Cited by 249Sleep and Wakefulness ResearchStress Responses and CortisolSleep and Work-Related Fatigue

The DOI matches its Crossref record; 35 of the 37 references it cites were found in a registry or an index.

Sleep deprivation effects on the activity of the hypothalamic–pituitary–adrenal and growth axes: potential clinical implications

Vgontzas, Alexandros N., Mastorakos, George, Bixler, Edward O., Kales, Anthony, Gold, Philip W., Chrousos, George P.·1999·Clinical Endocrinology

DOI 10.1046/j.1365-2265.1999.00763.x

Open this paper in CoChat — free account

Abstract

OBJECTIVES: Although several studies have shown that sleep deprivation is associated with increased slow wave sleep during the recovery night, the effects of sleep deprivation on cortisol and growth hormone (GH) secretion the next day and recovery night have not been assessed systematically. We hypothesized that increased slow wave sleep postsleep deprivation is associated with decreased cortisol levels and that the enhanced GH secretion is driven by the decreased activity of the HPA axis. DESIGN AND SUBJECTS: After four consecutive nights in the Sleep Laboratory, 10 healthy young men were totally deprived of sleep during the fifth night, and then allowed to sleep again on nights six and seven. Twenty‐four hour blood sampling was performed serially every 30 minutes on the fourth day, immediately following the previous night of sleep and on the sixth day, immediately after sleep deprivation. MEASUREMENT: Eight‐hour sleep laboratory recording, including electroencephologram, electro‐oculogram and electromyogram. Plasma cortisol and GH levels using specific immunoassay techniques. RESULTS: Mean plasma and time‐integrated (AUC) cortisol levels were lower during the postdeprivation nighttime period than on the fourth night (P < 0.05). Pulsatile analysis showed significant reduction of both the 24 h and daytime peak area (P < 0.05) and of the pulse amplitude (P < 0.01), but not of the pulse frequency. Also, the amount of time‐integrated GH was significantly higher for the first 4 h of the postdeprivation night compared to the predeprivation night (P < 0.05). Cross‐correlation analyses between the absolute values of the time‐series of each hormone value and percentage of each sleep stage per half hour revealed that slow wave sleep was negatively correlated with cortisol and positively correlated with GH with slow wave sleep preceding the secretion of these hormones. In contrast, indices of sleep disturbance, i.e. wake and stage 1 sleep, were positively correlated with cortisol and negatively correlated with GH. CONCLUSION: We conclude that sleep deprivation results in a significant reduction of cortisol secretion the next day and this reduction appears to be, to a large extent, driven by the increase of slow wave sleep during the recovery night. We propose that reduction of CRH and cortisol secretion may be the mechanism through which sleep deprivation relieves depression temporarily. Furthermore, deep sleep has an inhibitory effect on the HPA axis while it enhances the activity of the GH axis. In contrast, sleep disturbance has a stimulatory effect on the HPA axis and a suppressive effect on the GH axis. These results are consistent with the observed hypocortisolism in idiopathic hypersomnia and HPA axis relative activation in chronic insomnia. Finally, our findings support previous hypotheses about the restitution and immunoenhancement role of slow wave (deep) sleep.

Integrity signals

Registry

Crossref · 10.1046/j.1365-2265.1999.00763.x

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A manual for standardized terminology, techniques and scoring system for sleep stages in human subjects
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Self-citation
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Self-citation
Clinical and Biochemical Manifestations of Depression
Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190706 · Cited by 1,057
Self-citation
Sleep deprivation: effect on sleep stages and EEG power density in man
Borbély, A. A., Baumann, F., Brandeis, D., Strauch, I., & Lehmann, D. (1981) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(81)90225-x · Cited by 1,013
Sleep Loss Results in an Elevation of Cortisol Levels the Next Evening
(1997) · Sleep · doi:10.1093/sleep/20.10.865 · Cited by 745 · cited 1×
“, 1996) or elevated cortisol levels the next evening (Leproult et al., 1997).”
Background
Corticotropin releasing factor produces behavioural activation in rats
Sutton, R., Koob, G., le Moal, M., Rivier, J., & Vale, W. (1982) · Nature · doi:10.1038/297331a0 · Cited by 744
Biological actions of carotenoids 1
Bendich, A., & Olson, J. A. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.8.2656356 · Cited by 564
Clinical and Biochemical Manifestations of Depression
Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808113190606 · Cited by 547
Self-citation
Chronic insomnia and activity of the stress system
Vgontzas, A. N., Tsigos, C., Bixler, E. O., Stratakis, C. A., Zachman, K., Kales, A., Vela-Bueno, A., & Chrousos, G. P. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00302-4 · Cited by 401
Self-citation

