Peroxisomal fatty acid α- and β -oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases

Biochemistry of mammalian peroxisomes revisited

Wanders, R. J. A., & Waterham, H. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133329 · Cited by 995

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

Lodhi, I. J., & Semenkovich, C. F. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.002 · Cited by 605

Functions and Potential Applications of Glycolipid Biosurfactants — from Energy-Saving Materials to Gene Delivery Carriers —

Kitamoto, D., Isoda, H., & Nakahara, T. (2002) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(02)80149-9 · Cited by 468

Control of mitochondrial β-oxidation flux

Eaton, S. D. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00024-8 · Cited by 416

Alpha-Methylacyl-CoA Racemase

Zhou, M., Chinnaiyan, A. M., Kleer, C. G., Lucas, P. C., & Rubin, M. A. (2002) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200207000-00012 · Cited by 296

Fatty acid synthase: A metabolic oncogene in prostate cancer?

Baron, A., Migita, T., Tang, D., & Loda, M. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10708 · Cited by 292

Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report

Miller, W. P., Rothman, S. M., Nascene, D., Kivisto, T., DeFor, T. E., Ziegler, R. S., Eisengart, J., Leiser, K., Raymond, G., Lund, T. C., et al. (2011) · Blood · doi:10.1182/blood-2011-01-329235 · Cited by 290

Gene Expression Profiles in Rat Liver Treated With Perfluorooctanoic Acid (PFOA)

Guruge, K. S., Yeung, L. W. Y., Yamanaka, N., Miyazaki, S., Lam, P. K. S., Giesy, J. P., Jones, P. D., & Yamashita, N. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj011 · Cited by 232

III. Peroxisomal β-oxidation, PPARα, and steatohepatitis

Reddy, J. K. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1333 · Cited by 233

Liver fatty acid-binding protein and obesity

Atshaves, B. P., Martin, G. G., Hostetler, H. A., McIntosh, A. L., Kier, A. B., & Schroeder, F. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.01.005 · Cited by 231

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

Fourcade, S., Lopez-Erauskin, J., Galino, J., Duval, C., Naudi, A., Jove, M., Kemp, S., Villarroya, F., Ferrer, I., Pamplona, R., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn085 · Cited by 214

Identification of the peroxisomal β-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Ferdinandusse, S., Denis, S. W., Mooijer, P. A. W., Zhang, Z., Reddy, J. K., Spector, A. A., & Wanders, R. J. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31527-3 · Cited by 210

Mannosylerythritol lipids: a review

Arutchelvi, J., Bhaduri, S., Uppara, P. V., & Doble, M. (2008) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-008-0460-4 · Cited by 184

Metabolite transport across the peroxisomal membrane

Visser, W. F., van Roermund, C. W. T., IJlst, L., Waterham, H. R., & Wanders, R. J. A. (2006) · Biochemical Journal · doi:10.1042/bj20061352 · Cited by 169

PEX11β Deficiency Is Lethal and Impairs Neuronal Migration but Does Not Abrogate Peroxisome Function

Li, X., Baumgart, E., Morrell, J. C., Jimenez-Sanchez, G., Valle, D., & Gould, S. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4358-4365.2002 · Cited by 165

Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans

Zhang, S. O., Box, A., Xu, N., Men, J. L., Yu, J., Guo, F., Trimble, R., & Mak, H. Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912308107 · Cited by 160

PEX11 promotes peroxisome division independently of peroxisome metabolism

Li, X., & Gould, S. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112028 · Cited by 155

PEX11α Is Required for Peroxisome Proliferation in Response to 4-Phenylbutyrate but Is Dispensable for Peroxisome Proliferator-Activated Receptor Alpha-Mediated Peroxisome Proliferation

Li, X., Baumgart‐Vogt, E., Dong, G.-X., Morrell, J. C., Jiménez‐Sánchez, G., Valle, D. L., Smith, K. D., & Gould, S. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.23.8226-8240.2002 · Cited by 157

Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency

Ferdinandusse, S., Denis, S., Hogenhout, E. M., Koster, J., van Roermund, C. W. T., IJlst, L., Moser, A. B., Wanders, R. J. A., & Waterham, H. R. (2007) · Human Mutation · doi:10.1002/humu.20535 · Cited by 156

