Drug-induced oxidative stress and toxicity

Methods in Enzymology , Vol

Colowick, S. P., Joshi, M. D., Jagannathan, & KAPLAN, N. O. (1966) · Cited by 26,137 · see citing works

Pharmacological interventions for somatoform disorders in adults

Kleinstäuber, M., Witthöft, M., Steffanowski, A., van Marwijk, H., Hiller, W., & Lambert, M. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010628.pub2 · Cited by 11,361 · see citing works

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

Protein Oxidation in Aging, Disease, and Oxidative Stress

Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,339 · see citing works

Oxidative DNA damage: mechanisms, mutation, and disease

Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245 · see citing works

Role of Oxidative Modifications in Atherosclerosis

Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., & Gotoh, Y. (1997) · Science · doi:10.1126/science.275.5296.90 · Cited by 2,310 · see citing works

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

Gewirtz, D. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00307-4 · Cited by 2,242 · see citing works

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224 · see citing works

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins

Stadtman, E. R., & Levine, R. L. (2003) · Amino Acids · doi:10.1007/s00726-003-0011-2 · Cited by 1,968 · see citing works

Biomarkers of Oxidative Damage in Human Disease

Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani, A. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.061408 · Cited by 1,703 · see citing works

Free radicals and antioxidants in human health: current status and future prospects.

Devasagayam, T. P. A., Tilak, J. C., Boloor, K. K., Sane, K. S., Ghaskadbi, S., & Lele, R. D. (2004) · PubMed · Cited by 1,563 · see citing works

JNK signaling in apoptosis

Dhanasekaran, D. N., & Reddy, E. P. (2008) · Oncogene · doi:10.1038/onc.2008.301 · Cited by 1,529 · see citing works

Reactive oxygen species: role in the development of cancer and various chronic conditions.

Waris, G., & Ahsan, H. (2006) · Journal of Carcinogenesis · doi:10.1186/1477-3163-5-14 · Cited by 1,410 · see citing works

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372 · see citing works

Mechanisms of Cell Death in Oxidative Stress

Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,262 · see citing works

Akt signalling in health and disease

Hers, I., Vincent, E. E., & Tavaré, J. M. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.004 · Cited by 1,246 · see citing works

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,193 · see citing works

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4533 · Cited by 1,106 · see citing works

Cardiac Toxicity 4 to 20 Years After Completing Anthracycline Therapy

Steinherz, L. J. (1991) · JAMA · doi:10.1001/jama.1991.03470120074036 · Cited by 967 · see citing works

Role of oxidative stress and DNA damage in human carcinogenesis

Kryston, T. B., Georgiev, A. B., Pissis, P., & Georgakilas, A. G. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.016 · Cited by 927 · see citing works

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

Dalakas, M. C., Illa, I., Pezeshkpour, G. H., Laukaitis, J. P., Cohen, B. H., & Griffin, J. L. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004193221602 · Cited by 837 · see citing works

Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA

Collins, A. R., Duthie, S. J., & Dobson, V. L. (1993) · Carcinogenesis · doi:10.1093/carcin/14.9.1733 · Cited by 830 · see citing works

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

Šimůnek, T., Štěrba, M., Popelová, O., Adamcová, M., Hrdina, R., & Geršl, V. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70018-0 · Cited by 770 · see citing works

Base excision repair of oxidative DNA damage and association with cancer and aging

Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 685 · see citing works

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

Davies, K. J. A., & Doroshow, J. H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35746-0 · Cited by 633 · see citing works

Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells

Niedernhofer, L. J., Daniels, J. S., Rouzer, C. A., Greene, R. E., & Marnett, L. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212549200 · Cited by 578 · see citing works

Cardioprotective interventions for cancer patients receiving anthracyclines

van Dalen, E. C., Caron, H. N., Dickinson, H. O., & Kremer, L. C. M. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003917.pub4 · Cited by 553 · see citing works

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

Doroshow, J. H., & Davies, K. J. A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35747-2 · Cited by 542 · see citing works

The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic

Broder, S. E. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.10.002 · Cited by 521 · see citing works

Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products

Neeley, W. L., & Essigmann, J. M. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0600043 · Cited by 510 · see citing works

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity

Chirino, Y. I., & Pedraza‐Chaverrí, J. (2008) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2008.09.003 · Cited by 490 · see citing works

Molecular targets of oxidative stress

Avery, S. V. (2011) · Biochemical Journal · doi:10.1042/bj20101695 · Cited by 474 · see citing works

Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.

Childs, A. C., Phaneuf, S., Dirks, A. J., Phillips, T., & Leeuwenburgh, C. (2002) · PubMed · Cited by 451 · see citing works

Lipid peroxidation in aging brain and Alzheimer’s disease1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

Montine, T. J., Neely, M. D., Quinn, J. F., Beal, M. F., Markesbery, W. R., Roberts, L. J., & Morrow, J. D. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00807-9 · Cited by 449 · see citing works

Ubiquitin Conjugation Is Not Required for the Degradation of Oxidized Proteins by Proteasome

Shringarpure, R., Grune, T., Mehlhase, J., & Davies, K. J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206279200 · Cited by 438 · see citing works

Inhibition of Krebs Cycle Enzymes by Hydrogen Peroxide: A Key Role of α-Ketoglutarate Dehydrogenase in Limiting NADH Production under Oxidative Stress

Tretter, L., & Ádám‐Vizi, V. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08972.2000 · Cited by 422 · see citing works

Biological consequences of free radical-damaged DNA bases1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

Wallace, S. S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00827-4 · Cited by 419 · see citing works

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

Boelsterli, U. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00368-5 · Cited by 403 · see citing works

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

Filipski, K. K., Mathijssen, R. H. J., Mikkelsen, T. S., Schinkel, A. H., & Sparreboom, A. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.139 · Cited by 399 · see citing works

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

Zhang, Y.-W., Shi, J., Li, Y., & Wei, L. (2009) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-009-0051-8 · Cited by 387 · see citing works

Lipid Peroxidation in Diabetes Mellitus

Davı̀, G., Falco, A., & Patrono, C. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.256 · Cited by 377 · see citing works

Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice

Fortune, J. M., & Osheroff, N. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)64006-0 · Cited by 367 · see citing works

Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer

Bokemeyer, C., Berger, C. C., Hartmann, J. T., Kollmannsberger, C., Schmoll, H., Kuczyk, M., & Kanz, L. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.226 · Cited by 339 · see citing works

Drug-Induced Cutaneous Photosensitivity

Moore, D. E. (2002) · Drug Safety · doi:10.2165/00002018-200225050-00004 · Cited by 335 · see citing works

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H., & Takeda, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003412200 · Cited by 332 · see citing works

Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria

dos Santos, N. A. G., Bezerra, C. S. C., Martins, N. M., Curti, C., Bianchi, M. L. P., & dos Santos, A. C. (2007) · Archives of Toxicology · doi:10.1007/s00204-006-0173-2 · Cited by 329 · see citing works

Mechanism of Cisplatin Ototoxicity: Antioxidant System

Ravi, R., Somani, S. M., & Rybak, L. P. (1995) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1995.tb00167.x · Cited by 318 · see citing works

Evidence of a specific complex between adriamycin and negatively-charged phospholipids

Goormaghtigh, E., Chatelain, P., Caspers, J., & Ruysschaert, J. (1980) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(80)90145-5 · Cited by 310 · see citing works

Regulation of protein tyrosine phosphatases by reversible oxidation

Östman, A., Frijhoff, J., Sandin, Å., & Böhmer, F. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr104 · Cited by 288 · see citing works

Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity

Kim, H., Lee, J., Kim, S., Oh, G. S., Moon, H. K., Kwon, K., Park, C., Park, B. H., Lee, H.-K., Chung, S.-Y., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6054-09.2010 · Cited by 280 · see citing works

Protein oxidation and cellular homeostasis: Emphasis on metabolism

Cecarini, V., Gee, J., Fioretti, E., Amici, M., Angeletti, M., Eleuteri, A. M., & Keller, J. N. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.039 · Cited by 274 · see citing works

Mechanisms of Anthracycline Cardiac Injury: Can We Identify Strategies for Cardioprotection?

Sawyer, D. B., Peng, X., Chen, B., Pentassuglia, L., & Lim, C. C. (2010) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2010.06.007 · Cited by 271 · see citing works

Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels

Guzik, T. J., West, N. E. J., Pillai, R. G., Taggart, D. P., & Channon, K. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000018041.48432.b5 · Cited by 264 · see citing works

Cisplatin Generates Superoxide Anion by Interaction with DNA in a Cell-Free System

Masuda, H., Tanaka, T., & Takahama, U. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2306 · Cited by 254 · see citing works

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

Doroshow, J. H., Locker, G. Y., Ifrim, I., & Myers, C. E. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110328 · Cited by 245 · see citing works

Cisplatin nephrotoxicity

Daugaard, G., & Abildgaard, U. (1989) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00694330 · Cited by 235 · see citing works

Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis

Wallace, K. B. (2007) · Cardiovascular Toxicology · doi:10.1007/s12012-007-0008-2 · Cited by 222 · see citing works

Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death

Hickey, E. J., Raje, R. R., Reid, V. E., Gross, S. M., & Ray, S. D. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00560-3 · Cited by 220 · see citing works

Dexrazoxane

Cvetkovi, R. S., & Scott, L. J. (2005) · Drugs · doi:10.2165/00003495-200565070-00008 · Cited by 204 · see citing works

Cisplatin-Induced Long-Term Hearing Impairment Is Associated With Specific Glutathione S-Transferase Genotypes in Testicular Cancer Survivors

Oldenburg, J., Kraggerud, S. M., Cvancarova, M., Lothe, R. A., & Fosså, S. D. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.9599 · Cited by 195 · see citing works

Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical.

Till, G. O., Hatherill, J. R., Tourtellotte, W. W., Lutz, M. J., & Ward, P. A. (1985) · PubMed Central · Cited by 188 · see citing works

Base-excision repair of oxidative DNA damage by DNA glycosylases

Dizdaroğlu, M. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.01.033 · Cited by 185 · see citing works

Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide

Bray, J., Sludden, J., Griffin, M. J., Cole, M. F., Verrill, M. W., Jamieson, D., & Boddy, A. V. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605587 · Cited by 185 · see citing works

Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells

Benbrik, E., Chariot, P., Bonavaud, S. M., Ammisaid, M. T., Frisdal, É., Rey, C., Gherardi, R. K., & Barlovatz‐Meimon, G. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)05376-8 · Cited by 185 · see citing works

Role of p53 in Sensing Oxidative DNA Damage in Response to Reactive Oxygen Species-Generating Agents

Achanta, G., & Huang, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0494 · Cited by 184 · see citing works

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

Medicherla, B., & Goldberg, A. L. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803022 · Cited by 175 · see citing works

Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity

Yoshida, M., Shiojima, I., Ikeda, H., & Komuro, I. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.07.024 · Cited by 174 · see citing works

Impact of Long-Term Serum Platinum Concentrations on Neuro- and Ototoxicity in Cisplatin-Treated Survivors of Testicular Cancer

Sprauten, M., Darrah, T. H., Peterson, D. R., Campbell, M. E., Hannigan, R. E., Cvancarova, M., Beard, C. J., Haugnes, H. S., Fosså, S. D., Oldenburg, J., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.4025 · Cited by 169 · see citing works

Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairingin vitro

Purmal, A. A., Kow, Y. W., & Wallace, S. S. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.1.72 · Cited by 161 · see citing works

Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein

Karakaya, A. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.3.474 · Cited by 157 · see citing works

The cochlear targets of cisplatin: An electrophysiological and morphological time-sequence study

van Ruijven, M. W. M., de Groot, J. C. M. J., Klis, S. F. L., & Smoorenburg, G. F. (2005) · Hearing Research · doi:10.1016/j.heares.2005.03.023 · Cited by 155 · see citing works

Trastuzumab-induced cardiac dysfunction: A 'dual-hit'.

