Butt, A. M. (2009) · Glia · doi:10.1002/glia.20902 · Cited by 144 · see citing works
Neurotransmitter‐mediated signaling between axons and glial cells
Chiu, S. Y., & Kriegler, S. (1994) · Glia · doi:10.1002/glia.440110213 · Cited by 141 · see citing works
Synaptic signaling between neurons and glia
Lin, S., & Bergles, D. E. (2004) · Glia · doi:10.1002/glia.20060 · Cited by 141 · see citing works
Schizophrenia, myelination, and delayed corollary discharges: a hypothesis
Whitford, T. J., Ford, J. M., Mathalon, D. H., Kubicki, M., & Shenton, M. E. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq105 · Cited by 140 · see citing works
Neurotransmitter‐mediated calcium signalling in oligodendrocyte physiology and pathology
Butt, A. M. (2006) · Glia · doi:10.1002/glia.20424 · Cited by 128 · see citing works
Human myelin proteome and comparative analysis with mouse myelin
Ishii, A., Dutta, R., Wark, G. M., Hwang, S.-I., Han, D. K., Trapp, B. D., Pfeiffer, S. E., & Bansal, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905936106 · Cited by 119 · see citing works
Maxwell, W. L., McCreath, B. J., Graham, D. I., & Gennarelli, T. A. (1995) · Journal of Neurocytology · doi:10.1007/bf01215643 · Cited by 114 · see citing works
Ribosomes in axons – scrounging from the neighbors?
Twiss, J. L., & Fainzilber, M. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.02.007 · Cited by 107 · see citing works
Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors
Ouardouz, M., Coderre, E., Basak, A., Chen, A. A., Zamponi, G. W., Hameed, S., Rehak, R., Yin, X., Trapp, B. D., & Stys, P. K. (2009) · Annals of Neurology · doi:10.1002/ana.21533 · Cited by 107 · see citing works
Low, C., & Wee, K. S.-L. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064006 · Cited by 107 · see citing works
Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors
Ouardouz, M., Coderre, E., Zamponi, G. W., Hameed, S., Yin, X., Trapp, B. D., & Stys, P. K. (2009) · Annals of Neurology · doi:10.1002/ana.21539 · Cited by 104 · see citing works
Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 “NMDA” Receptor Subunits
Piña-Crespo, J., Talantova, M. V., Micu, I., States, B. A., Chen, H.-S. V., Tu, S., Nakanishi, N., Tong, G., Zhang, D., Heinemann, S. F., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1593-10.2010 · Cited by 102 · see citing works
Smothers, C. T., & Woodward, J. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123836 · Cited by 102 · see citing works
David, G., Modney, B. K., Scappaticci, K. A., Barrett, J. N., & Barrett, E. F. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp021037 · Cited by 93 · see citing works
Yamazaki, Y., Hozumi, Y., Kaneko, K., Sugihara, T., Fujii, S., Goto, K., & Kato, H. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000070 · Cited by 91 · see citing works
Helynck, G., Luu, B., Nussbaum, J. L., Picken, D. J., SKALIDIS, G., Trifilieff, É., DORSSELAER, A. V., Patrick, S. E. T. A., Sandeaux, R., Gavach, C., et al. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07518.x · Cited by 89 · see citing works
Depolarizing afterpotentials in myelinated axons of mammalian spinal cord
Blight, A. R., & Someya, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90118-6 · Cited by 89 · see citing works
White Matter Rafting––Membrane Microdomains in Myelin
DeBruin, L. S., & Harauz, G. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9137-4 · Cited by 87 · see citing works
Glutamatergic signaling in the brain's white matter
Bakiri, Y., Burzomato, V., Frugier, G., Hamilton, N. B., Káradóttir, R. T., & Attwell, D. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.015 · Cited by 83 · see citing works
Local Gene Expression in Axons and Nerve Endings: The Glia-Neuron Unit
Giuditta, A., Chun, J. T., Eyman, M., Cefaliello, C., Bruno, A. P., & Crispino, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00051.2006 · Cited by 82 · see citing works
Multiple Sclerosis as a Neuronal Disease
Waxman, S. G. (2000) · Archives of Neurology · doi:10.1001/archneur.57.1.22 · Cited by 80 · see citing works
Yu, S., & Ding, W. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00372-2 · Cited by 79 · see citing works
Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy
Micu, I., Ridsdale, A., Zhang, L., Woulfe, J., McClintock, J., Brantner, C. A., Andrews, S., & Stys, P. K. (2007) · Nature Medicine · doi:10.1038/nm1568 · Cited by 78 · see citing works
