Interleukin‐6, C‐Reactive Protein, and Tumor Necrosis Factor‐Alpha as Predictors of Mortality in Frail, Community‐Living Elderly Individuals

C-reactive protein: a critical update

Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 4,576 · see citing works

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354 · see citing works

MDS Cognitive Performance Scale(C)

Morris, J. N., Fries, B. E., Mehr, D. R., Hawes, C., Phillips, C., Mor, V., & Lipsitz, L. A. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.4.m174 · Cited by 1,852 · see citing works

Production of C-reactive protein and risk of coronary events in stable and unstable angina

Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511 · see citing works

Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly

Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J. B., & Mann, D. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00589-7 · Cited by 1,211 · see citing works

Inflammatory markers and loss of muscle mass (sarcopenia) and strength

Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.049 · Cited by 1,047 · see citing works

Serum IL‐6 Level and the Development of Disability in Older Persons

Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809 · see citing works

Subsystems Contributing to the Decline in Ability to Walk: Bridging the Gap Between Epidemiology and Geriatric Practice in the InCHIANTI Study

Ferrucci, L., Bandinelli, S., Benvenuti, E., Iorio, A. D., Macchi, C., Harris, T. B., & Guralnik, J. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03873.x · Cited by 797 · see citing works

Age-related inflammatory cytokines and disease

Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608 · see citing works

Comprehensive Clinical Assessment in Community Setting: Applicability of the MDS‐HC

Morris, J. N., Fries, B. E., Steel, K., Ikegami, N., Bernabei, R., Carpenter, G., Gilgen, R., Hirdes, J. P., & Topinková, E. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb02975.x · Cited by 566 · see citing works

Minimum Data Set for Home Care

Landi, F., Tua, E., Onder, G., Carrara, B., Sgadari, A., Rinaldi, C., Gambassi, G., Lattanzio, F., & Bernabei, R. (2000) · Medical Care · doi:10.1097/00005650-200012000-00005 · Cited by 491 · see citing works

A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians

Brüünsgaard, H., Andersen‐Ranberg, K., Jeune, B., Pedersen, B. K., Skinhøj, P., & Pedersen, B. K. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.7.m357 · Cited by 458 · see citing works

Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women

Volpato, S., Guralnik, J. M., Ferrucci, L., Balfour, J. L., Chaves, P. H. M., Fried, L. P., & Harris, T. B. (2001) · Circulation · doi:10.1161/01.cir.103.7.947 · Cited by 434 · see citing works

Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study

Roubenoff, R., Parise, H., Payette, H., Abad, L. W., D’Agostino, R. B., Jacques, P. F., Wilson, P. W. F., Dinarello, C. A., & Harris, T. B. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.05.001 · Cited by 397 · see citing works

Elevated levels of tumor necrosis factor alpha and mortality in centenarians

Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J. V. B., Pedersen, B. K., & Jeune, B. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00329-2 · Cited by 325 · see citing works

Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?

Vallance, P. J., Collier, J., & Bhagat, K. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09424-x · Cited by 308 · see citing works

Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons

Barbieri, M., Ferrucci, L., Ragno, E., Corsi, A., Bandinelli, S., Bonafè, M., Olivieri, F., Giovagnetti, S., Franceschi, C., Guralnik, J. M., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00319.2002 · Cited by 303 · see citing works

Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons

Reuben, D. B., Cheh, A. I., Harris, T. B., Ferrucci, L., Rowe, J. W., Tracy, R. P., & Seeman, T. E. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50157.x · Cited by 296 · see citing works

Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 −1082 promoter SNP and its interaction with TNF-α −308 promoter SNP

Lio, D., Scola, L., Crivello, A., Colonna-Romano, G., Candore, G., Bonafé, M., Cavallone, L., Marchegiani, F., Olivieri, F., Franceschi, C., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.4.296 · Cited by 181 · see citing works

C‐reactive protein levels as a direct indicator of interleukin‐6 levels in humans in vivo

Bataille, R., & Klein, B. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350824 · Cited by 164 · see citing works

Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Finnish Leukemia Group

Pelliniemi, T., Irjala, K. M. A., Mattila, K. J., Pulkki, K. J., Rajamäki, A., Tienhaara, A., Laakso, M., & Lahtinen, R. (1995) · Blood · doi:10.1182/blood.v85.3.765.bloodjournal853765 · Cited by 133 · see citing works

Prediction of Mortality Risk in the Elderly

Störk, S., Feelders, R. A., van den Beld, A. W., Steyerberg, E. W., Savelkoul, H. F. J., Lamberts, S. W. J., Grobbee, D. E., & Bots, M. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.062 · Cited by 132 · see citing works

Procoagulant Activity of Endothelial Cells after Infection with Respiratory Viruses

Bouwman, J. J. M., Bouter, K. P., Diepersloot, R. J. A., de Groot, P. G., Erkelens, D. W., & Visseren, F. L. J. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614014 · Cited by 130 · see citing works

Diverse Effect of Inflammatory Markers on Insulin Resistance and Insulin‐Resistance Syndrome in the Elderly

Abbatecola, A. M., Ferrucci, L., Grella, R., Bandinelli, S., Bonafè, M., Barbieri, M., Corsi, A. M., Lauretani, F., Franceschi, C., & Paolisso, G. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52112.x · Cited by 116 · see citing works

Interleukin-1 Receptor Antagonist, Interleukin-6, and C-Reactive Protein as Predictors of Mortality in Nonagenarians: The Vitality 90+ Study

Jylhä, M. K., Paavilainen, P., Lehtimäki, T. J., Goebeler, S., Karhunen, P. J., Hervonen, A., & Hurme, M. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.9.1016 · Cited by 102 · see citing works

Reactive oxygen intermediates as second messengers of a general pathogen response.

Pa, B., Ra, R., & Hl, P. (1996) · PubMed · Cited by 95 · see citing works

Neuroinflammation and the genetics of Alzheimer’s disease: The search for a pro-inflammatory phenotype

Franceschi, C., Valensin, S., Lescai, F., Olivieri, F., Licastro, F., Grimaldi, L. M. E., Monti, D., BENEDICTIS, G. D., & Bonafè, M. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351475 · Cited by 87 · see citing works

The ilSIRENTE study: a prospective cohort study on persons aged 80 years and older living in a mountain community of Central Italy

Landi, F., Russo, A., Cesari, M., Barillaro, C., Onder, G., Zamboni, V., Santis, A. D., Pahor, M., Ferrucci, L., & Bernabei, R. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03327416 · Cited by 65 · see citing works

Infection/Inflammation and Infarction

Swischuk, L. E., & Jadhav, S. P. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7747-1_2 · Cited by 1 · see citing works

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works

Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan

Campbell, J. P., & Turner, J. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00648 · Cited by 692 · see citing works

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

Tenorio, A. R., Zheng, Y., Bosch, R. J., Krishnan, S., Rodriguez, B. A., Hunt, P. W., Plants, J., Seth, A., Wilson, C. C., Deeks, S. G., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu254 · Cited by 551 · see citing works

Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity

Minciullo, P. L., Catalano, A., Mandraffino, G., Casciaro, M., Crucitti, A., Maltese, G., Morabito, N., Lasco, A., Gangemi, S., & Basile, G. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0377-3 · Cited by 433 · see citing works

Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

Puzianowska-Kuźnicka, M., Owczarz, M., Wieczorowska-Tobis, K., Nadrowski, P., Chudek, J., Slusarczyk, P., Skalska, A., Jonas, M., Franek, E., & Mossakowska, M. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0076-x · Cited by 445 · see citing works

The aging gut microbiome and its impact on host immunity

Bosco, N., & Noti, M. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00126-8 · Cited by 418 · see citing works

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., et al. (2018) · GeroScience · doi:10.1007/s11357-018-0042-y · Cited by 359 · see citing works

The impact of ageing on monocytes and macrophages

De Maeyer, R. P. H., & Chambers, E. S. (2021) · Immunology Letters · doi:10.1016/j.imlet.2020.12.003 · Cited by 275 · see citing works

Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation

Rasmussen, L. J. H., Petersen, J. E. V., & Eugen‐Olsen, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.780641 · Cited by 256 · see citing works

Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

Pan, F., Zhang, L., Li, M., Hu, Y., Zeng, B., Yuan, H., Zhao, L., & Zhang, C. (2018) · Microbiome · doi:10.1186/s40168-018-0440-5 · Cited by 237 · see citing works

Impact of comorbidity and frailty on prognosis in colorectal cancer patients: A systematic review and meta-analysis

Boakye, D., Rillmann, B., Walter, V., Jansen, L., Hoffmeister, M., & Brenner, H. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.02.003 · Cited by 225 · see citing works

miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases

Olivieri, F., Prattichizzo, F., Giuliani, A., Matacchione, G., Rippo, M. R., Sabbatinelli, J., & Bonafè, M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101374 · Cited by 221 · see citing works

Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

Pereira, B. I., Xu, X., & Akbar, A. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583019 · Cited by 182 · see citing works

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Puchta, A., Naidoo, A., Verschoor, C. P., Loukov, D., Thevaranjan, N., Mandur, T. S., Nguyen, P.-S., Jordana, M., Loeb, M. B., Xing, Z., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005368 · Cited by 173 · see citing works

The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence

Bauer, M. E., & la Fuente, M. D. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.01.001 · Cited by 164 · see citing works

Inflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges

Wyczałkowska-Tomasik, A., Czarkowska‐Pączek, B., Zielenkiewicz, M., & Pączek, L. (2015) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0357-7 · Cited by 165 · see citing works

Innate immune responses in the ageing lung.

Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156 · see citing works

Effects of Horticultural Therapy on Asian Older Adults: A Randomized Controlled Trial

Ng, T. K. S., Sia, A., Ng, M. K., Tan, C. T. Y., Chan, H. Y., Tan, C. H., Rawtaer, I., Feng, L., Mahendran, R., Larbi, A., et al. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081705 · Cited by 156 · see citing works

Association of Lymphopenia With Risk of Mortality Among Adults in the US General Population

Zidar, D. A., Al-Kindi, S. G., Liu, Y., Krieger, N. I., Perzynski, A. T., Osnard, M., Nmai, C., Anthony, D. D., Lederman, M. M., Freeman, M. L., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.16526 · Cited by 127 · see citing works

Altered immune system in frailty: Genetics and diet may influence inflammation

Pansarasa, O., Pistono, C., Davin, A., Bordoni, M., Mimmi, M. C., Guaita, A., & Cereda, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100935 · Cited by 121 · see citing works

C-Reactive Protein and Frailty in the Elderly: A Literature Review

Velissaris, D., Pantzaris, N. D., Koniari, I. C., Koutsogiannis, N., Karamouzos, V., Kotroni, I., Skroumpelou, A., & Ellul, J. (2017) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2959w · Cited by 120 · see citing works

The Mediterranean Diet Slows Down the Progression of Aging and Helps to Prevent the Onset of Frailty: A Narrative Review

Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2019) · Nutrients · doi:10.3390/nu12010035 · Cited by 120 · see citing works

The Effect of Physiological Stimuli on Sarcopenia; Impact of Notch and Wnt Signaling on Impaired Aged Skeletal Muscle Repair

Arthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 119 · see citing works

Dental Infection and Resistance—Global Health Consequences

Haque, M., Sartelli, M., & Haque, S. Z. (2019) · Dentistry Journal · doi:10.3390/dj7010022 · Cited by 121 · see citing works

Is immunosenescence influenced by our lifetime “dose” of exercise?

Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works

Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammatory Mediators but Not With Lymphocyte Subpopulations

Marcos-Pérez, D., Sánchez-Flores, M., Maseda, A., Lorenzo‐López, L., Millán-Calentí, J. C., Gostner, J. M., Fuchs, D., Pásaro, E., Laffón, B., & Valdiglesias, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01056 · Cited by 109 · see citing works

Intestinal alkaline phosphatase targets the gut barrier to prevent aging

Kühn, F., Adiliaghdam, F., Cavallaro, P. M., Hamarneh, S. R., Tsurumi, A., Hoda, R. S., Munoz, A. R., Dhole, Y., Ramirez, J. M., Liu, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134049 · Cited by 107 · see citing works

Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency

Alberro, A., Iribarren-López, A., Sáenz-Cuesta, M., Matheu, A., Vergara, I., & Otaegui, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-83991-7 · Cited by 102 · see citing works

Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins

Ticinesi, A., Meschi, T., Lauretani, F., Felis, G., Franchi, F., Pedrolli, C., Barichella, M., Benati, G., di Nuzzo, S., Ceda, G., et al. (2016) · Nutrients · doi:10.3390/nu8040186 · Cited by 101 · see citing works

Age and frailty as risk factors for the development of osteoarthritis

O’Brien, M. S., & McDougall, J. J. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.003 · Cited by 97 · see citing works

Inflamm‐aging of the stem cell niche: Breast cancer as a paradigmatic example

Bonafè, M., Storci, G., & Franceschi, C. (2011) · BioEssays · doi:10.1002/bies.201100104 · Cited by 93 · see citing works

Can blocking inflammation enhance immunity during aging?

Chambers, E. S., & Akbar, A. N. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.016 · Cited by 92 · see citing works

Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis

Knoop, V., Cloots, B., Costenoble, A., Debain, A., Azzopardi, R. V., Vermeiren, S., Jansen, B., Scafoglieri, A., Bautmans, I., Bautmans, I., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101261 · Cited by 89 · see citing works

Systemic inflammation and biological aging in the Health and Retirement Study

Meier, H. C. S., Mitchell, C. M., Karadimas, T., & Faul, J. D. (2023) · GeroScience · doi:10.1007/s11357-023-00880-9 · Cited by 88 · see citing works

Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing

Coperchini, F., Greco, A., Teliti, M., Croce, L., Chytiris, S., Magri, F., Gaetano, C., & Rotondi, M. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.08.004 · Cited by 87 · see citing works

Frailty in Rheumatic Diseases

Motta, F., Sica, A., & Selmi, C. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576134 · Cited by 90 · see citing works

The hormetic and hermetic role of IL-6

Forcina, L., Franceschi, C., & Musarò, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101697 · Cited by 85 · see citing works

Evaluating the physiological reserves of older patients with cancer: The value of potential biomarkers of aging?

Pallis, A. G., Hatse, S., Brouwers, B. A. H., Pawelec, G., Falandry, C., Wedding, U., Lago, L. D., Repetto, L., Ring, A. E., & Wildiers, H. P. M. W. (2013) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2013.09.001 · Cited by 84 · see citing works

Mobility and cognition are associated with wellbeing and health related quality of life among older adults: a cross-sectional analysis of the Vancouver Falls Prevention Cohort

Davis, J. C., Bryan, S., LI, L. C., Best, J. R., Hsu, C. L., Gomez, C., Vertes, K. A., & Liu-Ambrose, T. Y. L. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0076-2 · Cited by 82 · see citing works

Population-based RNA profiling in Add Health finds social disparities in inflammatory and antiviral gene regulation to emerge by young adulthood

Cole, S. W., Shanahan, M. J., Gaydosh, L. M., & Harris, K. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821367117 · Cited by 79 · see citing works

A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?

Hohman, L. S., & Osborne, L. C. (2022) · Aging Cell · doi:10.1111/acel.13700 · Cited by 83 · see citing works

Circulating interleukin-6 levels and cardiovascular and all-cause mortality in the elderly population: A meta-analysis

Li, H., Liu, W., & Xie, J. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.08.007 · Cited by 76 · see citing works

C-reactive protein, bone loss, fracture, and mortality in elderly women: a longitudinal study in the OPRA cohort

Berglundh, S., Malmgren, L., Luthman, H., McGuigan, F. E., & Åkesson, K. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2951-7 · Cited by 73 · see citing works

Zinc Gluconate-Loaded Chitosan Nanoparticles Reduce Severity of Collagen-Induced Arthritis in Wistar Rats