Show all 37 references

Research works printed but not linked: 4

Chrousos G.P., 1993, Side effects of glucocorticoid treatment, Journal of the American Medical Association, 269, 2110, 10.1001/jama.1993.03500160080036 · DOI
10.1210/jc.81.2.482 · DOI
10.1210/jc.78.1.131 · DOI
Van Cauter E.&Turek F.W.(1994) Endocrine and other biological rhythms. In:Endocrinology (Ed. L.J. Degroot) pp.2487–2548.Saunders Philadelphia.

Sorted by citations

Items 101–200 of 249

Poor Sleep Quality and Sleep Apnea Are Associated with Higher Resting Energy Expenditure in Obese Individuals with Short Sleep Duration
de Jonge, L., Zhao, X., Mattingly, M. S., Zuber, S. M., Piaggi, P., Csákó, G., Cizza, G., & for the NIDDK Sleep Extension Study Group (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2858 · Cited by 42
Sleep extension increases IGF-I concentrations before and during sleep deprivation in healthy young men
Chennaoui, M., Arnal, P. J., Drogou, C., Sauvet, F., & Gomez-Mérino, D. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0110 · Cited by 41
Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes
Atrooz, F., Liu, H., Kochi, C., & Salim, S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.021 · Cited by 41
Prolonged psychological stress suppresses cortisol secretion
Žarković, M., Stefanova, E. D., Ćirić, J., Penezić, Z., Kostić, V., Šumarac‐Dumanović, M., Μacut, D., Ivović, M., & Gligorovic, P. V. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01925.x · Cited by 40
Fibromyalgia, physical activity, and daily functioning: The importance of efficacy and health-related quality of life
Culos-Reed, S. N., & Brawley, L. R. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200012)13:6 · Cited by 66
Mood and metabolic consequences of sleep deprivation as a potential endophenotype’ in bipolar disorder
Aydin, A., Selvi, Y., Besiroglu, L., Boysan, M., Atli, A., Ozdemir, O., Kilic, S., & Balaharoglu, R. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.007 · Cited by 40
Sleep Pathologies in Depression and the Clinical Utility of Polysomnography
Sculthorpe, L. D., & Douglass, A. B. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005500704 · Cited by 39
Sleep Deprivation: Cytokine and Neuroendocrine Effects on Perception of Effort
Cullen, T., Thomas, G., & Wadley, A. J. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002207 · Cited by 41
Neuroendocrine Regulation of Sleep Disturbances in PTSD
Neylan, T. C., Otte, C., Yehuda, R., & Marmar, C. R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.015 · Cited by 39
Cortisol, sleep, and recovery – Some gender differences but no straight associations
Eek, F., Karlson, B., Garde, A. H., Hansen, Å. M., & Ørbæk, P. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.003 · Cited by 39
Altered diurnal pattern of steroid hormones in relation to various behaviors, external factors and pathologies: A review
Collomp, K., Baillot, A., Forget, H., Coquerel, A., Rieth, N., & Vibarel-Rebot, N. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.039 · Cited by 41
From sleep duration to childhood obesity—what are the pathways?
Börnhorst, C., Hense, S., Ahrens, W., Hebestreit, A., Reisch, L. A., Barba, G., von Kries, R., & Bayer, O. (2012) · European Journal of Pediatrics · doi:10.1007/s00431-011-1670-8 · Cited by 37
Normal Physiology of ACTH and GH Release in the Hypothalamus and Anterior Pituitary in Man
Lim, C. T., & Khoo, B. C. E. (2014) · Cited by 36
Metabolic Syndrome Pathophysiology and Clinical Presentation
Handelsman, Y. (2008) · Toxicologic Pathology · doi:10.1177/0192623308329288 · Cited by 36
Hypnotic enhancement of slow-wave sleep increases sleep-associated hormone secretion and reduces sympathetic predominance in healthy humans
Besedovsky, L., Cordi, M. J., Wißlicen, L., Martínez-Albert, E., Jan Born, A., & Rasch, B. (2022) · Communications Biology · doi:10.1038/s42003-022-03643-y · Cited by 41
Sleep and suicidality in school-aged adolescents: a prospective study with 2-year follow-up
