131I‐6β‐Iodomethylnorcholesterol scintigraphy: an assessment of its role in the investigation of adrenocortical incidentalomas
Abstract
OBJECTIVE: Most incidentally discovered adrenal tumours ('incidentaloma') are benign adrenocortical adenomas. It has been suggested that 131I-6 beta-iodomethylnorcholesterol (IMC) scan could specify the degree of functional autonomy of such adenomas depending on whether they prevent contralateral adrenal tracer uptake. Our purpose was to examine this hypothesis in a correlated scintigraphic and endocrine study. DESIGN: Prospective study evaluating the prevalence of unilateral IMC uptake (tumour uptake with no visualization of the contralateral adrenal gland) and bilateral uptake (uptake in both the tumoral and the contralateral adrenal glands) in patients with unilateral incidentaloma. Comparison of adrenocortical function and of IMC scan after dexamethasone (DXM) in the two scintigraphic groups thus defined. PATIENTS: Thirty-five patients with a unilateral mass highly suggestive of benign adrenocortical adenoma on CT scan. MEASUREMENTS: The IMC scan was performed in basal conditions (baseline scan) and after DXM (suppression scan). Adrenocortical function assessment included basal measurements of 11-deoxycortisol, 17 alpha-hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulphate (DHEAS), plasma cortisol and ACTH, urinary free cortisol (UFC), overnight and low-dose DXM suppression test, and CRH test. RESULTS: The baseline scan showed 16 patients (46%) with unilateral uptake (group A) and 19 (54%) with bilateral uptake (group B). Patients in group A exhibited lower ACTH values at 0800h (P = 0.05) and higher cortisol values after an overnight DXM suppression test (P = 0.02), than did patients in group B. In addition, 3 patients in group A failed the overnight and the low-dose DXM suppression tests. Adrenal masses were larger in group A than group B (P = 0.04) and an inverse correlation was found in the whole population between tumour size and ACTH value at 0800h (P = 0.05). On the suppression scan performed in 14 patients (7 in each group), patients in group A continued to exhibit unilateral tumour uptake and bilateral uptake was suppressed in 72% of patients in group B. An adrenal mass was removed in 3 patients of group A with confirmed benign adrenocortical adenomas. In the post-surgical period, the contralateral gland was again visualized in a baseline scan and the hormonal evaluation returned to the normal range. CONCLUSION: Unilateral 131I-6 beta-iodomethylnorcholesterol tumour uptake is a frequent feature in benign adrenocortical adenomas. Hormonal data and scintigraphic profiles obtained after dexamethasone, as well as hormonoscintigraphic changes observed after surgery, provide evidence that unilateral uptake is related to functioning adenomas with various degrees of autononomy and suggest that the 131I-6 beta-iodomethylnorcholesterol scan could be a valuable tool for screening 'subclinical' Cushing's adenomas.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The 1-mg dexamethasone suppression test is the most used test for diagnosing subclinical hypercortisolism.
“To date, the 1-mg DST is the most used test to diagnose SH, either alone (34 -36, 38, 44 -46) or in combination with other parameters (9, 18, 21, 32, 37, 39, 42, 49, 52-54, 56, 60, 61).”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [38]
Several studies and the French Society for Endocrinology have proposed a lower 1-mg dexamethasone suppression test cutoff to increase sensitivity.
“Several studies (19,21,32,34,38,39,44,46,49,53,60,61,67) and recently the French Society for Endocrinology (68), however, have proposed a lower cutoff to increase sensitivity.”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [38]
Determining ACTH levels after CRH does not add any advantage to screening for subclinical hypercortisolism.
“The determination of ACTH levels after CRH does not seem to add any advantage (1,23,34,35,37,38,46) to screening for SH.”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [38]
Cited by
Sorted by citations
The clinically inapparent adrenal mass: update in diagnosis and management
Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781 · see citing works
Prevalence and natural history of adrenal incidentalomas
Barzon, L., Sonino, N., Fallo, F., Palu, G., & Boscaro, M. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490273 · Cited by 642 · see citing works
“Ambrosi et al. 1995 (51) 32 2.5 55 2.7 12.5 0 0 3.13 0 78.1 Aso & Homma 1992 (16) 210 0.7 53 4.9 3.3 23.3 3.3 4.29 1.4 36.7 Bardet et al. 1996 (52) 46 NR NR 2.6 6.5 4.4 0 4.35 2.2 69.6 Barzon et al. 2002 (53) 284 1.5 56 3.6 11.3 5.9 2.1 8.80 2.8 64.8 Bastounis et al. 1997 (54) 86 1.5 61 4.1 3.5…”
InfluentialAME Position Statement on adrenal incidentaloma
Terzolo, M., Stigliano, A., Chiodini, I., Loli, P., Furlani, L., Arnaldi, G., Reimondo, G., Pia, A., Toscano, V., Zini, M., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-1147 · Cited by 519 · see citing works
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“A large number of clinical studies have investigated the characteristics of AIs (Table 3 (39, 40,42,46-84)).”
