Cited by 2,752Nitric Oxide and Endothelin EffectsHemoglobin structure and functionEicosanoids and Hypertension Pharmacology

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Nitric oxide synthases in mammals

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Knowles, R G, Moncada, S·1994·Biochemical Journal

DOI 10.1042/bj2980249PMC PMC1137932

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Research Article| March 01 1994 Nitric oxide synthases in mammals R G Knowles; R G Knowles 1Wellcome Research Laboratories, Langley Court, Beckenham BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar S Moncada S Moncada 1Wellcome Research Laboratories, Langley Court, Beckenham BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8728 Print ISSN: 0264-6021 © 1994 The Biochemical Society, London1994 Biochem J (1994) 298 (2): 249–258. https://doi.org/10.1042/bj2980249 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation R G Knowles, S Moncada; Nitric oxide synthases in mammals. Biochem J 1 March 1994; 298 (2): 249–258. doi: https://doi.org/10.1042/bj2980249 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1994 The Biochemical Society, London1994 Article PDF first page preview Close Modal You do not currently have access to this content.

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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Self-citation
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Self-citation
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Self-citation
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308
Localization of nitric oxide synthase indicating a neural role for nitric oxide
Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107
Self-citation

Show all 129 references

Research works printed but not linked: 22

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrnes, R. E. and Chaudhuri, G. (1987) Proc. Nati. Acad. Sci. U.S.A. 84, 9265-9269
Knowles, R. G., Palacios, M., Palmer, R. M. J. and Moncada, S. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 5159-5162
Bredt, D. S. and Snyder, S. H. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 682-685
Hope, B. T., Michael, G. J., Knigge, K. M. and Vincent, S. R. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 2811-2814
Dawson, T. M., Bredt, D. S., Fotuhi, M., Hwang, P. M. and Snyder, S. H. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7797-7801
Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Forstermann, U. and Murad, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 365-369
Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F. and Nathan, C. F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7773-7777
Pollock, J. S., Forstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M. and Murad, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 10480-10484
Evans, T., Carpenter, A. and Cohen, J. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 5361-5365
Fdrstermann, U., Pollock, J. S., Schmidt, H. H. H. W., Heller, M. and Murad, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 1788-1792
Giovanelli, J., Campos, K. L. and Kaufman, S. (1991) Proc. Nati. Acad. Sci. U.S.A. 88, 7091-7095
Lamas, S., Marsden, P. A., Li, G. K., Tempst, P. and Michel, T. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6348-6352
Lowenstein, C. J., Glaft, G. S., Bredt, D. S. and Snyder, S. H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6711-6715
Beckman, J. S., Beckman, T. W. Chen, J., Marshall, P. A. and Freeman, B. A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 1620-1624 59
Bogle, R. G., Moncada, S., Pearson, J. D. and Mann, G. E. (1992) Br. J. Pharmacol. 105, 768-770
Nichol, C. A., Lee, C. L., Edelstein, M. P., Chao, J. Y. and Duch, D. S. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 1546-1550
Charles, I. G., Palmer, R. M. J., Hickery, M. S., Bayliss, M. T., Chubb, A. P., Hall, V. S., Moss, D. W. and Moncada, S. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 11419-11423 115
Geller, D. A., Lowenstein, C. J., Shapiro, R. A., Nussler, A. K., Di Silvio, M., Wang, S. C., Nakayama, D. K., Simmons, R. L., Snyder, S. H. and Billiar, T. M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 3491-3495 117
Xu, W., Charles, I. G., Moncada, S., Gorman, P., Sheer, D., Liu, L. and Emson, P. (1994) Genome, in the press 120
Radomski, M. W., Palmer, R. M. J. and Moncada, S. (1990) Proc. Natl. Acad. Sci.
Weiner, C. P., Lizasoain, I., Baylis, S., Knowles, R. G., Charles, I. G. and Moncada, S. (1994) Proc. Nati. Acad. Sci. U.S.A., in the press 129
Bagetta, G., Corasaniti, M. T., Melino, G., Paoletti, A. M., Finazzi-Agro, A. and Nistico, G. (1994) Biochem. Biophys. Res. Commun., in the press 131

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Kareem, B. N., Karlsen, F., Holm, R., Hennig, E. M., Suo, Z., Emilsen, E., Hellesylt, E., & Nesland, J. M. (1997) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199712)183:4 · Cited by 4
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Shukla, A., Rasik, A. M., & Shankar, R. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006977513146 · Cited by 70
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Morbidelli, L., Donnini, S., & Ziche, M. (2004) · Cancer treatment and research · doi:10.1007/978-1-4419-8871-3_11 · Cited by 70
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Farshbaf, M. J., & Kiani‐Esfahani, A. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.12.002 · Cited by 71
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Umbreen, S., Lubega, J., Cui, B., Pan, Q., Jiang, J., & Loake, G. J. (2018) · Journal of Experimental Botany · doi:10.1093/jxb/ery184 · Cited by 69
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Authors: Knowles, R. G., & Moncada, S.
Affiliations: Wellcome Trust (GB)
ORCID: Moncada, S
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1994-03-01
Volume: 298
Issue: 2
Pages: 249-258
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj2980249
PMC: PMC1137932
OpenAlex: W1764308599
Cited by: 2,752
References: 129
Citations by year: 2026: 14 · 2025: 28 · 2024: 27 · 2023: 41 · 2022: 52 · 2021: 46 · 2020: 80 · 2019: 63 · 2018: 56 · 2017: 72 · 2016: 68 · 2015: 77 · 2014: 92 · 2013: 73 · 2012: 96
FWCI: 19.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: nitric oxide synthase, nitric oxide, mammalian enzymes, enzyme structure, enzyme regulation, heme oxygenase, tetrahydrobiopterin, flavoprotein, cytochrome b5, NADPH, NADPH/NADP+ ratio, mammalian physiology
MeSH terms: Amino Acid Oxidoreductases, Animals, Calcium, Chromosome Mapping, Endothelium, Vascular, Enzyme Induction, Humans, Isoenzymes, Mammals, Neurons, Nitric Oxide Synthase

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Nitric oxide synthases in mammals

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