Osteoclast–osteoblast communication

Matsuo, Koichi; Irie, Naoko

doi:10.1016/j.abb.2008.03.027

Cited by 780Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

Osteoclast–osteoblast communication

Matsuo, Koichi, Irie, Naoko·2008·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2008.03.027

Open this paper in CoChat — free account

Abstract

Cells in osteoclast and osteoblast lineages communicate with each other through cell-cell contact, diffusible paracrine factors and cell-bone matrix interaction. Osteoclast-osteoblast communication occurs in a basic multicellular unit (BMU) at the initiation, transition and termination phases of bone remodeling. At the initiation phase, hematopoietic precursors are recruited to the BMU. These precursors express cell surface receptors including c-Fms, RANK and costimulatory molecules, such as osteoclast-associated receptor (OSCAR), and differentiate into osteoclasts following cell-cell contact with osteoblasts, which express ligands. Subsequently, the transition from bone resorption to formation is mediated by osteoclast-derived 'coupling factors', which direct the differentiation and activation of osteoblasts in resorbed lacunae to refill it with new bone. Bidirectional signaling generated by interaction between ephrinB2 on osteoclasts and EphB4 on osteoblast precursors facilitates the transition. Such interaction is likely to occur between osteoclasts and lining cells in the bone remodeling compartment (BRC). At the termination phase, bone remodeling is completed by osteoblastic bone formation and mineralization of bone matrix. Here, we describe molecular communication between osteoclasts and osteoblasts at distinct phases of bone remodeling.

Integrity signals

Registry

Crossref · 10.1016/j.abb.2008.03.027

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bone remodeling is a cycle comprised of three phases: initiation of bone resorption by osteoclasts, transition from resorption to new bone formation, and bone formation by osteoblasts.
“Bone remodeling is a highly complex process by which old bone is replaced by new bone, in a cycle comprised of three phases: (1) initiation of bone resorption by osteoclasts, (2) the transition (or reversal period) from resorption to new bone formation, and (3) the bone formation by osteoblasts [10, 11].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [11]
Basic multicellular units (BMUs) are temporary anatomical structures formed in bone cavities, comprised of osteoclasts ahead forming the cutting cone and osteoblasts behind forming the closing cone, associated with blood vessels and peripheral innervation.
“In these cavities, there is the formation of temporary anatomical structures called basic multicellular units (BMUs), which are comprised of a group of osteoclasts ahead forming the cutting cone and a group of osteoblasts behind forming the closing cone, associated with blood vessels and the peripheral innervation [11, 166].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [11]
The bone remodeling cycle begins with an initiation phase (bone resorption by osteoclasts), followed by a transition/reversal phase, then bone formation by osteoblasts, completed by coordinated actions of osteocytes and bone lining cells.
“The bone remodeling cycle begins with an initiation phase, which consists of bone resorption by osteoclasts, followed by a phase of bone formation by osteoblasts but between these two phases, there is a transition (or reversal) phase. The cycle is completed by coordinated actions of osteocytes and bone lining cells [10, 11].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [11]

