The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
Open accessAbstract
Submitochondrial particles from bovine heart in which NADH dehydrogenase is reduced by either addition of NADH and rotenone or by reversed electron transfer generate 0.9 +/- 0.1 nmol of O2-/min per mg of protein at pH 7.4 and at 30 degrees C. When NADH is used as substrate, rotenone, antimycin and cyanide increase O2- production. In NADH- and antimycin-supplemented submitochondrial particles, rotenone has a biphasic effect: it increases O2- production at the NADH dehydrogenase and it inhibits O2- production at the ubiquinone-cytochrome b site. The generation of O2- by the rotenone, the uncoupler carbonyl cyanide rho-trifluoromethoxyphenylhydrazone and oligomycin at concentrations similar to those required to inhibit energy-dependent succinate-NAD reductase. Cyanide did not affect O2- generation at the NADH dehydrogenase, but inhibited O2- production at the ubiquinone-cytochrome b site. Production of O2- at the NADH dehydrogenase is about 50% of the O2- generation but the ubiquinone-cytochrome b area at pH 7.4. Additivity of the two mitochondrial sites of O2- generation was observed over the pH range from 7.0 to 8.8. AN O2–dependent autocatalytic process that requires NADH, submitochondrial particles and adrenaline is described.
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“O2•− is one of the most important reactive oxygen species ROS responsible for oxidative stress in bio-organisms and is generated as a by-product of the mitochondrial respiratory chain [8].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [8]
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Self-citationThe Respiratory Chain and Oxidative Phosphorylation
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Self-citationOxidases and Related Redox Systems
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Self-citationRespiratory chain linked H2O2 production in pigeon heart mitochondria
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Maklashina, E., Kotlyar, A. B., Karliner, J. S., & Cecchini, G. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01369-3 · Cited by 37
Huang, X., Chen, X., He, Y., Yu, X., Li, S., Gao, N., Niu, L., Mao, Y., Wang, Y., Wu, X., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006414 · Cited by 38
Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats
Saribeyoglu, K., Aytac, E., Pekmezci, S., Saygili, S., Uzun, H., Ozbay, G., Aydin, S., & Seymen, H. O. (2011) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2011.11.007 · Cited by 38
Fujita, Y., Ito, M., Nozawa, Y., Yoneda, M., Oshida, Y., & Tanaka, M. (2007) · Mitochondrion · doi:10.1016/j.mito.2006.11.003 · Cited by 34
The ambiguous aspects of oxygen
Napolitano, G., Fasciolo, G., & Venditti, P. (2022) · Oxygen · doi:10.3390/oxygen2030027 · Cited by 30
Long chain fatty acyl-CoA modulation of H2O2 release at mitochondrial complex I
Bortolami, S., Comelato, E., Zoccarato, F., Alexandre, A., & Cavallini, L. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9126-1 · Cited by 13
Metadata
- Authors
- Turrens, J. F., & Boveris, A.
- Affiliations
- Universidad de Buenos Aires (AR)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1980-11-01
- Volume
- 191
- Issue
- 2
- Pages
- 421-427
- ISSN
- 0264-6021 (ISSN-L)
- PMC
- PMC1162232
- OpenAlex
- W2271272206
- Cited by
- 1,601
- References
- 29
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 11 · 2023: 15 · 2022: 24 · 2021: 23 · 2020: 24 · 2019: 30 · 2018: 46 · 2017: 37 · 2016: 43 · 2015: 47 · 2014: 47 · 2013: 53 · 2012: 58
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- superoxide, NADH dehydrogenase, bovine heart mitochondria, rotenone, antimycin, uncoupling, oligomycin, cyanide, epinephrine, superoxide production, pH dependence
- MeSH terms
- Animals, Antimycin A, Cattle, Cyanides, Cytochrome Reductases, Hydrogen-Ion Concentration, Mitochondria, Heart, NADH Dehydrogenase, Oxygen, Rotenone, Submitochondrial Particles, Superoxides, In Vitro Techniques
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