Effect of Infused Branched-Chain Amino Acids on Muscle and Whole-Body Amino Acid Metabolism in Man
Abstract
1. Using the forearm balance method, together with systemic infusions of l-[ring-2,6-3H]phenylalanine and l-[1-14C]leucine, we examined the effects of infused branched-chain amino acids on whole-body and skeletal muscle amino acid kinetics in 10 postabsorptive normal subjects; 10 control subjects received only saline. 2. Infusion of branched-chain amino acids caused a four-fold rise in arterial branched-chain amino acid levels and a two-fold rise in branched-chain keto acids; significant declines were observed in circulating levels of most other amino acids, including phenylalanine, which fell by 34%. Plasma insulin levels were unchanged from basal levels (8 ± 1 μ-units/ml). 3. Whole-body phenylalanine flux, an index of proteolysis, was significantly suppressed by branched-chain amino acid infusion (P < 0.002), and forearm phenylalanine production was also inhibited (P < 0.03). With branched-chain amino acid infusion total leucine flux rose, with marked increments in both oxidative and non-oxidative leucine disposal (P < 0.001). Proteolysis, as measured by endogenous leucine production, showed a modest 12% decrease, although this was not significant when compared with saline controls. The net forearm balance of leucine and other branched-chain amino acids changed from a basal net output to a marked net uptake (P < 0.001) during branched-chain amino acid infusion, with significant stimulation of local leucine disposal. Despite the rise in whole-body non-oxidative leucine disposal, and in forearm leucine uptake and disposal, forearm phenylalanine disposal, an index of muscle protein synthesis, was not stimulated by infusion of branched-chain amino acids. 4. The results suggest that in normal man branched-chain amino acid infusion suppresses skeletal muscle proteolysis independently of any rise of plasma insulin. Muscle branched-chain amino acid uptake rose dramatically in the absence of any apparent increase in muscle protein synthesis, as measured by phenylalanine disposal, or in branched-chain keto acid release. Thus, an increase in muscle branched-chain amino acid concentrations and/ or local branched-chain amino acid oxidation must account for the increased disposal of branched-chain amino acids.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BCAAs have been shown to regulate skeletal muscle protein synthesis and muscle recovery.
“BCAAs are catabolized in the muscle and have been shown to regulate skeletal muscle protein synthesis and muscle recovery [11].”
Cites
Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.
Gelfand, R. A., & Barrett, E. J. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113033 · Cited by 522 · see citing works
Self-citationWahren, J., Felig, P., & Hagenfeldt, L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108375 · Cited by 368 · see citing works
Castellino, P., Luzi, L., Simonson, D. C., Haymond, M. W., & DeFronzo, R. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113272 · Cited by 342 · see citing works
Origin and Possible Significance of Alanine Production by Skeletal Muscle
Odessey, R., Khairallah, E. A., & Goldberg, A. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81283-8 · Cited by 335 · see citing works
Garlick, P. J., & Grant, I. S. (1988) · Biochemical Journal · doi:10.1042/bj2540579 · Cited by 286 · see citing works
Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart.
Chua, B., Siehl, D. L., & Morgan, H. E. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86898-9 · Cited by 186 · see citing works
Branched chains support postoperative protein synthesis.
Fb, C., Upson, D., Angelico, R., Wiles, C. E., Lyons, J. M., Faulkenbach, L., & Paysinger, J. R. (1982) · PubMed · Cited by 148 · see citing works
Multifunctional control of amino acids of deprivation-induced proteolysis in liver. Role of leucine.
Pösö, A. R., Wert, J. J., & Mortimore, G. E. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33686-x · Cited by 142 · see citing works
Hagenfeldt, L., Eriksson, S., & Wahren, J. (1980) · Clinical Science · doi:10.1042/cs0590173 · Cited by 111 · see citing works
The effect of leucine infusion on substrate flux across the human forearm
Abumrad, N. N., Robinson, R. P., Gooch, B. R., & LACY, W. W. (1982) · Journal of Surgical Research · doi:10.1016/0022-4804(82)90126-3 · Cited by 86 · see citing works
Report of a Research Workshop: Branched‐Chain Amino Acids in Stress and Injury
Brennan, M. F., Cerra, F. B., DALY, J. M., Fischer, J. E., Moldawer, L. L., Smith, R. J., Vinnars, E., Wannemacher, R. W., & Young, V. R. (1986) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607186010005446 · Cited by 82 · see citing works
Leucine meal increases glutamine and total nitrogen release from forearm muscle.
