CoChat
Sign Up
Cited by 162Neuroscience and Neuropharmacology ResearchRegulation of Appetite and ObesityMemory and Neural Mechanisms

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Leptin: a potential cognitive enhancer?

Harvey, J., Shanley, L.J., O'Malley, D., Irving, A.J.·2005·Biochemical Society Transactions
DOI 10.1042/bst0331029
Open this paper in CoChat — free account

Abstract

It is well documented that the hormone leptin signals information regarding the status of fat stores to hypothalamic nuclei, which in turn control feeding behaviour and body weight. However, leptin and its receptor are widely expressed in many extra-hypothalamic brain regions, including hippocampus, brain stem and cerebellum. Moreover, evidence is accumulating that leptin has other neuronal functions that are unrelated to its effects on energy homeostasis. Indeed a role for leptin in neuronal development has been suggested as leptin-deficient rodents display abnormal brain development and leptin actively participates in the development of the hypothalamus. In the hippocampus, leptin is a potential cognitive enhancer as genetically obese rodents with dysfunctional leptin receptors display impairments in hippocampal synaptic plasticity. Moreover, direct administration of leptin into the hippocampus can facilitate hippocampal LTP (long-term potentiation) in vivo and improve memory processing in mice. At the cellular level, we have also shown that leptin has the capacity to convert short-term potentiation into LTP. Here, we review the data that leptin influences hippocampal synaptic plasticity via enhancing NMDA (N-methyl-D-aspartate) receptor function. We also provide evidence that rapid trafficking of NMDA receptors to the plasma membrane may underlie the effects of leptin on excitatory synaptic strength.

Overview

Integrity signals

Registry

Crossref · 10.1042/bst0331029

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 39 references

Research works printed but not linked: 1

  1. Farr, 2004, Soc. Neurosci. Abstr., 24, 210

Cited by

Sorted by citations

Items 101–161 of 161

Related

See all

Metadata

Authors
Harvey, J., Shanley, L. J., O'Malley, D., & Irving, A. J.
Affiliations
  • University of Dundee (GB)
  • Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K.
ORCID
Irving, A.J.
Venue
Biochemical Society Transactions
Publisher
Portland Press Ltd.
Published
2005-10-26
Volume
33
Issue
5
Pages
1029-1032
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
DOI
10.1042/bst0331029
OpenAlex
W1968293808
Cited by
162
References
39
Citations by year
2025: 7 · 2024: 4 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 16 · 2013: 11 · 2012: 19
FWCI
3.12
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical Society Transactions (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
leptin, leptin receptor, hippocampus, synaptic plasticity, long-term potentiation, short-term potentiation, NMDA receptor, memory, cognitive enhancement, neuronal development, hypothalamus, energy homeostasis, ob/ob mice, obesity, receptor trafficking
MeSH terms
Animals, Brain, Cognition, Humans, Receptors, Cell Surface, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Long-Term Potentiation, Leptin, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review