The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works
Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182 · see citing works
Novel Regulators of Bone Formation: Molecular Clones and Activities
Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R., Hewick, R. M., & Wang, E. A. (1988) · Science · doi:10.1126/science.3201241 · Cited by 3,874 · see citing works
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351 · see citing works
Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts
Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701 · see citing works
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789 · see citing works
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735 · see citing works
Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558 · see citing works
Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro1
Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S.-I., Yano, K., Fujise, N., Sato, Y., Goto, M., Yamaguchi, K., Kuriyama, M., et al. (1998) · Endocrinology · doi:10.1210/endo.139.3.5837 · Cited by 1,201 · see citing works
Effects of mechanical forces on maintenance and adaptation of form in trabecular bone
Huiskes, R., Ruimerman, R. R., van Lenthe, H., & Janssen, J. J. (2000) · Nature · doi:10.1038/35015116 · Cited by 1,180 · see citing works
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · see citing works
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis, and regulation of bone mass and calcium metabolism.
Li, J., Sarosi, I., Yan, X.-Q., Morony, S., Capparelli, C., Tan, H.-L., McCabe, S., Elliott, R., Scully, S., Van, G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1566 · Cited by 1,119 · see citing works
Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency
Gelb, B. D., Shi, G., Chapman, H. A., & Desnick, R. J. (1996) · Science · doi:10.1126/science.273.5279.1236 · Cited by 1,022 · see citing works
Eph receptor signalling casts a wide net on cell behaviour
Pasquale, E. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1662 · Cited by 1,013 · see citing works
Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts
Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.025 · Cited by 1,013 · see citing works
Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein
Brunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011 · see citing works
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995 · see citing works
OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION
Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., & Suda, T. (1988) · Endocrinology · doi:10.1210/endo-123-5-2600 · Cited by 934 · see citing works
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
Säftig, P., Hunziker, E. B., Wehmeyer, O., Jones, S. J., BOYDE, A., Rommerskirch, W., Moritz, J. D., Schu, P. V., & FIGURA, K. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13453 · Cited by 909 · see citing works
Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
van Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893 · see citing works
Regulation of osteoblastogenesis and bone mass by Wnt10b
Bennett, C. N., Longo, K. A., Hahn, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., & MacDougald, O. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408742102 · Cited by 882 · see citing works
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.001 · Cited by 848 · see citing works
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., et al. (2004) · Nature · doi:10.1038/nature02444 · Cited by 828 · see citing works
CSF-1 regulation of the wandering macrophage: complexity in action
Pixley, F. J., & Stanley, E. R. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.016 · Cited by 807 · see citing works
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.
McHugh, K. P., Hodivala-Dilke, K., Zheng, M., Namba, N., Lam, J. D., Novack, D., Feng, X., Ross, F., Hynes, R. O., & Teitelbaum, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8905 · Cited by 786 · see citing works
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works
Self-citation
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells
Kollet, Ó., Dar, A., Shivtiel, S., Kalinkovich, A., Lapid, K., Sztainberg, Y., Tesio, M., Samstein, R. M., Goichberg, P., Spiegel, A., et al. (2006) · Nature Medicine · doi:10.1038/nm1417 · Cited by 774 · see citing works
Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo
Verborgt, O., Gibson, G. J., & Schaffler, M. B. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.60 · Cited by 731 · see citing works
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis
Frattini, A., Orchard, P. J., Sobacchi, C., Giliani, S. C., Abinun, M., Mattsson, J. P., Keeling, D. J., Andersson, A., Wallbrandt, P., Zecca, L., et al. (2000) · Nature Genetics · doi:10.1038/77131 · Cited by 669 · see citing works