Ansari, M. M., Ahmad, A., Mishra, R. K., Raza, S. S., & Khan, R. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00427 · Cited by 73 · see citing works

Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing

Kapétanovic, R., Bokil, N. J., & Sweet, M. J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.005 · Cited by 69 · see citing works

Biomarkers of the ageing immune system and their association with frailty – A systematic review

Hoi, E. T. V., de Glas, N. A., Portielje, J. E. A., van Heemst, D., van den Bos, F., Jochems, S. P., & Mooijaart, S. P. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112163 · Cited by 72 · see citing works

Effects of 8-week combined training on body composition, isokinetic strength, and cardiovascular disease risk factors in older women

Lee, J. S., Kim, C. G., Seo, T. B., Kim, H. G., & Yoon, S. J. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0257-4 · Cited by 69 · see citing works

Frailty assessment: from clinical to radiological tools

Bentov, I., Kaplan, S. J., Pham, T. N., & Reed, M. J. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.03.034 · Cited by 69 · see citing works

Strength training reduces circulating interleukin-6 but not brain-derived neurotrophic factor in community-dwelling elderly individuals

Forti, L. N., Njemini, R., Beyer, I., Eelbode, E., Meeusen, R., Mets, T., & Bautmans, I. (2014) · AGE · doi:10.1007/s11357-014-9704-6 · Cited by 67 · see citing works

Aminocellulose-grafted-polycaprolactone coated gelatin nanoparticles alleviate inflammation in rheumatoid arthritis: A combinational therapeutic approach

Ansari, M. M., Ahmad, A., Kumar, A., Alam, P., Khan, T. H., Jayamurugan, G., Raza, S. S., & Khan, R. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117600 · Cited by 68 · see citing works

Different aspects of frailty and COVID-19: points to consider in the current pandemic and future ones

Hussien, H., Nastasa, A., Apetrii, M., Nistor, I., Petrović, M., & Covic, A. C. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02316-5 · Cited by 67 · see citing works

Getting under the skin: Social isolation and biological markers in the National Health and Aging Trends Study

Cudjoe, T., Selvakumar, S., Chung, S.-E., Latkin, C. A., Roth, D. L., Thorpe, R. J., & Boyd, C. M. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17518 · Cited by 71 · see citing works

Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies?

Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 65 · see citing works

Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation

Ligon, M. M., Wang, C., DeJong, E. N., Schulz, C., Bowdish, D. M. E., & Mysorekar, I. U. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0290-x · Cited by 64 · see citing works

Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice

Han, C. J., Ding, D., Lopez, M.-C., Manohar, S., Zhang, Y., Kim, M., Park, H., White, K., Kim, Y. H., Linser, P. J., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2493-16.2016 · Cited by 64 · see citing works

Wound healing: insights into autoimmunity, ageing, and cancer ecosystems through inflammation and IL-6 modulation

Lacina, L., Kolář, M., Pfeiferová, L., Gál, P., & Smetana, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403570 · Cited by 65 · see citing works

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

Smorenberg, A., Peters, E. J. G., van Daele, P. L. A., Nossent, E. J., & Muller, M. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.11.024 · Cited by 61 · see citing works

Efficacy of Cooling Centers for Mitigating Physiological Strain in Older Adults during Daylong Heat Exposure: A Laboratory-Based Heat Wave Simulation

Meade, R. D., Notley, S. R., Akerman, A. P., McCormick, J. J., King, K. E., Sigal, R. J., & Kenny, G. P. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11651 · Cited by 60 · see citing works

Biological ageing and frailty markers in breast cancer patients

Brouwers, B. A. H., Dalmasso, B., Hatse, S., Laenen, A., Kenis, C., Swerts, E., Neven, P., Smeets, A., Schöffski, P., & Wildiers, H. P. M. W. (2015) · Aging · doi:10.18632/aging.100745 · Cited by 59 · see citing works

State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions

Lavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/cphy.c200033 · Cited by 74 · see citing works

