Expression and function of semaphorin 7A in bone cells
Open accessAbstract
Background information. Sema‐7A is a glycosylphosphatidylinositol‐anchored semaphorin that was first identified in the immune system. It is a member of a large family of proteins involved in axon guidance signalling. Sema‐7A is expressed in the myeloid and the lymphoid lineage and seems to be involved in cytokine expression and chemotaxy through its receptor Plexin C1. However, it can promote axon outgrowth, acting through a β1 subunit‐containing integrin receptor. Results and conclusions. In the present study, we have investigated its regulation and function in bone cells. Semiquantitative reverse transcriptase—PCR demonstrated that Sema‐7A mRNA is present during all stages of osteoblast differentiation and maturation in mouse calvaria cells and in MC3T3 cell line in vitro. Its expression is also regulated during primary osteoclast differentiation in vitro. We report that Sema‐7A is capable of increasing the migration of MC3T3 cells and that this process is mediated by the mitogen‐activated protein kinase pathway in osteoblasts, probably through the integrin subunit β1. Moreover, the addition of recombinant soluble Sema‐7A to the culture enhances osteoclast fusion. These findings indicate for the first time the possible involvement of Sema‐7A in bone cell differentiation.
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Semaphorins are involved in cell-cell communication between osteoclasts and osteoblasts during bone remodeling.
“In bone, it has been suggested that semaphorins are also involved in cell-cell communication between osteoclasts and osteoblasts during the bone remodeling cycle [174–176].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [174]
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- Authors
- Delorme, G., Saltel, F., Bonnelye, E., Jurdic, P., & Machuca‐Gayet, I.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Machuca‐Gayet, Irma
- Venue
- Biology of the Cell
- Publisher
- Wiley
- Published
- 2005-07
- Volume
- 97
- Issue
- 7
- Pages
- 589-597
- ISSN
- 0248-4900 (ISSN-L)
- 1768-322X
- OpenAlex
- W2031056152
- Cited by
- 89
- References
- 26
- Citations by year
- 2025: 3 · 2024: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 9 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 7
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biology of the Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ligue Contre le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- SEMA7A, bone cells, osteogenic differentiation, osteoclastogenesis, osteoclast fusion, cell migration, beta1 integrin, MAPK signaling, MC3T3-E1 cells, calvaria cells, GPI-anchored proteins, bone formation
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Humans, Microscopy, Fluorescence, Osteoblasts, Osteoclasts, RNA, Messenger, Antigens, CD, Semaphorins, Mice, GPI-Linked Proteins
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