Aoki, T. T., Brennan, M. F., Fitzpatrick, G. F., & Knight, D. C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110406 · Cited by 76 · see citing works
Lundholm, K., Edström, S., Ekman, L. G., Karlberg, I. H., Walker, P., & Scherstén, T. (1981) · Clinical Science · doi:10.1042/cs0600319 · Cited by 70 · see citing works
The disposal of an intravenously administered amino acid load across the human forearm
Abumrad, N. N., Rabin, D. D., Wise, K. L., & LACY, W. W. (1982) · Metabolism · doi:10.1016/0026-0495(82)90235-9 · Cited by 62 · see citing works
In Vivo Effects of Branched Chain Amino Acids on Muscle Protein Synthesis in Fasted Rats
Buse, M. G. (1981) · Hormone and Metabolic Research · doi:10.1055/s-2007-1019316 · Cited by 52 · see citing works
Effects of leucine, isoleucine, or threonine infusion on leucine metabolism in humans
Schwenk, W. F., & Haymond, M. W. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.4.e428 · Cited by 35 · see citing works
Pozefsky, T., & Walser, M. (1977) · Metabolism · doi:10.1016/0026-0495(77)90069-5 · Cited by 27 · see citing works
Branched-chain amino acids in surgically stressed patients
Takala, J. A., Klossner, J., Irjala, J. K., & Hannula, S. (1983) · Springer eBooks · doi:10.1007/978-94-011-5918-0_6 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neinast, M. D., Murashige, D., & Arany, Z. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114455 · Cited by 727 · see citing works
International Society of Sports Nutrition position stand: protein and exercise
Campbell, B., Kreider, R. B., Ziegenfuss, T., La Bounty, P., Roberts, M., Burke, D., Landis, J., Lopez, H., & Antonio, J. (2007) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-4-8 · Cited by 716 · see citing works
A molecular model of human branched-chain amino acid metabolism
Suryawan, A., Hawes, J. W., Harris, R. A., Shimomura, Y., Jenkins, A. E., & Hutson, S. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.1.72 · Cited by 414 · see citing works
Branched-Chain Amino Acids Activate Key Enzymes in Protein Synthesis after Physical Exercise
Blomstrand, E., Eliasson, J., Karlsson, H. K., & Köhnke, R. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.269s · Cited by 395 · see citing works
Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?
Wolfe, R. R. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0184-9 · Cited by 337 · see citing works
Human muscle protein synthesis and breakdown during and after exercise
Kumar, V., Atherton, P. J., Smith, K., & Rennie, M. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91481.2008 · Cited by 285 · see citing works
Karlsson, H. K. R., Nilsson, P.-A., Nilsson, J., Chibalin, A. V., Zierath, J. R., & Blomstrand, E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2003 · Cited by 282 · see citing works
Branched chain amino acids, aging and age-related health
Couteur, D. G. L., Solon‐Biet, S. M., Cogger, V. C., Ribeiro, R. V., de Cabo, R., Raubenheimer, D., Cooney, G. J., & Simpson, S. J. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101198 · Cited by 233 · see citing works
Nutritional strategies to attenuate muscle disuse atrophy
Wall, B. T., & van Loon, L. J. (2013) · Nutrition Reviews · doi:10.1111/nure.12019 · Cited by 228 · see citing works
Helms, E. R., Aragon, A. A., & Fitschen, P. J. (2014) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-11-20 · Cited by 266 · see citing works
Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans
Nair, K. S., Schwartz, R. G., & Welle, S. L. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.5.e928 · Cited by 225 · see citing works
Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men
Wall, B. T., Hamer, H. M., de Lange, A., Kiskini, A., Groen, B. B. L., Senden, J. M. G., Gijsen, A. P., Verdijk, L. B., & van Loon, L. J. C. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2012.09.002 · Cited by 220 · see citing works
Metabolic response to injury and sepsis: changes in protein metabolism
Biolo, G., Toigo, G., Ciocchi, B., Situlin, R., Iscra, F., Gullo, A., & Guarnieri, G. (1997) · Nutrition · doi:10.1016/s0899-9007(97)83044-4 · Cited by 203 · see citing works
Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein
Smith, K., Reynolds, N., Downie, S., Patel, A. A., & Rennie, M. J. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.1.e73 · Cited by 197 · see citing works
Glynn, E. L., Fry, C. S., Drummond, M. J., Timmerman, K. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2010) · The Journal of Nutrition · doi:10.3945/jn.110.127647 · Cited by 194 · see citing works
Fryburg, D. A. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e331 · Cited by 180 · see citing works
Hormonal and Signaling Role of Branched-Chain Amino Acids
Nair, K. S., & Short, K. R. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.6.1547s · Cited by 172 · see citing works
Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle
Louard, R. J., Fryburg, D. A., Gelfand, R. A., & Barrett, E. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116124 · Cited by 169 · see citing works
Self-citationKomar, B., Schwingshackl, L., & Hoffmann, G. (2015) · The Journal of nutrition, health and aging · doi:10.1007/s12603-014-0559-4 · Cited by 161 · see citing works
Jackman, S. R., Witard, O. C., Philp, A., Wallis, G. A., Baar, K., & Tipton, K. D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00390 · Cited by 145 · see citing works
Growth hormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans
Fryburg, D. A., & Barrett, E. J. (1993) · Metabolism · doi:10.1016/0026-0495(93)90285-v · Cited by 145 · see citing works
Self-citationSkeletal muscle responses to negative energy balance: Effects of dietary protein
Carbone, J. W., McClung, J. P., & Pasiakos, S. M. (2012) · Advances in Nutrition · doi:10.3945/an.111.001792 · Cited by 138 · see citing works
Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin
Boirie, Y., Short, K. R., Ahlman, B., Charlton, M., & Nair, K. S. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2652 · Cited by 137 · see citing works
Xu, Z.-R., Tan, Z.-J., Zhang, Q., Gui, Q.-F., & Yang, Y.-M. (2015) · British Journal of Nutrition · doi:10.1017/s0007114514002475 · Cited by 136 · see citing works
Assessment of Branched-Chain Amino Acid Status and Potential for Biomarkers
Tom, A., & Nair, K. S. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.324s · Cited by 137 · see citing works
MacLean, D. A., Graham, T. E., & Saltin, B. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.6.e1010 · Cited by 132 · see citing works
Evidence for a catabolic role of glucagon during an amino acid load.
Charlton, M., Adey, D., & Nair, K. S. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118782 · Cited by 128 · see citing works
Veeneman, J. M., Kingma, H. A., Boer, T. S., Stellaard, F., de Jong, P. E., Reijngoud, D., & Huisman, R. M. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00264.2002 · Cited by 122 · see citing works
Denne, S. C., Karn, C. A., Ahlrichs, J. A., Dorotheo, A. R., Wang, J., & Liechty, E. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118473 · Cited by 116 · see citing works
Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes
Leenders, M., & van Loon, L. J. C. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00443.x · Cited by 112 · see citing works
ENGELEN, M. P. K. J., Rutten, E. P. A., de Castro, C. L. N., Wouters, E. F. �., Schols, A. M. W. J., & Deutz, N. E. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.431 · Cited by 108 · see citing works
Observations of Branched-Chain Amino Acid Administration in Humans
Matthews, D. E. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1580s · Cited by 107 · see citing works
Kaspy, M. S., Hannaian, S. J., Bell, Z. W., & Churchward‐Venne, T. A. (2023) · Nutrition Research Reviews · doi:10.1017/s0954422423000197 · Cited by 109 · see citing works
Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis
Louard, R. J., Barrett, E. J., & Gelfand, R. (1995) · Metabolism · doi:10.1016/0026-0495(95)90047-0 · Cited by 105 · see citing works
Self-citationBCAA intake affects protein metabolism in muscle after but not during exercise in humans
Blomstrand, E., & Saltin, B. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e365 · Cited by 103 · see citing works
Welle, S. L., & Thornton, C. A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.4.e677 · Cited by 103 · see citing works
Effect of insulin on system A amino acid transport in human skeletal muscle.