Soy Food Intake and Circulating Levels of Inflammatory Markers in Chinese Women

Wu, S., Shu, X. O., Chow, W., Xiang, Y., Zhang, X., Li, H., Cai, Q., Ji, B., Cai, H., Rothman, N., et al. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.04.001 · Cited by 56 · see citing works

Age-related changes in the immune system and challenges for the development of age-specific vaccines

Doherty, M. T., Weinberger, B., Didierlaurent, A. M., & Lambert, P. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2477300 · Cited by 63 · see citing works

Osteosarcopenic obesity and its components—osteoporosis, sarcopenia, and obesity—are associated with blood cell count-derived inflammation indices in older Chinese people

Nie, Y., Yan, Z., Yin, H. Y., Shan, L., Wang, J., & Wu, Q. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03225-x · Cited by 52 · see citing works

Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis

McFarland, K. N., & Chakrabarty, P. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01179-3 · Cited by 48 · see citing works

Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: A regression and CART approach in the BELFRAIL study

Adriaensen, W. J., Matheï, C., Vaes, B., Pottelbergh, G. V., Wallemacq, P. E., & Degryse, J. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.06.005 · Cited by 47 · see citing works

Poor Trabecular Microarchitecture at the Distal Radius in Older Men with Increased Concentration of High-Sensitivity C-Reactive Protein—The Strambo Study

Rolland, T., Boutroy, S., Vilayphiou, N., Blaizot, S., Chapurlat, R. D., & Szulc, P. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9598-1 · Cited by 47 · see citing works

A Comprehensive Analysis of Cytokine Network in Centenarians

Pinti, M., Gibellini, L., Tartaro, D. L., Biasi, S. D., Nasi, M., Borella, R., Fidanza, L., Neroni, A., Troiano, L., Franceschi, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032719 · Cited by 48 · see citing works

Genetic background, epigenetic factors and dietary interventions which influence human longevity

Costa, D., Scognamiglio, M., Fiorito, C., Benincasa, G., & Claudio Napoli, A. (2019) · Biogerontology · doi:10.1007/s10522-019-09824-3 · Cited by 45 · see citing works

The effects of weight cycling on lifespan in male C57BL/6J mice

List, E. O., Berryman, D. E., Wright‐Piekarski, J., Jara, A., Funk, K. M., & Kopchick, J. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.203 · Cited by 44 · see citing works

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

Wawrzyniak-Gramacka, E., Hertmanowska, N., Tylutka, A., Morawin, B., Wacka, E., Gutowicz, M., & Zembroń-Łacny, A. (2021) · Nutrients · doi:10.3390/nu13113696 · Cited by 44 · see citing works

Associations between Cognition and Hand Function in Older People Diagnosed with Mild Cognitive Impairment or Dementia

Hesseberg, K., Tangen, G. G., Pripp, A. H., & Bergland, A. (2020) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000510382 · Cited by 43 · see citing works

Are aging biomarkers clinically relevant in oncogeriatrics?

Falandry, C., Gilson, É., & Rudolph, K. L. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.08.004 · Cited by 39 · see citing works

Insulin resistance and systemic inflammation, but not metabolic syndrome phenotype, predict 9 years mortality in older adults

Zuliani, G., Morieri, M. L., Volpato, S., Maggio, M. G., Cherubini, A., Francesconi, D., Bandinelli, S., Paolisso, G., Guralnik, J. M., & Ferrucci, L. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.959 · Cited by 36 · see citing works

Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial

Wieczorek, M., Schwarz, F., Sadlon, A., Abderhalden, L. A., Molino, C. D. G. R. C., Spahn, D. R., Schaer, D. J., Orav, E. J., Egli, A., & Bischoff-Ferrari, H. A. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01955-3 · Cited by 36 · see citing works

Age-Related Differences in Biomarkers of Acute Inflammation During Hospitalization for Sepsis

Ginde, A. A., Blatchford, P. J., Trzeciak, S., Hollander, J. E., Birkhahn, R., Otero, R., Osborn, T. M., Moretti, E., Nguyen, H. T., Gunnerson, K. J., et al. (2014) · Shock · doi:10.1097/shk.0000000000000182 · Cited by 35 · see citing works

Association of serum glycine levels with metabolic syndrome in an elderly Chinese population

Li, X., Sun, L., Zhang, W., Li, H., Wang, S., Mu, H., Zhou, Q., Zhang, Y., Tang, Y., Wang, Y., et al. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0325-4 · Cited by 35 · see citing works

Risk Factors for Frailty and Cardiovascular Diseases: Are They the Same?

