Spare respiratory capacity, oxidative stress and excitotoxicity

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

Rothman, S. M., & Olney, J. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190202 · Cited by 2,428

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727

Glutamate neurotoxicity in cortical cell culture

Choi, D. W., Maulucci-Gedde, M., & Kriegstein, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00357.1987 · Cited by 1,506

NMDA-dependent superoxide production and neurotoxicity

Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183

Glutamate release in severe brain ischaemia is mainly by reversed uptake

Rossi, D. J., Oshima, T., & Attwell, D. (2000) · Nature · doi:10.1038/35002090 · Cited by 1,128

The release and uptake of excitatory amino acids

Nicholls, D. G., & Attwell, D. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90129-v · Cited by 1,092

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

Novelli, A., Reilly, J. A., Lysko, P. G., & Henneberry, R. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90765-2 · Cited by 961

Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

Mayer, M. L., & Westbrook, G. L. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016883 · Cited by 943

Glutamate-induced neuron death requires mitochondrial calcium uptake

Stout, A. K., Raphael, H. M., Kanterewicz, B. I., Klann, E., & Reynolds, I. J. (1998) · Nature Neuroscience · doi:10.1038/1577 · Cited by 630

The mitochondrial permeability transition from in vitro artifact to disease target

Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05213.x · Cited by 627

Lactation stage impacts the glycolytic function of bovine CD4+ T cells during ex vivo activation

Eder, J. M., Gorden, P. J., Lippolis, J. D., Reinhardt, T. A., & Sacco, R. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-60691-2 · Cited by 20

Rapid dendritic and axonal responses to neuronal insults

Mizielinska, S., Greenwood, S. M., Tummala, H., & Connolly, C. N. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371389 · Cited by 18

An Investigation of the Dynamic Thiol/Disulfide Homeostasis, As a Novel Oxidative Stress Plasma Biomarker, in Children With Autism Spectrum Disorders

Efe, A., Neşeli̇oğlu, S., & Soykan, A. A. (2020) · Autism Research · doi:10.1002/aur.2436 · Cited by 18

Lipopolysaccharide From E. coli Increases Glutamate-Induced Disturbances of Calcium Homeostasis, the Functional State of Mitochondria, and the Death of Cultured Cortical Neurons

Бакаева, З. В., Lizunova, N. V., Tarzhanov, I. A., Boyarkin, D., Petrichuk, S. V., Pinelis, V. G., Fisenko, А. P., Tuzikov, A. B., Sharipov, R. R., & Surin, A. M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.811171 · Cited by 18

Evidence of impaired mitochondrial cellular bioenergetics in ocular fibroblasts derived from glaucoma patients

Vallabh, N. A., Armstrong, J. A., Czanner, G., McDonagh, B., Choudhary, A., Criddle, D. N., & Willoughby, C. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.07.009 · Cited by 18

Techniques to Investigate Neuronal Mitochondrial Function and its Pharmacological Modulation

Oliveira, J. M. A. (2011) · Current Drug Targets · doi:10.2174/138945011795528895 · Cited by 18

Mitochondrial Function, Oxidative Stress, Inflammation and Thrombolytic Treatment in Ischemic Stroke

Kovacheva, E., Gevezova, M., Koeva, M., Mihaylova, V., Kormova, V., Kostadinova, E. P., Kostadinova, Y., Kazakova, M., & Sarafian, V. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110289 · Cited by 17

The nuclear background influences the penetrance of the near-homoplasmic m.1630 A > G MELAS variant in a symptomatic proband and asymptomatic mother

Uittenbogaard, M. N., Wang, H., Zhang, V. W., Wong, L. C., Brantner, C. A., Gropman, A. L., & Chiaramello, A. (2019) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2019.01.022 · Cited by 17

Guanosine Neuroprotection of Presynaptic Mitochondrial Calcium Homeostasis in a Mouse Study with Amyloid-β Oligomers

da Silva, J. S., Nonose, Y., Rohden, F., Ferreira, P. C. L., Fontella, F. U., da Rocha, A. S., Brochier, A. W., Apel, R. V., de Lima, T. M., Seminotti, B., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02064-4 · Cited by 17

Metabolic Profiling of Female Tg2576 Mouse Brains Provides Novel Evidence Supporting Intranasal Low-Dose Pioglitazone for Long-Term Treatment at an Early Stage of Alzheimer’s Disease

Wong, L. R., Wong, P., & Ho, P. C. (2020) · Biomedicines · doi:10.3390/biomedicines8120589 · Cited by 16

Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara

Casertano, M., Genovese, M., Santi, A., Pranzini, E., Balestri, F., Piazza, L., CORSO, A. D., Avunduk, S., Imperatore, C., Menna, M., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020528 · Cited by 16

Peroxynitrite Contributes to Behavioral Responses, Increased Trigeminal Excitability, and Changes in Mitochondrial Function in a Preclinical Model of Migraine

Lackovic, J., Jeevakumar, V., Burton, M. D., Price, T. J., & Dussor, G. O. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1366-22.2023 · Cited by 15

Neuroprotective Potential of Peptides HFRWPGP (ACTH6–9PGP), KKRRPGP, and PyrRP in Cultured Cortical Neurons at Glutamate Excitotoxicity

Бакаева, З. В., Surin, A. M., Lizunova, N. V., Zgodova, A., Krasilnikova, I. A., Fisenko, А. P., Frolov, D., Андреева, Л. А., Myasoedov, N. F., & Pinelis, V. G. (2020) · Doklady Biochemistry and Biophysics · doi:10.1134/s1607672920020040 · Cited by 16

Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity

Zgodova, A., Павлова, С. И., Nekrasova, A., Boyarkin, D., Pinelis, V. G., Surin, A. M., & Валериевна, Б. З. (2022) · Membranes · doi:10.3390/membranes12111052 · Cited by 14

Mitochondrial metabolism in aging: Effect of dietary interventions

Cerqueira, F. M., & Kowaltowski, A. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.009 · Cited by 14

Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential

Meshrkey, F., Scheulin, K. M., Littlejohn, C. M., Stabach, J., Saikia, B. B., Thorat, V., Huang, Y., LaFramboise, T., Lesnefsky, E. J., Rao, R. R., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03546-7 · Cited by 13

Adaptation of metabolism to multicellular aggregation, hypoxia and obese stromal cell incorporation as potential measure of survival of ovarian metastases

Compton, S. L. E., Pyne, E. S., Liu, L., Guinan, J., Shea, A. A., Grieco, J. P., Frisard, M. I., & Schmelz, E. M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112397 · Cited by 12

Palmitoylcarnitine impairs immunity in decompensated cirrhosis

Zhang, I. W., Sánchez-Rodríguez, M. B., López‐Vicario, C., Casulleras, M., Duran‐Güell, M., Flores‐Costa, R., Aguilar, F., Rothe, M., Segalés, P., García‐Ruiz, C., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101187 · Cited by 12

Immune cells phenotype and bioenergetic measures in CD4+ T cells differ between high and low feed efficient dairy cows

Arshad, U., Kennedy, K. M., de la Paz, M. C., Kendall, S. J., Cangiano, L. R., & White, H. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-66345-x · Cited by 11

Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments

Sorokina, M. Y., Bobkov, D. E., Хромова, Н. В., Vilchinskaya, N. A., Shenkman, B. S., Kostareva, A. A., & Dmitrieva, R. I. (2024) · Skeletal Muscle · doi:10.1186/s13395-024-00362-2 · Cited by 10

Metabolic Regulation of T Cell Immunity

Vignali, P., Barbi, J. J., & Pan, F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1170-6_2 · Cited by 10

Effect of Mitochondrial and Cytosolic FXN Isoform Expression on Mitochondrial Dynamics and Metabolism

Agrò, M., & Díaz‐Nido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218251 · Cited by 10

Dramatic effect of glycolysis inhibition on the cerebellar granule cells bioenergetics

Khodorov, B. I., Mikhailova, M. M., Bolshakov, A. P., Surin, A. M., Sorokina, E. G., Rozhnev, S. A., & Pinelis, V. G. (2012) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747812010060 · Cited by 8

Fueling Memories

Powell, J. D., & Pollizzi, K. N. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.003 · Cited by 7

Magnetic Resonance Spectroscopy Studies in Bipolar Disorder Patients: Focus on the Potential Role of Oxidative Stress

Dusi, N., Cecchetto, F., & Brambilla, P. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_9 · Cited by 6

STF-083010 an inhibitor of IRE1α endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential

Hatoková, Z., Evinová, A., & Račay, P. (2023) · Toxicology in Vitro · doi:10.1016/j.tiv.2023.105652 · Cited by 5

The omega-3 DHA induces pyroptosis and mitochondrial dysfunction in ovarian cancer cells via ROS and caspase-1 activation