Osteoclast-derived activity in the coupling of bone formation to resorption
Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 659 · see citing works
Essential role of β-catenin in postnatal bone acquisition.
Holmen, S. L., Zylstra, C. R., Mukherjee, A., Sigler, R. E., Faugere, M.-C., Bouxsein, M. L., Deng, L., Clemens, T. L., & Williams, B. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501900200 · Cited by 584 · see citing works
Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos
Matsuo, K., Galson, D. L., Chen, Z., Peng, L., Laplace, C., Wang, K. Z. Q., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313973200 · Cited by 569 · see citing works
Self-citation
v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation
Lee, S.-H., Rho, J., Jeong, D., Sul, J., Kim, T. S., Kim, N., Kang, J.-S., Miyamoto, T. K., Suda, T., Lee, S., et al. (2006) · Nature Medicine · doi:10.1038/nm1514 · Cited by 547 · see citing works
Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption
Ross, F. P., Chappel, J., Alvarez, J. I., Sander, D., Butler, W. T., Farach-Carson, M. C., Mintz, K. A., Robey, P. G., Teitelbaum, S. L., & Cheresh, D. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98430-9 · Cited by 537 · see citing works
Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization
Gowen, M., Lazner, F., Dodds, R. A., Kapadia, R. D., Feild, J. A., Tavaria, M. D., Bertoncello, I., Drake, F. H., Zavarselk, S., Tellis, I., et al. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.10.1654 · Cited by 491 · see citing works
NFAT and Osterix cooperatively regulate bone formation
Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B. D., Nakashima, K., & Takayanagi, H. (2005) · Nature Medicine · doi:10.1038/nm1270 · Cited by 490 · see citing works
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification
Li, Y., Chen, W., Liang, Y., Li, E., & Stashenko, P. (1999) · Nature Genetics · doi:10.1038/70563 · Cited by 467 · see citing works
The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
Mócsai, A., Humphrey, M., Ziffle, J. V. V., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S., Lanier, L., Lowell, C., & Nakamura, M. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401602101 · Cited by 436 · see citing works
Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.
Pfeilschifter, J., & Mundy, G. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.2024 · Cited by 434 · see citing works
Osteocytes as Dynamic Multifunctional Cells
Bonewald, L. F. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.018 · Cited by 414 · see citing works
The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation
Everts, V., Delaissé, J. M., Korper, W., Jansen, D. C., Tigchelaar-Gutter, W., Saftig, P., & Beertsen, W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.77 · Cited by 411 · see citing works
Semaphorins and their receptors in immune cell interactions
Suzuki, K., Kumanogoh, A., & Kikutani, H. (2008) · Nature Immunology · doi:10.1038/ni1553 · Cited by 400 · see citing works
Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic Markers
Hauge, E. M., Qvesel, D., Eriksen, E. F., Mosekilde, L., & Melsen, F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1575 · Cited by 397 · see citing works
The coupling of bone formation to bone resorption: A critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis
PARFITT, A. M. (1982) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(82)90002-9 · Cited by 396 · see citing works
Trafficking of Matrix Collagens Through Bone-Resorbing Osteoclasts
Nesbitt, S. A., & Horton, M. A. (1997) · Science · doi:10.1126/science.276.5310.266 · Cited by 378 · see citing works
Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
Hayman, A. R., Jones, S. J., BOYDE, A., Foster, D. B., Colledge, W. H., Carlton, M. B. L., Evans, M. J., & Cox, T. M. (1996) · Development · doi:10.1242/dev.122.10.3151 · Cited by 374 · see citing works
Bone quality: the material and structural basis of bone strength
Seeman, E. (2007) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0793-5 · Cited by 358 · see citing works
Calcineurin/NFAT Signaling in Osteoblasts Regulates Bone Mass
Winslow, M. M., Pan, M., Starbuck, M. W., Gallo, E. M., Deng, L., Karsenty, G., & Crabtree, G. R. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.006 · Cited by 354 · see citing works
Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone Remodelling
Hattner, R. S., Epker, B. N., & Frost, H. M. (1965) · Nature · doi:10.1038/206489a0 · Cited by 343 · see citing works
Mutations in the a3 subunit of the vacuolar H+-ATPase cause infantile malignant osteopetrosis
Kornak, U. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.13.2059 · Cited by 343 · see citing works