Piotrowicz, K., & Gąsowski, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-33330-0_5 · Cited by 36 · see citing works

Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Uchio, R., Kawasaki, K., Okuda-Hanafusa, C., Saji, R., Muroyama, K., Murosaki, S., Yamamoto, Y., & Hirose, Y. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00748-8 · Cited by 34 · see citing works

Advances in Osteoimmunology: Pathophysiologic Concepts and Treatment Opportunities

Rauner, M., Sipos, W., Thiele, S., & Pietschmann, P. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000342426 · Cited by 34 · see citing works

Significance of serum immune markers in identification of global functional impairment in the oldest old: cross-sectional results from the BELFRAIL study

Adriaensen, W. J., Matheï, C., Pottelbergh, G. V., Vaes, B., Legrand, D., Wallemacq, P. E., & Degryse, J. (2013) · AGE · doi:10.1007/s11357-013-9558-3 · Cited by 33 · see citing works

Pathophysiology and emerging biomarkers of cardiovascular-renal-hepato-metabolic syndrome

Nzobokela, J., Muchaili, L., Mwambungu, A., Masenga, S. K., & Kirabo, A. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1661563 · Cited by 36 · see citing works

Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers

Extermann, M., Leeuwenburgh, C., Samiian, L., Sehovic, M., Xu, J., Cubitt, C. L., Jacobsen, P. B., Pahor, M., Grobmyer, S. R., & Manini, T. M. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.09.004 · Cited by 32 · see citing works

Gait and balance one year after stroke; relationships with lesion side, subtypes of cognitive impairment and neuroimaging findings—a longitudinal, cohort study

Ursin, M. H., Bergland, A., Fure, B., Thommessen, B., Hagberg, G., Øksengård, A. R., & Ihle‐Hansen, H. (2018) · Physiotherapy · doi:10.1016/j.physio.2018.07.007 · Cited by 31 · see citing works

Inflammation-related genes are associated with epigenetic aging in HIV

the HNRP Group, Sundermann, E. E., Hussain, M., Moore, D. J., Horvath, S., Lin, D. T. S., Kobor, M. S., & Levine, A. J. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00777-4 · Cited by 31 · see citing works

The prognostic value of high-sensitivity C-reactive protein and prealbumin for short-term mortality in acutely hospitalized multimorbid elderly patients: A prospective cohort study

Nouvenne, A., Ticinesi, A., Lauretani, F., Maggio, M. G., Lippi, G., Prati, B., Borghi, L., & Meschi, T. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0626-5 · Cited by 31 · see citing works

Elevated Systolic Blood Pressure in Male GH Transgenic Mice Is Age Dependent

Jara, A., Benner, C. M., Sim, D., Liu, X., List, E. O., Householder, L. A., Berryman, D. E., & Kopchick, J. J. (2014) · Endocrinology · doi:10.1210/en.2013-1899 · Cited by 30 · see citing works

A healthy lifestyle is a social lifestyle: The vital link between social connection and health outcomes

Proctor, A. S., Barth, A., & Holt‐Lunstad, J. (2023) · Lifestyle Medicine · doi:10.1002/lim2.91 · Cited by 29 · see citing works

Combined lowering of low grade systemic inflammation and insulin resistance in metabolic syndrome patients treated with Ginkgo biloba

Siegel, G., Ermilov, E. A., Knes, O., & Rodríguez, M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.023 · Cited by 29 · see citing works

Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis

Imbrechts, M., Avau, A., Vandenhaute, J., Malengier‐Devlies, B., Put, K., Mitera, T., Berghmans, N., Burton, O. T., Junius, S., Liston, A., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800468 · Cited by 28 · see citing works