Gong, Q., Li, S., Wang, S., Li, H., & Han, L. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112918 · Cited by 33
Diagnostic and Therapeutic Approach to Sleep Disorders, High Blood Pressure and Cardiovascular Diseases: A Consensus Document by the Italian Society of Hypertension (SIIA)
the Italian Society of Hypertension (SIIA), Pinto, R. D., SIIA Young Researchers Study Group, President of, S. I. I. A., Past President of, S. I. I. A., Italian Society of Hypertension (SIIA), Grassi, G. M., Ferri, C., Pengo, M. F., Lombardi, C., et al. (2021) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-021-00436-y · Cited by 35
The impact of sleep restriction while performing simulated physical firefighting work on cortisol and heart rate responses
Wolkow, A. P., Aisbett, B., Reynolds, J., Ferguson, S. A., & Main, L. C. (2015) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-015-1085-3 · Cited by 36
Effects of sleep loss in men and women with insufficient sleep suffering from chronic disease: A model for supportive nursing care
Edéll‐Gustafsson, U., Gustavsson, G., & Uhlin, P. Y. (2003) · International Journal of Nursing Practice · doi:10.1046/j.1440-172x.2003.00402.x · Cited by 32
The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation
Frau, R., Bini, V., Soggiù, A., Scheggi, S., Pardu, A., Fanni, S., Roncada, P., Puligheddu, M., Marrosu, F., Caruso, D., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.13 · Cited by 32
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., & Challet, É. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00009-3 · Cited by 34
Nonlinear dynamics in Clinical Pharmacology: the paradigm of cortisol secretion and suppression
Dokoumetzidis, A., Iliadis, A., & Macheras, P. E. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01600.x · Cited by 27
Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: A [31]P MRS brain imaging study
Trksak, G. H., Jensen, J. E., Plante, D. T., Penetar, D. M., Tartarini, W. L., Maywalt, M. A., Brendel, M., Dorsey, C. M., Renshaw, P. F., & Lukas, S. E. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.07.022 · Cited by 26
Sleep quality mediates the effect of chronotype on resilience in the time of COVID-19
Bazzani, A., Bruno, S., Frumento, P., Sanabria, F. C., Turchetti, G., & Faraguna, U. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1895199 · Cited by 26
Effects of amphetamine, diazepam and caffeine on polysomnography (EEG, EMG, EOG)-derived variables measured using telemetry in Cynomolgus monkeys
Authier, S., Bassett, L., Pouliot, M., Rachalski, A., Troncy, É., Paquette, D., & Mongrain, V. (2014) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2014.05.003 · Cited by 26
Self management of fatal familial insomnia. Part 1: what is FFI?
Schenkein, J., & Montagna, P. (2006) · PubMed Central · Cited by 24
Burnout and sleep
Ekstedt, M. (2005) · Figshare · Cited by 24
Resting energy expenditure in OSAS: the impact of a single CPAP application
Fekete, K., Boutou, A., Pitsiou, G., Chavouzis, N., Pataka, A., Athanasiou, I., Ilonidis, G., Kontakiotis, T., Argyropoulou, P., & Kioumis, I. P. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1194-y · Cited by 23
Type 2 diabetes affects sleep quality by disrupting the respiratory function
Colbay, G., Çetın, M., Çölbay, M., Berker, D. S., & Güler, S. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12225 · Cited by 22
Modulation of Endocrine Function by Sleep-Wake Homeostasis and Circadian Rhythmicity
Pannain, S., & Cauter, E. V. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.001 · Cited by 22
Sleep opportunities and periodic light exposures: Impact on biomarkers, performance and sleepiness
Figueiro, M. G., & Rea, M. S. (2011) · Lighting Research & Technology · doi:10.1177/1477153511404175 · Cited by 22
HPA Axis and Sleep
Nicolaides, N. C., Vgontzas, A. N., Kritikou, I., & Chrousos, G. P. (2016) · Europe PMC (PubMed Central) · Cited by 22
Self-citation
