Cited by 72Systemic Lupus Erythematosus ResearchVenous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis Mechanisms

Anticardiolipin antibodies as a risk factor for venous thromboembolism in a population‐based prospective study

Runchey, Shauna S., Folsom, Aaron R., Tsai, Michael Y., Cushman, Mary, McGovern, Paul D.·2002·British Journal of Haematology

Abstract

Anticardiolipin antibodies, one of the family of 'antiphospholipid' antibodies, increase the risk of venous thromboembolism in the presence of autoimmune disease. Our objective was to determine prospectively whether there is a positive association between anticardiolipin antibodies and venous thromboembolism in ostensibly healthy adults. We conducted a nested case-control study (n = 317 patients and n = 655 control subjects) in a longitudinal study of over 20 000 participants. Baseline (prediagnosis) anticardiolipin IgG and IgM antibodies were assessed by enzyme-linked immunoassays. Venous thromboembolism was validated using standardized criteria for venous thrombosis and pulmonary embolism. There was no association between anticardiolipin antibodies and subsequent venous thromboembolism occurrence, overall or in any subgroup. For example, the multivariate-adjusted relative risk was 0.88 (95% confidence interval, 0.43, 1.78) for greater than versus less than the 95th percentile of anticardiolipin IgG. In conclusion, in this general population sample, an elevated anticardiolipin antibody level was not a risk factor for venous thromboembolism.

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Crossref · 10.1046/j.1365-2141.2002.03949.x

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Authors
Runchey, S. S., Folsom, A. R., Tsai, M. Y., Cushman, M., & McGovern, P. D.
Affiliations
  • University of Minnesota (US)
  • University of Vermont (US)
Corresponding author
Folsom, Aaron R.
Venue
British Journal of Haematology
Publisher
Wiley
Published
2002-12
Volume
119
Issue
4
Pages
1005-1010
ISSN
  • 0007-1048 (ISSN-L)
  • 1365-2141
OpenAlex
W2079155196
Cited by
72
References
23
Citations by year
2025: 1 · 2022: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 7
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Locations
  • British Journal of Haematology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc085079-024, n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc055022-024, n01hc085086-022, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
  • National Heart, Lung, and Blood Institute (N01-HC55022, N01-HC-55018, N01 HC 55020, N01 HC 55019, N01 HC85086, N01‐HC‐55015, N01-HC55021, N01-HC85079)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords
anticardiolipin antibodies, venous thromboembolism, antiphospholipid antibodies, pulmonary embolism, venous thrombosis, thrombosis risk factors, healthy adults
MeSH terms
Aged, Aged, 80 and over, Female, Humans, Immunoglobulin G, Immunoglobulin M, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Reference Values, Risk Factors, Thromboembolism, Odds Ratio, Case-Control Studies, Antibodies, Anticardiolipin, Venous Thrombosis

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