An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly

Bell, M. R., & Kutzler, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114175 · Cited by 29 · see citing works

Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment

Pan, Y., & Ma, L. (2024) · Aging and Disease · doi:10.14336/ad.2024.0258 · Cited by 28 · see citing works

Aging and immunotherapies: New horizons for the golden ages

Hamilton, J. A. G., & Henry, C. J. (2020) · Aging and Cancer · doi:10.1002/aac2.12014 · Cited by 28 · see citing works

Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose

Lei, S., Zhang, Z., Xie, G., Zhao, C., Miao, Y., Chen, D., Zhang, G., Liu, H., Peng, C., Hou, Y., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104941 · Cited by 27 · see citing works

Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes

Sabbatinelli, J., Matacchione, G., Giuliani, A., Ramini, D., Rippo, M. R., Procopio, A. D., Bonafè, M., & Olivieri, F. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111667 · Cited by 27 · see citing works

Synchronizing our clocks as we age: the influence of the brain-gut-immune axis on the sleep-wake cycle across the lifespan

Sgro, M., Kodila, Z. N., Brady, R. D., Reichelt, A. C., Mychasiuk, R., & Yamakawa, G. R. (2021) · SLEEP · doi:10.1093/sleep/zsab268 · Cited by 25 · see citing works

Recent clinical trials with stem cells to slow or reverse normal aging processes

Garay, R. P. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1148926 · Cited by 26 · see citing works

Repeated measures of body mass index and C-reactive protein in relation to all-cause mortality and cardiovascular disease: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES)

O’Doherty, M. G., Jørgensen, T., Borglykke, A., Brenner, H., Schöttker, B., Wilsgaard, T., Siganos, G., Kavousi, M., Hughes, M., Müezzinler, A., et al. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9954-8 · Cited by 25 · see citing works

Redox Regulation in Aging Lungs and Therapeutic Implications of Antioxidants in COPD

Kiyokawa, H., Hoshino, Y., Sakaguchi, K., Muro, S., & Yodoi, J. (2021) · Antioxidants · doi:10.3390/antiox10091429 · Cited by 25 · see citing works

From reactive to proactive: Continuous protein monitoring for preventive health care

Donnelly, J. M., Neff, R. A., Sedlack, A. J. H., Juska, V. B., Ayala‐Cardona, L. F., Bass, J. T., McNally, E. M., Shah, S. J., Alshurafa, N. I., Kimchi, E. Y., et al. (2025) · Science · doi:10.1126/science.ady6497 · Cited by 25 · see citing works

C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults

Beleigoli, A. M. R., Boersma, E. H., Diniz, M. D. F. H. S., Vidigal, P. G., Lima‐Costa, M. F., & Ribeiro, A. L. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075809 · Cited by 24 · see citing works

Interleukin-1 Receptor Antagonist, Interleukin-6, and C-Reactive Protein as Predictors of Mortality in Nonagenarians: The Vitality 90+ Study

Jylhä, M. K., Paavilainen, P., Lehtimäki, T. J., Goebeler, S., Karhunen, P. J., Hervonen, A., & Hurme, M. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.9.1016 · Cited by 102 · see citing works

Three‐Year Change in Inflammatory Markers in Elderly People and Mortality: The Invecchiare in Chianti Study

Alley, D. E., Crimmins, E. M., Bandeen‐Roche, K., Guralnik, J. M., & Ferrucci, L. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01390.x · Cited by 61 · see citing works

Interleukin-1 Receptor Antagonist, Interleukin-6, and C-Reactive Protein as Predictors of Mortality in Nonagenarians: The Vitality 90þ Study

Paavilainen, P., Goebeler, S., Karhunen, P. J., Hervonen, A., & Hurme, M. (2014)

Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: A regression and CART approach in the BELFRAIL study

Adriaensen, W. J., Matheï, C., Vaes, B., Pottelbergh, G. V., Wallemacq, P. E., & Degryse, J. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.06.005 · Cited by 47 · see citing works

Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly

Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works