A Review of the Literature Regarding Sleep and Cardiometabolic Disease in African Descent Populations
WHITESELL, P. L., Obi, J., Tamanna, N., & Sumner, A. E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00140 · Cited by 22
Pentagastrin-induced sleep panic attacks: panic in the absence of elevated baseline arousal
Geraci, M. F., Anderson, T. S., Slate, S. O., Post, R. M., & McCann, U. D. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01402-6 · Cited by 22
Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond
Bioletto, F., Varaldo, E., Gasco, V., Maccario, M., Arvat, E., Ghigo, E., & Grottoli, S. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09933-6 · Cited by 24
Actigraphy-based sleep characteristics and aortic stiffness: the Multi-Ethnic Study of Atherosclerosis
Logan, J. G., Kang, H., Mason, J. E., Sohn, M., Lin, G., Lima, J. A. C., Punjabi, N. M., Redline, S. S., & Kwon, Y. (2018) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2018.09.008 · Cited by 21
The associations between adolescent sleep, diurnal cortisol patterns and cortisol reactivity to dexamethasone suppression test
Pesonen, A., Martikainen, S., Kajantie, E., Heinonen, K., Wehkalampi, K., Lahti, J. M. T., Strandberg, T. E., & Räikkönen, K. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.005 · Cited by 21
The central CLOCK system and the stress axis in health and disease
Kassi, E. N., & Chrousos, G. P. (2013) · HORMONES · doi:10.14310/horm.2002.1402 · Cited by 20
Self-citation
Reregulation of cortisol levels and sleep in patients with prescription opioid use disorder during long-term residential treatment
Mukherjee, D., Stankoski, D. M., Tilden, S. E., Huhn, A. S., Bixler, E. O., Kong, L., Meyer, R. E., Deneke, E., Freet, C. S., & Bunce, S. C. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108931 · Cited by 19
Self-citation
Endocrine rhythms of growth hormone release: Insights from animal studies
Steyn, F. J., & Ngo, S. T. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.10.009 · Cited by 20
Cytokine and microRNA levels during different periods of paradoxical sleep deprivation and sleep recovery in rats
Brianza-Padilla, M., Sánchez‐Muñoz, F., Vázquez-Palacios, G., Huang, F., Almanza-Pérez, J. C., Bojalil, R., & Bonilla‐Jaime, H. (2018) · PeerJ · doi:10.7717/peerj.5567 · Cited by 19
Sleep Disruption During Pregnancy
Sloan, E. P. (2008) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.10.009 · Cited by 19
Sleep and hypothalamic pituitary adrenal axis responses to metyrapone in posttraumatic stress disorder
Inslicht, S. S., Rao, M. N., Richards, A. L., O’Donovan, A., Gibson, C. J., Baum, T., Metzler, T. J., & Neylan, T. C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.002 · Cited by 20
Augmentation of pharmacotherapy by sleep deprivation with sleep phase advance in treatment-resistant depression
Kurczewska, E., Ferensztajn-Rochowiak, E., Jasińska-Mikołajczyk, A., Chłopocka-Woźniak, M., & Rybakowski, J. K. (2019) · Pharmacopsychiatry · doi:10.1055/a-0695-9138 · Cited by 17
A Novel Ashwagandha (Withania somnifera) Formulation Mitigates Sleep Deprivation-Induced Cognitive Impairment and Oxidative Stress in a Rat Model
Er, B., Ozmen, B., Şahin, E., Orhan, C., Şahin, N., Morde, A. A., Padigaru, M., & Şahin, K. (2025) · Biomolecules · doi:10.3390/biom15050710 · Cited by 18
Relationships between lifestyle patterns and cardio-renal-metabolic parameters in patients with type 2 diabetes mellitus: A cross-sectional study
Ogihara, T., Mita, T., Osonoi, Y., Osonoi, T., Saito, M., Tamasawa, A., Nakayama, S., Someya, Y., Ishida, H., Gosho, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173540 · Cited by 16
Mid-term effects of serial sleep deprivation therapy implemented in cognitive-behavioral treatment on the neuroendocrine response to clomipramine in patients with major depression
Kundermann, B., Strate, P., Hemmeter-Spernal, J., Huber, M., Krieg, J.-C., & Lautenbacher, S. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.09.004 · Cited by 16
