The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Angiopoietin-like 4: a decade of research
Open accessAbstract
The past decade has seen a rapid development and increasing recognition of ANGPTL4 (angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic and non-metabolic conditions. ANGPTL4 has been recognised as a central player in various aspects of energy homoeostasis, at least in part, via the inhibitory interaction between the coiled-coil domain of ANGPTL4 and LPL (lipoprotein lipase). The fibrinogen-like domain of ANGPTL4 interacts and activates specific integrins to facilitate wound healing, modulates vascular permeability, and regulates ROS (reactive oxygen species) level to promote tumorigenesis. The present review summarizes these landmark findings about ANGPTL4 and highlights several important implications for future clinical practice. Importantly, these implications have also raised many questions that are in urgent need of further investigations, particularly the transcription regulation of ANGPTL4 expression, and the post-translation cleavage and modifications of ANGPTL4. The research findings over the past decade have laid the foundation for a better mechanistic understanding of the new scientific discoveries on the diverse roles of ANGPTL4.
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Cites
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Genes that mediate breast cancer metastasis to lung
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TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
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Self-citationAngiopoietins 3 and 4: Diverging gene counterparts in mice and humans
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Cited by
Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance
Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631
Hepatokines and metabolism: Deciphering communication from the liver
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Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer
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Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
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Singh, A. K., Chaube, B., Zhang, X., Sun, J., Citrin, K. M., Canfrán-Duque, A., Aryal, B., Rotllan, N., Varela, L., Lee, R. G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140989 · Cited by 115
Metadata
- Authors
- Zhu, P., Goh, Y. Y., Chin, H. F. A., Kersten, S., & Tan, N. S.
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 2011-12-22
- Volume
- 32
- Issue
- 3
- Pages
- 211-219
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W2097381469
- Cited by
- 261
- References
- 65
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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