The DOI matches its Crossref record; 80 of the 84 references it cites were found in a registry or an index.
Adrenarche—physiology, biochemistry and human disease
Open accessAbstract
Summary: Adrenarche refers to the onset of dehydroepiandrosterone (DHEA) and DHEA‐sulphate (DHEA‐S) production from the adrenal zona reticularis that can be detected at around 6 years of age. The phenotypic result of adrenarche is pubarche or the development of axillary and pubic hair that occurs in both girls and boys at about age 8. The phenomenon of adrenarche is unique to human beings and to some Old World primates, and a reversal of adrenarche appears to occur in the ageing process. Premature and exaggerated adrenarche can be indicative of future onset of adult diseases, thus increasing the clinical relevance of adrenarche. The physiological triggers of adrenarche and the role(s) of DHEA‐S remain speculative. However, the biochemical pathways that define adrenarche have been characterized in detail, and the appearance of key enzymes and cofactors in the adrenal zona reticularis track with the progression of adrenarche. This article reviews the clinical manifestations of adrenarche, the biochemistry of the enzymes involved in DHEA‐S production, and the cell biology of the adrenal zona reticularis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“By contrast, the zona reticularis expresses large amounts of P450c17 and cytochrome b 5 (201), maximizing 17,20-lyase activity (189), so that DHEA is produced, much of which is sulfated to DHEAS by SULT2A1 (648).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [648]
The cited source says what the claim attributes to it.
In the citing paper
“Thus, the pattern of steroid products secreted by each adrenal zone is determined by the enzymes produced in that zone and may be logically deduced from an understanding of their specific enzymatic properties (648).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [648]
In the citing paper
“The transition from childhood to juvenility is marked by the event of “adrenal puberty” or adrenarche (Auchus and Rainey, 2004; Ibáñez et al., 2000).”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Auchus and Rainey, 2004
In the citing paper
“During that time, the development of a distinct zona reticularis is accompanied by an extreme increase in the adrenal androgen precursor production due to the decreased expression of HSD3B2 in conjunction with increased CYB5A expression [[34], [35], [36], [37], [38]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776
Legro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/er.18.6.774 · Cited by 1,167
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
Arlt, W., Callies, F., van Vlijmen, J. C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411401 · Cited by 644
Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer
Auchus, R. J., Lee, T. C., & Miller, W. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3158 · Cited by 541
Self-citationDahlgren, E., Johansson, S., Lindstedt, G., Knutsson, F., Odén, A., Janson, P. O., Mattson, L.-A., Crona, N., & Lundberg, P.-A. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90704-m · Cited by 527
Dahlgren, E., Johansson, S., Lindstedt, G., Knutsson, F., Odén, A., Janson, P. O., Mattson, L.-Å., Crona, N., & Lundberg, P. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54892-4 · Cited by 463
Morales, A. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.6.1360 · Cited by 458
Research works printed but not linked: 14
- 10.1210/jc.81.10.3558 · DOI · Paper page
- 10.1210/jc.83.10.3695 · DOI
- 10.1080/713602799 · DOI
- 10.1210/jc.81.3.1237 · DOI · Paper page
- 10.1210/jc.84.6.2104 · DOI · Paper page
- 10.1210/jc.87.6.2611 · DOI
- 10.1210/jc.84.9.3382 · DOI · Paper page
- 10.1210/jc.80.2.614 · DOI
- 10.1210/jc.79.4.1012 · DOI
- 10.1210/jc.78.1.36 · DOI · Paper page
- 10.1210/jc.81.11.3961 · DOI
- 10.1210/jc.83.8.2916 · DOI
- 10.1210/jc.87.8.3871 · DOI
- 10.1210/jc.79.6.1811 · DOI
Cited by
Sorted by citations
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458
Self-citationThe Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
Sex, attachment, and the development of reproductive strategies
Giudice, M. D. (2009) · Behavioral and Brain Sciences · doi:10.1017/s0140525x09000016 · Cited by 602
Puberty : ontogeny, neuroendocrinology, physiology, and disorders
Styne, D. M., Grumbach, M. M., Dennis, M., Styne, J., & Melvin, M. N. (1998) · Time to knit · doi:10.1016/b978-1-4160-2911-3.50026-1 · Cited by 546
Escobar-Morreale, H. F., Carmina, E., Dewailly, D., Gambineri, A., Kelestimur, F., Moghetti, P., Pugeat, M., Qiao, J., Wijeyaratne, C. N., Witchel, S. F., et al. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr042 · Cited by 494
Metadata
- Authors
- Auchus, R. J., & Rainey, W. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Auchus, Richard J.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2003-11-24
- Volume
- 60
- Issue
- 3
- Pages
- 288-296
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2119552011
- Cited by
- 296
- References
- 84
- Citations by year
- 2026: 13 · 2025: 5 · 2024: 5 · 2023: 17 · 2022: 11 · 2021: 11 · 2020: 12 · 2019: 7 · 2018: 13 · 2017: 16 · 2016: 19 · 2015: 13 · 2014: 18 · 2013: 10 · 2012: 18
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- adrenarche, dehydroepiandrosterone, DHEA sulfate, adrenal zona reticularis, pubarche, premature adrenarche, adrenal steroidogenesis, aging, Old World primates, enzyme cofactors
- MeSH terms
- Adolescent, Adrenal Cortex Diseases, Adrenal Cortex Hormones, Child, Child Development, Female, Hair, Humans, Male, Puberty, Zona Reticularis, Dehydroepiandrosterone Sulfate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
