Cited by 332RNA Research and SplicingRNA and protein synthesis mechanismsRNA regulation and disease

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Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

Sawicka, Kirsty, Bushell, Martin, Spriggs, Keith A., Willis, Anne E.·2008·Biochemical Society Transactions

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Abstract

PTB (polypyrimidine-tract-binding protein) is a ubiquitous RNA-binding protein. It was originally identified as a protein with a role in splicing but it is now known to function in a large number of diverse cellular processes including polyadenylation, mRNA stability and translation initiation. Specificity of PTB function is achieved by a combination of changes in the cellular localization of this protein (its ability to shuttle from the nucleus to the cytoplasm is tightly controlled) and its interaction with additional proteins. These differences in location and trans-acting factor requirements account for the fact that PTB acts both as a suppressor of splicing and an activator of translation. In the latter case, the role of PTB in translation has been studied extensively and it appears that this protein is required for an alternative form of translation initiation that is mediated by a large RNA structural element termed an IRES (internal ribosome entry site) that allows the synthesis of picornaviral proteins and cellular proteins that function to control cell growth and cell death. In the present review, we discuss how PTB regulates these disparate processes.

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“RBPs contain various structural motifs, such as the RNA-recognition motif (RRM), dsRNA-binding domain, zinc finger domain, and others [85], and several of these may be involved in circRNA binding.”
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Zhang, X., Wang, W., Zhu, W., Dong, J., Cheng, Y., Yin, Z., & Shen, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225573 · Cited by 906
“Recently, RNA pull-down and LC-MS assays have revealed that lncRNA MEG3 binds polypyrimidine tract-binding protein 1 (PTBP1), which belongs to the hnRNPs subfamily and controls almost all aspects of mRNA metabolism [96].”
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Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedPreprint
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The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells.
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See all 332

Authors: Sawicka, K., Bushell, M., Spriggs, K. A., & Willis, A. E.
Affiliations: University of Nottingham (GB)
ORCID: Sawicka, Kirsty
Bushell, Martin
Spriggs, Keith A.
Willis, Anne E.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2008-07-22
Volume: 36
Issue: 4
Pages: 641-647
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst0360641
OpenAlex: W1995239307
Cited by: 332
References: 85
Citations by year: 2026: 7 · 2025: 13 · 2024: 21 · 2023: 18 · 2022: 29 · 2021: 11 · 2020: 15 · 2019: 20 · 2018: 17 · 2017: 10 · 2016: 14 · 2015: 16 · 2014: 24 · 2013: 19 · 2012: 31
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: polypyrimidine tract-binding protein, PTB, RNA-binding proteins, splicing regulation, polyadenylation, mRNA stability, translation initiation, internal ribosome entry site, nucleocytoplasmic shuttling, protein-protein interaction
MeSH terms: Animals, Virus Replication, RNA-Binding Proteins, Alternative Splicing, RNA Stability, RNA Transport, Polypyrimidine Tract-Binding Protein

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Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

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