Sleep deprivation and hypothalamic-pituitary-adrenal (HPA) axis activity in depressed patients
Schüle, C., Baghai, T. C., Zwanzger, P., Minov, C., Padberg, F., & Rupprecht, R. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00027-9 · Cited by 16
Aspectos psicológicos da síndrome da fibromialgia juvenil: revisão de literatura
Goulart, R., Pessoa, C., & Junior, I. L. (2016) · Revista Brasileira de Reumatologia · doi:10.1016/j.rbr.2015.07.008 · Cited by 15
Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster
Thompson, J. B., Su, O. O., Yang, N., & Bauer, J. H. (2020) · Biology Open · doi:10.1242/bio.054361 · Cited by 15
Sleep quality and risk of recurrent aphthous ulcers: A Spanish cohort study
Tohidinik, H. R., Rodríguez-Fernández, A., Regueira‐Méndez, C., & Takkouche, B. (2021) · Oral Diseases · doi:10.1111/odi.13955 · Cited by 15
Insufficient sleep may alter cortical excitability near the migraine attack: A blinded TMS crossover study
Mykland, M. S., Uglem, M., Stovner, L. J., Brenner, E., Snoen, M. S., Gravdahl, G. B., Sand, T., & Omland, P. M. (2023) · Cephalalgia · doi:10.1177/03331024221148391 · Cited by 15
A State-of-Art Review of the Vicious Circle of Sleep Disorders, Diabetes and Neurodegeneration Involving Metabolism and Microbiota Alterations
Versace, S., Pellitteri, G., Sperotto, R., Tartaglia, S., Porto, A. D., Catena, C., Gigli, G. L., Cavarape, A., & Valente, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310615 · Cited by 17
Metabolic Complications of Obstructive Sleep Apnea Syndrome
Ahmed, Q. A. A. (2008) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31815f2c1a · Cited by 15
The Impact of Growth Hormone Therapy on Sleep-Related Health Outcomes in Children with Prader–Willi Syndrome: A Review and Clinical Analysis
Zaffanello, M., Pietrobelli, A., PIACENTINI, G. L., Guzzo, A., & Antoniazzi, F. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175504 · Cited by 14
Oscilações do cortisol na depressão e sono/vigília
Saraiva, E., Fortunato, J. M., & Gavina, C. (2005) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 12
Longitudinal relationships between self‐efficacy, post‐traumatic distress and salivary cortisol among motor vehicle accident survivors
Cieślak, R., Benight, C. C., Łuszczyńska, A., & Laudenslager, M. L. (2011) · Stress and Health · doi:10.1002/smi.1379 · Cited by 16
Subjective and objective sleep quality in elderly individuals: The role of psychogeriatric evaluation
Valle, V. I.-D., Silva, J., Castelló-Domenech, A. B., Martínez-Martínez, M., Verdejo, Y., Sanantonio-Camps, L., & Cauli, O. (2018) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2018.03.010 · Cited by 14
The Diagnosis and Treatment of Chronic Insomnia in Adults
Vgontzas, A. N. (2005) · SLEEP · doi:10.1093/sleep/28.9.1047 · Cited by 14
Self-citation
Work stress and overtime work: Effects on cortisol, sleep, sleepiness and health
Dahlgren, A. (2006) · PsycEXTRA Dataset · doi:10.1037/e529872013-001 · Cited by 15
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., Turek, F. W., & Cauter, E. V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00011-3 · Cited by 14
Hair cortisol concentration associates with insomnia and stress symptoms in breast cancer survivors
Ahabrach, H., Mlili, N. E., Mafla-España, M. A., & Cauli, O. (2023) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2023.07.006 · Cited by 12
Sleep Duration Is Closely Associated with Suicidal Ideation and Suicide Attempt in Korean Adults: A Nationwide Cross-Sectional Study
Ko, Y., Moon, J. E., & Han, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115594 · Cited by 12
Psychological aspects of juvenile fibromyalgia syndrome: a literature review
Goulart, R., Pessoa, C., & Lombardi, I. (2015) · Revista Brasileira de Reumatologia (English Edition) · doi:10.1016/j.rbre.2015.07.017 · Cited by 15
Narcolepsy and risk of cardiovascular outcomes beyond stimulant use
Riaz, M., Bhattacharjee, R., Lo‐Ciganic, W., Wilson, D. L., Wickwire, E. M., Malhotra, A., Kaufmann, C. N., & Park, H. (2025) · SLEEP · doi:10.1093/sleep/zsaf197 · Cited by 11