Ultrastructure of the osteocyte process and its pericellular matrix
You, L., Weinbaum, S., Cowin, S. C., & Schaffler, M. B. (2004) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20050 · Cited by 328 · see citing works
Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling
Ryu, J., Kim, H. J., Chang, E., Huang, H., Banno, Y., & Hong‐Hee, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601430 · Cited by 318 · see citing works
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
Brannan, C. I., Lyman, S. D., Williams, D. E., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4671 · Cited by 303 · see citing works
Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice
Lagasse, E., & Weissman, I. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80290-1 · Cited by 287 · see citing works
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation
Bennett, C. N., Ouyang, H., Li, Y., Zeng, Q., Gerin, I., Sousa, K. M., Lane, T. F., Krishnan, V., Hankenson, K. D., & MacDougald, O. A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070810 · Cited by 282 · see citing works
Transforming Growth Factor β Affects Osteoclast Differentiation via Direct and Indirect Actions
Quinn, J. M. W., Itoh, K., Udagawa, N., Häusler, K., Yasuda, H., Shima, N., Mizuno, A., Higashio, K., Takahashi, N., Suda, T., et al. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1787 · Cited by 278 · see citing works
A Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation
Kim, N., Takami, M., Rho, J., Josien, R., & Choi, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011681 · Cited by 274 · see citing works
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
Takegahara, N., Takamatsu, H., Toyofuku, T., Tsujimura, T., Okuno, T., Yukawa, K., Mizui, M., Yamamoto, M., Prasad, D. V., Suzuki, K., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1416 · Cited by 270 · see citing works
Apatite-mediated Actin Dynamics in Resorbing Osteoclasts
Saltel, F., Destaing, O., Bard, F., Eichert, D., & Jurdic, P. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-06-0522 · Cited by 267 · see citing works
Dynamic histomorphometry of alveolar bone remodeling in the adult rat
Vignery, A., & Baron, R. (1980) · The Anatomical Record · doi:10.1002/ar.1091960210 · Cited by 260 · see citing works
Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?
Karsdal, M. A., Martin, T. J., Bollerslev, J., Christiansen, C., & Henriksen, K. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070109 · Cited by 242 · see citing works
Stromal Cell-Derived Factor-1 (SDF-1) Recruits Osteoclast Precursors by Inducing Chemotaxis, Matrix Metalloproteinase-9 (MMP-9) Activity, and Collagen Transmigration
Yu, X., Huang, Y., Collin‐Osdoby, P., & Osdoby, P. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.8.1404 · Cited by 241 · see citing works
NOTCH1 Regulates Osteoclastogenesis Directly in Osteoclast Precursors and Indirectly via Osteoblast Lineage Cells
Bai, S., Kopan, R., Zou, W., Hilton, M. J., Ong, C., Long, F., Ross, F. P., & Teitelbaum, S. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707000200 · Cited by 236 · see citing works
Parathyroid Hormone Stimulates Osteoblastic Expression of MCP-1 to Recruit and Increase the Fusion of Pre/Osteoclasts
Li, X., Qin, L., Bergenstock, M., Bevelock, L. M., Novack, D. V., & Partridge, N. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611781200 · Cited by 232 · see citing works
Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts
Wright, L. M., Maloney, W. J., YU, X., Kindle, L., Collin‐Osdoby, P., & Osdoby, P. (2005) · Bone · doi:10.1016/j.bone.2005.01.021 · Cited by 231 · see citing works
Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/β-Catenin but Not Bone Morphogenetic Protein Signaling
Deregowski, V., Gazzerro, E., Priest, L., Rydziel, S., & CANALIS, E. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508370200 · Cited by 231 · see citing works
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.
Grano, M., Galimi, F., Zambonin, G., Colucci, S. C., Cottone, E., Zallone, A. Z., & Comoglio, P. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7644 · Cited by 221 · see citing works
‘Calcium-activated’ intracellular calcium elevation: A novel mechanism of osteoclast regulation
Zaidi, M., Datta, H. K., Patchell, A., Moonga, B. S., & MacIntyre, I. M. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91143-1 · Cited by 214 · see citing works
Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption
Tan, S., de Vries, T. J., Kuijpers‐Jagtman, A. M., Semeins, C. M., Everts, V. E., & Klein‐Nulend, J. (2007) · Bone · doi:10.1016/j.bone.2007.07.019 · Cited by 212 · see citing works
Critical Regulation of Bone Morphogenetic Protein-induced Osteoblastic Differentiation by Delta1/Jagged1-activated Notch1 Signaling