Bonadonna, R. C., Saccomani, M. P., Cobelli, C., & DeFronzo, R. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116230 · Cited by 101 · see citing works
Protein Metabolism in Insulin-Dependent Diabetes Mellitus ,
Charlton, M., & Nair, K. S. (1998) · Journal of Nutrition · doi:10.1093/jn/128.2.323s · Cited by 99 · see citing works
Branched‐chain amino acids protect against dexamethasone‐induced soleus muscle atrophy in rats
Yamamoto, D., Maki, T., Herningtyas, E. H., Ikeshita, N., Shibahara, H., Sugiyama, Y., Nakanishi, S., Iida, K., Iguchi, G., Takahashi, Y., et al. (2010) · Muscle & Nerve · doi:10.1002/mus.21621 · Cited by 93 · see citing works
Protein and energy metabolism in type 1 diabetes
Hebert, S. L., & Nair, K. S. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.09.001 · Cited by 90 · see citing works
Pisters, P. W. T., Pearlstone, D. B., & Toroslan, M. H. (1993) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369309084669 · Cited by 88 · see citing works
Liu, Z., Jahn, L. A., Long, W., Fryburg, D. A., Wei, L., & Barrett, E. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7481 · Cited by 87 · see citing works
Self-citationBlomstrand, E., Andersson, S. K., Hassmén, P., Ekblom, B. T., & Newsholme, E. A. (1995) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1995.tb09839.x · Cited by 85 · see citing works
Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein
Tipton, K. D., Elliott, T. A., Ferrando, A. A., Aarsland, A. A., & Wolfe, R. R. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-006 · Cited by 81 · see citing works
Liu, Z., Jahn, L. A., Wei, L., Long, W., & Barrett, E. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020424 · Cited by 83 · see citing works
Self-citationRapid suppression of protein degradation in skeletal muscle after oral feeding of leucine in rats
Nagasawa, T., Kido, T., Yoshizawa, F., Ito, Y., & NISHIZAWA, N. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00209-1 · Cited by 82 · see citing works
MANDERS, R. J. F., Little, J. P., Forbes, S. C., & Candow, D. G. (2012) · Nutrients · doi:10.3390/nu4111664 · Cited by 79 · see citing works
Efficacy of the Branched-Chain Amino Acids in the Treatment of Tardive Dyskinesia in Men
Richardson, M. A., Bevans, M. L., Read, L. L., Chao, H. M., Clelland, J. D., Suckow, R. F., Maher, T. J., & Citrome, L. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1117 · Cited by 74 · see citing works
Biotechnology in the Production of Pharmaceutical Industry Ingredients: Amino Acids
Ivanov, K., Stoimenova, А., Obreshkova, D. P., & Saso, L. (2013) · Biotechnology & Biotechnological Equipment · doi:10.5504/bbeq.2012.0134 · Cited by 71 · see citing works
Kobayashi, H., Kato, H., Hirabayashi, Y., Murakami, H., & Suzuki, H. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.234s · Cited by 70 · see citing works
Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats
May, R. C., Masud, T., Logue, B. A., Bailey, J., & England, B. K. (1992) · Kidney International · doi:10.1038/ki.1992.223 · Cited by 70 · see citing works
The Regulation of Body and Skeletal Muscle Protein Metabolism by Hormones and Amino Acids
Liu, Z., Long, W., Fryburg, D. A., & Barrett, E. J. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.212s · Cited by 69 · see citing works
Self-citationOral Branched‐Chain Amino Acids Decrease Whole‐Body Proteolysis
Ferrando, A. A., Williams, B. D., Stuart, C. A., Lane, H. W., & Wolfe, R. R. (1995) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719501900147 · Cited by 68 · see citing works
Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression
Jung, M. K., Okekunle, A. P., Lee, J. E., Sung, M. K., & Lim, Y. J. (2021) · Journal of Cancer Prevention · doi:10.15430/jcp.2021.26.4.237 · Cited by 64 · see citing works
Effect of leucine on amino acid and glucose metabolism in humans
Nair, K. S., Matthews, D. E., Welle, S. L., & Braiman, T. (1992) · Metabolism · doi:10.1016/0026-0495(92)90057-h · Cited by 66 · see citing works
Protein metabolism in diabetes mellitus
Abu-Lebdeh, H. S., & Nair, K. S. (1996) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(96)80741-5 · Cited by 60 · see citing works
Attenuation of the protein wasting associated with bed rest by branched-chain amino acids
Stein, T. P., Schluter, M. D., Leskiw, M. J., & Boden, G. H. (1999) · Nutrition · doi:10.1016/s0899-9007(99)00120-3 · Cited by 59 · see citing works
Interrelationship between Physical Activity and Branched-Chain Amino Acids
Gleeson, M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1591s · Cited by 59 · see citing works
Dudgeon, W. D., Kelley, E. P., & Scheett, T. P. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0112-9 · Cited by 57 · see citing works
Chanet, A., Salles, J., Guillet, C., Giraudet, C., Berry, A., Patrac, V., Domingues-Faria, C., Tagliaferri, C., Bouton, K., Bertrand‐Michel, J., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.02.024 · Cited by 55 · see citing works
Branched-chain amino acid supplementation during bed rest: effect on recovery
Stein, T. P., Donaldson, M. R., Leskiw, M. J., Schluter, M. D., Baggett, D. W., & Boden, G. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00481.2002 · Cited by 53 · see citing works
The new metabolic treatments for sarcopenia
Barillaro, C., Liperoti, R., Martone, A. M., Onder, G., & Landi, F. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0030-0 · Cited by 53 · see citing works
Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle
Liu, Z., Li, G., Kimball, S. R., Jahn, L. A., & Barrett, E. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00457.2003 · Cited by 51 · see citing works
Self-citationGuillet, C., Zangarelli, A., Mishellany‐Dutour, A., Rousset, P., Sornet, C., Dardevet, D. P., & Boirie, Y. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.02.011 · Cited by 49 · see citing works
Newman, E., Heslin, M. J., Wolf, R., Pisters, P. W. T., & Brennan, M. F. (1994) · Metabolism · doi:10.1016/0026-0495(94)90159-7 · Cited by 47 · see citing works
Emerging role for branched-chain amino acids metabolism in fibrosis
Wu, T., Wang, M., Ning, F., Zhou, S., Hu, X., Xin, H., Reilly, S. N., & Zhang, X. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106604 · Cited by 44 · see citing works
Temporal responses of protein synthesis in human skeletal muscle to feeding
McNurlan, M. A., Essén, P., Milne, E., Vinnars, E., Garlick, P. J., & Wernerman, J. (1993) · British Journal Of Nutrition · doi:10.1079/bjn19930014 · Cited by 45 · see citing works
Tatpati, L. L., Irving, B. A., Tom, A., Bigelow, M. L., Klaus, K., Short, K. R., & Nair, K. S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1822 · Cited by 44 · see citing works