Sleep disturbances in affective disorders
Staner, L., Luthringer, R., & Bon, O. L. (2006) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7440-3_7 · Cited by 11
Circadian Rhythms in Neuroendocrine Systems
Arble, D. M., Copinschi, G., Vitaterna, M. H., Cauter, E. V., & Turek, F. W. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10012-5 · Cited by 10
Bir Semptom ve Bir Hastalık Olarak Uykusuzluk
Yetki̇n, S., & Aydın, H. (2014) · Journal of Turkish Sleep Medicine · doi:10.4274/jtsm.01 · Cited by 10
Reprint of “Effects of amphetamine, diazepam and caffeine on polysomnography (EEG, EMG, EOG)-derived variables measured using telemetry in Cynomolgus monkeys”
Authier, S., Bassett, L., Pouliot, M., Rachalski, A., Troncy, É., Paquette, D., & Mongrain, V. (2014) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2014.10.004 · Cited by 9
THE ECOLOGY OF BIPOLAR DISORDER: THE IMPORTANCE OF SLEEP
Umlauf, M. G., & Shattell, M. M. (2005) · Issues in Mental Health Nursing · doi:10.1080/01612840591008267 · Cited by 9
Schlafdauer und Übergewicht
Hense, S., & Bayer, O. (2011) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-011-1368-0 · Cited by 8
The effects of chronic sleep restriction on the hypothalamic-pituitary-adrenal axis and its interaction with abstinence from opioid use
Everson, C. A., Szabó, A., Olsen, C. M., Glaeser, B., & Raff, H. (2025) · SLEEP · doi:10.1093/sleep/zsaf107 · Cited by 7
Sleep and Resilience
Lee, S.-J., Park, C., Kim, B., Lee, C.-S., Cha, B., & Lee, D. (2015) · Sleep Medicine and Psychophysiology · doi:10.14401/kasmed.2015.22.2.53 · Cited by 7
Dynamic evaluation of the hypothalamic–pituitary–adrenal and growth hormone axes and metabolic consequences in chronic insomnia; a case–control study
İsmailoğulları, S., Bolattürk, Ö. F., Karaca, Z., Taheri, S., Bayramov, K. K., Keleştimur, F., & Aksu, M. (2017) · Sleep and Biological Rhythms · doi:10.1007/s41105-017-0120-z · Cited by 7
Development of a hyponatremia screening tool (ABCDF‐S score) for patients with hypertension using thiazide diuretic agents
Kanchanasurakit, S., Saokaew, S., Siriplabpla, W., Arsu, A., Boonmak, W., & Watcharasiriphong, W. (2020) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13123 · Cited by 7
Neurobiological Disturbances in Insomnia: Clinical Utility of Objective Measures of Sleep
Pejovic, S., & Vgontzas, A. N. (2010) · Medical psychiatry · doi:10.3109/9781420080803.007 · Cited by 7
Self-citation
Prevalence of hyponatremia and associated factors in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry (FKR) study
Inoue, M., Nakai, K., Tanaka, S., Mitsuiki, K., Tokumoto, M., Tsuruya, K., Kitazono, T., & Nakano, T. (2023) · Clinical and Experimental Nephrology · doi:10.1007/s10157-023-02395-1 · Cited by 7
Gene expression profiles in gastric mucosa of sleep deprivation rats
Xi Zhong, S. H. E. N. (2000) · World Journal of Gastroenterology · doi:10.3748/wjg.v6.i5.754 · Cited by 7
Stress hormones in obstructive sleep apnea complications: the role of cortisol
Crawford-Achour, É., Martin, M. S., & Roche, F. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.10.004 · Cited by 7
The Effect of Aerobic Exercise on Variation of Oxidative Stress, hs-CRP and Cortisol Induced by Sleep Deficiency
Park, J.-S., Murlasits, Z., & Kim, S. (2023) · Healthcare · doi:10.3390/healthcare11081201 · Cited by 6
Chronobiology and Sleep on Resilience
Jeon, H. J., & Lee, S.-J. (2019) · Chronobiology in Medicine · doi:10.33069/cim.2019.0026 · Cited by 5
Neubewertung der klassischen osteopathischen Feldtheorie am Beispiel von Perzeption und Wahrnehmung
Hartmann, C. J., & Pöttner, M. (2011) · Osteopathische Medizin · doi:10.1016/j.ostmed.2011.07.017 · Cited by 6
Physical Activity, Emotional Stress, Sleep Disturbances, and Daily Fluctuations in Chronic Fatigue Symptomatology
Gaitanis, P., Tooley, G. A., & Edwards, B. (2007) · Journal of Applied Biobehavioral Research · doi:10.1111/j.1751-9861.2005.tb00004.x · Cited by 5