Nobta, M., Tsukazaki, T., Shibata, Y., Chang, X., Moriishi, T., Sakano, S., Shindo, H., & Yamaguchi, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412891200 · Cited by 211 · see citing works
Interaction between osteoblast and osteoclast: impact in bone disease.
Phan, T. C. A., Xu, J., & Zheng, M. (2004) · PubMed · doi:10.14670/hh-19.1325 · Cited by 207 · see citing works
Mammalian collagenase predisposes bone surfaces to osteoclastic resorption
Chambers, T. J., Darby, J. A., & Fuller, K. (1985) · Cell and Tissue Research · doi:10.1007/bf00214590 · Cited by 203 · see citing works
In Vivo Analysis of Wnt Signaling in Bone
Glass, D. A., & Karsenty, G. (2007) · Endocrinology · doi:10.1210/en.2006-1372 · Cited by 200 · see citing works
Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact.
Jimi, E., Nakamura, I., Amano, H., Taguchi, Y., Tsurukai, T., Tamura, M., Takahashi, N., & Suda, T. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754795 · Cited by 198 · see citing works
Osteocytes inhibit osteoclastic bone resorption through transforming growth factor‐β: Enhancement by estrogen*
Heino, T. J., Hentunen, T. A., & Väänänen, H. K. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10109 · Cited by 191 · see citing works
Transgenic Mice Overexpressing Tartrate-Resistant Acid Phosphatase Exhibit an Increased Rate of Bone Turnover
Angel, N. Z., Walsh, N. C., Forwood, M. R., Ostrowski, M. C., Cassady, A. I., & Hume, D. A. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.103 · Cited by 187 · see citing works
Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment
Fattore, A. D., Peruzzi, B., Rucci, N., Recchia, I., Cappariello, A., Longo, M., Fortunati, D., Ballanti, P., Iacobini, M., Luciani, M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.036673 · Cited by 181 · see citing works
A unified theory for osteonal and hemi-osteonal remodeling
van Oers, R. F. M., Ruimerman, R. R., Tanck, E., Hilbers, P. A. J., & Huiskes, R. (2007) · Bone · doi:10.1016/j.bone.2007.10.009 · Cited by 177 · see citing works
The Bone Remodeling Compartment: A Circulatory Function for Bone Lining Cells
Parfitt, A. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1583 · Cited by 169 · see citing works
High Extracellular Calcium Concentrations Directly Stimulate Osteoclast Apoptosis
Lorget, F., Kamel, S., Mentaverri, R., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2229 · Cited by 161 · see citing works
Remodeling and Vascular Spaces in Bone
Eriksen, E. F., Eghbali-Fatourechi, G. Z., & Khosla, S. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060910 · Cited by 158 · see citing works
Cellular kinetics of the bone remodeling sequence in the rat
Van, P. T., Vignery, A., & Baron, R. (1982) · The Anatomical Record · doi:10.1002/ar.1092020403 · Cited by 158 · see citing works
Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption
Karsdal, M. A., Henriksen, K., Sørensen, M. G., Gram, J., Schaller, S., Dziegiel, M. H., Heegaard, A., Christophersen, P., Martin, T. J., Christiansen, C., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62269-9 · Cited by 155 · see citing works
Hypothalamic Control of Bone Formation: Distinct Actions of Leptin and Y2 Receptor Pathways
Baldock, P. A. J., Sainsbury, A., Allison, S. J., Lin, E.-J. D., Couzens, M., Boey, D., Enriquez, R. F., During, M. J., Herzog, H., & Gardiner, E. M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050523 · Cited by 149 · see citing works
Accelerated Turnover of Metaphyseal Trabecular Bone in Mice Overexpressing Cathepsin K
Kiviranta, R., Morko, J. P., Uusitalo‐Järvinen, H., Aro, H. T., VUORIO, E. I., & Rantakokko, J. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.8.1444 · Cited by 142 · see citing works
Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress
Jiang, J. X. (2006) · Frontiers in bioscience · doi:10.2741/2159 · Cited by 140 · see citing works
Platelet-Derived Growth Factor BB Secreted From Osteoclasts Acts as an Osteoblastogenesis Inhibitory Factor
Kubota, K., Sakikawa, C., Katsumata, M., Nakamura, T., & Wakabayashi, K. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.257 · Cited by 130 · see citing works
A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis.Preprint
Johnson, M. R., Polymeropoulos, M. H., Vos, H. L., Luna, R. I. O. D., & Francomano, C. A. (1996) · Genome Research · doi:10.1101/gr.6.11.1050 · Cited by 130 · see citing works
Imatinib Promotes Osteoblast Differentiation by Inhibiting PDGFR Signaling and Inhibits Osteoclastogenesis by Both Direct and Stromal Cell-Dependent Mechanisms
O’Sullivan, S., Naot, D., Callon, K. E., Porteous, F., Horne, A. M., Wattie, D. J., Watson, M., Cornish, J., Browett, P., & Grey, A. B. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070719 · Cited by 128 · see citing works
Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells
Yamada, T., Yamazaki, H., Yamane, T., Yoshino, M., Okuyama, H., Tsuneto, M., Kurino, T., Hayashi, S., & Sakano, S. (2003) · Blood · doi:10.1182/blood-2002-06-1740 · Cited by 124 · see citing works
Mice Lacking Cathepsin K Maintain Bone Remodeling but Develop Bone Fragility Despite High Bone Mass
Li, C. Y., Jepsen, K. J., Majeska, R. J., Zhang, J., Ni, R., Gelb, B. D., & Schaffler, M. B. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060313 · Cited by 121 · see citing works
An electron-microscopic study of the bone-remodeling sequence in the rat
Tran, P. V., Vignery, A., & Baron, R. (1982) · Cell and Tissue Research · doi:10.1007/bf00214682 · Cited by 118 · see citing works
EBF2 Regulates Osteoblast-Dependent Differentiation of Osteoclasts
Kieslinger, M., Roessler, S. K., Dobreva, G. D., Dorn, T., Croci, L., Erben, R. G., Consalez, G. G., & Grosschedl, R. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.10.009 · Cited by 118 · see citing works
Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts
Fuller, K., Lawrence, K. M., Ross, J. L., Grabowska, U. B., Shiroo, M., Samuelsson, B., & Chambers, T. J. (2007) · Bone · doi:10.1016/j.bone.2007.09.044 · Cited by 115 · see citing works
Osteoprotegerin in the Inner Ear May Inhibit Bone Remodeling in the Otic Capsule
Zehnder, A. F., Kristiansen, A. G., Adams, J. C., Merchant, S. N., & McKenna, M. J. (2005) · The Laryngoscope · doi:10.1097/01.mlg.0000150702.28451.35 · Cited by 112 · see citing works
Boning up on Ephrin Signaling
Mundy, G. R., & Elefteriou, F. (2006) · Cell · doi:10.1016/j.cell.2006.07.015 · Cited by 111 · see citing works
Topographically induced bone formation in vitro: Implications for bone implants and bone grafts
Gray, C., BOYDE, A., & Jones, S. J. (1996) · Bone · doi:10.1016/8756-3282(95)00456-4 · Cited by 110 · see citing works
ADAM8: A Novel Osteoclast Stimulating Factor
Choi, S. J., Han, J.-H., & Roodman, G. D. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.5.814 · Cited by 107 · see citing works
Receptor Activator of NF-κB Ligand and Osteoprotegerin Regulate Proinflammatory Cytokine Production in Mice
Maruyama, K., Takada, Y., Ray, N., Kishimoto, Y., Penninger, J. M., Yasuda, H., & Matsuo, K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3799 · Cited by 105 · see citing works
Self-citation
Intercellular Adhesion Molecule 1 Discriminates Functionally Different Populations of Human Osteoblasts: Characteristic Involvement of Cell Cycle Regulators
Tanaka, Y., Maruo, A., Fujii, K., Nomi, M., Nakamura, T., Eto, S., & Minami, Y. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.10.1912 · Cited by 94 · see citing works
Osteoblast-like Cells Complete Osteoclastic Bone Resorption and Form New Mineralized Bone Matrix In Vitro
Mulari, M. T. K., Qu, Q., H�rk�nen, P. L., & V��n�nen, H. K. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0172-3 · Cited by 93 · see citing works
Expression of Semaphorin‐3A and its receptors in endochondral ossification: Potential role in skeletal development and innervation
Gomez, C. G., Burt‐Pichat, B., Mallein‐Gérin, F., Merle, B., Delmas, P. D., Skerry, T. M., Vico, L., Malaval, L., & Chenu, C. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20512 · Cited by 91 · see citing works
A Phage Display Technique Identifies a Novel Regulator of Cell Differentiation
Sheu, T., Schwarz, E. M., Martinez, D. A., O’Keefe, R. J., Rosier, R. N., Zuscik, M. J., & Puzas, J. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208292200 · Cited by 89 · see citing works
Expression and function of semaphorin 7A in bone cells
Delorme, G., Saltel, F., Bonnelye, E., Jurdic, P., & Machuca‐Gayet, I. (2005) · Biology of the Cell · doi:10.1042/bc20040103 · Cited by 89 · see citing works
The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts
Dana, T. (1999) · Frontiers in bioscience · doi:10.2741/graves · Cited by 88 · see citing works
α9β1: A Novel Osteoclast Integrin That Regulates Osteoclast Formation and Function
Rao, H., Lu, G., Kajiya, H., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060718 · Cited by 86 · see citing works
Regulation of Osteoblast Differentiation by Pasteurella Multocida Toxin (PMT): A Role for Rho GTPase in Bone Formation
Harmey, D., Stenbeck, G., Nobes, C. D., Lax, A. J., & Grigoriadis, A. E. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040105 · Cited by 85 · see citing works
Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP‐1 and RANTES
Kim, M. S., Magno, C. L., Day, C. J., & Morrison, N. A. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20649 · Cited by 83 · see citing works
The osteocyte as a wiring transmission system.
Marotti, G. (2000) · PubMed · Cited by 81 · see citing works
Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures
Mashiba, T., Turner, C. H., Hirano, T., Forwood, M. R., Jacob, D., Johnston, C. C., & Burr, D. B. (2001) · Bone · doi:10.1016/s8756-3282(01)00575-0 · Cited by 78 · see citing works
Skeletal Renewal and Metabolic Bone Disease
Harris, W. H., & Heaney, R. P. (1969) · New England Journal of Medicine · doi:10.1056/nejm196901302800507 · Cited by 75 · see citing works
A Novel Osteoblast-derived C-type Lectin That Inhibits Osteoclast Formation
Zhou, H., Kartsogiannis, V., Hu, Y. S., Elliott, J., Quinn, J. M. W., McKinstry, W. J., Gillespie, M. T., & Ng, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011554200 · Cited by 74 · see citing works
ADAM gene expression and regulation during human osteoclast formation
Verrier, S., Hogan, A., McKie, N., & Horton, M. A. (2004) · Bone · doi:10.1016/j.bone.2003.12.029 · Cited by 73 · see citing works
The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue
(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70 · see citing works
Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin
Kanzaki, S., Ito, M., Takada, Y., Ogawa, K., & Matsuo, K. (2006) · Bone · doi:10.1016/j.bone.2006.01.155 · Cited by 69 · see citing works
Self-citation
Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts
Togari, A., Mogi, M., Arai, M., Yamamoto, S., & Koshihara, Y. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02700-1 · Cited by 65 · see citing works
Quantitative regional associations between remodeling, modeling, and osteocyte apoptosis and density in rabbit tibial midshafts
Hedgecock, N. L., Hadi, T. M., Chen, A. A., Curtiss, S. B., Martin, R. B., & Hazelwood, S. J. (2006) · Bone · doi:10.1016/j.bone.2006.10.006 · Cited by 62 · see citing works
Altered Collagen in Tartrate-Resistant Acid Phosphatase (TRAP)-Deficient Mice: A Role for TRAP in Bone Collagen Metabolism
Roberts, S. J., Knott, L., Avery, N. C., et al. (2007) · Calcified Tissue International · doi:10.1007/s00223-007-9032-2 · Cited by 57 · see citing works
Osteoclast Inhibitory Lectin, a Family of New Osteoclast Inhibitors
Zhou, H., Kartsogiannis, V., Quinn, J. M. W., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209059200 · Cited by 52 · see citing works
Use of a Phage Display Technique to Identify Potential Osteoblast Binding Sites Within Osteoclast Lacunae
Sheu, T., Schwarz, E. M., O’Keefe, R. J., et al. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.5.915 · Cited by 51 · see citing works
A Novel Recognition System for MHC Class I Molecules Constituted by PIR
Takai, T. (2005) · Advances in immunology · doi:10.1016/s0065-2776(05)88005-8 · Cited by 50 · see citing works
Negative Feedback Loop in the Bim–Caspase-3 Axis Regulating Apoptosis and Activity of Osteoclasts
Wakeyama, H., Akiyama, T., Takahashi, K., Amano, H., Kadono, Y., Nakamura, M., Oshima, Y., Itabe, H., Nakayama, K., Nakayama, K., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070619 · Cited by 46 · see citing works
Transmigration: A New Property of Mature Multinucleated Osteoclasts
Saltel, F., Chabadel, A., Zhao, Y., Lafage-Proust, M.-H., Clézardin, P., Jurdic, P., & Bonnelye, E. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060821 · Cited by 41 · see citing works
Osteoclasts Secrete the Chemotactic Cytokine Mim-1
Falany, M. L., Thames, A. M., McDonald, J. M., Blair, H. C., McKenna, M. A., Moore, R. E., Young, M. K., & Williams, J. P. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4307 · Cited by 35 · see citing works
Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro
Nakamura, A., Ly, C., Cipetić, M., Sims, N. A., Vieusseux, J. L., Kartsogiannis, V., Bouralexis, S., Saleh, H., Zhou, H., Price, J. T., et al. (2007) · Bone · doi:10.1016/j.bone.2006.09.001 · Cited by 33 · see citing works
Characterization of Sugar Binding by Osteoclast Inhibitory Lectin
Gange, C., Quinn, J. M. W., Zhou, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312518200 · Cited by 32 · see citing works
Dissolution of the inorganic phase of bone leading to release of calcium regulates osteoclast survival
Nielsen, R. H., Karsdal, M. A., Sørensen, M. G., Dziegiel, M. H., & Henriksen, K. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.145 · Cited by 29 · see citing works
Deletion of Membrane-Bound Steel Factor Results in Osteopenia in Mice
Lotinun, S., Evans, G. L., Turner, R. T., & Oursler, M. J. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041209 · Cited by 29 · see citing works
The nature and function of mononuclear cells on the resorbed surfaces of bone in the reversal phase during remodeling
Domon, T., Suzuki, R., Takata, K., et al. (2001) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/s0940-9602(01)80027-3 · Cited by 18 · see citing works

