The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
Open accessAbstract
SUMMARY: Ageing is associated with low-grade inflammation and markers such as IL-6 possess prognostic value. Tumour necrosis-alpha (TNF-α) initiates the inflammatory cascade and has been linked to several age-associated disorders. It remains, however, unknown if TNF-α is associated with mortality in old populations. The aim of the present study was to investigate if serum levels of TNF-α were associated with all-cause mortality independently of interleukin (IL)-6 in a prospective study of 333 relatively healthy 80-year-old people. A Cox regression model was used to explore effects of TNF-α and IL-6 on survival in the following 6 years. A total of 133 participants died during this follow-up period. TNF-α was associated with mortality in men, but not in women, whereas low-grade elevations in IL-6 were associated strongly with mortality in both sexes. TNF-α explained only 7% of the variability in IL-6 and effects of the two cytokines were independent of each other as well as of other traditional risk factors for death [smoking, blood pressure, physical exercise, total cholesterol, co-morbidity, body mass index (BMI) and intake of anti-inflammatory drugs]. These findings indicate that at least in old populations chronic elevated levels of TNF-α and IL-6 have different biological functions that trigger age-associated pathology and cause mortality.
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“Together with other experiments from recent times, these findings suggest an important role of sleep for immune defense (47, 79).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [79]
In the citing paper
“In addition, higher inflammatory activity, measured by plasma or serum interleukin (IL)-6, tumour necrosis factor-α (TNF-α) and C-reactive protein (CRP), has also been associated with shorter survival (Baune et al. 2011; Bruunsgaard et al. 2003; Giovannini et al. 2011).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Bruunsgaard et al. 2003
In the citing paper
“Cross-sectional studies demonstrate an association between physical inactivity and low-grade systemic inflammation in healthy subjects [71–75], in elderly people [76, 77], and in patients with intermittent claudication [78].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [76]
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The anti-inflammatory effect of exercise
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Self-citationThe Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“Inflammatory dysregulation has been suggested as a potential mechanism linking sleep duration and mortality, given that inflammatory markers appear to be independent predictors of mortality risk in older populations (78, 567).”
BackgroundAge and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
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Molecular inflammation: Underpinnings of aging and age-related diseases
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Metadata
- Authors
- BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., & PEDERSEN, B. K.
- Affiliations
- Department of Infectious Diseases, H:S, Rigshospitalet, University of Copenhagen
- Glostrup Hospital (DK)
- Center for Preventive Medicine, Glostrup University Hospital
- Bispebjerg Hospital (DK)
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-24
- Volume
- 132
- Issue
- 1
- Pages
- 24-31
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- PMC
- PMC1808682
- OpenAlex
- W1983973676
- Cited by
- 300
- References
- 45
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 18 · 2022: 27 · 2021: 15 · 2020: 20 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 14 · 2015: 9 · 2014: 8 · 2013: 13 · 2012: 17
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical & Experimental Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- TNF-α, interleukin-6, all-cause mortality, low-grade inflammation, aging, older adults, serum cytokines, sex differences, prognostic factors, age-related diseases
- MeSH terms
- Aged, Aged, 80 and over, Cause of Death, Death, Female, Humans, Male, Predictive Value of Tests, Prospective Studies, Regression Analysis, Risk Factors, Sex Factors, Tumor Necrosis Factor-alpha, Interleukin-6, Comorbidity, Survival Rate
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