Pasquarelli-do-Nascimento, G., Bezerra, S. P., Manchine, J. P., Lago, N. C. S., Braz-de-Melo, H. A., da Cruz, N. S., Bellozi, P. M. Q., Rocha, A. P., Santos, I. D. O., Lago, F. G., et al. (2026) · Cell Death Discovery · doi:10.1038/s41420-025-02854-6 · Cited by 4

Dysfunctional Postnatal Mitochondrial Energy Metabolism in a Patient with Neurodevelopmental Defects Caused by Intrauterine Growth Restriction Due to Idiopathic Placental Insufficiency

Uittenbogaard, M. N., Gropman, A. L., Whitehead, M. T., Brantner, C. A., Gropman, E., & Chiaramello, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031386 · Cited by 4

Supplementation with aspalathin and sulforaphane protects cultured cardiac cells against dyslipidemia-associated oxidative damage

Mthembu, S. X. H., Mazibuko-Mbeje, S. E., Silvestri, S., Orlando, P., Nkambule, B. B., Muller, C. J. F., Tiano, L., & Dludla, P. V. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100346 · Cited by 3

C1orf35 contributes to high anabolic metabolism by simultaneously promoting aerobic glycolysis and oxidative phosphorylation in multiple myeloma cells

He, R., Xiong, W., Luo, S., Dang, R., Zhou, X., Wu, Y., Hu, W.-X., & Hu, J. (2026) · Cancer Gene Therapy · doi:10.1038/s41417-026-01002-1 · Cited by 2

Differentiation of Embryonic Stem Cells into Glutamatergic Neurons (Methods)

Lin, Y. (2012) · Springer eBooks · doi:10.1007/978-94-007-2993-3_5 · Cited by 2

Oxidative stress tolerance and salicylic acid levels in early-flowering populations derived from two cultivars of annual flax (Linum usitatissimum L.)

Santacroce, A., Kothari, S. S., Wang, M., Thiyagarajah, B., Ko, S. H., Gunasekar, S., Ridi, S. A., Chin, M. J., & Brown, J. C. L. (2024) · Plant Growth Regulation · doi:10.1007/s10725-024-01209-y · Cited by 1

Respirometry parameters as indicators of neurotoxicity

Moncada-Restrepo, M., & Chambers, J. W. (2025) · Advances in neurotoxicology · doi:10.1016/bs.ant.2025.05.001 · Cited by 1

Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications

Lee, J., You, J. H., Park, H. J., Roh, J.-L., & Paek, S. H. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00709-4 · Cited by 1

Mechanisms Underlying the Selective Vulnerability of Developing Human White Matter

Rosenberg, P. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_6 · Cited by 1

Therapeutic role of phytoconstituents in treatment of cerebral ischemia/reperfusion injury

Dhakad, P. K., Sharma, P. K., Kumar, S., Kumar, N., Dudhe, R., & Mishra, R. (2016) · Journal of Pharmacognosy and Phytochemistry · Cited by 1

Zinc and docosahexaenoic acid metabolism in brain cells

Sadli, N. (2012)

OVERCOMING SELF-REACTIVITY THROUGH IMMUNOLOGICAL AND METABOLIC REDOX MODULATION

Delmastro-Greenwood, M. M. (2012) · D-Scholarship@Pitt (University of Pittsburgh)

LeakRegulation and Physiology of Mitochondrial Proton

Dalton, N. D., Peterson, K. L., Gu, Y., Matkovich, S. J., Murphy, A. N., Ling, H., Divakaruni, A. S., Zambon, A. C., King, M. S., Kunji, E. R. S., et al. (2015)

PADIDĖJĘS JAUTRUMAS MAISTO PRIEDAMS: GLUTAMATO KLINIKINIAI ASPEKTAI

Ėmužytė, R., Firantienė, R., Sasnauskienė, S., Kalibatienė, D., & Kinčinienė, O. (2014) · Medicinos teorija ir praktika · doi:10.15591/mtp.2014.051

Exenatide as a novel treatment for Parkinson's Disease

Avilés-Olmos, I. (2013) · UCL Discovery (University College London)

Activity Dependent Changes to Astrocyte Resting Calcium

Mehina, E. M. F. (2016) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/24694

Comparative Analysis of the Mitochondrial Physiology of Pancreatic b

Patel, P., Gouvin, L. M., Brown, M., Khalil, A., Henchey, E., & Heuck, A. P. (2014)

Molecular mechanisms regulating CD8+ T cell differentiation following external cues

Cullen, J. G. (2018) · Minerva Access (University of Melbourne)

Faculty Opinions recommendation of Mitochondrial dysfunction in airway disease.