Zeglinski, M. R., Lüdke, A., Jassal, D. S., & Singal, P. K. (2011) · Europe PMC (PubMed Central) · Cited by 151 · see citing works

Anticancer drugs and cardiotoxicity: Insights and perspectives in the era of targeted therapy

Raschi, E., Vasina, V. I., Ursino, M. G., Boriani, G., Martoni, A. A., & Ponti, F. D. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.002 · Cited by 150 · see citing works

[38] Protein oxidative damage

Shacter, E. B. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19040-8 · Cited by 144 · see citing works

Drug-induced Cardiac Mitochondrial Toxicity and Protection: From Doxorubicin to Carvedilol

Pereira, G. C., Silva, A. M., Diogo, C. V., Carvalho, F. S., Monteiro, P. F., & Oliveira, P. J. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796904812 · Cited by 136 · see citing works

The Role of the NADPH Oxidase Complex, p38 MAPK, and Akt in Regulating Human Monocyte/Macrophage Survival

Wang, Y., Zeigler, M. M., Lam, G. K., Hunter, M. G., Eubank, T. D., Khramtsov, V. V., Tridandapani, S., Sen, C. K., & Marsh, C. B. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0165oc · Cited by 128 · see citing works

Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)

Burger, H., Zoumaro-Djayoon, A. D., Boersma, A., Helleman, J., Berns, E., Mathijssen, R. H. J., Loos, W., & Wiemer, E. A. C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00569.x · Cited by 122 · see citing works

Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance

Harrison, J. F. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki759 · Cited by 120 · see citing works

Savior and slayer: the two faces of p53

Bensaad, K., & Vousden, K. H. (2005) · Nature Medicine · doi:10.1038/nm1205-1278 · Cited by 113 · see citing works

Influence of the Local Helical Conformation on the Guanine Modifications Generated from One-Electron DNA Oxidation

Spassky, A., & Angelov, D. (1997) · Biochemistry · doi:10.1021/bi962761d · Cited by 110 · see citing works

Liver injury caused by drugs: an update

Stirnimann, G., & Kessebohm, K. (2010) · Swiss Medical Weekly · doi:10.4414/smw.2010.13080 · Cited by 110 · see citing works

Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis

Gago-Domínguez, M., Jiang, X., & Castelao, J. E. (2007) · Breast Cancer Research · doi:10.1186/bcr1628 · Cited by 109 · see citing works

Cardiac toxicity with anti-HER-2 therapies-what have we learned so far?

de Azambuja, E., Bedard, P. L., Suter, T. M., & Piccart, M. J. (2009) · Targeted Oncology · doi:10.1007/s11523-009-0112-2 · Cited by 108 · see citing works

Pharmacogenomics of Cisplatin-Induced Ototoxicity

Mukherjea, D., & Rybak, L. P. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.48 · Cited by 106 · see citing works

Protective effects of carvedilol against doxorubicin-induced cardiomyopathy in rats

Matsui, H., Morishima, I., Numaguchi, Y., Toki, Y., Okumura, K., & Hayakawa, T. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00362-8 · Cited by 103 · see citing works

The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

Yu, S., Lee, S.-K., Johnson, R. E., Prakash, L., & Prakash, S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.382-388.2003 · Cited by 102 · see citing works

Future opportunities in preventing cisplatin induced ototoxicity

van den Berg, J. H., Beijnen, J. H., Balm, A. J. M., & Schellens, J. H. M. (2006) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2006.04.011 · Cited by 101 · see citing works

Randomized study of a short course of weekly cisplatin with or without amifostine in advanced head and neck cancer

Planting, A. S. T., Catimel, G., Mulder, P. H. M. D., de Graeff, A., Höppener, F., Verweij, I., Oster, W., & Vermorken, J. B. (1999) · Annals of Oncology · doi:10.1023/a:1008353505916 · Cited by 99 · see citing works

Steady-State and Pre-Steady-State Kinetic Analysis of 8-Oxo-7,8-dihydroguanosine Triphosphate Incorporation and Extension by Replicative and Repair DNA Polymerases

Einolf, H. J., Schnetz‐Boutaud, N. C., & Guengerich, F. P. (1998) · Biochemistry · doi:10.1021/bi981346d · Cited by 97 · see citing works

A semiquantitative analysis of the effects of cisplatin on the rat stria vascularis

Meech, R. P., Campbell, K. C. M., Hughes, L. P., & Rybak, L. P. (1998) · Hearing Research · doi:10.1016/s0378-5955(98)00116-6 · Cited by 97 · see citing works

Mechanism of oxidative DNA damage repair and relevance to human pathology

D’Errico, M., Parlanti, E., & Eugenia Dogliotti, Y. (2007) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2007.10.003 · Cited by 91 · see citing works

Creating context for the use of DNA adduct data in cancer risk assessment: II. Overview of methods of identification and quantitation of DNA damage

Himmelstein, M. W., Boogaard, P. J., Cadet, J., Farmer, P. B., Kim, J. H., Martin, E. A., Persaud, R., & Shuker, D. E. G. (2009) · Critical Reviews in Toxicology · doi:10.1080/10408440903164163 · Cited by 87 · see citing works

Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage

Dizdaroğlu, M. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.07.003 · Cited by 84 · see citing works

An introduction to the metabolic determinants of anthracycline cardiotoxicity

Menna, P., Recalcati, S., Cairo, G., & Minotti, G. (2007) · Cardiovascular Toxicology · doi:10.1007/s12012-007-0011-7 · Cited by 83 · see citing works

Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins.

Bandyopadhyay, S. K., & Gronostajski, R. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43973-7 · Cited by 77 · see citing works

Investigation of the adducts formed by reaction of malondialdehyde with adenosine

Stone, K., Ksebati, M. B., & Marnett, L. J. (1990) · Chemical Research in Toxicology · doi:10.1021/tx00013a006 · Cited by 77 · see citing works

Mitochondrial and Nuclear p53 Localization in Cardiomyocytes: Redox Modulation by Doxorubicin (Adriamycin)?

Nithipongvanitch, R., Ittarat, W., Cole, M. P., Tangpong, J., Clair, D. K. S., & Oberley, T. D. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1632 · Cited by 73 · see citing works

Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: Classification criteria and application to drug candidates

Onoue, S., Kawamura, K., Igarashi, N., Zhou, Y., Fujikawa, M., Yamada, H., Tsuda, Y., Seto, Y., & Yamada, S. (2008) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2008.03.026 · Cited by 71 · see citing works

Nuclear Transport: A Switch for the Oxidative Stress—Signaling Circuit?

