Cited by 162Neuroscience and Neuropharmacology ResearchRegulation of Appetite and ObesityMemory and Neural Mechanisms

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Leptin: a potential cognitive enhancer?

Harvey, J., Shanley, L.J., O'Malley, D., Irving, A.J.·2005·Biochemical Society Transactions

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Abstract

It is well documented that the hormone leptin signals information regarding the status of fat stores to hypothalamic nuclei, which in turn control feeding behaviour and body weight. However, leptin and its receptor are widely expressed in many extra-hypothalamic brain regions, including hippocampus, brain stem and cerebellum. Moreover, evidence is accumulating that leptin has other neuronal functions that are unrelated to its effects on energy homeostasis. Indeed a role for leptin in neuronal development has been suggested as leptin-deficient rodents display abnormal brain development and leptin actively participates in the development of the hypothalamus. In the hippocampus, leptin is a potential cognitive enhancer as genetically obese rodents with dysfunctional leptin receptors display impairments in hippocampal synaptic plasticity. Moreover, direct administration of leptin into the hippocampus can facilitate hippocampal LTP (long-term potentiation) in vivo and improve memory processing in mice. At the cellular level, we have also shown that leptin has the capacity to convert short-term potentiation into LTP. Here, we review the data that leptin influences hippocampal synaptic plasticity via enhancing NMDA (N-methyl-D-aspartate) receptor function. We also provide evidence that rapid trafficking of NMDA receptors to the plasma membrane may underlie the effects of leptin on excitatory synaptic strength.

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Authors: Harvey, J., Shanley, L. J., O'Malley, D., & Irving, A. J.
Affiliations: University of Dundee (GB)
Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K.
ORCID: Irving, A.J.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2005-10-26
Volume: 33
Issue: 5
Pages: 1029-1032
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst0331029
OpenAlex: W1968293808
Cited by: 162
References: 39
Citations by year: 2025: 7 · 2024: 4 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 16 · 2013: 11 · 2012: 19
FWCI: 3.12
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: leptin, leptin receptor, hippocampus, synaptic plasticity, long-term potentiation, short-term potentiation, NMDA receptor, memory, cognitive enhancement, neuronal development, hypothalamus, energy homeostasis, ob/ob mice, obesity, receptor trafficking
MeSH terms: Animals, Brain, Cognition, Humans, Receptors, Cell Surface, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Long-Term Potentiation, Leptin, Receptors, Leptin

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Leptin: a potential cognitive enhancer?

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