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Nagdas, S., Kashatus, J. A., Nascimento, A., Hussain, S. S., Trainor, R. E., Pollock, S. R., Adair, S. J., Michaels, A. D., Sesaki, H., Stelow, E. B., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.031 · Cited by 151

Radioisotopic determination of l-carnitine content in foods commonly eaten in Western countries

Demarquoy, J., Georges, B., Rigault, C., Royer, M.-C., Clairet, A., Soty, M., Lekounoungou, S., & Borgne, F. L. (2003) · Food Chemistry · doi:10.1016/j.foodchem.2003.09.023 · Cited by 148

Metabolic Plasticity in Resting and Thrombin Activated Platelets

Ravi, S., Chacko, B. K., Sawada, H., Kramer, P. A., Johnson, M. S., Benavides, G. A., O’Donnell, V. B., Marques, M. B., & Darley-Usmar, V. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123597 · Cited by 150

Effect of Maternal Obesity on Placental Lipid Metabolism

Calabuig-Navarro, V., Haghiac, M., Minium, J., Glazebrook, P. A., Ranasinghe, G. C., Hoppel, C. L., Mouzon, S. H., Catalano, P., & O’Tierney-Ginn, P. (2017) · Endocrinology · doi:10.1210/en.2017-00152 · Cited by 144

Identification of the peroxisomal β-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids

Ferdinandusse, S., Denis, S. W., van Roermund, C. W. T., Wanders, R. J. A., & Dacremont, G. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300512-jlr200 · Cited by 144

Mitochondrial β‐oxidation in Aspergillus nidulans

Maggio‐Hall, L. A., & Keller, N. P. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04340.x · Cited by 144

Regulatory Genes Controlling Fatty Acid Catabolism and Peroxisomal Functions in the Filamentous Fungus Aspergillus nidulans

Hynes, M. J., Murray, S. L., Duncan, A. E., Khew, G. S.-W., & Davis, M. A. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.5.794-805.2006 · Cited by 137

The hypotriglyceridemic effect of dietary n−3 FA is associated with increased β‐oxidation and reduced leptin expression

Ukropec, J., Reseland, J. E., Gašperíková, D., DEMCÁKOVÁ, E., Madsen, L., Berge, R. K., Rustan, A. C., Klimeś, I., Drevon, C. A., & ŠEBÖKOVÁ, E. (2003) · Lipids · doi:10.1007/s11745-006-1156-z · Cited by 136

Shared components of mitochondrial and peroxisomal division

Schrader, M. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.01.004 · Cited by 134

Mistargeting of Peroxisomal EHHADH and Inherited Renal Fanconi's Syndrome

Klootwijk, E. D., Reichold, M., Helip‐Wooley, A., Tolaymat, A., Broeker, C., Robinette, S. L., Reinders, J., Peindl, D. E., Renner, K., Eberhart, K., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307581 · Cited by 129

Peroxisomal ABC transporters

Theodoulou, F. L., Holdsworth, M. J., & Baker, A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.095 · Cited by 119

In Silico Prediction of the Peroxisomal Proteome in Fungi, Plants and Animals

Emanuelsson, O., Elofsson, A., von HEIJNE, G., & Cristóbal, S. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00553-9 · Cited by 117

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

Hulshagen, L., Krysko, O., Bottelbergs, A., Huyghe, S., Klein, R., Van Veldhoven, P. P., De Deyn, P. P., D'Hooge, R., Hartmann, D., & Baes, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4968-07.2008 · Cited by 115

Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata

Brites, P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg236 · Cited by 116

Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance

Kemp, S., Theodoulou, F. L., & Wanders, R. J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01435.x · Cited by 115

Peroxisomal-protein import: is it really that complex?