Kodiha, M., & Stochaj, U. (2011) · Journal of Signal Transduction · doi:10.1155/2012/208650 · Cited by 70 · see citing works

LIVING AND DYING IN THE NINETEENTH CENTURY.

Jg, G., & Ps, R. (1963) · PubMed · Cited by 69 · see citing works

The cytoprotective effect of butin against oxidative stress is mediated by the up‐regulation of manganese superoxide dismutase expression through a PI3K/Akt/Nrf2‐dependent pathway

Zhang, R., Chae, S., Lee, J. H., & Hyun, J. W. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24068 · Cited by 61 · see citing works

BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure

Singh, K. K., Shukla, P. C., Quan, A., Desjardins, J., Lovren, F., Pan, Y., Garg, V., Gosal, S., Garg, A., Szmitko, P. E., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.292664 · Cited by 59 · see citing works

Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy

Kohler, J. J., Cucoranu, I. C., Fields, E. J., Green, E., He, S., Hoying‐Brandt, A., Russ, R. B., Abuin, A., Johnson, D., Hosseini, S. H., et al. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.39 · Cited by 57 · see citing works

Renal Proximal Tubule Segment-Specific Nephrotoxicity: An Overview on Biomarkers and Histopathology

Cristofori, P. G., Zanetti, E., Fregona, D., Piaia, A., & Trevisan, A. (2007) · Toxicologic Pathology · doi:10.1080/01926230601187430 · Cited by 57 · see citing works

Involvement of H2O2Production in Cisplatin-Induced Nephrotoxicity

Tsutsumishita, Y., Onda, T., Okada, K., Takeda, M., Endou, H., Futaki, S., & Niwa, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7962 · Cited by 56 · see citing works

Long-Term Exposure to AZT, but not d4T, Increases Endothelial Cell Oxidative Stress and Mitochondrial Dysfunction

Kline, E. R., Bassit, L., Hernández-Santiago, B. I., Detorio, M., Liang, B., Kleinhenz, D. J., Walp, E. R., Dikalov, S., Jones, D. P., Schinazi, R. F., et al. (2008) · Cardiovascular Toxicology · doi:10.1007/s12012-008-9029-8 · Cited by 55 · see citing works

Acute Seizure Activity Promotes Lipid Peroxidation, Increased Nitrite Levels and Adaptive Pathways Against Oxidative Stress in the Frontal Cortex and Striatum

Júnior, H. V. N., Fonteles, M. M. D. F., & de Freitas, R. M. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.3.8488 · Cited by 48 · see citing works

Heart to heart with trastuzumab: a review on cardiac toxicity

Cosimo, S. D. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0203-8 · Cited by 46 · see citing works

A Mitochondrial Target Sequence Polymorphism in Manganese Superoxide Dismutase Predicts Inferior Survival in Breast Cancer Patients Treated with Cyclophosphamide

Glynn, S. A., Boersma, B. J., Howe, T. M., Edvardsen, H., Geisler, S. B., Goodman, J. E., Ridnour, L. A., Lønning, P. E., Børresen‐Dale, A., Naume, B., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0119 · Cited by 45 · see citing works

Propofol ameliorates doxorubicin-induced oxidative stress and cellular apoptosis in rat cardiomyocytes

Lai, H., Yeh, Y., Wang, L. C., Ting, C.-T., Lee, W. L., Lee, H. W., Wang, K. Y., Wu, A., Su, C., & Liu, T. J. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.10.001 · Cited by 41 · see citing works

High‐Dose Cisplatin With Amifostine: Ototoxicity and Pharmacokinetics

Ekborn, A., Hansson, J., Ehrsson, H., Eksborg, S., Wallin, I., Wagenius, G., & Laurell, G. F. E. (2004) · The Laryngoscope · doi:10.1097/00005537-200409000-00030 · Cited by 40 · see citing works

The cardioprotective effect of the iron chelator dexrazoxane (ICRF-187) on anthracycline-mediated cardiotoxicity

Kwok, J., & Richardson, D. R. (2000) · Redox Report · doi:10.1179/135100000101535898 · Cited by 35 · see citing works

Pharmacogenetics of genes across the doxorubicin pathway

Jamieson, D., & Boddy, A. V. (2011) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2011.610180 · Cited by 35 · see citing works

Ascorbate-induced oxidation of glyceraldehyde-3-phosphate dehydrogenase

Schmalhausen, E. V., Pleten, A. P., & Muronetz, V. I. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01421-9 · Cited by 32 · see citing works

Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding

Diao, Y., Liu, W., Wong, C. C. L., Wang, X., Lee, K., Cheung, P.-Y., Pan, L., Xu, T., Han, J., Yates, J. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007225107 · Cited by 31 · see citing works

Pro‐oxidant Properties of AZT and other Thymidine Analogues in Macrophages: Implication of the Azido Moiety in Oxidative Stress

Amatore, C. A., Arbault, S., Jaouen, G., Koh, A. C. W., Leong, W. K., Top, S., Valleron, M.-A., & Woo, C. H. (2010) · ChemMedChem · doi:10.1002/cmdc.200900464 · Cited by 24 · see citing works

LIPID PEROXIDATION AND PARKINSON'S DISEASE

Pall, H., Williams, A. C., Blake, D. R., Winyard, P. G., & Lunec, J. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92913-2 · Cited by 22 · see citing works

Increase of Enzyme Activities following the in vitro Peroxidation of Normal Human Red Blood Cells

Carrons, J. L. V., Pujades, M. A., & Colomer, D. (2017) · Enzyme · doi:10.1159/000469088 · Cited by 17 · see citing works

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484 · see citing works

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Zhou, Z., Song, J., Nie, L., & Chen, X. S. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,104 · see citing works

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445 · see citing works

3D tumor spheroids: an overview on the tools and techniques used for their analysis

Costa, E. C., Moreira, A. F., de Melo-Diogo, D., Gaspar, V. M., Carvalho, M. P., & Correia, I. J. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.11.002 · Cited by 929 · see citing works

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

Burridge, P. W., Li, Y. F., Matsa, E., Wu, H., Ong, S., Sharma, A., Holmström, A., Chang, A. C. Y., Coronado, M. J., Ebert, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4087 · Cited by 746 · see citing works

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Nunes, A. S., Barros, A. S., Costa, E. C., Moreira, A. F., & Correia, I. J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26845 · Cited by 721 · see citing works

Lipid droplet functions beyond energy storage

Welte, M. A., & Gould, A. P. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.006 · Cited by 574 · see citing works

Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?