Axon‐schwann cell interaction in the squid nerve fibre
Villegas, J. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009940 · Cited by 78 · see citing works
VORBRODT, A. W., Lossinsky, A. S., & Wı́sniewski, H. M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90245-1 · Cited by 77 · see citing works
Neuregulin 1–erbB4 pathway in schizophrenia: From genes to an interactome
Banerjee, A., MacDonald, M. L., Borgmann‐Winter, K. E., & Hahn, C.-G. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.011 · Cited by 77 · see citing works
Structural and functional studies of gap junction channels
Nakagawa, S., Maeda, S., & Tsukihara, T. (2010) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.05.003 · Cited by 65 · see citing works
Fiber Content of the Fornix in Schizophrenia: Lack of Evidence for a Primary Limbic Encephalopathy
Chance, S. A., Highley, J. R., Esiri, M. M., & Crow, T. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1720 · Cited by 57 · see citing works
Glutamate receptor‐mediated ischemic injury of premyelinated central axons
Alix, J. J. P., & Fern, R. F. (2009) · Annals of Neurology · doi:10.1002/ana.21767 · Cited by 55 · see citing works
Ca++-ATPase in the central nervous system: an EM cytochemical study.
Mata, M. M., & Fink, D. J. (1989) · Journal of Histochemistry & Cytochemistry · doi:10.1177/37.7.2525142 · Cited by 55 · see citing works
Is Na + K ATPase a Myelin‐Associated Enzyme?
Reiss, D. S., Lees, M. B., & Sapirstein, V. S. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb00581.x · Cited by 52 · see citing works
Alix, J. J. P., DOLPHIN, A. C., & Fern, R. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.155077 · Cited by 50 · see citing works
Oligodendrocytes: Facilitating Axonal Conduction by More Than Myelination
Yamazaki, Y., Hozumi, Y., Kaneko, K., Fujii, S., Goto, K., & Kato, H. (2009) · The Neuroscientist · doi:10.1177/1073858409334425 · Cited by 50 · see citing works
Brand‐Schieber, E., & Werner, P. (2003) · Glia · doi:10.1002/glia.10136 · Cited by 50 · see citing works
Ouardouz, M., Malek, S. A., Coderre, E., & Stys, P. K. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116798 · Cited by 49 · see citing works
Stys, P. K., Lehning, E. J., Saubermann, A. J., & LoPachin, R. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68051920.x · Cited by 48 · see citing works
Immunolocalization of the Na+–Ca2+ exchanger in mammalian myelinated axons
Steffensen, I., Waxman, S. G., Mills, L. R., & Stys, P. K. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00868-8 · Cited by 47 · see citing works
Functional glutamate transport in rodent optic nerve axons and glia
Arranz, A. M., Hussein, A., Alix, J. J. P., Pérez‐Cerdá, F., Allcock, N., Matute, C., & Fern, R. F. (2008) · Glia · doi:10.1002/glia.20703 · Cited by 45 · see citing works
Profiling Axonal mRNA Transport
Willis, D. E., & Twiss, J. L. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-005-8_21 · Cited by 42 · see citing works
Fischer, I., & Sapirstein, V. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31477-1 · Cited by 41 · see citing works
Protein interactions with lipid bilayers: The channels of kidney plasma membrane proteolipids
Tosteson, M. T., & Sapirstein, V. S. (1981) · The Journal of Membrane Biology · doi:10.1007/bf01969448 · Cited by 41 · see citing works
Multiple Sclerosis As A Neuronal Disease
(2005) · Elsevier eBooks · doi:10.1016/b978-0-12-738761-1.x5000-7 · Cited by 40 · see citing works
Receptors for Neurotransmitters and Hormones
Kettenmann, H., & Steinhäuser, C. (2004) · Neuroglia · doi:10.1093/acprof:oso/9780195152227.003.0010 · Cited by 34 · see citing works
Gap Junction Disorders of Myelinating Cells
Kleopa, K. A., Orthmann‐Murphy, J. L., & Sargiannidou, I. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.5.397 · Cited by 32 · see citing works
The spaces between membrane bilayers within PNS myelin as characterized by X-ray diffraction
Blaurock, A. E. (1981) · Brain Research · doi:10.1016/0006-8993(81)90914-8 · Cited by 28 · see citing works
Brand‐Schieber, E., & Werner, P. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00469-5 · Cited by 25 · see citing works
