Augmentation of pharmacotherapy by sleep deprivation with sleep phase advance in treatment-resistant depression
Abstract
INTRODUCTION: The aim was to assess the efficacy of total sleep deprivation (TSD) with sleep phase advance (SPA) in treatment-resistant depression (TRD) and associated biochemical factors. METHODS: We studied nine males and 12 females, aged 49±14 years, with treatment-resistant unipolar or bipolar depression, receiving antidepressant and mood-stabilizing drugs. The four-day schedule included single TSD and three consecutive nights with SPA. Biochemical markers were measured on the day before and on 1st, 7th and 14th day after the TSD. RESULTS: Ten subjects met criteria for response, defined as a reduction of ≥50% in the Hamilton Depression Rating Scale, on the 14th day. Concentrations of cortisol at baseline were lower in responders, and they decreased during therapy in both groups. In responders, there was an increase of interleukin-10 (IL-10) and IL-1β on the 14th day. DISCUSSION: Our preliminary study demonstrated the efficacy of pharmacotherapy augmentation by TSD and SPA in half of the patients with TRD. The main biochemical factors related to clinical response included status of cortisol and increase in IL-10 and IL-1β levels.
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Recent studies on combined chronotherapy have reported lower response rates than the presumed average of 50% with the exception of two cohort studies.
“Moreover, recent studies on combined chronotherapy have reported lower response rates (20, 39, 44, 58) than the presumed average of 50% (45) with the exception of two cohort studies (22, 62).”
From Total Sleep Deprivation Followed by Bright Light Therapy as Rapid Relief for Depression: A Pragmatic Randomized Controlled Trial (2021) · cites this paper as [62]
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668 · see citing works
Mood disorders and allostatic load
McEwen, B. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00177-x · Cited by 1,135 · see citing works
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921 · see citing works
Manber, R., Edinger, J. D., Gress, J. L., Pedro-Salcedo, M. G. S., Kuo, T. F., & Kalista, T. (2008) · Sleep · doi:10.1093/sleep/31.4.489 · Cited by 868 · see citing works
Report by the ACNP Task Force on Response and Remission in Major Depressive Disorder
Rush, A. J., Kraemer, H. C., Sackeim, H. A., Fava, M., Trivedi, M. H., Frank, E., Ninan, P. T., Thase, M. E., Gelenberg, A. J., Kupfer, D. J., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301131 · Cited by 707 · see citing works
The cortisol awakening response - normal values and confounds.
Wüst, S., Wolf, J. M., Hellhammer, D. H., Federenko, I. S., Schommer, N. C., & Kirschbaum, C. (2000) · PubMed · Cited by 700 · see citing works
Wu, J. C., & Bunney, W. E. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.1.14 · Cited by 614 · see citing works
Glucocorticoids and the Th1/Th2 Balance
Elenkov, I. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.010 · Cited by 607 · see citing works
Köhler, C. A., Freitas, T. H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., de Andrade, N. Q., Morris, G., Fernandes, B. S., Brunoni, A. R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0632-1 · Cited by 449 · see citing works
Sleep deprivation in depression: what do we know, where do we go?
Wirz-Justice, A., & Van den Hoofdakker, R. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00125-0 · Cited by 429 · see citing works
Pariante, C. M. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.04.001 · Cited by 382 · cited 1× · see citing works
“Such dysregulation in the immune system [34] can be explained by the concept of allostasis formulated by Sterling and Eyer in 1988.”
BackgroundEffects of antidepressants on the production of cytokines
Kenis, G., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003164 · Cited by 370 · see citing works
Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
van Cauter, E., Holmbäck, U., Knutson, K., Leproult, R., Miller, A., Nedeltcheva, A., Pannain, S., Penev, P., Tasali, E., & Spiegel, K. (2007) · Hormone Research in Paediatrics · doi:10.1159/000097543 · Cited by 353 · see citing works
Wu, J. C., Buchsbaum, M. S., Gillin, J. C., Tang, C. Y., Cadwell, S., Wiegand, M. H., Najafi, A., Klein, E., Hazen, K., & Bunney, W. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1149 · Cited by 327 · see citing works
Haroon, E., Daguanno, A. W., Woolwine, B. J., Goldsmith, D. R., Baer, W. M., Wommack, E. C., Felger, J. C., & Miller, A. H. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.026 · Cited by 291 · see citing works
Wu, J. C., Kelsoe, J. R., Schachat, C., Bunney, B. G., DeModena, A., Golshan, S., Gillin, J. C., Potkin, S. G., & Bunney, W. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.018 · Cited by 263 · see citing works
Berlim, M. T., & Turecki, G. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.03.009 · Cited by 249 · see citing works
Vgontzas, A. N., Mastorakos, G., Bixler, E. O., Kales, A., Gold, P. W., & Chrousos, G. P. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00763.x · Cited by 249 · see citing works
Activation of human monocytes by the pineal hormone melatonin.
