Cited by 357RNA Research and SplicingRNA and protein synthesis mechanismsCancer-related molecular mechanisms research

The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells.

Open access
Matoulkova, Eva, Michalova, Eva, Vojtesek, Borivoj, Hrstka, Roman·2012·RNA Biology

Abstract

The untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we summarize the information known to date about 3'end processing, sequence characteristics including related binding proteins and the role of 3'UTRs in several selected signaling pathways to delineate their importance in the regulatory processes in mammalian cells. In addition to reviewing recent advances in the more well known aspects, such as cleavage and polyadenylation processes that influence mRNA stability and location, we concentrate on some newly emerging concepts of the role of the 3'UTR, including alternative polyadenylation sites in relation to proliferation and differentiation and the recognition of the multi-functional properties of non-coding RNAs, including miRNAs that commonly target the 3'UTR. The emerging picture is of a highly complex set of regulatory systems that include autoregulation, cooperativity and competition to fine tune proteosynthesis in context-dependent manners.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4161/rna.20231

Cites

150 of 150 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The function of the 3′ UTR is to maintain mRNA stability.

    “Conversely, the function of the 3′ UTR is to maintain mRNA stability.135,136”

    From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [136]

  • Sequences of 5′ and 3′ untranslated regions (UTRs) play a key role in the stability of mRNA molecules and in their translational efficiency.

    “Sequences of 5′ and 3′ untranslated regions (UTRs) are responsible for translational efficiency and stability of mRNA.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Matoulkova, E., Michalova, E., Vojtesek, B., & Hrstka, R.
Affiliations
Masaryk Memorial Cancer Institute (CZ)
Corresponding author
Hrstka, Roman
Venue
RNA Biology
Published
2012-05
Volume
9
Issue
5
Pages
563-576
ISSN
  • 1547-6286 (ISSN-L)
  • 1555-8584
OpenAlex
W2054574453
Cited by
357
References
150
Citations by year
2026: 13 · 2025: 14 · 2024: 14 · 2023: 25 · 2022: 31 · 2021: 38 · 2020: 47 · 2019: 43 · 2018: 45 · 2017: 21 · 2016: 19 · 2015: 16 · 2014: 20 · 2013: 11
FWCI
1.40
Type
journal article
Language
en
Open access
Locations
  • RNA Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Regional Development Fund (CZ.1.05/2.1.00/03.0101)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
3' untranslated region, post-transcriptional regulation, mRNA stability, mRNA localization, 3' end processing, cleavage and polyadenylation, microRNA, non-coding RNA, autoregulation, cell proliferation and differentiation, signaling pathways, mammalian cells
MeSH terms
Animals, Base Sequence, Humans, Promoter Regions, Genetic, RNA Processing, Post-Transcriptional, RNA, Messenger, RNA-Binding Proteins, 3' Untranslated Regions, Polyadenylation, RNA Interference, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review