Kamasawa, N., Sik, A., Morita, M., Yasumura, T., Davidson, K. G., Nagy, J. I., & Rash, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.027 · Cited by 22 · see citing works
Fischer, I., Durrie, R., & Sapirstein, V. S. (1994) · Neurochemical Research · doi:10.1007/bf00968705 · Cited by 22 · see citing works
Ropte, S., Scheidt, P., & Friede, R. L. (1990) · Journal of Neurocytology · doi:10.1007/bf01217302 · Cited by 20 · see citing works
Mršulja, B. J., Zalewski, A. A., & Coping, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)91170-9 · Cited by 19 · see citing works
Sapirstein, V. S., Durrie, R., Cherksey, B. D., Beard, M. E., Flynn, C. J., & Fischer, I. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490320415 · Cited by 19 · see citing works
Nikolaeva, M. A., Richard, S., Mouihate, A., & Stys, P. K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5729-08.2009 · Cited by 19 · see citing works
Felts, P. A., & Smith, K. J. (1996) · Journal of Neurocytology · doi:10.1007/bf02284794 · Cited by 13 · see citing works
The Structure of Myelinated Axons in the CNS
Hildebrand, C., & Mohseni, S. (2005) · Elsevier eBooks · doi:10.1016/b978-012738761-1/50002-x · Cited by 10 · see citing works
Cherksey, B. D., Durrie, R., Braun, P. E., & Sapirstein, V. S. (1994) · Neurochemical Research · doi:10.1007/bf00968722 · Cited by 8 · see citing works
Preparation of Giant Myelin Vesicles and Proteoliposomes to Register Ionic Channels
Regueiro, P., Monreal, J., Díaz, R. S., & Sierra, F. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67052146.x · Cited by 7 · see citing works
Dolapchieva, S. (1995) · PubMed · Cited by 4 · see citing works
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Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism
Saab, A. S., Tzvetavona, I. D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H. M., Huang, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.016 · Cited by 590 · see citing works
“Oligodendroglial NMDA receptors are localized in specialized microdomains of myelinating processes (Stirling and Stys, 2010; Stys, 2011) and also face the periaxonal space (Micu et al.”
InfluentialWill the real multiple sclerosis please stand up?
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Neuroprotection and repair in multiple sclerosis
Franklin, R. J. M., ffrench‐Constant, C., Edgar, J. M., & Smith, K. J. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.200 · Cited by 274 · see citing works
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Butt, A. M., Fern, R. F., & Matute, C. (2014) · Glia · doi:10.1002/glia.22674 · Cited by 133 · see citing works
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The back and forth of axonal injury and repair after stroke
Hinman, J. D. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000149 · Cited by 78 · see citing works
Merino, P., Díaz, A., Jeanneret, V., Wu, F., Torre, E. R., Cheng, L., & Yepes, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.761650 · Cited by 76 · see citing works
Oligodendrocyte-mediated myelin plasticity and its role in neural synchronization
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Eising, E., Huisman, S. M. H., Mahfouz, A. E., Vijfhuizen, L. S., Anttila, V., Winsvold, B. S., Kurth, T., Ikram, M. A., Freilinger, T. M., Kaprio, J. A., et al. (2016) · Human Genetics · doi:10.1007/s00439-016-1638-x · Cited by 55 · see citing works
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Hanics, J., Barna, J., Xiao, J., Millán, J. L., Fonta, C., & Négyessy, L. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1455-z · Cited by 55 · see citing works
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Jensen, S. K., & Yong, V. W. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.04.003 · Cited by 44 · see citing works
Vassall, K. A., Bessonov, K., Avila, M. D., Polverini, E., & Harauz, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068175 · Cited by 43 · see citing works
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Proctor, D. T., Stotz, S. C., Scott, L. O. M., de la Hoz, C. L. R., Poon, K. W. C., Stys, P. K., & Colicos, M. A. (2015) · Glia · doi:10.1002/glia.22875 · Cited by 39 · see citing works
Ahmed, M. A. M., Avila, M. D., Polverini, E., Bessonov, K., Bamm, V. V., & Harauz, G. (2012) · Biochemistry · doi:10.1021/bi300998x · Cited by 33 · see citing works