Morrey, K. M., McLachlan, J. A., Serkin, C. D., & Bakouche, O. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2671 · Cited by 221 · see citing works
Bunney, B. G., & Bunney, W. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.020 · Cited by 181 · see citing works
Benedetti, F., Barbini, B., Fulgosi, M. C., Colombo, C., Dallaspezia, S., Pontiggia, A., & Smeraldi, E. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1207 · Cited by 180 · see citing works
A Pilot Study of Cognitive-Behavioral Therapy of Insomnia in People with Mild Depression
Taylor, D. J., Lichstein, K. L., Weinstock, J., Sanford, S. D., & Temple, J. R. (2006) · Behavior Therapy · doi:10.1016/j.beth.2006.04.002 · Cited by 174 · see citing works
Chronotherapeutics for Affective Disorders: A Clinician's Manual for Light and Wake Therapy
Wirz‐Justice, A., Benedetti, F., & Terman, M. (2009) · Cited by 168 · see citing works
Towards a unified model of neuroendocrine–immune interaction
Petrovsky, N. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.01029.x · Cited by 160 · see citing works
Meta-analysis of the antidepressant effects of acute sleep deprivation
Boland, E. M., Rao, H., Dinges, D. F., Smith, R. V., Goel, N., Detre, J. A., Basner, M., Sheline, Y. I., Thase, M. E., & Gehrman, P. R. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16r11332 · Cited by 132 · cited 1× · see citing works
“Sleep deprivation (SD) is a method of chronotherapy for depression, with well-documented efficacy at the level of 45–50 % [1].”
MethodVgontzas, A. N., Pejovic, S., Zoumakis, E., Lin, H. ‐., Bentley, C. M., Bixler, E. O., Sarrigiannidis, A., Basta, M., & Chrousos, G. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0774 · Cited by 129 · see citing works
Benedetti, F., Riccaboni, R., Locatelli, C., Poletti, S., Dallaspezia, S., & Colombo, C. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08455 · Cited by 116 · see citing works
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.870 · Cited by 114 · see citing works
Comorbidity between epilepsy and depression: Role of hippocampal interleukin-1β
Mazarati, A. M., Pineda, E., Shin, D. H., Tio, D. L., Taylor, A. N., & Sankar, R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.001 · Cited by 112 · see citing works
Benedetti, F., Barbini, B., Campori, E., Fulgosi, M. C., Pontiggia, A., & Colombo, C. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00034-6 · Cited by 110 · see citing works
Gorgulu, Y., & Çalıyurt, O. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.016 · Cited by 101 · see citing works
The effects of lithium on ex vivo cytokine production
Rapaport, M. H., & Manji, H. K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01144-1 · Cited by 98 · see citing works
Interleukin-1beta Causes Fluoxetine Resistance in an Animal Model of Epilepsy-Associated Depression
Pineda, E. A., Hensler, J. G., Sankar, R., Shin, D. H., Burke, T. F., & Mazarati, A. M. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0110-4 · Cited by 83 · see citing works
Ebert, D. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00237-8 · Cited by 78 · see citing works
Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder
Benedetti, F., Poletti, S., Hoogenboezem, T. A., Locatelli, C., de Wit, H., Wijkhuijs, A. J. M., Colombo, C., & Drexhage, H. A. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m11310 · Cited by 74 · see citing works
Benedetti, F., Lucca, A., Brambilla, F., Colombo, C., & Smeraldi, E. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00255-5 · Cited by 73 · see citing works
Echizenya, M., Suda, H., Takeshima, M., Inomata, Y., & Shimizu, T. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.022 · Cited by 71 · see citing works
Wu, J. C., Gillin, J. C., Buchsbaum, M. S., Schachat, C., Darnall, L. A., Keator, D. B., Fallon, J. H., & Bunney, W. E. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.07.030 · Cited by 66 · see citing works
Neurophysiological Effects of Sleep Deprivation in Healthy Adults, a Pilot Study
Klumpers, U. M. H., Veltman, D. J., van Tol, M., Kloet, R. W., Boellaard, R., Lammertsma, A. A., & Hoogendijk, W. J. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116906 · Cited by 65 · see citing works
Effects of sleep deprivation on serotonin function in depression
Salomon, R. M., Delgado, P. L., Licinio, J., Krystal, J. H., Heninger, G. R., & Charney, D. S. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90595-9 · Cited by 62 · see citing works
Naps after total sleep deprivation in depressed patients: Are they depressiogenic?
