Systemic inflammation (Interleukin 6) predicts all-cause mortality in men: results from a 9-year follow-up of the MEMO Study
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This study aimed to investigate the association of biomarkers among circulating pro-inflammatory cytokines with all-cause mortality in elderly community dwellings of the MEMO study, Germany. All-cause mortality (cancer, cardiovascular diseases (CVD), and other causes of death) was assessed in a general population sample (N = 385) of the elderly (age 65-83 years) 9 years after baseline assessment in 1998. As markers of inflammation, a variety of cytokines (IL-1beta, IL-4sR, IL-6, IL-8, IL-10, IL-12, TNF-alpha) were assessed in serum. Cox proportional Hazard model was used to estimate the association of cytokines with all-cause mortality over 9 years. In total, 110 deaths had occurred during follow-up (cancer N = 36; CVD N = 56; other = 18). Deaths were more frequent in male (N = 76, 37.4%) as compared to females (N = 40, 21.9%; p = 0.001). Among individual cytokines, IL-1 beta, IL-6, IL-8, IL-10, and TNF-alpha were associated with all-cause mortality, of which IL-6, IL-8, and IL-10 remained significant after adjusting for confounders. When the upper tertiles of these cytokines were compared to the lower tertiles, only IL-6 was consistently related to all-cause mortality independently of the level of adjustment and showing a dose-response relationship between IL-6 tertiles and risk of death. This effect originated in the male population. The study shows that IL-6 is a powerful predictor of all-cause mortality in male elderly community dwellings. Higher levels of IL-6 may reflect a chronic low-level systemic inflammation prospectively increasing the risk of death in the elderly.
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Higher inflammatory activity, measured by plasma or serum interleukin (IL)-6, tumour necrosis factor-α (TNF-α) and C-reactive protein (CRP), has also been associated with shorter survival.
“In addition, higher inflammatory activity, measured by plasma or serum interleukin (IL)-6, tumour necrosis factor-α (TNF-α) and C-reactive protein (CRP), has also been associated with shorter survival (Baune et al. 2011; Bruunsgaard et al. 2003; Giovannini et al. 2011).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Baune et al. 2011
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- Authors
- Baune, B. T., Rothermundt, M., Ladwig, K. H., Meisinger, C., & Berger, K.
- Affiliations
- James Cook University (AU)
- University of Münster (DE)
- Helmholtz Munich (DE)
- Corresponding author
- Baune, Bernhard T.
- Venue
- AGE
- Published
- 2010-07-09
- Volume
- 33
- Issue
- 2
- Pages
- 209-217
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC3127470
- OpenAlex
- W2089874034
- Cited by
- 95
- References
- 37
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 14 · 2013: 6 · 2012: 7
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AGE (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-6, systemic inflammation, all-cause mortality, inflammatory cytokines, older men, community-dwelling older adults, interleukin-8, IL-10, TNF-α, IL-1β, sex differences, mortality prediction
- MeSH terms
- Aged, Aged, 80 and over, Cardiovascular Diseases, Cause of Death, Female, Humans, Inflammation, Male, Mortality, Neoplasms, Biomarkers, Interleukin-6, Proportional Hazards Models, Cytokines, Interleukin-8, Interleukin-10
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