Hoarau-Véchot, J., Rafii, A., Touboul, C., & Pasquier, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010181 · Cited by 489 · see citing works

Glutathione S-Transferases: Role in Combating Abiotic Stresses Including Arsenic Detoxification in Plants

Kumar, S., & Trivedi, P. K. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00751 · Cited by 459 · see citing works

Occurrence, interactive effects and ecological risk of diclofenac in environmental compartments and biota - a review

Sathishkumar, P., Meena, R. A. A., Thavamani, P., Ashokkumar, V., Palvannan, T., & Gu, F. L. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134057 · Cited by 448 · see citing works

Near‐Infrared Upconversion Mesoporous Cerium Oxide Hollow Biophotocatalyst for Concurrent pH‐/H 2 O 2 ‐Responsive O 2 ‐Evolving Synergetic Cancer Therapy

Yao, C., Wang, W., Wang, P., Zhao, M., Li, X., & Zhang, F. (2018) · Advanced Materials · doi:10.1002/adma.201704833 · Cited by 447 · see citing works

RONS and Oxidative Stress: An Overview of Basic Concepts

Aranda‐Rivera, A. K., Cruz‐Gregorio, A., Arancibia‐Hernández, Y. L., Cruz, E. Y. H., & Pedraza‐Chaverrí, J. (2022) · Oxygen · doi:10.3390/oxygen2040030 · Cited by 406 · see citing works

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

Huang, C.-C., Chia, W.-T., Chung, M.-F., Lin, K.-J., Hsiao, C.-W., Jin, C., Lim, W.-H., Chen, C.-C., & Sung, H.-W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b01784 · Cited by 372 · see citing works

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Kesharwani, P., Ma, R., Sang, L., Fatima, M., Sheikh, A., Abourehab, M. A. S., Gupta, N., Chen, Z., & Zhou, Y. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01798-8 · Cited by 351 · see citing works

Induction of oxidative stress by bisphenol A and its pleiotropic effects

Gassman, N. R. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22072 · Cited by 337 · see citing works

Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib

Gorini, S., Angelis, A. D., Berrino, L., Malara, N., Rosano, G. M. C., & Ferraro, E. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7582730 · Cited by 329 · see citing works

Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

Angsutararux, P., Luanpitpong, S., & Issaragrisil, S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/795602 · Cited by 289 · see citing works

Role of endoplasmic reticulum stress in drug‐induced toxicity

Foufelle, F., & Fromenty, B. (2016) · Pharmacology Research & Perspectives · doi:10.1002/prp2.211 · Cited by 244 · see citing works

A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis

Yang, S., Chu, S., Gao, Y., Ai, Q., Liu, Y., Li, X., & Chen, N. (2019) · Cells · doi:10.3390/cells8070738 · Cited by 237 · see citing works

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

Polonchuk, L., Chabria, M., Badi, L., Hoflack, J.-C., Figtree, G., Davies, M. J., & Gentile, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-06385-8 · Cited by 223 · see citing works

Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development

Al-Gubory, K. H. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.03.002 · Cited by 222 · see citing works

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Ghosh, R., Alajbegović, A., & Gomes, A. V. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/536962 · Cited by 197 · see citing works

Protein Quality Control under Oxidative Stress Conditions

Dahl, J., Gray, M. J., & Jakob, U. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.02.014 · Cited by 194 · see citing works

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells

Srivastava, A., Amreddy, N., Babu, A., Panneerselvam, J., Mehta, M., Muralidharan, R., Chen, A., Zhao, Y. D., Razaq, M., Riedinger, N., et al. (2016) · Scientific Reports · doi:10.1038/srep38541 · Cited by 187 · see citing works

Oxidative DNA damage induced by ROS-modulating agents with the ability to target DNA: A comparison of the biological characteristics of citrus pectin and apple pectin

Salehi, F., Behboudi, H., Kavoosi, G., & Ardestani, S. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-32308-2 · Cited by 157 · see citing works

Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila

Martelli, F., Zhongyuan, Z., Wang, J., Wong, C., Karagas, N. E., Roessner, U., Rupasinghe, T., Venkatachalam, K., Perry, T., Bellen, H. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011828117 · Cited by 175 · see citing works

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

Xiao, Q., Zhu, W., Feng, W., Lee, S. S., Leung, A. W., Shen, J., Gao, L., & Xu, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01534 · Cited by 170 · see citing works

Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis

Ma, Y., Yang, L., Ma, J., Lu, L., Wang, X., Ren, J. T., & Yang, J. Z. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.12.021 · Cited by 147 · see citing works

Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice

Sahu, B. D., Kumar, J. M., Kuncha, M., Borkar, R. M., Srinivas, R., & Sistla, R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.11.018 · Cited by 141 · see citing works

Reactive oxygen species induce Cox‐2 expression via TAK1 activation in synovial fibroblast cells

Onodera, Y., Teramura, T., Takehara, T., Shigi, K., & Fukuda, K. (2015) · FEBS Open Bio · doi:10.1016/j.fob.2015.06.001 · Cited by 140 · see citing works

An update on oxidative stress-mediated organ pathophysiology

Rashid, K., Sinha, K., & Sil, P. C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.09.026 · Cited by 139 · see citing works

Redox control of cancer cell destruction

Hegedűs, C., Kovács, K. É., Polgár, Z., Regdon, Z., Szabó, É., Robaszkiewicz, A., Forman, H. J., Martner, A., & Virág, L. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.015 · Cited by 137 · see citing works

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Hou, K., Shen, J., Yan, J., Zhai, C., Zhang, J., Pan, J.-A., Zhang, Y., Jiang, Y., Wang, Y., Lin, R. Z., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103456 · Cited by 138 · see citing works

Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle

de Lima, E. A., Yamashita, A. S., Pimentel, G. D., de Sousa, L. G. O., dos Santos, R. V. T., Gonçalves, C. L., STRECK, E. L., Lira, F. S., & Neto, J. C. R. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12104 · Cited by 133 · see citing works

Sulforaphane protects the heart from doxorubicin-induced toxicity

Singh, P., Sharma, R., McElhanon, K. E., Allen, C. D., Megyesi, J. K., Beneš, H., & Singh, S. P. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.028 · Cited by 129 · see citing works

Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance

Yang, J., Li, W., Luo, L., Jiang, M., Zhu, C., Qin, B., Yin, H., Yuan, X., Yin, X., Zhang, J., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.004 · Cited by 126 · see citing works

Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery

Wang, L.-F., Lin, Y.-S., Huang, N., Yu, C.-Y., Tsai, W.-L., Chen, J., Kubota, T., Matsuoka, M., Chen, S.-R., Yang, C.-S., et al. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0038 · Cited by 127 · see citing works

Synergy, Additive Effects, and Antagonism of Drugs with Plant Bioactive Compounds

Chaachouay, N. (2025) · Drugs and Drug Candidates · doi:10.3390/ddc4010004 · Cited by 123 · see citing works

Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity†

Barberino, R. D. S., Menezes, V. G., Ribeiro, A. E. A. S., Palheta, R. C., Jiang, X., Smitz, J. E. J., & Matos, M. H. T. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox053 · Cited by 121 · see citing works

Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy at a single dose

Luo, Z., Tian, H., Liu, L., Chen, Z., Liang, R., Chen, Z., Wu, Z., Ma, A.-Q., Zheng, M., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.25409 · Cited by 119 · see citing works

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

Kopecka, J., Campia, I., Jacobs, A., Frei, A. P., Ghigo, D., Wollscheid, B., & Riganti, C. (2015) · Oncotarget · doi:10.18632/oncotarget.2882 · Cited by 118 · see citing works

Effects of pharmaceutical PEGylation on drug metabolism and its clinical concerns

Zhang, X., Wang, H., Ma, Z., & Wu, B. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.967679 · Cited by 117 · see citing works

Hepatotoxic effect of ochratoxin A and citrinin, alone and in combination, and protective effect of vitamin E: In vitro study in HepG2 cell

Gayathri, L., Dhivya, R., Dharumadurai, D., Periasamy, V. S., Alshatwi, A. A., & Akbarsha, M. A. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.06.009 · Cited by 113 · see citing works

The Adverse Outcome Pathway approach in nanotoxicology

Gerloff, K., Landesmann, B., Worth, A. P., Munn, S., Palosaari, T., & Whelan, M. (2016) · Computational Toxicology · doi:10.1016/j.comtox.2016.07.001 · Cited by 104 · see citing works

Oxidative stress: fundamentals and advances in quantification techniques

Krishnamurthy, H. K., Pereira, M., Rajavelu, I., Jayaraman, V., Krishna, K., Wang, T., Bei, K., & Rajasekaran, J. J. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1470458 · Cited by 116 · see citing works

A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells

Barciszewska, A., Gurda, D., Głodowicz, P., Nowak, S., & Naskręt-Barciszewska, M. Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136669 · Cited by 103 · see citing works

Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study

Danwilai, K., Konmun, J., Sripanidkulchai, B., & Subongkot, S. (2017) · Cancer Management and Research · doi:10.2147/cmar.s124016 · Cited by 103 · see citing works

Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis

Tang, X., Лю, Б., Wang, X., Yu, Q., & Fang, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030848 · Cited by 103 · see citing works

Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships

Hielscher, A. C., & Gerecht, S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.015 · Cited by 103 · see citing works

Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis

Cesari, I. M., Carvalho, É., Rodrigues, M. F., Mendonça, B. D. S., Amoêdo, N. D., & Rumjanek, F. D. (2014) · International Journal of Cell Biology · doi:10.1155/2014/572097 · Cited by 101 · see citing works

Wheat phenolics suppress doxorubicin-induced cardiotoxicity via inhibition of oxidative stress, MAP kinase activation, NF-κB pathway, PI3K/Akt/mTOR impairment, and cardiac apoptosis

Sahu, R., Dua, T. K., Das, S., Feo, V. D., & Dewanjee, S. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.01.034 · Cited by 101 · see citing works

A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

Lai, B. F. L., Lu, R. X. Z., Huyer, L. D., Kakinoki, S., Yazbeck, J., Wang, E. Y., Wu, Q., Zhang, B., & Radisic, M. (2021) · Nature Protocols · doi:10.1038/s41596-020-00490-1 · Cited by 101 · see citing works

The Effect of β-Carotene, Tocopherols and Ascorbic Acid as Anti-Oxidant Molecules on Human and Animal In Vitro/In Vivo Studies: A Review of Research Design and Analytical Techniques Used

Miazek, K., Beton-Mysur, K., Śliwińska, A., & Brożek-Płuska, B. (2022) · Biomolecules · doi:10.3390/biom12081087 · Cited by 108 · see citing works

Plasmalogen phospholipids protect internodal myelin from oxidative damage

Luoma, A. M., Kuo, F., Cakici, O., Crowther, M. N., Denninger, A. R., Avila, R. L., Brites, P., & Kirschner, D. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.012 · Cited by 97 · see citing works

Modulation of mitochondrial functions by xenobiotic-induced microRNA: From environmental sentinel organisms to mammals

Burgos-Aceves, M. A., Cohen, A., Paolella, G., Lepretti, M., Smith, Y., Faggio, C., & Lionetti, L. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.109 · Cited by 95 · see citing works

Mitochondria: Inadvertent targets in chemotherapy-induced skeletal muscle toxicity and wasting?

Sorensen, J. C., Cheregi, B. D., Timpani, C. A., Nurgali, K., Hayes, A., & Rybalka, E. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3045-3 · Cited by 95 · see citing works

Vitamin E as an Antioxidant in Female Reproductive Health

Mutalip, S. S. M., Rahim, S. A., & Rajikin, M. H. (2018) · Antioxidants · doi:10.3390/antiox7020022 · Cited by 91 · see citing works

Biosafety assessment of graphene nanosheets on leaf ultrastructure, physiological and yield traits of Capsicum annuum L. and Solanum melongena L.

