Cited by 8RNA and protein synthesis mechanismsRNA modifications and cancerRNA Research and Splicing

Ribosomal flavours: An acquired taste for specific mRNAs?

Bates, Christian, Hubbard, Simon J., Ashe, Mark P.·2018·Biochemical Society Transactions

Abstract

The regulation of translation is critical in almost every aspect of gene expression. Nonetheless, the ribosome is historically viewed as a passive player in this process. However, evidence is accumulating to suggest that variations in the ribosome can have an important influence on which mRNAs are translated. Scope for variation is provided via multiple avenues, including heterogeneity at the level of both ribosomal proteins and ribosomal RNAs and their covalent modifications. Together, these variations provide the potential for hundreds, if not thousands, of flavours of ribosome, each of which could have idiosyncratic preferences for the translation of certain messenger RNAs. Indeed, perturbations to this heterogeneity appear to affect specific subsets of transcripts and manifest as cell-type-specific diseases. This review provides a historical perspective of the ribosomal code hypothesis, before outlining the various sources of heterogeneity, their regulation and functional consequences for the cell.

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Crossref · 10.1042/bst20180160

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Authors
Bates, C., Hubbard, S. J., & Ashe, M. P.
Affiliations
Manchester Academic Health Science Centre (GB)
Venue
Biochemical Society Transactions
Published
2018-11-12
Volume
46
Issue
6
Pages
1529-1539
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
OpenAlex
W2901536600
Cited by
8
References
151
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 1
FWCI
0.10
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical Society Transactions (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Funders
  • Wellcome Trust (210002/Z/17/Z)
  • Biotechnology and Biological Sciences Research Council (BB/P018270/1, BB/K005979/1, BB/N000757/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
ribosome heterogeneity, translational regulation, ribosomal proteins, ribosomal RNA, covalent modification, ribosome biogenesis
MeSH terms
Animals, Humans, Ribosomes, RNA, Messenger, Gene Expression

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