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Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer

Carbone, Carmine, Piro, Geny, Merz, Valeria, Simionato, Francesca, Santoro, Raffaela, Zecchetto, Camilla, Tortora, Giampaolo, Melisi, Davide·2018·International Journal of Molecular Sciences
DOI 10.3390/ijms19020431PMC PMC5855653
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Abstract

Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment is a key event in cancer development and progression. In the last decade, emerging evidences supported the autocrine and paracrine activity of the members of the Angiopoietin-like (ANGPTL) protein family in angiogenesis, inflammation and in the regulation of different steps of carcinogenesis and metastasis development. Thus, ANGPTL proteins become attractive either as prognostic or predictive biomarkers, or as novel target for cancer treatment. Here, we outline the current knowledge about the functions of the ANGPTL proteins in angiogenesis, cancer progression and metastasis. Moreover, we discuss the most recent evidences sustaining their role as prognostic or predictive biomarkers for cancer therapy. Although the role of ANGPTL proteins in cancer has not been fully elucidated, increasing evidence suggest their key effects in the proliferative and invasive properties of cancer cells. Moreover, given the common overexpression of ANGPTL proteins in several aggressive solid tumors, and their role in tumor cells and cells of the tumor microenvironment, the field of research about ANGPTL proteins network may highlight new potential targets for the development of future therapeutic strategies.

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Figure 1 Schematic representation of ANGPTL proteins structure. The ANGPTL family has three conserved domains; a N-terminal signal peptide, a coiled coil domain and a fibrinogen like domain.
Figure 1 Schematic representation of ANGPTL proteins structure. The ANGPTL family has three conserved domains; a N-terminal signal peptide, a coiled coil domain and a fibrinogen like domain.CC BY · PubMed Central

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Metadata

Authors
Carbone, C., Piro, G., Merz, V., Simionato, F., Santoro, R., Zecchetto, C., Tortora, G., & Melisi, D.
Affiliations
  • Digestive Molecular Clinical Oncology Research Unit, Department of Medicine, University of Verona, 37134 Verona, Italy
  • Medical Oncology Unit, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy
  • Laboratory of Oncology and Molecular Therapy, Department of Medicine, University of Verona, 37134 Verona, Italy
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-02-01
Volume
19
Issue
2
Pages
431
ISSN
1422-0067
DOI
10.3390/ijms19020431
PMC
PMC5855653
Cited by
200
References
7
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • AIRC IG (19111, 18599)
  • Basic Research Project 2015
  • Celgene Research Award 2017

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CoChat. (2026). Citation check: Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer. https://app.cochat.ai/papers/10.3390/ijms19020431
The paper
Carbone, C., Piro, G., Merz, V., Simionato, F., Santoro, R., Zecchetto, C., Tortora, G., & Melisi, D. (2018). Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms19020431