Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 274

The DOI matches its Crossref record.

Myopathy in Bone Loss of Ageing: Improvement by Treatment with 1α-hydroxycholecalciferol and Calcium

Sørensen, O. H., Lund, BI., Saltin, B., Lund, BJ., Andersen, R. B., Hjorth, L., Melsen, F., Mosekilde, L.·1979·Clinical Science
DOI 10.1042/cs0560157
Open this paper in CoChat — free account

Abstract

1. Eleven patients with the bone loss of ageing were treated with the vitamin D analogue 1α-hydroxycholecalciferol and calcium for 3–6 months. 2. Muscle biopsies were taken from the vastus lateralis before and after the treatment and the activity of several enzymes was measured. Succinate dehydrogenase and total phosphorylase activities, which are a measure of the oxidative capacity, were low and increased significantly with the treatment. The lactate dehydrogenase activity, which can be taken as a measure of the anaerobic metabolism, was normal and did not change with treatment. The phosphagen stores, ATP and creatine phosphate were low and increased to normal with treatment. 3. Histochemical classification of the fibre composition revealed that the treatment induced an increase in the relative number of fast-twitch a (FTa or type II A) fibres accompanied by a reduction of the fast-twitch b (FTb or type II B) fibres. The cross-sectional area of the FTa fibres also increased with the treatment. 4. The present findings indicate that treatment with the active vitamin D analogue, 1α-hydroxycholecalciferol, and calcium improves the myopathy associated with the bone loss of ageing.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1042/cs0560157

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cited by

Metadata

Authors
Sørensen, O. H., Lund, B., Saltin, B., Lund, B., Andersen, R. B., Hjorth, L., Melsen, F., & Mosekilde, L.
Venue
Clinical Science
Publisher
Portland Press Ltd.
Published
1979-02-01
Volume
56
Issue
2
Pages
157-161
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
DOI
10.1042/cs0560157
OpenAlex
W185981718
Cited by
274
References
0
FWCI
1.58
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.