The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Vitamin D and cancer: a review of molecular mechanisms
Open accessAbstract
The population-based association between low vitamin D status and increased cancer risk can be inconsistent, but it is now generally accepted. These relationships link low serum 25OHD (25-hydroxyvitamin D) levels to cancer, whereas cell-based studies show that the metabolite 1,25(OH)2D (1,25-dihydroxyvitamin D) is a biologically active metabolite that works through vitamin D receptor to regulate gene transcription. In the present review we discuss the literature relevant to the molecular events that may account for the beneficial impact of vitamin D on cancer prevention or treatment. These data show that although vitamin D-induced growth arrest and apoptosis of tumour cells or their non-neoplastic progenitors are plausible mechanisms, other chemoprotective mechanisms are also worthy of consideration. These alternative mechanisms include enhancing DNA repair, antioxidant protection and immunomodulation. In addition, other cell targets, such as the stromal cells, endothelial cells and cells of the immune system, may be regulated by 1,25(OH)2D and contribute to vitamin D-mediated cancer prevention.
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Selective Evolution of Stromal Mesenchyme with p53 Loss in Response to Epithelial Tumorigenesis
Hill, R., Song, Y., Cardiff, R. D., & Van Dyke, T. (2005) · Cell · doi:10.1016/j.cell.2005.09.030 · Cited by 324
1,25‐dihydroxyvitamin D 3 promotes IL‐10 production in human B cells
Heine, G., Niesner, U., Chang, H., Steinmeyer, A., Zügel, U., Zuberbier, T., Radbruch, A., & Worm, M. (2008) · European Journal of Immunology · doi:10.1002/eji.200838216 · Cited by 311
Széles, L., Keresztes, G., Töröcsik, D., Balajthy, Z., Krenács, L., Póliska, S., Steinmeyer, A., Zuegel, U., Pruenster, M., Rot, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803345 · Cited by 234
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Expression of vitamin D receptor decreases during progression of pigmented skin lesions
Brożyna, A. A., Jozwicki, W., Janjetovic, Z., & Slominski, A. T. (2011) · Human Pathology · doi:10.1016/j.humpath.2010.09.014 · Cited by 120
Cited by
Vitamin D-effects on skeletal and extraskeletal health and the need for supplementation
Wacker, M., & Holick, M. (2013) · Nutrients · doi:10.3390/nu5010111 · Cited by 733
The serum vitamin D metabolome: what we know and what is still to discover
Tuckey, R. C., Cheng, C. Y. S., & Slominski, A. T. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.09.003 · Cited by 245
Vitamin D and chronic diseases: the current state of the art
Muscogiuri, G., Altieri, B., Annweiler, C., Balercia, G., Pal, H. B., Boucher, B. J., Cannell, J. J., Foresta, C., Grübler, M. R., Kotsa, K., et al. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1804-x · Cited by 151
Slominski, A. T., Brożyna, A. A., Zmijewski, M. A., Jóźwicki, W., Jetten, A. M., Mason, R. S., Tuckey, R. C., & Elmets, C. A. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.3 · Cited by 136
Selected vitamin D metabolic gene variants and risk for Autism Spectrum Disorder in the charge study
Schmidt, R. J., Hansen, R. L., Hartiala, J., Allayee, H., Sconberg, J. L., Schmidt, L. C., Volk, H. E., & Tassone, F. (2015) · Early Human Development · doi:10.1016/j.earlhumdev.2015.05.008 · Cited by 68
Metadata
- Authors
- Fleet, J. C., Desmet, M., Johnson, R., & Li, Y.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2011-12-14
- Volume
- 441
- Issue
- 1
- Pages
- 61-76
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2018730905
- Cited by
- 407
- References
- 7
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- green
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