The ambiguous aspects of oxygen
Open accessAbstract
For most living beings, oxygen is an essential molecule for survival, being the basis of biological oxidations, which satisfy most of the energy needs of aerobic organisms. Oxygen can also behave as a toxic agent posing a threat to the existence of living beings since it can give rise to reactive oxygen species (ROS) that can oxidise biological macromolecules, among which proteins and lipids are the preferred targets. Oxidative damage can induce cell, tissue, and organ dysfunction, which leads to severe body damage and even death. The survival of the aerobic organism depends on the development of an elaborate antioxidant defence system adapted to the normal level of atmospheric oxygen. The production of ROS in the aerobic organism can occur accidentally from exposure to pollutants or radiation, but occurs constantly during normal metabolic reactions. Cells have evolved using ROS to their advantage. Indeed, ROS are used as signalling molecules in numerous physiological processes, including muscle contraction, regulation of insulin release, and adaptation to environmental changes. Therefore, supplementation with antioxidants must be used wisely. A low level of ROS is essential for adaptation processes, so an excess of antioxidants can be harmful. Conversely, in conditions where ROS production increases, antioxidants can be useful to avoid cellular dysfunction.
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Radicals are continuously generated by most organisms as a result of the use of O2 as a terminal electron acceptor in the mitochondrial electron transport chains and in cytochrome P450.
“In fact, radicals are continuously generated by most organisms as a result of the use of O2 as a terminal electron acceptor in the mitochondrial electron transport chains and in cytochrome P450 [4].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [4]
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Alexandrova, A., Mihova, S., Tsvetanova, E. R., Andreeva, M., Pramatarov, G., Petrov, G., Chipev, N. H., Doncheva, V. G., Stefanova, K., Grandova, M., et al. (2025) · Microplastics · doi:10.3390/microplastics4030050 · Cited by 8 · see citing works
Charoenphun, N., Ali, A. M. M., Balaji, P., & Venkatachalam, K. (2023) · Horticulturae · doi:10.3390/horticulturae9080938 · Cited by 7 · see citing works
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Tomajoli, M. T. M., Donato, P. D., Corte, V. D., Covone, G., Fasciolo, G., Geremia, E., Petito, A., Tonietti, L., Inno, L., Rotundi, A., et al. (2025) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2025.111825 · Cited by 5 · see citing works
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Geremia, E., Buonocore, E., Venditti, P., Adamos, I., Paolacci, S., Agnisola, C., & Napolitano, G. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1766656 · Cited by 2 · see citing works
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Interaction of Strigolactones with Reactive Oxygen Species in Plants
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Self-citation
- Authors
- Napolitano, G., Fasciolo, G., & Venditti, P.
- Affiliations
- Parthenope University of Naples (IT)
- University of Naples Federico II (IT)
- Corresponding author
- Venditti, Paola
- Venue
- Oxygen
- Publisher
- MDPI AG
- Published
- 2022-09-14
- Volume
- 2
- Issue
- 3
- Pages
- 382-409
- ISSN
- 2673-9801 (ISSN-L)
- OpenAlex
- W4296108113
- Cited by
- 30
- References
- 203
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 10 · 2022: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Oxygen (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- reactive oxygen species, oxidative stress, antioxidant defense, ROS signalling, antioxidant supplementation, aerobic metabolism, biological oxidation
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