Gould, S. J., & Collins, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm807 · Cited by 114

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis

Fourcade, S., Ruiz, M., Camps, C., Schlüter, A., Houten, S. M., Mooyer, P. A. W., Pàmpols, T., Dacremont, G., Wanders, R. J. A., Giròs, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90736.2008 · Cited by 104

Arabidopsis Mutants in Short- and Medium-chain Acyl-CoA Oxidase Activities Accumulate Acyl-CoAs and Reveal That Fatty Acid β-Oxidation Is Essential for Embryo Development

Rylott, E. L., Rogers, C. A., Gilday, A. D., Edgell, T., Larson, T. R., & Graham, I. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300826200 · Cited by 104

Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders

Takemoto, Y., Suzuki, Y., Horibe, R., Shimozawa, N., Wanders, R. J. A., & Kondo, N. (2003) · Brain and Development · doi:10.1016/s0387-7604(03)00033-0 · Cited by 101

Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial β-oxidation by long chain acyl-CoA dehydrogenase

Clark-Taylor, T., & Clark-Taylor, B. E. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.01.011 · Cited by 98

A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase

Ferdinandusse, S., Denis, S. W., van Roermund, C. W. T., Preece, M. A., Koster, J., Ebberink, M. S., Waterham, H. R., & Wanders, R. J. A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.12.032 · Cited by 96

Inhibition of Lactate Dehydrogenase Activity as an Approach to Cancer Therapy

FIUME, L., Manerba, M., Vettraino, M., & Stefano, G. D. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.13.206 · Cited by 96

Mitochondrial β‐oxidation regulates organellar integrity and is necessary for conidial germination and invasive growth in M agnaporthe oryzae

Patkar, R., Ramos‐Pamplona, M., Gupta, A. P., Yang, F., & Naqvi, N. I. (2012) · Molecular Microbiology · doi:10.1111/mmi.12060 · Cited by 96

Genomewide transcriptional signatures of migratory flight activity in a globally invasive insect pest

Jones, C. M., Papanicolaou, A., Mironidis, G. K., VONTAS, J. G., Yang, Y., Lim, K. S., Oakeshott, J. G., Bass, C., & Chapman, J. W. (2015) · Molecular Ecology · doi:10.1111/mec.13362 · Cited by 95

Biodegradation of Polyester Polyurethane by the Marine Fungus Cladosporium Halotolerans 6upa1

Zhang, K., Hu, J., Yang, S., Xu, W., Wang, Z., Zhuang, P., Grossart, H., & Luo, Z.-H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129406 · Cited by 94

Peroxisomal multifunctional protein-2: The enzyme, the patients and the knockout mouse model.

Huyghe, S., Mannaerts, G. P., Baes, M., & Van Veldhoven, P. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.006 · Cited by 91

Neurodegeneration with Brain Iron Accumulation Disorders: Valuable Models Aimed at Understanding the Pathogenesis of Iron Deposition

Levi, S., & Tiranti, V. (2019) · Pharmaceuticals · doi:10.3390/ph12010027 · Cited by 90

Peroxisome Proliferators and Peroxisome Proliferator-Activated Receptor α

Reddy, J. K. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63787-x · Cited by 89

The ins and outs of peroxisomes: Co-ordination of membrane transport and peroxisomal metabolism

Rottensteiner, H., & Theodoulou, F. L. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.012 · Cited by 84

The rat liver peroxisomal membrane forms a permeability barrier for cofactors but not for small metabolites in vitro

Antonenkov, V. D., Sormunen, R. T., & Hiltunen, J. K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01485 · Cited by 87

A mouse model for α-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids

Savolainen, K., Kotti, T. J., Schmitz, W., Savolainen, T. I., Sormunen, R. T., Ilves, M., Vainio, S. J., Conzelmann, E., & Hiltunen, J. K. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh107 · Cited by 83

Elevated α-Methylacyl-CoA Racemase Enzymatic Activity in Prostate Cancer

Kumar‐Sinha, C., Shah, R. B., Laxman, B., Tomlins, S. A., Harwood, J., Schmitz, W., Conzelmann, E., Sanda, M. G., Wei, J. T., Rubin, M. A., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63167-7 · Cited by 79

Metabolic reprogramming of clear cell renal cell carcinoma

Zhu, H., Wang, X., Lu, S., & Ou, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1195500 · Cited by 83

The chemical biology of branched-chain lipid metabolism

Mukherji, M., Schofield, C. J., Wierzbicki, A. S., Jansen, G. A., Wanders, R. J. A., & Lloyd, M. D. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00016-x · Cited by 77