Younes, N. A., Dawood, M. F. A., & Wardany, A. A. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.04.097 · Cited by 90 · see citing works

Ebselen induces reactive oxygen species (ROS)‐mediated cytotoxicity inSaccharomyces cerevisiaewith inhibition of glutamate dehydrogenase being a target

Azad, G. K., Singh, V., Mandal, P., Singh, P. K., Golla, U., Baranwal, S., Chauhan, S., & Tomar, R. S. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.01.002 · Cited by 90 · see citing works

Detection of Reactive Oxygen Species by a Carbon-Dot–Ascorbic Acid Hydrogel

Bhattacharya, S., Sarkar, R., Nandi, S., Porgador, A., & Jelinek, R. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b03749 · Cited by 89 · see citing works

Oxidative Stress and First-Line Antituberculosis Drug-Induced Hepatotoxicity

Yew, W. W., Chang, K. C., & Chan, D. P. C. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02637-17 · Cited by 91 · see citing works

Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals

Matthee, C., Brown, A. R., Lange, A., & Tyler, C. R. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c09576 · Cited by 90 · see citing works

On mechanism behind UV-A light enhanced antibacterial activity of gallic acid and propyl gallate against Escherichia coli O157:H7

Wang, Q., de Oliveira, E. F., Alborzi, S., Bastarrachea, L. J., & Tikekar, R. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-08449-1 · Cited by 89 · see citing works

Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: A critical review

Ali, W., Zhang, H., Junaid, M., Mao, K., Xu, N., Chang, C., Rasool, A., Aslam, M. W., Ali, J., & Yang, Z. (2020) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2020.1740042 · Cited by 90 · see citing works

Magnetic hyperthermia and pH-responsive effective drug delivery to the sub-cellular level of human breast cancer cells by modified CoFe2O4 nanoparticles

Oh, Y., Santhamoorthy, M., Manivasagan, P., Bharathiraja, S., & Oh, J. (2016) · Biochimie · doi:10.1016/j.biochi.2016.11.012 · Cited by 86 · see citing works

Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types

Doherty, K. R., Talbert, D. R., Trusk, P. B., Moran, D. M., Shell, S. A., & Bacus, S. S. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.03.008 · Cited by 82 · see citing works

Chlorella-gold nanorods hydrogels generating photosynthesis-derived oxygen and mild heat for the treatment of hypoxic breast cancer

Lee, C., Lim, K., Kim, S. S., Thien, L. X., Lee, E. S., Oh, K. T., Choi, H., & Youn, Y. S. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.011 · Cited by 82 · see citing works

Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences

Vuda, M., & Kamath, A. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.10.005 · Cited by 83 · see citing works

Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity

Weng, K., Kurokawa, Y. K., Hajek, B., Paladin, J. A., Shirure, V. S., & George, S. C. (2019) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2019.0248 · Cited by 82 · see citing works

Discovery of New Monocarbonyl Ligustrazine–Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer

Ai, Y., Zhu, B., Ren, C., Kang, F., Li, J., Huang, Z., Lai, Y., Peng, S., Ding, K., Tian, J., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01203 · Cited by 79 · see citing works

Curcumin alleviates colistin-induced nephrotoxicity and neurotoxicity in rats via attenuation of oxidative stress, inflammation and apoptosis

Edrees, N. E., Galal, A. A. A., Monaem, A. R. A., Beheiry, R. R., & Metwally, M. M. M. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.08.012 · Cited by 80 · see citing works

Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids

Dai, F., Liu, G., Li, Y., Yan, W., Wang, Q., Yang, J., Lu, D., Ding, D., Lin, D., & Zhou, B. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.017 · Cited by 79 · see citing works

Venlafaxine-Induced Cytotoxicity Towards Isolated Rat Hepatocytes Involves Oxidative Stress and Mitochondrial/Lysosomal Dysfunction

Ahmadian, E., Babaei, H., Nayebi, A. M., Eftekhari, A., & Eghbal, M. A. (2016) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2016.066 · Cited by 79 · see citing works

Assessing the effect of human pharmaceuticals (carbamazepine, diclofenac and ibuprofen) on the marine clam Ruditapes philippinarum: An integrative and multibiomarker approach

Trombini, C., Hampel, M., & Blasco, J. (2019) · Aquatic Toxicology · doi:10.1016/j.aquatox.2019.01.004 · Cited by 79 · see citing works

High-Dose Vitamin C for Cancer Therapy

Mussa, A., Idris, R. A. M., Ahmed, N., Ahmad, S., Murtadha, A. H., Din, T. A. D. A. T., Yean, C. Y., Rahman, W. F. W. A., Lazim, N. M., Uskoković, V., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15060711 · Cited by 81 · see citing works

Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people

Yew, W. W., Yoshiyama, T., Leung, C. C., & Chan, D. P. C. (2018) · Respirology · doi:10.1111/resp.13303 · Cited by 78 · see citing works

Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells

Pal, M. K., Jaiswar, S. P., Srivastav, A. K., Goyal, S., Dwivedi, A., Verma, A., Singh, J., Pathak, A. K., Sankhwar, P., & Ray, R. S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.10.019 · Cited by 76 · see citing works

β-caryophyllene, a dietary phytocannabinoid attenuates oxidative stress, inflammation, apoptosis and prevents structural alterations of the myocardium against doxorubicin-induced acute cardiotoxicity in rats: An in vitro and in vivo study

Taee, H. A., Azimullah, S., Meeran, M. F. N., Almheiri, M. K. A., Jasmi, R. A. A., Tariq, S., Khan, M. A., Adeghate, E. A., & Ojha, S. K. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172467 · Cited by 75 · see citing works

β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced chronic cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in rats

Meeran, M. F. N., Taee, H. A., Azimullah, S., Tariq, S., Adeghate, E. A., & Ojha, S. K. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.028 · Cited by 74 · see citing works