BackgroundCawood, T. J., Hunt, P. J., O'Shea, D., Cole, D., & Soule, S. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0234 · Cited by 300 · see citing works
Occult Cushing’s syndrome in type-2 diabetes
Catargi, B., Rigalleau, V., Poussin, A., Ronci-Chaix, N., Bex, V., Vergnot, V., Gin, H., Roger, P., & Tabarin, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030254 · Cited by 287 · see citing works
Subclinical Cushing’s syndrome
Reincke, M. (2000) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70115-8 · Cited by 285 · see citing works
Diagnosis and Treatment of Subclinical Hypercortisolism
Chiodini, I. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2722 · Cited by 279 · see citing works
“The determination of ACTH levels after CRH does not seem to add any advantage (1, 23, 34, 35, 37, 38, 46) to screening for SH.”
BackgroundRisk Factors and Long-Term Follow-Up of Adrenal Incidentalomas1
Barzon, L., Scaroni, C. M., Sonino, N., Fallo, F., Paoletta, A., & Boscaro, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5444 · Cited by 255 · see citing works
Subclinical Cushing’s syndrome in adrenal incidentalomas
Terzolo, M., Bovio, S., Reimondo, G., Pia, A., Osella, G., Borretta, G., & Angeli, A. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.008 · Cited by 179 · see citing works
Incidentally Discovered Adrenal Tumors: Endocrine and Scintigraphic Correlates1
Barzon, L., Scaroni, C. M., Sonino, N., Fallo, F., Gregianin, M., Macrì, C., & Boscaro, M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4501 · Cited by 184 · see citing works
Brunt, L. M., & Moley, J. F. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0029-0 · Cited by 137 · see citing works
Chidiac, R. M., & Aron, D. C. (1997) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70242-5 · Cited by 140 · see citing works
Exploration and management of adrenal incidentalomas.
Tabarin, A., Bardet, S., Bertherat, J. Y., Dupas, B., Chabre, O., Hamoir, E., Laurent, F., Tenenbaum, F., Cazalda, M., Lefèbvre, H., et al. (2008) · Annales d Endocrinologie · doi:10.1016/j.ando.2008.09.003 · Cited by 129 · see citing works
Self-citationEndogenous subclinical hypercortisolism: diagnostic uncertainties and clinical implications.
Tsagarakis, S., Vassiliadi, D., & Thalassinos, N. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344133 · Cited by 113 · see citing works
DIAGNOSIS AND MANAGEMENT OF ADRENAL INCIDENTALOMAS
Barzon, L., & Boscaro, M. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67888-3 · Cited by 111 · see citing works
Laparoscopic adrenalectomy—indications and technique
Lal, G., & Duh, Q. (2003) · Surgical Oncology · doi:10.1016/s0960-7404(03)00036-7 · Cited by 107 · see citing works
Biochemical screening for subclinical cortisol-secreting adenomas amongst adrenal incidentalomas.
Valli, N., Catargi, B., Ronci, N., Vergnot, V, Leccia, F., Ferriere, J., Chene, G., Grenier, N., Laurent, F., & Tabarin, A. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440401 · Cited by 83 · see citing works
MANAGEMENT APPROACHES TO ADRENAL INCIDENTALOMAS
Mantero, F., & Arnaldi, G. (2000) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70119-5 · Cited by 83 · see citing works
Subclinical Cushing's syndrome.