Vertebral Subluxation and Systems Biology: An Integrative Review Exploring the Salutogenic Influence of Chiropractic Care on the Neuroendocrine-Immune System
Haas, A., Chung, J., Kent, C. D., Mills, B., & McCoy, M. (2024) · Cureus · doi:10.7759/cureus.56223 · Cited by 6
The Effect of Cold Exposure on the Hormonal and Metabolic Responses to Sleep Deprivation
Caine-Bish, N. L., Potkanowicz, E. S., Otterstetter, R., Marcinkiewicz, J. L., Kamimori, G. H., & Glickman, E. L. (2005) · Wilderness and Environmental Medicine · doi:10.1580/pr37-04.1 · Cited by 5
Features of eating behavior, emotional state and metabolic parameters in obese patients with insomnia
Викторовна, С. Н., Poluektov, M. G., Савельева, Л. В., Melnithenko, G. A., Katsya, G. V., & Goncharov, N. P. (2014) · Obesity and metabolism · doi:10.14341/omet2014224-29 · Cited by 5
Antidepressant effects of acute sleep deprivation are reduced in highly controlled environments
Goldschmied, J., Boland, E. M., Palermo, E. H., Barilla, H., Dinges, D. F., Detre, J. A., Basner, M., Sheline, Y. I., Rao, H., & Gehrman, P. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.116 · Cited by 4
Influence de la nutrition sur le sommeil et la vigilance
Guézennec, C.-Y., & Duclos, M. (2005) · Cahiers de Nutrition et de Diététique · doi:10.1016/s0007-9960(05)80479-1 · Cited by 4
Neurobiological Disturbances in Insomnia: Clinical Utility of Objective Measures of Sleep
Pejovic, S., & Vgontzas, A. N. (2016) · doi:10.3109/9781420080803-9 · Cited by 4
Self-citation
Transitions to synchronization induced by synaptic increasing in coupled tonic neurons with electrical synapses
Li, R., Xu, B.-L., Chen, D., Zhou, J., & Yuan, W.-J. (2023) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2023.114104 · Cited by 4
Cognitive, neuroanatomical and neuroendocrine effects of long-term rotating shift work in a nursing sample
Pavlis, A. (2007) · Victoria University Research Repository (Victoria University) · Cited by 4
Hypocretins in Endocrine Regulation
López, M., Tena‐Sempere, M., García‐Caballero, T., Señarís, R. M., & Diéguez, C. (2005) · Springer eBooks · doi:10.1007/0-387-25446-3_27 · Cited by 4
Short Sleep Duration is Associated with Central Arterial Stiffness in Children Independent of Other Lifestyle Behaviors
Stoner, L. R., Higgins, S., Black, K. E., Boggess, K., Meyer, M. L., Chou, A., Galland, B. C., Haszard, J. J., Meredith-Jones, K., Saeedi, P., et al. (2020) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-020-00062-5 · Cited by 3
Neurobiological Risk Factors and Predictors of Vulnerability and Resilience to PTSD
Bar‐Shai, M., & Klein, E. (2014) · Springer eBooks · doi:10.1007/978-1-4899-7522-5_2 · Cited by 3
Effects of Sleep Deprivation and Sleepiness on Society and Driving
Grandner, M. A., & Mian, R. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_4 · Cited by 3
The effect of miR‐10b on growth hormone in pituitary cells of Yanbian yellow cattle by somatostatin receptor 2
Ji, J., Jin, T., Lou, A., Zhang, R., Chen, Y., Xiang, S., Cui, C., Yu, L., & Guan, L.-Z. (2020) · Animal Science Journal · doi:10.1111/asj.13420 · Cited by 3
Acute sleep deprivation in humans
Casale, C. E., Brieva, T. E., Yamazaki, E. M., Antler, C. A., & Goel, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00005-0 · Cited by 3
Sleep, gut microbiota, and mind-body medicine
Das, M., Muralitharan, G., Saini, S., & Patra, S. (2025) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2025.100128 · Cited by 3
Sleep restriction does not affect orthostatic tolerance in the simulated microgravity environment
Grenon, S. M., Hurwitz, S., Sheynberg, N., Xiao, X. G., Judson, B., Ramsdell, C. D., Kim, C., Cohen, R. J., & Williams, G. H. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00328.2004 · Cited by 2
Psychoneuroimmunology: A Hallmark in Developmental Programming and Epigenetics
Ashonibare, V. J., & Akhigbe, R. E. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_18 · Cited by 2