Flagged first, then by citations

Sorted by citations

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works
Disorders of Bone Remodeling
Feng, X., & McDonald, J. M. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130203 · Cited by 1,272 · see citing works
Osteoprotection by semaphorin 3A
Hayashi, M., Nakashima, T., Taniguchi, M., Kodama, T., Kumanogoh, A., & Takayanagi, H. (2012) · Nature · doi:10.1038/nature11000 · Cited by 606 · see citing works
Suppression of bone formation by osteoclastic expression of semaphorin 4D
Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R. H., & Takayanagi, H. (2011) · Nature Medicine · doi:10.1038/nm.2489 · Cited by 498 · see citing works
A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone
Andersen, T. L., Sondergaard, T. E., Skorzynska, K. E., Dagnaes-Hansen, F., Plesner, T. L., Hauge, E. M., Plesner, T., & Delaisse, J.-M. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080627 · Cited by 325 · see citing works
Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches
Niu, Y., Wang, Z., Shi, Y., Dong, L., & Wang, C. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.012 · Cited by 213 · see citing works
Osteoclast-secreted SLIT3 coordinates bone resorption and formation
Kim, B.-J., Lee, Y.-S., Lee, S.-Y., Baek, W.-Y., Choi, Y. J., Moon, S. A., Lee, S. H., Kim, J.-E., Chang, E.-J., Kim, E.-Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91086 · Cited by 174 · see citing works
Pituitary Diseases and Bone
Mazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181 · see citing works
Bone cell interactions through Eph/ephrin: Bone modeling, remodeling and associated diseases
Matsuo, K., & Otaki, N. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20888 · Cited by 167 · see citing works
Self-citation
Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders
Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165 · see citing works
Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs
Lassen, N. E., Andersen, T. L., Pløen, G. G., Søe, K., Hauge, E. M., Harving, S., Eschen, G. E. T., & Delaisse, J.-M. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3091 · Cited by 152 · see citing works
Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells
Grigoriadis, A. E., Kennedy, M., Bozec, A., Brunton, F., Stenbeck, G., Park, I.-H., Wagner, E. F., & Keller, G. M. (2010) · Blood · doi:10.1182/blood-2009-07-234690 · Cited by 151 · see citing works
Coupling factors involved in preserving bone balance
Kim, B.-J., & Koh, J.-M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2981-y · Cited by 111 · see citing works
Bone cell communication factors and Semaphorins
Negishi-Koga, T., & Takayanagi, H. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.183 · Cited by 90 · see citing works
An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis
Weng, W., Li, H., & Zhu, S. (2022) · Genes · doi:10.3390/genes13050806 · Cited by 65 · see citing works
Mapping the spatial atlas of the human bone tissue integrating spatial and single-cell transcriptomics
Lin, W., Li, Y., Qiu, C., Zou, B., Gong, Y., Zhang, X., Tian, D., Sherman, W., Sanchez, F., Wu, D., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkae1298 · Cited by 46 · see citing works
Cellular crosstalk in the bone marrow niche
Huang, Z., Iqbal, Z., Zhao, Z., Liu, J., Alabsi, A. M., Shabbir, M., Mahmood, A., Liang, Y., Li, W., & Deng, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05900-6 · Cited by 34 · see citing works

Authors: Matsuo, K., & Irie, N.
Affiliations: Keio University (JP)
Corresponding author: Matsuo, Koichi
ORCID: Matsuo, Koichi
Irie, Naoko
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2008-05
Volume: 473
Issue: 2
Pages: 201-209
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2008.03.027
OpenAlex: W2089162996
Cited by: 780
References: 130
Citations by year: 2026: 20 · 2025: 19 · 2024: 41 · 2023: 43 · 2022: 62 · 2021: 58 · 2020: 61 · 2019: 50 · 2018: 40 · 2017: 40 · 2016: 35 · 2015: 44 · 2014: 42 · 2013: 47 · 2012: 59
FWCI: 3.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords: bone remodeling, basic multicellular unit, osteoclastogenesis, osteogenic differentiation, RANK, c-fms, osteoclast-associated receptor, coupling coefficient, ephrin-B2, EphB4, bone lining cells, cell-cell contact, paracrine signaling, bone matrix mineralization
MeSH terms: Animals, Bone Resorption, Cell Communication, Cell Differentiation, Humans, Osteoblasts, Osteoclasts, Receptors, Cell Surface, Signal Transduction, Receptor, Macrophage Colony-Stimulating Factor, Bone Remodeling, Ephrins, RANK Ligand

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Osteoclast–osteoblast communication

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks