Nitric oxide synthases in mammals

Nitric oxide: physiology, pathophysiology, and pharmacology.

Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074

Vascular endothelial cells synthesize nitric oxide from L-arginine

Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308

Localization of nitric oxide synthase indicating a neural role for nitric oxide

Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107

Neuronal NADPH diaphorase is a nitric oxide synthase.

Hope, B. T., Michael, G. J., Knigge, K. M., & Vincent, S. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2811 · Cited by 1,908

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

Xie, Q. W., Cho, H. J., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A. H., Troso, T., & Nathan, C. (1992) · Science · doi:10.1126/science.1373522 · Cited by 1,888

Histochemical mapping of nitric oxide synthase in the rat brain

Vincent, S. R., & Kimura, H. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90184-4 · Cited by 1,868

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

Rees, D. D., Palmer, R. M. J., Schulz, R., Hodson, H. F., & Moncada, S. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14151.x · Cited by 1,856

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

Dawson, T. M., Bredt, D. S., Fotuhi, M., Hwang, P. M., & Snyder, S. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7797 · Cited by 1,843

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,601

Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite

Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

Knowles, R. G., Palacios‐Callender, M., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5159 · Cited by 1,431

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,348

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.10043 · Cited by 1,097

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

Lamas, S., Marsden, P. A., Li, G. K., Tempst, P., & Michel, T. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6348 · Cited by 982

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 979

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

Hibbs, J. B., Vavrin, Z., & Taintor, R. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.2.550 · Cited by 938

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

Feelisch, M., & Noack, E. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90493-6 · Cited by 887

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

Lyons, C., Orloff, G. J., & Cunningham, J. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42704-4 · Cited by 866

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

Geller, D. A., Lowenstein, C. J., Shapiro, R. A., Nussler, A. K., Silvio, M. D., Wang, S. C., Nakayama, D. K., Simmons, R. L., Snyder, S. H., & Billiar, T. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3491 · Cited by 821

Isoforms of nitric oxide synthase Characterization and purification from different cell types

Förstermann, U., Schmidt, H. H. H. W., Pollock, J. S., Sheng, H., Mitchell, J. A., Warner, T. D., Nakane, M., & Murad, F. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90581-o · Cited by 817

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816

Generation of superoxide by purified brain nitric oxide synthase

Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H., & Rosen, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35745-4 · Cited by 750

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S., Uematsu, M., Nerem, R. M., Alexander, R. W., & Murphy, T. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116092 · Cited by 735

Biological Roles of Nitric Oxide

Snyder, S. H., & Bredt, D. S. (1992) · Scientific American · doi:10.1038/scientificamerican0592-68 · Cited by 720

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

Tayeh, M. A., & Marletta, M. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47163-9 · Cited by 687

Calmodulin is a subunit of nitric oxide synthase from macrophages.

Cho, H. J., Xie, Q. W., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., & Nathan, C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.2.599 · Cited by 635

Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases

Salter, M., Knowles, R. G., & Moncada, S. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81123-p · Cited by 630

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

Schmidt, H. H. H. W., Gagné, G. D., Nakane, M., Pollock, J. S., MILLER, M. F., & Murad, F. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.10.1382087 · Cited by 610

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

Palmer, R. M. J., & Moncada, S. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(89)80219-0 · Cited by 606

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

White, K. A., & Marletta, M. A. (1992) · Biochemistry · doi:10.1021/bi00144a001 · Cited by 605

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

Lowenstein, C. J., Glatt, C. S., Bredt, D. S., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6711 · Cited by 600

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

Janssens, S. P., Shimouchi, A., Quertermous, T., Bloch, D. B., & Bloch, K. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42066-2 · Cited by 592

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

Förstermann, U., Pollock, J. S., Schmidt, H. H. H. W., Heller, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1788 · Cited by 592

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

Rees, D. D., Cellek, S., Palmer, R. M. J., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80068-3 · Cited by 590

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

Stuehr, D. J., Kwon, N. S., Nathan, C. F., Griffith, O. W., Feldman, P. L., & Wiseman, J. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38112-2 · Cited by 575

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

Kwon, N. S., Nathan, C. F., & Stuehr, D. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47089-0 · Cited by 570

The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

Cross, A. R., & Jones, O. T. G. (1986) · Biochemical Journal · doi:10.1042/bj2370111 · Cited by 551

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

Nakane, M., Schmidt, H. H. H. W., Pollock, J. S., Förstermann, U., & Murad, F. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81210-q · Cited by 546

