A prospective study of anticardiolipin antibodies as a risk factor for venous thrombosis in a general population (the HUNT study)
Open accessAbstract
We prospectively examined whether there is an association between elevated anticardiolipin antibody levels and the risk for a future first venous thrombosis (VT) in a general population. We studied this in a large population-based nested case-cohort study of 508 VT cases and 1464 matched control subjects from a cohort of 66,140 participants in the Health Study of Nord-Trøndelag in Norway. Venous thrombosis was validated using standardized criteria for venous thrombosis and pulmonary embolism. Prethrombotic serum anticardiolipin antibodies were measured by an enzyme-linked immunoassay. There was no association between elevated anticardiolipin antibody levels and subsequent venous thrombosis, overall or after stratification by sex, different age groups or idiopathic vs. secondary thrombosis. The overall odds ratio was 1.11 (95% CI: 0.71-1.74) for greater than vs. less than the 95th percentile of anticardiolipin antibody levels. In conclusion, in this general population sample elevated anticardiolipin antibody levels was not a risk factor for subsequent venous thrombosis.
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Retrospective, case-control and cross-sectional studies with different designs, patient selection criteria, aPL profiles and risk factors have produced contradictory results.
“Retrospective, [1][2][3][4] case-control [5][6][7][8][9][10][11][12] and cross-sectional 13,14 studies with different designs, patient selection criteria, aPL profiles and risk factors have produced contradictory results.”
From Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study. (2011) · cites this paper as [10]
The Introduction (page unavailable) reports differing findings across prior studies, and the Discussion (page unavailable) contrasts the HUNT results with other studies while identifying differences in design, participant selection and antibody assays. Our copy does not establish the sentence’s specific claim about cross-sectional studies or show that differing risk factors account for the contradictory results. (LLM, conf=0.82)
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- Authors
- NAESS, I. A., CHRISTIANSEN, S. C., CANNEGIETER, S. C., ROSENDAAL, F. R., & HAMMERSTROEM, J.
- Affiliations
- Leiden University Medical Center (NL)
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 4
- Issue
- 1
- Pages
- 44-49
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W2064072392
- Cited by
- 74
- References
- 6
- Citations by year
- 2025: 2 · 2022: 2 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 10
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- anticardiolipin antibodies, venous thrombosis, thrombosis risk factors, antiphospholipid antibodies, idiopathic venous thrombosis, pulmonary embolism, HUNT study, general population
- MeSH terms
- Adult, Aged, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Incidence, Odds Ratio, Case-Control Studies, Antibodies, Anticardiolipin, Venous Thrombosis
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