The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functions

Rolfsson, Ó., Palsson, B. Ø., & Thiele, I. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-155 · Cited by 77

Peroxisomal Multifunctional Protein 2 Is Essential for Lipid Homeostasis in Sertoli Cells and Male Fertility in Mice

Huyghe, S., Schmalbruch, H., Gendt, K. D., Verhoeven, G., Guillou, F., Veldhoven, P. P. V., & Baes, M. I. (2006) · Endocrinology · doi:10.1210/en.2005-1571 · Cited by 76

Classification and molecular pathogenesis of NBIA syndromes

Meo, I. D., & Tiranti, V. (2018) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2018.01.008 · Cited by 75

Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal

Vermillion, K. L., Anderson, K. J., Hampton, M. E., & Andrews, M. T. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00108.2014 · Cited by 77

A dietary enzyme: α-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma

Jiang, Z., Fanger, G. R., Banner, B. F., Woda, B. A., Algate, P. A., Dresser, K., Xu, J., Reed, S. G., Rock, K. L., & Chu, P. G. (2003) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2003.07.003 · Cited by 74

Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance

Noland, R. C., Woodlief, T., Whitfield, B. R., Manning, S. M., Evans, J. R., Dudek, R. W., Lust, R. M., & Cortright, R. N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00399.2006 · Cited by 68

Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice

Haque, J. A., McMahan, R. S., Campbell, J. S., Shimizu‐Albergine, M., Wilson, A. M., Botta, D., Bammler, T. K., Beyer, R. P., Montine, T. J., Yeh, M. M., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.112 · Cited by 66

Peroxisomal and Mitochondrial β-Oxidation Pathways Influence the Virulence of the Pathogenic Fungus Cryptococcus neoformans

Kretschmer, M., Wang, J., & Kronstad, J. W. (2012) · Eukaryotic Cell · doi:10.1128/ec.00128-12 · Cited by 64

Peroxisomes, myelination, and axonal integrity in the CNS

Baes, M., & Aubourg, P. (2009) · The Neuroscientist · doi:10.1177/1073858409336297 · Cited by 65

OCTN3 is a mammalian peroxisomal membrane carnitine transporter

Lamhonwah, A., Ackerley, C. A., Tilups, A., Edwards, V., Wanders, R. J. A., & Tein, I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.170 · Cited by 65

Story behind meldonium–from pharmacology to performance enhancement: a narrative review

Schobersberger, W., Dünnwald, T., Gmeiner, G., & Blank, C. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096357 · Cited by 61

Mechanism of toxicity of the branched‐chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment

Reiser, G., Schönfeld, P., & Kahlert, S. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.002 · Cited by 63

The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes

Rönicke, S., Kruska, N., Kahlert, S., & Reiser, G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.08.005 · Cited by 62

In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O)

Kowalik, D., Haller, F., Adamski, J., & Möller, G. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.08.001 · Cited by 61

Localization of MCT 2 at peroxisomes is associated with malignant transformation in prostate cancer

Valença, I., Pértega‐Gomes, N., Vizcaino, J. R., Henrique, R., Lopes, C., Baltazar, F., & Ribeiro, D. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12481 · Cited by 59

Hyperpipecolic acidaemia: a diagnostic tool for peroxisomal disorders

Peduto, A., Baumgartner, M. R., Verhoeven‐Duif, N. M., Rabier, D., Spada, M., Nassogne, M., Poll‐The, B. T., Bonetti, G., Jakobs, C., & Saudubray, J. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.04.010 · Cited by 59

In Vitro and In Vivo Study of Octacosanol Metabolism

Menéndez, R., Marrero, D., Más, R., Fernández, I., González, L., & González, R. M. D. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2004.12.006 · Cited by 56

Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver

Chen, X., Shang, L., Deng, S., Li, P., Chen, K., Gao, T., Zhang, X., Chen, Z., & Zeng, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013583 · Cited by 55

Overexpression of Peroxisome Proliferator-activated Receptor-α (PPARα)-regulated Genes in Liver in the Absence of Peroxisome Proliferation in Mice Deficient in both l- and d-Forms of Enoyl-CoA Hydratase/Dehydrogenase Enzymes of Peroxisomal β-Oxidation System

