The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve
Open accessAbstract
Aims To investigate the relationship between adrenal gland function and pressor response to noradrenaline in septic shock. Methods Basal cortisol level, noradrenaline—mean arterial pressure dose‐response curve and cortisol response to intravenous corticotrophin bolus were obtained in nine patients fulfilling usual criteria for septic shock and in six normal volunteers. In patients with septic shock, dose‐response curve to noradrenaline was determined a second time 60 min after a 50 mg intravenous hydrocortisone bolus. Results As compared with controls, patients with septic shock had increased basal cortisol levels (mean±s.d.: 1564±818 vs 378±104 nmol l−1, P=0.002, 95% confidence interval for difference in means: [452, 1920]) and a blunted cortisol response to corticotrophin (403±461 vs 1132±195 nmol l−1, P=0.008, [−1163, −295]). Five patients had impaired adrenal function reserve. As compared with controls, septic patients displayed a moderate and non significant decrease in pressor sensitivity to noradrenaline (P=0.112). As compared with patients with adequate adrenal response, patients with impaired adrenal function reserve showed a significant decrease in pressor sensitivity to noradrenaline (P=0.038). In septic patients, hydrocortisone improved pressor response to noradrenaline (P=0.032). This effect was more marked in patients with impaired adrenal function reserve so that, as compared with patients with adequate response, the difference was no longer significant (P=0.123). Conclusions In septic shock, impaired adrenal function reserve may partly be accounted for by the depressed pressor sensitivity to noradrenaline. The latter may be substantially improved by physiological doses of hydrocortisone.
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Le Gall, J.-R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.270.24.2957 · Cited by 7,773
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Pathogenetic Mechanisms of Septic Shock
Epstein, F. H., & Parrillo, J. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282008 · Cited by 1,548
Parrillo, J. E., Parker, M. M., Natanson, C., Suffredini, A. F., Danner, R. L., Cunnion, R. E., & Ognibene, F. P. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-227 · Cited by 1,179
Parati, G., Casadei, R., Groppelli, A., Di Rienzo, M., & Mancia, G. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.647 · Cited by 899
Reversal of late septic shock with supraphysiologic doses of hydrocortisone
Bollaert, P.-E., Charpentier, C., Levy, B., Debouverie, M., Audibert, G., & Larcan, A. (1998) · Critical Care Medicine · doi:10.1097/00003246-199804000-00010 · Cited by 872
Sprung, C. L., Caralis, P. V., Marcial, E. H., Pierce, M., Gelbard, M. A., Long, W. M., Duncan, R. C., Tendler, M. D., & Karpf, M. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411013111801 · Cited by 765
Oelkers, W. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351607 · Cited by 737
Glauser, M. P., Zanetti, G., Baumgartner, J.-D., & Cohen, J. (1991) · The Lancet · doi:10.1016/0140-6736(91)91452-z · Cited by 716
Cited by
Annane, D. (2002) · JAMA · doi:10.1001/jama.288.7.862 · Cited by 3,087
Annane, D. (2000) · JAMA · doi:10.1001/jama.283.8.1038 · Cited by 1,000
Self-citationKeh, D., Boehnke, T., Weber-Cartens, S., Schulz, C., Ahlers, O., Bercker, S., Volk, H.-D., Doecke, W.-D., Falke, K. J., & Gerlach, H. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200205-446oc · Cited by 600
Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update
Hollenberg, S. M., Ahrens, T. S., Annane, D., Astiz, M. E., Chalfin, D. B., Dasta, J. F., Heard, S. O., Martin, C., Napolitano, L. M., Susla, G. M., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000139761.05492.d6 · Cited by 521
Annane, D., Pastores, S. M., Rochwerg, B., Arlt, W., Balk, R. A., Beishuizen, A., Briegel, J., Carcillo, J., Christ-Crain, M., Cooper, M. S., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4919-5 · Cited by 371
Metadata
- Authors
- Annane, Bellissant, Sebille, Lesieur, Mathieu, Raphael, & Gajdos
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1998-12
- Volume
- 46
- Issue
- 6
- Pages
- 589-597
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W1600551951
- Cited by
- 291
- References
- 30
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Annane, Bellissant, Sebille, Lesieur, Mathieu, Raphael, & Gajdos. (1998). Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. British Journal of Clinical Pharmacology. https://doi.org/10.1046/j.1365-2125.1998.00833.x
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