Rockland, K. S., & Nayyar, N. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00004 · Cited by 28 · see citing works
Tang, X., Li, Z., Zhang, W., & Yao, Z. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.07.006 · Cited by 27 · see citing works
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González, G. M., Hart, B. A. ‘., Bugiani, M., Plemel, J. R., Schenk, G. J., Kooij, G., & Luchicchi, A. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02923-1 · Cited by 19 · see citing works
Bergaglio, T., Luchicchi, A., & Schenk, G. J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.610295 · Cited by 15 · see citing works
Bessonov, K., Vassall, K. A., & Harauz, G. (2012) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2012.11.006 · Cited by 12 · see citing works
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Oost, W., Meilof, J. F., & Baron, W. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05690-0 · Cited by 7 · see citing works
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He, J., Qian, L., Li, Z., Wang, Y., Liu, K., Wei, H., Sun, Y., He, J., Yao, K., Weng, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53302-5 · Cited by 7 · see citing works
Liley, D. T. J. (2014) · Springer eBooks · doi:10.1007/978-3-642-54593-1_14 · Cited by 6 · see citing works
A myelinic channel system for motor-driven organelle transportPreprint
Chapple, K. J., Green, T. R. F., Wirth, S., Chen, Y.-H., Gerwig, U. C., Aicher, M. L., Kim, Y., Komarek, L., Brown, A. M., Crawford, C. L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.02.591488 · Cited by 6 · see citing works
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Velumian, A. A., & Samoilova, M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_1 · Cited by 5 · see citing works
Cisneros-Mejorado, A., Ordaz, R. P., Garay, E., & Arellano, R. O. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1369730 · Cited by 5 · see citing works
Liley, D. T. J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7320-6_69-1 · Cited by 3 · see citing works
Excitotoxicity and Axon Degeneration
King, A. E., & Vickers, J. C. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_145 · Cited by 2 · see citing works
Liley, D. T. J. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6675-8_69 · Cited by 2 · see citing works
Smith, C. U. M. (2014) · History, philosophy and theory of the life sciences · doi:10.1007/978-94-017-8774-1_14 · Cited by 1 · see citing works
Metabolic Injury of Oligodendrocytes and Myelin
Stys, P. K. (2012) · doi:10.1093/med/9780199794591.003.0052 · Cited by 1 · see citing works
Axonal Loss and Neurodegeneration in Multiple Sclerosis
Dutta, R., Chen, J. M., Ohno, N., Ontaneda, D., & Trapp, B. D. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch20 · Cited by 1 · see citing works
The role of oligodendrocytes in higher-order circuit functions
Corona, S. Y. M. (2018) · doi:10.53846/goediss-7137
Liley, D. T. J. (2022) · Springer eBooks · doi:10.1007/978-1-0716-1006-0_69 · Cited by 1 · see citing works
Vitantonio, A. T., Dimovasili, C., Liu, Y., Ye, B., Lee, J. R., Hartigan, M., Bouchard, B., Ray, M. H., Conner, B., Vaughan, K. L., et al. (2025) · Aging Cell · doi:10.1111/acel.70298
Masson, M. L. P. (2024) · theses.fr (ABES) · doi:10.70675/7f680c8dz2453z40c7z9047z982a66a8bfd5
Microenvironmental Regulation of Central Nervous System Myelination and Remyelination
Wang, Y., Tan, L., Lao, L., Huang, X., Zhang, S., & Sun, H. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin43257
- Authors
- Stys, P. K.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Stys, Peter K.
- ORCID
- Stys, Peter K.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 34
- Issue
- 8
- Pages
- 393-400
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1964610585
- Cited by
- 51
- References
- 115
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 10
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Multiple Sclerosis Society
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- myelination, myelin sheath, axons, neurotransmitter release, neurotransmitter uptake, activity-dependent signaling, myelin maintenance, bidirectional signaling, demyelinating disease, myelinated axons
- MeSH terms
- Animals, Axons, Demyelinating Diseases, Humans, Myelin Sheath, Synapses, Receptors, Neurotransmitter
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