Jahn, L. A., Barrett, E. J., Genco, M., Wei, L., Spraggins, T. A., & Fryburg, D. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5522 · Cited by 44 · see citing works
Self-citationBRANCHED CHAIN AMINO ACIDS AND THEIR IMPORTANCE IN NUTRITION
Brestenský, M., Nitrayová, S., Patraš, P., Heger, J., & Nitray, J. (2015) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.15414/jmbfs.2015.5.2.197-202 · Cited by 45 · see citing works
van Sloun, B., Goossens, G. H., Erdõs, B., Lenz, M., van Riel, N. A. W., & Arts, I. C. W. (2020) · Nutrients · doi:10.3390/nu12103211 · Cited by 43 · see citing works
Effects of insulin on whole‐body and regional amino acid metabolism
Tessari, P. (1994) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610100304 · Cited by 43 · see citing works
Park, S., Church, D. D., Azhar, G., Schutzler, S. E., Ferrando, A., & Wolfe, R. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-0340-5 · Cited by 40 · see citing works
Leucine Supplementation in Cancer Cachexia: Mechanisms and a Review of the Pre-Clinical Literature
Beaudry, A. G., & Law, M. L. (2022) · Nutrients · doi:10.3390/nu14142824 · Cited by 40 · see citing works
Whole-body metabolic fate of branched-chain amino acids
Blair, M. C., Neinast, M. D., & Arany, Z. P. (2021) · Biochemical Journal · doi:10.1042/bcj20200686 · Cited by 38 · see citing works
Emerging Roles of Branched-Chain Amino Acid Supplementation in Human Diseases
Tamanna, N., & Mahmood, N. (2014) · International Scholarly Research Notices · doi:10.1155/2014/235619 · Cited by 39 · see citing works
SANTOS, C. D. S., & Nascimento, F. E. L. (2019) · Einstein (São Paulo) · doi:10.31744/einstein_journal/2019rb4898 · Cited by 40 · see citing works
Amino acid supplements to improve athletic performance
Wagenmakers, A. J. M. (1999) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-199911000-00019 · Cited by 39 · see citing works
Mohta, S., Anand, A., Sharma, S., Qamar, S., Agarwal, S., Gunjan, D., Singh, N., Madhusudhan, K. S., Pandey, R. M., & Saraya, A. (2022) · Hepatology International · doi:10.1007/s12072-022-10334-7 · Cited by 38 · see citing works
Effect of hyperinsulinemia on ovine fetal leucine kinetics during prolonged maternal fasting
Liechty, E. A., Boyle, D. W., Moorehead, H., Liu, Y. M., & Denne, S. C. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.4.e696 · Cited by 38 · see citing works
Lv, X., Zhou, C., Yan, Q., Tan, Z., Kang, J., & Tang, S. (2022) · Nutrition · doi:10.1016/j.nut.2022.111797 · Cited by 38 · see citing works
Lien, K. A., Sauer, W. H., Mosenthin, R., Souffrant, W. B., & Dugan, M. E. R. (1997) · Journal of Animal Science · doi:10.2527/1997.751148x · Cited by 37 · see citing works
Lang, C. H., Pruznak, A. M., Navaratnarajah, M., Rankine, K. A., Deiter, G. M., Magne, H., Offord, E., & Breuillé, D. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00618.2012 · Cited by 34 · see citing works
Koh, F. H.-X., Chua, J. M. W., Tan, J. L., Foo, F. J., Tan, W. J., Sivarajah, S. S., Ho, L. M. L., Teh, B. T., & Chew, M. (2021) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v13.i8.734 · Cited by 34 · see citing works
Wolfe, R. R., Park, S., Kim, I., Starck, C. S., Marquis, B. J., Ferrando, A. A., & Moughan, P. J. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00294.2018 · Cited by 31 · see citing works
Leucine: a key amino acid in ageing-associated sarcopenia?