Terzolo, M., Reimondo, G., Bovio, S., & Angeli, A. (2004) · Pituitary · doi:10.1007/s11102-005-4024-6 · Cited by 80 · see citing works
Adrenal incidentaloma: a diagnostic challenge
Anagnostis, P. G., Karagiannis, A. I., Τζιόμαλος, Κ., Kakafika, A. I., Athyros, V. G., & Mikhailidis, D. P. (2009) · HORMONES · doi:10.14310/horm.2002.1233 · Cited by 79 · see citing works
Tsagarakis, S., Roboti, C., Kokkoris, P., Vasiliou, V., Alevizaki, C., & Thalassinos, N. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00509.x · Cited by 75 · see citing works
Reznik, Y., Lefebvre, H., Rohmer, V., Charbonnel, B., Tabarin, A., Rodien, P., Lecomte, P., Bardet, S., Coffin, C., & Mahoudeau, J. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02048.x · Cited by 71 · see citing works
“Such a scintigraphic profile is considered a valuable tool for the diagnosis of autonomously functioning adenomas (Bardet et al., 1996; Barzon et al., 1998; Valli et al., 2001) and a recent study showed that the lack of cortisol suppression following the 1 mg dexamethasone test correlates well with…”
MethodSubclinical Cushing's syndrome
Terzolo, M., Bovio, S., Pia, A. R., Osella, G., Borretta, G., Angeli, A., & Reimondo, G. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000800013 · Cited by 67 · see citing works
Tsagarakis, S., Kokkoris, P., Roboti, C., Malagari, C., Kaskarelis, J., Vlassopoulou, V., Alevizaki, C. C., & Thalassinos, N. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00464.x · Cited by 63 · see citing works
Subclinical Cushing’s syndrome
Leo, M. D., Cozzolino, A., Colao, A. A. L., & Pivonello, R. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.02.001 · Cited by 63 · see citing works
Arnaldi, G., Masini, A., Giacchetti, G., Taccaliti, A., Faloia, E., & Mantero, F. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000001000007 · Cited by 61 · see citing works
Fagour, C., Bardet, S., Rohmer, V., Arimone, Y., Lecomte, P., Valli, N., & Tabarin, A. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0299 · Cited by 58 · see citing works
Self-citationAdrenal incidentalomas — a continuing management dilemma
Nawar, R., & Aron, D. C. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.00951 · Cited by 56 · see citing works
Kandathil, A., Wong, K. K., Wale, D. J., Zatelli, M. C., Maffione, A. M., Gross, M. D., & Rubello, D. (2014) · Endocrine · doi:10.1007/s12020-014-0440-6 · Cited by 39 · see citing works
Endocrine incidentalomas—challenges imposed by incidentally discovered lesions
Vassiliadi, D. A., & Tsagarakis, S. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.92 · Cited by 37 · see citing works
Adrenal Cortical Imaging With I-131 NP-59 SPECT-CT
Wong, K. K., Komissarova, M., Avram, A. M., Fig, L. M., & Gross, M. D. (2010) · Clinical Nuclear Medicine · doi:10.1097/rlu.0b013e3181f4a16d · Cited by 36 · see citing works
“In patients with a suspected hormonally active adrenal mass, venous sampling or NP-59 imaging have been proved useful.(8,9) Adrenal cortical scintigraphy has been used to confirm and characterize hormonal hyperfunction of adrenal origin, either from a discrete mass or a process involving both adrenal glands.”
BackgroundRadiological evaluation of adrenal incidentalomas – Current methods and future prospects
McDermott, S., O’Connor, O. J., Cronin, C. G., & Blake, M. A. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.07.005 · Cited by 30 · see citing works
Pituitary, adrenal and thyroid incidentalomas
Turner, H. E., Moore, N. R., Byrne, J. V., & Wass, J. A. H. (1998) · Endocrine Related Cancer · doi:10.1677/erc.0.0050131 · Cited by 31 · see citing works
The clinical evaluation of silent adrenal masses
Ambrosi, B., Passini, E., Re, T., & Barbetta, L. (1997) · Journal of Endocrinological Investigation · doi:10.1007/bf03347983 · Cited by 23 · see citing works
Parathyroid incidentaloma discovered during thyroid ultrasound imaging
Pesenti, M., Frasoldati, A., Azzarito, C., et al. (1999) · Journal of Endocrinological Investigation · doi:10.1007/bf03343646 · Cited by 23 · see citing works
Bardet, S., Rohmer, V., de Casson, F. B., Coffin, C., Ronci, N., Sabatier, J., Lecomte, P., Audran, M., Henry-Amar, M., & Tabarin, A. (2002) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(02)00606-9 · Cited by 22 · see citing works
Self-citationAdrenal incidentalomas and glucocorticoid autonomy
Aron, D. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00522.x · Cited by 20 · see citing works
“Low DHEAS levels have also been found in several series, suggesting its use as a marker for adrenal adenoma (Osellat l., 1994; Bardet et al., 1996; Flecchiaet al., 1995).”