Penn, R. B. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727442441.793546216

STING signaling modulates CD8 T cell memory fitness via differential TCR signaling

Quaney, M. J. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/91618

Characterizing Metabolic Changes in Cancer Cells After Treatment with an Extract Created from Walnuts

Huang, C. Y. (2022) · doi:10.31979/etd.5yvb-sh7e

Changes in the mitochondrial function of fibroblast-like cells exposed to copper oxide nanoparticles

Ryabova, Y. V., Bushueva, T. V., Minigalieva, I. A., Карпова, Е. П., & Sutunkova, M. P. (2023) · Toxicological Review · doi:10.47470/0869-7922-2023-31-6-392-398

Regulation of Megalin and Clathrin-Mediated Endocytosis by Amp-Activated Protein Kinase

Leshchyshyn, N. (2024) · doi:10.32920/25234420.v1

Effects of Short-Term Treatment of Hanwoo Satellite Cells with Various Concentrations of Cortisol

Kim, L., Yu, D., Choi, H., Kim, J. J., Ban, J., Shim, K. S., & Kang, D. (2025) · Animals · doi:10.3390/ani15192847

Effects of cell growth and temperature on mitochondrial physiology of Drosophila melanogaster embryonic cell linePreprint

Rosa, R. S., Mendonça, A. P. M., Oliveira, M., de Carvalho, D. B., Vázquez, L., & de Oliveira, M. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.25.690158

Additional file 1 of Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential

Meshrkey, F., Scheulin, K. M., Littlejohn, C. M., Stabach, J., Saikia, B. B., Thorat, V., Huang, Y., LaFramboise, T., Lesnefsky, E. J., Rao, R. R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24522583

Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)

Meshrkey, F., Scheulin, K. M., Saikia, B. B., Stabach, J., Rao, R. R., West, F. D., & Iyer, S. (2026) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-026-04201-z

Effects of cell growth progression and short-term slight temperature changes on mitochondrial physiology of Drosophila melanogaster embryonic cell line

Rosa, R. S., Mendonça, A. P. M., Oliveira, M. P., de Carvalho, D. B., Vázquez, L., & Oliveira, M. F. (2026) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2026.104948

Modélisation par processus des interactions entre ARN et protéines : une approche formelle

Maestri, S. (2020) · doi:10.70675/452a56caz35a1z4befz99f1z380261e85be5

Small Molecule Activators of Antitumor Immunity

Singh, V. P., & Uesugi, M. (2026) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6c00316

From mitochondrial signal to discovery decision: a reserve–demand framework for translational risk assessment

Rogers, G. W., & Will, Y. (2026) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2026.2697796

Potent Anti-adipogenic Activity of Cyclopeptide Mallotumide A on Murine 3T3-L1 Adipocytes

Laowittawat, C., Boonprasert, P., Sawektreeratana, N., Hongthong, S., Reutrakul, V., Kuhakarn, C., & Jitrapakdee, S. (2026) · ACS Omega · doi:10.1021/acsomega.6c04167

Structural and enzymatic differences between human MDH isoforms underlie differential sensitivity to metabolic intermediatesPreprint

Berndsen, C., Kayll, A. J., Rahman, R., Scanlan, S. E., Tester, J. R., Beaver, T., Caroline, T., Neve-Hoversten, S., Mandanis, T., Gentile, L., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7302430

Integrated Functional and Metabolomic Profiling of Melanoma Cells Treated with Redox-Active Compounds

Bonanomi, M., & Gaglio, D. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5619-8_27

Excitotoxicity and mitochondria

Nicholls, D. G., Budd, S. L., Ward, M. W., & Castilho, R. F. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660055 · Cited by 63

Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity

Nicholls, D. G., Johnson-Cadwell, L. I., Vesce, S., Jekabsons, M. B., & Yadava, N. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21290 · Cited by 173

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate

Jekabsons, M. B., & Nicholls, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401540200 · Cited by 140

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

Schinder, A. F., Olson, E. C., Spitzer, N. C., & Montal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06125.1996 · Cited by 770

Excitotoxic Injury to Mitochondria Isolated from Cultured Neurons

Kushnareva, Y. E., Wiley, S. E., Ward, M. W., Andreyev, A. Y., & Murphy, A. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503090200 · Cited by 76