Jia, Y., Qi, C., Zhang, Z., Hashimoto, T., Rao, M. S., Huyghe, S., Suzuki, Y., Veldhoven, P. P. V., Baes, M. I., & Reddy, J. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306363200 · Cited by 55

RNA interference of peroxisome-related genes inC. elegans: a new model for human peroxisomal disorders

Petriv, O. I., Pilgrim, D. B., Rachubinski, R. A., & Titorenko, V. I. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00044.2002 · Cited by 53

Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2

Lu, X., Zhang, X., Zhang, Y., Zhang, K., Zhan, C., Shi, X., Li, Y., Zhao, J., Bai, Y., Wang, Y., et al. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.22967 · Cited by 53

Characteristic Acylcarnitine Profiles in Inherited Defects of Peroxisome Biogenesis: A Novel Tool for Screening Diagnosis Using Tandem Mass Spectrometry

Rizzo, C., Boenzi, S., Wanders, R. J. A., Durán, M., Caruso, U., & Dionisi‐Vici, C. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000064902.59052.0f · Cited by 53

Anti-obesity and anti-diabetic effects of ethanol extract of Artemisia princeps in C57BL/6 mice fed a high-fat diet

Yamamoto, N., Kanemoto, Y., Ueda, M., Kawasaki, K., Fukuda, I., & Ashida, H. (2011) · Food Funct. · doi:10.1039/c0fo00129e · Cited by 52

Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice

Zhang, T., Yamashita, Y., Yasuda, M. T., Yamamoto, N., & Ashida, H. (2014) · Food & Function · doi:10.1039/c4fo00525b · Cited by 52

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants

Bülow, M. H., Wingen, C., Senyilmaz, D., Gosejacob, D., Sociale, M., Bauer, R., Schulze, H., Sandhoff, K., Teleman, A. A., Hoch, M., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-08-0535 · Cited by 52

The Physiological and Pathological Role of Acyl-CoA Oxidation

Szrok-Jurga, S., Czumaj, A., Turyn, J., Hebanowska, A., Świerczyński, J., Śledziński, T., & Stelmańska, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914857 · Cited by 55

Targeting Carnitine Biosynthesis: Discovery of New Inhibitors against γ-Butyrobetaine Hydroxylase

Tārs, K., Leitāns, J., Kazāks, A., Zelencova-Gopejenko, D., Liepinsh, E., Kuka, J., Makrecka‐Kuka, M., Loļa, D., Andrianovs, V., Gustina, D., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401603e · Cited by 51

Sequential Ordered Fatty Acid α Oxidation and Δ9 Desaturation Are Major Determinants of Lipid Storage and Utilization in Differentiating Adipocytes

Su, X., Han, X., Yang, J., Mancuso, D. J., Chen, J., Bickel, P. E., & Gross, R. W. (2004) · Biochemistry · doi:10.1021/bi035867z · Cited by 50

Stereochemistry of the peroxisomal branched-chain fatty acid α- and β-oxidation systems in patients suffering from different peroxisomal disorders

Ferdinandusse, S., Rusch, H., van Lint, A. E. M., Dacremont, G., Wanders, R. J. A., & Vreken, P. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30150-4 · Cited by 49

Looking Beyond Morphology: Cancer Gene Expression Profiling Using DNA Microarrays

Luo, J., Isaacs, W. B., Trent, J. M., & Duggan, D. J. (2003) · Cancer Investigation · doi:10.1081/cnv-120025096 · Cited by 49

Reinvestigation of Peroxisomal 3-Ketoacyl-CoA Thiolase Deficiency: Identification of the True Defect at the Level of d-Bifunctional Protein

Ferdinandusse, S., van Grunsven, E. G., Oostheim, W., Denis, S. W., Hogenhout, E. M., IJlst, L., van Roermund, C. W. T., Waterham, H. R., Goldfischer, S. L., & Wanders, R. J. A. (2002) · The American Journal of Human Genetics · doi:10.1086/340970 · Cited by 48

Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice

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[31] Peroxisomal fatty acid oxidation and cellular redox

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