BackgroundStarker, L. F., Kunstman, J. W., & Carling, T. (2014) · Surgical Clinics of North America · doi:10.1016/j.suc.2014.02.008 · Cited by 21 · see citing works
Endocrine Scintigraphy with Hybrid SPECT/CT
Wong, K. K., Fig, L. M., Youssef, E., Ferretti, A., Rubello, D., & Gross, M. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1030 · Cited by 18 · see citing works
Katabami, T., Ishii, S., Obi, R., Asai, S., & Tanaka, Y. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0281 · Cited by 17 · see citing works
“Some authors performed ACS under dexamethasone suppression, and others calculated the average of the adrenal gland uptake on different days [18, 19].”
BackgroundRadiopharmaceuticals drug interactions: a critical review
Santos‐Oliveira, R., Smith, S. W., & Carneiro-Leão, A. M. D. A. (2008) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652008000400008 · Cited by 18 · see citing works
Subclinical Cushing’s Syndrome
Beuschlein, F., & Reincke, M. (2005) · Springer eBooks · doi:10.1007/3-540-26861-8_7 · Cited by 15 · see citing works
Donadio, F., Morelli, V., Salcuni, A. S., Eller-Vainicher, C., Carletto, M., Castellani, M., Dellavedova, L., Scillitani, A., Beck-Peccoz, P., & Chiodini, I. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346511 · Cited by 13 · see citing works
The impact of mild autonomous cortisol secretion and proposed interventions
Iriarte-Durán, M. B., Donato, S., Herrera-Martínez, A. D., Vega, A., Casinello, J. M. J., Marazuela, M., & Castro, M. A. (2025) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2025.2480704 · Cited by 9 · see citing works
“One of these consists of administering DXM 2 mg/day for 6 days (suppression scan) and Lugol’s solution starting 48 h prior to scan to avoid the accumulation of 131 I in the thyroid [47].”
Valeri, A., Bergamini, C., Manca, G., Mannelli, M., Presenti, L., Peri, A., Borrelli, A., & Tonelli, P. (2005) · Journal of Laparoendoscopic & Advanced Surgical Techniques · doi:10.1089/lap.2005.15.451 · Cited by 9 · see citing works
Tabarin, A., Bardet, S., Bertherat, J. Y., Chabre, O., Dupas, B., Hamoir, E., Laurent, F., Tenenbaum, F., Cazalda, M., Rohmer, V., et al. (2008) · Annales d Endocrinologie · doi:10.1016/j.ando.2008.09.002 · Cited by 7 · see citing works
“La fixation exclusive du traceur ur l’IS est associée en moyenne à un taux d’ACTH plus bas et es valeurs de cortisolémies après freinage minute plus élevées u’une fixation bilatérale asymétrique [65,66].”
BackgroundSelf-citationDIAGNOSIS AND MANAGEMENT OF ADRENAL INCIDENTALOMAS
Barzon, L., & Boscaro, M. (2000) · The Journal of Urology · doi:10.1097/00005392-200002000-00003 · Cited by 6 · see citing works
Adrenal Causes of Hypercortisolism
Cavagnini, F., & Giraldi, F. P. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00102-7 · Cited by 5 · see citing works
Nakajo, M., Jinguji, M., Tani, A., et al. (2020) · European Journal of Radiology · doi:10.1016/j.ejrad.2020.109397 · Cited by 4 · see citing works
Gross, M. D., KOROBKIN, M. T., Hussain, H. K., Cho, K. J., & Chuong, B. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00105-2 · Cited by 3 · see citing works
Tumores suprarrenales clínicamente asintomáticos (incidentalomas suprarrenales)
de Diego, J. S. (2001) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(01)74773-0 · Cited by 3 · see citing works
Terzolo, M., Osella, G., Alı̀, A., & Angeli, A. (2000) · Endocrine updates · doi:10.1007/978-1-4615-4341-1_10 · Cited by 4 · see citing works
Aron, D. C., & Kievit, J. (2003) · CRC Press eBooks · doi:10.1201/9780203912997.ch35 · Cited by 3 · see citing works
van Heerden, J. A. (1998) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(98)00066-0 · Cited by 3 · see citing works
Conduite à tenir face à un incidentalome surrénalien associé à une hypertension artérielle
Mathonnet, M. (2005) · Annales de Chirurgie · doi:10.1016/j.anchir.2005.03.003 · Cited by 2 · see citing works