Lycopene Attenuates Tulathromycin and Diclofenac Sodium-Induced Cardiotoxicity in Mice

Abdel‐Daim, M. M., Eltaysh, R., Hassan, A. M., & Mousa, S. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020344 · Cited by 73 · see citing works

Curcuma Longa (Curcumin) Decreases In Vivo Cisplatin-Induced Ototoxicity Through Heme Oxygenase-1 Induction

Fetoni, A. R., Eramo, S. L. M., Paciello, F., Rolesi, R., Podda, M. V., Troiani, D., & Paludetti, G. (2014) · Otology & Neurotology · doi:10.1097/mao.0000000000000302 · Cited by 73 · see citing works

Human corneal cell culture models for drug toxicity studies

Rönkkö, S., Vellonen, K., Järvinen, K., Toropainen, E., & Urtti, A. O. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0330-y · Cited by 73 · see citing works

Oxidative stress and antioxidants in diabetes mellitus

Rafieian‐Kopaei, M., Ghasemi‐Dehnoo, M., Amini-Khoei, H., & Lorigooini, Z. (2020) · Asian Pacific Journal of Tropical Medicine · doi:10.4103/1995-7645.291036 · Cited by 71 · see citing works

Platinum anti-cancer drugs: Free radical mechanism of Pt-DNA adduct formation and anti-neoplastic effect

Fong, C. W. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.006 · Cited by 71 · see citing works

Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes

Aryal, B., & Rao, V. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158376 · Cited by 70 · see citing works

Nicorandil combats doxorubicin–induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway

Khames, A., Khalaf, M. M., Gad, A. M., El‐Raouf, O. M. A., & Kandeil, M. A. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108777 · Cited by 70 · see citing works

The Effect of Boric Acid and Borax on Oxidative Stress, Inflammation, ER Stress and Apoptosis in Cisplatin Toxication and Nephrotoxicity Developing as a Result of Toxication

Hazman, Ö., Bozkurt, M. F., Fidan, A. F., Uysal, F. E., & Çelik, S. (2018) · Inflammation · doi:10.1007/s10753-018-0756-0 · Cited by 69 · see citing works

Etoposide induced cytotoxicity mediated by ROS and ERK in human kidney proximal tubule cells

Shin, H., Kwon, H., Lee, J., Anwar, M. A., & Choi, S. (2016) · Scientific Reports · doi:10.1038/srep34064 · Cited by 69 · see citing works

Oxidative stress in melanocyte senescence and melanoma transformation

Meierjohann, S. (2013) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.11.005 · Cited by 67 · see citing works

Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis

Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works

Prochloraz alone or in combination with nano-CuO promotes the conjugative transfer of antibiotic resistance genes between Escherichia coli in pure water

Guo, A., Zhou, Q., Bao, Y., Qian, F., & Zhou, X. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127761 · Cited by 66 · see citing works

Fungicide prochloraz induces oxidative stress and DNA damage in vitro

Lundqvist, J., Hellman, B. E., & Oskarsson, A. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.03.002 · Cited by 65 · see citing works

Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder

Xia, Q., Wei, L., Zhang, Y. L., Kong, H., Shi, Y., Wang, X. B., Chen, X., Han, L., & Liu, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01457 · Cited by 65 · see citing works

Augmentation of NAD+ by NQO1 attenuates cisplatin-mediated hearing impairment

Kim, H.-J., Oh, G., Shen, A., Lee, S.-B., Choe, S.-K., Kwon, K.-B., Lee, S., Seo, K.-S., Th, K., Park, R., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.255 · Cited by 64 · see citing works

Isoliquiritigenin prevents Doxorubicin-induced hepatic damage in rats by upregulating and activating SIRT1

Al-Qahtani, W. H., Alshammari, G. M., Ajarem, J. S., Al-Zahrani, A. Y., Alzuwaydi, A., Eid, R. A., & Yahya, M. A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112594 · Cited by 63 · see citing works

Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system

Potnuri, A. G., Allakonda, L., & Lahkar, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.068 · Cited by 63 · see citing works

Review of the Protective Mechanism of Curcumin on Cardiovascular Disease

Yang, C., Zhu, Q., Chen, Y., Ji, K., Li, S., Wu, Q., Pan, Q., & Li, J. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s445555 · Cited by 62 · see citing works

Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Roles of Honey, Royal Jelly, and Propolis in Suppressing Nephrotoxicity Induced by Doxorubicin in Male Albino Rats

Mohamed, H. K., Mobasher, M. A., Ebiya, R. A., Hassen, M. T., Hagag, H. M., El-Sayed, R., Abdel-Ghany, S. E., Said, M. M., & Awad, N. S. (2022) · Antioxidants · doi:10.3390/antiox11051029 · Cited by 61 · see citing works

Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

Cheruku, S. P., Ramalingayya, G. V., Chamallamudi, M. R., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K., & Kumar, N. (2017) · Cytotechnology · doi:10.1007/s10616-017-0138-8 · Cited by 61 · see citing works

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Patterson, S., & Fairlamb, A. H. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180426164352 · Cited by 61 · see citing works

doi:10.1155/2012/645460 Review Article

Stress, D.-I. O., Deavall, D. G., Martin, E. A., Horner, J. M., & Roberts, R. (2016)

Oxidative stress injury in doxorubicin-induced cardiotoxicity

Mei, S., Hong, L., Xinyong, C., Bin, X., Ping, Z., & Shao, L. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.02.013 · Cited by 571 · see citing works

Drug-Induced Oxidative Stress and Cellular Toxicity

Mani, S., Tyagi, S., Pal, K. V., Jaiswal, H., Jain, A., Gulati, A., & Singh, M. (2021) · Molecular and integrative toxicology · doi:10.1007/978-3-030-83446-3_4 · Cited by 11 · see citing works

ROS in Carcinogenesis and Anticancerous Drug-Induced Toxicity

Rani, V., & Gupta, K. (2014) · Springer eBooks · doi:10.1007/978-81-322-2035-0_14 · Cited by 2 · see citing works

Iron signaling and oxidant damage

Kalyanaraman, B. (2007) · Cardiovascular Toxicology · doi:10.1007/s12012-007-0025-1 · Cited by 22 · see citing works