Inhibition of nitric oxide synthesis by methylene blue

Mayer, B., Brünner, F., & Schmidt, K. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90072-5 · Cited by 536

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

Heinzel, B., John, M., Klatt, P., Böhme, E., & Mayer, B. (1992) · Biochemical Journal · doi:10.1042/bj2810627 · Cited by 530

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

Buxton, I. L. O., Cheek, D. J., Eckman, D. M., Westfall, D. P., Sanders, K. M., & Keef, K. D. (1993) · Circulation Research · doi:10.1161/01.res.72.2.387 · Cited by 508

Mammalian Nitric Oxide Synthases

Stuehr, D. J., & Griffith, O. W. (1992) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470123119.ch8 · Cited by 507

Molecular cloning and characterization of human endothelial nitric oxide synthase

Marsden, P. A., Schappert, K. T., Chen, H. S., Flowers, M. A., Sundell, C. L., Wilcox, J. N., Lamas, S., & Michel, T. M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80697-f · Cited by 489

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

Sessa, W. C., Harrison, J. K., Barber, C. M., Zeng, D., Durieux, M. E., d’Angelo, D., Lynch, K. R., & Peach, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49528-8 · Cited by 469

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1

Stuehr, D. J., Fasehun, O. A., Kwon, N. S., Gross, S. S., Gonzalez, J. A., Levi, R., & Nathan, C. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.1.1703974 · Cited by 465

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

Rosa, M. D., Radomski, M. W., Carnuccio, R., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91583-e · Cited by 454

Purification of a Ca2+/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

Mayer, B., John, M., & Böhme, E. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80848-d · Cited by 449

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

Gross, S. S., & Levi, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35667-9 · Cited by 443

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

Mayer, B., John, M., Heinzel, B., Werner, E. R., WACHTER, H., Schultz, G., & Böhme, E. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81031-3 · Cited by 421

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

Gross, S. S., JAFFE, E. A., Levi, R., & Kilbourn, R. G. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90965-a · Cited by 389

Feedback inhibition of nitric oxide synthase activity by nitric oxide

Assreuy, J., Cunha, F. Q., Liew, F. Y., & Moncada, S. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb12886.x · Cited by 389

Arginine is a physiological precursor of endothelium-derived nitric oxide

Schmidt, H. H. H. W., Nau, H., Wittfoht, W., Gerlach, J. C., Prescher, K.-E., Klein, M. M., Niroomand, F., & Böhme, E. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90101-x · Cited by 389

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

Knowles, R. G., Merrett, M., Salter, M., & Moncada, S. (1990) · Biochemical Journal · doi:10.1042/bj2700833 · Cited by 388

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

Knowles, R. G., Salter, M., Brooks, S. L., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91551-3 · Cited by 384

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Förstermann, U., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.365 · Cited by 381

Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney

Ogawa, T., Kimoto, M., & Sasaoka, K. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81786-0 · Cited by 364

Nitric oxide synthase: Irreversible inhibition by L-N -Nitroarginine in brain and

Dwyer, M. A., Bredt, D. S., & Snyder, S. H. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90403-t · Cited by 360

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

Stuehr, D. J., & Ikeda‐Saito, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36718-3 · Cited by 348

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

Nunokawa, Y., Ishida, N., & Tanaka, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1188 · Cited by 317

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

Charles, I. G., Palmer, R. M. J., Hickery, M. S., Bayliss, M. T., Chubb, A., Hall, V. S., Moss, D. W., & Moncada, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11419 · Cited by 291

Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.

Leone, A., Palmer, R. M. J., Knowles, R. G., Francis, P. L., Ashton, D., & Moncada, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54352-0 · Cited by 290

The transport of cationic amino acids across the plasma membrane of mammalian cells

White, M. F. (1985) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(85)90015-2 · Cited by 289

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

Werner‐Felmayer, G., Werner, E. R., Fuchs, D., Hausen, A., Reibnegger, G. J., & WACHTER, H. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1599 · Cited by 287

Induction of Nitric Oxide Synthase in Human Chondrocytes

Palmer, R. M. J., Hickery, M. S., Charles, I. G., Moncada, S., & Bayliss, M. T. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1637 · Cited by 281

Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine

Furfine, E. S., Harmon, M. F., Paith, J. E., & Garvey, E. P. (1993) · Biochemistry · doi:10.1021/bi00084a017 · Cited by 280

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

Nakane, M., Mitchell, J. A., Förstermann, U., & Murad, F. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81351-8 · Cited by 274

Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase

Mayer, B., Schmidt, K., Humbert, P., & Böhme, E. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91513-1 · Cited by 271

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

Gross, S. S., Stuehr, D. J., Aisaka, K., JAFFE, E. A., Levi, R., & Griffith, O. W. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91245-n · Cited by 269

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

Rogers, N. E., & Ignarro, L. J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91550-a · Cited by 252

Identification of N‐iminoethyl‐ l ‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

McCall, T., Feelisch, M., Palmer, R. M. J., & Moncada, S. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12159.x · Cited by 252

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

Kwon, N. S., Nathan, C. F., Gilker, C. D., Griffith, O. W., Matthews, D. E., & Stuehr, D. J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77366-3 · Cited by 247

Purification of nitric oxide synthase from rat macrophages

Yui, Y., Hattori, R., Kosuga, K., Eizawa, H., Hiki, K., & Kawai, C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98932-5 · Cited by 243

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

Palacios‐Callender, M., Knowles, R. G., Palmer, R. M. J., & Moncada, S. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(89)80037-3 · Cited by 237

Kinetic characteristics of nitric oxide synthase from rat brain

Knowles, R. G., Palacios‐Callender, M., Palmer, R. M. J., & Moncada, S. (1990) · Biochemical Journal · doi:10.1042/bj2690207 · Cited by 202

Endothelial cells metabolize NG -monomethyl-L-arginine to L-citrulline and subsequently to L-arginine

Hecker, M., Mitchell, J. A., Harris, H. J., Katsura, M., Thiemermann, C., & Vane, J. R. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90627-y · Cited by 184

Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts.

White, M. F., Gazzola, G. C., & Christensen, H. N. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34742-2 · Cited by 180

Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine

Bush, P. A., Gonzalez, N. E., Griscavage, J. M., & Ignarro, L. J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91720-b · Cited by 179

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

Billiar, T. R., CURRAN, R. D., Stuehr, D. J., Stadler, J., Simmons, R. L., & Murray, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91133-d · Cited by 175

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l ‐arginine transporter

Bogle, R., Moncada, S., Pearson, J. D., & Mann, G. E. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09053.x · Cited by 169

Immunological detection of nitric oxide synthase(s) in human tissues using heterologous antibodies suggesting different isoforms

Springall, D. R., Riveros‐Moreno, V., Buttery, L. D. K., Suburo, Á. M., Bishop, A. E., Merrett, M., Moncada, S., & Polak, J. M. (1992) · Histochemistry and Cell Biology · doi:10.1007/bf00271040 · Cited by 168

Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.

Sessa, W. C., Barber, C. M., & Lynch, K. R. (1993) · Circulation Research · doi:10.1161/01.res.72.4.921 · Cited by 164

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

Schmidt, K., Werner, E. R., Mayer, B., WACHTER, H., & Kukovetz, W. R. (1992) · Biochemical Journal · doi:10.1042/bj2810297 · Cited by 164

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

Giovanelli, J., Campos, K. L., & Kaufman, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7091 · Cited by 162

Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone

McCall, T., Palmer, R. M. J., & Moncada, S. (1991) · European Journal of Immunology · doi:10.1002/eji.1830211032 · Cited by 160

The 1989 Ulf von Euler Lecture Studies on endothelium‐dependent vasodilation and the endothelium‐derived relaxing factor

Furchgott, R. F. (1990) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1990.tb08923.x · Cited by 159

Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: Requirement for inducible and constitutive components

Stuehr, D. J., Kwon, N. S., Gross, S. S., Thiel, B., Levi, R., & Nathan, C. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92615-6 · Cited by 149

Nitric oxide synthesis in endothelial cytosol: Evidence for a calcium-dependent and a calcium-independent mechanism

M�lsch, A., Bassenge, E., & Busse, R. (1989) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169688 · Cited by 146

Brain nitric oxide synthase is a haemoprotein

Klatt, P., Schmidt, K., & Mayer, B. (1992) · Biochemical Journal · doi:10.1042/bj2880015 · Cited by 146

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Endothelial nitric oxide synthase is myristylated

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Glucocorticoids do not affect the induction of a novel calcium-dependent nitric oxide synthase in rabbit chondrocytes

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Localization of brain nitric oxide synthase (NOS) to human chromosome 12

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Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells

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Cytosolic and Membrane-Bound Nitric Oxide Synthase

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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

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Role of nitric oxide in inflammatory diseases

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