Mild autonomous cortisol secretion: Diagnosis
Pinto, L., & Donato, S. (2026) · Vitamins and hormones · doi:10.1016/bs.vh.2026.02.005 · Cited by 1 · see citing works
Estudios de imagen funcional de la corteza adrenal
Prado-Wohlwend, S. (2020) · Revista Española de Medicina Nuclear e Imagen Molecular · doi:10.1016/j.remn.2020.08.010 · Cited by 1 · see citing works
Hindle, E., Calzada-Nocaudie, M., Keller, I., & Askienazy, S. (2008) · Springer eBooks · doi:10.1007/978-3-540-28026-2_14 · Cited by 1 · see citing works
Functional imaging studies of the adrenal cortex
Prado-Wohlwend, S. (2020) · Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) · doi:10.1016/j.remnie.2020.10.006 · Cited by 1 · see citing works
Síndrome de Cushing subclínico
Salvador, J., gÓmez, F., & Santos, E. (2004) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(04)74618-5 · Cited by 1 · see citing works
Marina, S. R., Sánchez-Covisa, M. A., Vicente, A. M. A. G., García, V. M. P., Solís, S. R., Romera, M. C., & Castrejón, Á. S. (2004) · Revista Española de Medicina Nuclear · doi:10.1016/s0212-6982(04)72277-6 · Cited by 1 · see citing works
A propósito de un caso de embolismo aéreo en cirugía de la glándula suprarrenal
Villarroya, B. I., Torres, A. B., Gomez, R., et al. (2000) · Anestesia Analgesia Reanimación
Radiopharmaceutical Drug Interactions Interacciones Medicamentosas con Radiofarmacéuticos
Santos‐Oliveira, R. (2008)
Wong, K. K., Francis, I. R., Hussain, H. K., Cho, K. J., & Gross, M. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00106-2
(2000) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456320003700420
Nunes, M.-L., & Tabarin, A. (2011) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(11)53091-4
Adrenal insidentaloma’lı hastalarda klinik, biyokimyasal ve radyolojik retrospektif analiz
Eser, Z. E., Gen, R., Eser, K., Sezer, K., & Akbay, E. (2022) · Mersin üniversitesi sağlık bilimleri dergisi/Mersin üniversitesi sağlık bilimleri dergisi · doi:10.26559/mersinsbd.1109724
Eser, Z. E., Gen, R., Eser, K., Sezer, K., & Akbay, E. (2024) · Proceedings of Anticancer Research · doi:10.26689/par.v8i1.6105
Computed Tomography/Magnetic Resonance Imaging of Adrenocortical Carcinoma
KOROBKIN, M. T., Avram, A. M., & Hussain, H. K. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_6
“The more widespread application of high-resolution anatomic imaging to screen the abdomen for diseases or to stage diseases unrelated to the adrenal has identified a growing number of unexpected adrenal masses or “incidentalomas” [5–8].”
BackgroundIncidental Adrenal Mass with Suspicious Features
Lal, G., Lee, J. A., Duh, Q., et al. (2008) · Springer eBooks · doi:10.1007/978-0-387-76671-3_36
- Authors
- Bardet, S., Rohmer, V., Murat, A., Guillemot, C., Maréchaud, R., Chupin, M., Lecomte, P., Simon, D., Delemer, B., Schneebelli, S., Beutter, D., Jacquin, V., Peltier, P., Charbonnel, B., & the West France Study Group on Incidentalomas (WFSGI)
- Affiliations
- Centre François Baclesse (FR)
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1996-05
- Volume
- 44
- Issue
- 5
- Pages
- 587-596
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2008084707
- Cited by
- 71
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2020: 4 · 2016: 1 · 2015: 1 · 2014: 3 · 2012: 2
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- adrenal adenoma, functional autonomy, dexamethasone suppression test, ACTH, cortisol, 17-hydroxyprogesterone, 11-deoxycortisol, dehydroepiandrosterone sulfate, urinary free cortisol
- MeSH terms
- Adenoma, Adosterol, Adrenal Cortex, Adrenal Cortex Neoplasms, Adrenocorticotropic Hormone, Aged, Corticotropin-Releasing Hormone, Dexamethasone, Female, Humans, Hydrocortisone, Iodine Radioisotopes, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Radionuclide Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