Riemann, D. W., Wiegand, M. H., Lauer, C. J., & Berger, T. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90099-3 · Cited by 60 · see citing works
Voderholzer, U., Valerius, G., Schaerer, L., Riemann, D. W., Giedke, H., Schwärzler, F., Berger, T., & Wiegand, M. H. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0408-7 · Cited by 60 · see citing works
Simma, N., Bose, T., Kahlfuß, S., Mankiewicz, J., Lowinus, T., Lühder, F., Schüler, T., Schraven, B. L., Heine, M., & Bommhardt, U. (2014) · Cell Communication and Signaling · doi:10.1186/s12964-014-0075-5 · Cited by 56 · see citing works
Müller, H. ‐., Riemann, D. W., Berger, T., & Müller, W. E. G. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03407.x · Cited by 53 · see citing works
Selected Cytokine Profiles during Remission in Bipolar Patients
Remlinger-Molenda, A., Wójciak, P., Michalak, M., Karczewski, J., & RYBAKOWSKI, J. K. (2012) · Neuropsychobiology · doi:10.1159/000339949 · Cited by 46 · see citing works
Self-citationMurck, H., Schubert, M. I., Schmid, D. A., SCHÜSSLER, P., Steiger, A., & Auer, D. P. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.04.009 · Cited by 43 · see citing works
Voderholzer, U., Hohagen, F., Klein, T., Jungnickel, J., Kirschbaum, C., Berger, T., & Riemann, D. W. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1404 · Cited by 43 · see citing works
Fundamentals of Psychoneuroimmunology
Song, C., & Leonard, B. E. (2000) · Cited by 40 · see citing works
Martiny, K., Refsgaard, E., Lund, V., Lunde, M., Thougaard, B., Lindberg, L., & Bech, P. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12402 · Cited by 37 · see citing works
Voderholzer, U., Fiebich, B. L., Dersch, R. S., Feige, B., Piosczyk, H., Kopasz, M., Riemann, D. W., & Lieb, K. (2012) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.11060142 · Cited by 37 · see citing works
Meaningful aspects of the term ‘mood stabilizer’
RYBAKOWSKI, J. K. (2018) · Bipolar Disorders · doi:10.1111/bdi.12608 · Cited by 34 · see citing works
Self-citation[Activity of selected cytokines in bipolar patients during manic and depressive episodes].
Remlinger-Molenda, A., Wójciak, P., Michalak, M., & RYBAKOWSKI, J. K. (2012) · PubMed · Cited by 30 · see citing works
Self-citationSleep deprivation as a method of chronotherapy in the treatment of depression
Dopierała, E., & RYBAKOWSKI, J. K. (2015) · Psychiatria Polska · doi:10.12740/pp/30455 · Cited by 28 · see citing works
Self-citationGiedke, H., Wormstall, H., & Haffner, H. T. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90062-l · Cited by 27 · see citing works
Gazal, M., Jansen, K., Souza, L. D. D. M., Oses, J. P., Magalhães, P. V. D. S., Pinheiro, R. T., Ghisleni, G., Quevedo, L. D. Á., Kaster, M. P., Kapczinski, F. P., et al. (2015) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2014-1452 · Cited by 27 · see citing works
Wake and light therapy for moderate-to-severe depression – a randomized controlled trial
Kragh, M., Martiny, K., Videbech, P., Møller, D. N., Wihlborg, C. S., Lindhardt, T., & Larsen, E. R. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12741 · Cited by 25 · see citing works
Staging of unipolar affective illness
Ferensztajn‐Rochowiak, E., Remlinger-Molenda, A., & RYBAKOWSKI, J. K. (2014) · Psychiatria Polska · doi:10.12740/pp/24239 · Cited by 20 · see citing works
Self-citation
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Meta-analysis of sleep deprivation in the acute treatment of bipolar depression
Gottlieb, J. F., Goel, N., Chen, S., & Young, M. A. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13255 · Cited by 44 · see citing works
Ioannou, M., Szabó, Z., Widmark-Jensen, M., Vyrinis, G., Karlsson, C., & Steingrimsson, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.705090 · Cited by 13 · see citing works
- Authors
- Kurczewska, E., Ferensztajn-Rochowiak, E., Jasińska-Mikołajczyk, A., Chłopocka-Woźniak, M., & Rybakowski, J. K.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 2018-09-10
- Volume
- 52
- Issue
- 04
- Pages
- 186-192
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W2892083472
- Cited by
- 17
- References
- 60
- Citations by year
- 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- total sleep deprivation, sleep phase advance, treatment-resistant depression, bipolar depression, major depressive disorder, cortisol, IL-10, IL-1β, inflammatory markers, antidepressant response
- MeSH terms
- Adult, Aged, Antidepressive Agents, Bipolar Disorder, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Sleep Deprivation, Chronotherapy, Young Adult, Depressive Disorder, Treatment-Resistant
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