Dardevet, D. P., Rieu, I., Fafournoux, P., Sornet, C., Combaret, L., Bruhat, A., Mordier, S. B., Mosoni, L., & Grizard, J. (2003) · Nutrition Research Reviews · doi:10.1079/nrr200252 · Cited by 31 · see citing works
The effect of insulin on glucose and protein metabolism in the forearm of cancer patients
Newman, E., Heslin, M. J., Wolf, R., Pisters, P. W. T., & Brennan, M. F. (1992) · Surgical Oncology · doi:10.1016/0960-7404(92)90086-z · Cited by 29 · see citing works
Everman, S., Meyer, C., Tran, L., Hoffman, N., Carroll, C. C., Dedmon, W. L., & Katsanos, C. S. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00120.2016 · Cited by 28 · see citing works
Aquilani, R., Boselli, M., D’Antona, G., Baiardi, P., Boschi, F., Viglio, S., Iadarola, P., Pasini, E., Barbieri, A., Dossena, M., et al. (2014) · BioMed Research International · doi:10.1155/2014/964365 · Cited by 27 · see citing works
Mels, C. M. C., Schutte, A. E., Schutte, R., Huisman, H. W., Smith, W. T., Fourie, C. M. T., Kruger, R., van Rooyen, J. M., Malan, N. T., & Malan, L. (2013) · Amino Acids · doi:10.1007/s00726-013-1611-0 · Cited by 27 · see citing works
Lee, A. J., Beno, D. W. A., Zhang, X., Shapiro, R. D., Mason, M., Mason-Bright, T., Surber, B. W., & Edens, N. K. (2015) · Amino Acids · doi:10.1007/s00726-015-1920-6 · Cited by 25 · see citing works
Nutritional Support for the Cancer Patient
Harrison, L. E. (2006) · Springer eBooks · doi:10.1007/0-387-31056-8_84 · Cited by 25 · see citing works
The role of total parenteral nutrition in the patient with cancer.
Harrison, L. E., & Brennan, M. F. (1995) · Current problems in surgery · doi:10.1016/s0011-3840(05)80013-9 · Cited by 20 · see citing works
Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart.
Young, L. H., Dahl, D. M., Rauner, D., & Barrett, E. J. (1992) · Circulation Research · doi:10.1161/01.res.71.2.393 · Cited by 24 · see citing works
Self-citationEffects of insulin and amino acid infusion on leucine and phenylalanine kinetics in type 1 diabetes
Inchiostro, S., Biolo, G., Bruttomesso, D., Fongher, C., Sabadin, L., Carlini, M., Duner, E., Tiengo, A., & Tessari, P. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.2.e203 · Cited by 22 · see citing works
Pavis, G. F., Abdelrahman, D. R., Murton, A. J., Wall, B. T., Stephens, F. B., & Dirks, M. L. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13284 · Cited by 17 · see citing works
Maternal Diabetes Leads to Adaptation in Embryonic Amino Acid Metabolism during Early Pregnancy
Gürke, J., Hirche, F., Thieme, R., Haucke, E., Schindler, M., Stangl, G. I., Fischer, B., & Santos, A. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127465 · Cited by 20 · see citing works
Functional Foods, Beverages, and Ingredients in Athletics
Spano, M. (2010) · Strength and conditioning journal · doi:10.1519/ssc.0b013e3181c20d1c · Cited by 20 · see citing works
Adeva‐Andany, M. M., Fernández‐Fernández, C., López-Pereiro, Y., Calvo‐Castro, I., & Carneiro-Freire, N. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.06.025 · Cited by 19 · see citing works
Bennet, W. M., O’Keefe, S. J., & Haymond, M. W. (1993) · Metabolism · doi:10.1016/0026-0495(93)90234-f · Cited by 19 · see citing works
- Authors
- Louard, R. J., Barrett, E. J., & Gelfand, R. A.
- Affiliations
- Yale University (US)
- ORCID
- Barrett, Eugene J.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1990-11-01
- Volume
- 79
- Issue
- 5
- Pages
- 457-466
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W14752674
- Cited by
- 157
- References
- 18
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32dk007476-15)
- U.S. Public Health Service
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 38578, R01DK038578, DK07476)
- National Center for Research Resources (RR 125)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- branched-chain amino acids, amino acid metabolism, skeletal muscle proteolysis, muscle protein synthesis, leucine flux, amino acid kinetics, branched-chain keto acids
- MeSH terms
- Adolescent, Adult, Amino Acids, Branched-Chain, Female, Forearm, Humans, Infusions, Intravenous, Insulin, Kinetics, Leucine, Male, Muscle Proteins, Muscles, Phenylalanine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