Authors: Vgontzas, A. N., Mastorakos, G., Bixler, E. O., Kales, A., Gold, P. W., & Chrousos, G. P.
Affiliations: Pennsylvania State University (US)
National and Kapodistrian University of Athens (GR)
National Institute of Mental Health (US)
National Institutes of Health (US)
Corresponding author: Vgontzas, Alexandros N.
ORCID: Mastorakos, George
Gold, Philip W.
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 1999-08
Volume: 51
Issue: 2
Pages: 205-215
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1046/j.1365-2265.1999.00763.x
OpenAlex: W2063403260
Cited by: 249
References: 37
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 12 · 2016: 16 · 2015: 13 · 2014: 17 · 2013: 10 · 2012: 12
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 876 d)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: NIH Clinical Center
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: sleep deprivation, hypothalamic-pituitary-adrenal axis, growth hormone secretion, cortisol, slow-wave sleep, recovery sleep, pulsatile hormone secretion, sleep disorders, sleep stages, depression, corticotropin-releasing factor, growth hormone axis, healthy young men, plasma hormone levels, sleep efficiency
MeSH terms: Adult, Circadian Rhythm, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Sleep Deprivation, Growth Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sleep deprivation effects on the activity of the hypothalamic–pituitary–adrenal and growth axes: potential clinical implications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks